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A Single Dose Of Psilocybin Can Lead To ‘Rapid’ And ‘Long-Lasting’ Improvements In Depression, Study Indicates

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A single dose of psilocybin, combined with therapy sessions, significantly improved depression symptoms within days and lasted for months, according to a first study published by the Swedish Medical Association.

Researchers from the Karolinska Institutet and the Stockholm Brain Stimulation Clinic conducted a phase 2 randomized clinical trial with 35 participants with moderate-to-severe depression who received a 25-milligram dose of psilocybin or placebo niacin.

For the study, published last week in JAMA Psychiatry, patients also underwent five psychotherapy sessions to complete either the psychedelic experience or a placebo.

The psilocybin cohort showed, on average, clinically observable improvements at day 8 compared to the placebo group.

“This finding means that psilocybin may be an alternative to standard treatments when symptom relief is important,” the paper says.

“A single dose of psilocybin was associated with rapid antidepressant effects.”

By the sixth week of the trial, 53 percent of the psilocybin cohort was considered to be in remission from depression, while only 6 percent of the placebo group said so.

However, the researchers found that the overall effect faded after a year.

“Our results suggest that psilocybin may provide rapid and clinically meaningful improvements in depression and may serve as an alternative to standard treatment when symptom reduction is important.” analyze Author Hampus Yngwe said in a press release.

“However, the long-term effects are uncertain. Repeated treatments may be needed to prevent relapse,” he said. “This needs to be investigated in larger studies.”

“Our findings indicate that psilocybin may be a valuable addition to current treatments due to its rapid onset and relatively long-lasting effects, although the duration may not be as long as previous uncontrolled studies suggest. Therefore, repeated dosing or maintenance therapy may be needed to prevent relapse.”

Johan Lundberg, professor of neuroscience at the Karolinska Institute, add “It is important to emphasize that the treatment is not without risk and that some patients need additional support.”

This is the first randomized, double-blind study in Sweden investigating psilocybin for depression. The researchers received funding from the Swedish Research Council and Norrsken Mind.

However, this is hardly the only research to suggest that a single dose of psychedelic therapy can have lasting effects in the treatment of a variety of mental health conditions.

For example, another study recently published by the American Medical Association (AMA) found this A dose of psilocybin, an integrated psychotherapy, appears to be a “safe and effective” treatment option. for people with cocaine use disorders (CUD).

That study was published about two months after the AMA released another study that found this A single dose of psilocybin combined with therapy “significantly increased long-term abstinence.” compared to nicotine patches from cigarettes. This indicates that psychedelics “have potential in the treatment of tobacco use disorder,” the researchers said.

As psychedelic policy reform progresses in the United States legislature and Congress, Americans have shown increasing interest in exploring the therapeutic potential of substances such as psilocybin. To that point, a RAND Corporation study recently found that nearly 10 million American adults microdosed psychedelic drugs such as psilocybin, LSD, or MDMA. in 2025

A scientific review published by the AMA last year Psilocybin use has “surged” in the US in recent years amid the decriminalization movement and given the “promising results of clinical trials” regarding its therapeutic potential. But the document also noted that current federal laws present a “significant barrier” to researchers better understanding the true impacts of the psychedelic substance.

Meanwhile, another study last year found that psilocybin assisted psychotherapy “It showed significant reductions in alcohol consumption and high rates of smoking cessation” and has the potential to reduce opioid addiction.

On the other hand, in 2024, two more investigations – including the contributions of a top federal drug official.studied psychedelics and alcohol use disorder (AUD)..

One found that a single dose of psilocybin was “safe and effective in reducing alcohol consumption in AUD patients,” and the other concluded that classic psychedelics such as psilocybin and LSD “have demonstrated potential to treat drug addiction, particularly AUD.”

That year, the National Institute of Health also announced the same It would put $2.4 million toward studies on the use of psychedelics to treat methamphetamine use disorders.– The funding comes as federal health officials report a sharp increase in deaths from methamphetamine and other psychostimulants in recent years, with fatal overdoses from the substances increasing nearly fivefold between 2015 and 2022.

In 2023, the National Institute on Drug Abuse (NIDA) announced that a $1.5 million in funding rounds to further study psychedelics and addiction.

Meanwhile, the Trump administration has Steps have recently been taken to explore the therapeutic potential of psychedelics such as ibogainewhich has been touted as a potentially life-saving treatment option for people with serious mental health conditions such as post-traumatic stress disorder (PTSD) and substance use disorder.

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It’s Marijuana Time tracking hundreds of cannabis, psychedelic and drug policy bills in state legislatures and Congress this year. Patreon supporters by pledging at least $25/month, you can get access to our interactive maps, charts and listening calendars so they don’t miss any developments.

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Other studies have also suggested that psychedelics could hopefully unlock new avenues for treating addiction. A first study carried out in 2023 shed some new light. Psychedelic-assisted therapy works for people with alcohol use disorder.

In 2024, the National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health (NIH), He identified the treatment of alcohol use disorder as one of the possible benefits of psilocybinalthough the substance remains a Schedule I controlled substance under US law.

The agency highlighted a 2022 study that “suggests that psilocybin may be helpful for alcohol use disorders.” The study found that people in psilocybin-assisted therapy had fewer drinking days than the control group over 32 weeks, and the NCCIH said it “suggests that psilocybin may be helpful for alcohol use disorders.”

user photo Dick Culbert.

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We don’t really deal with a lot of mites because of our IPM program

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8 hours ago

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June 9, 2026

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Flora Farms Pest Management Program it is built to reduce to nothing depending on the harvestso the plant ends up clean. Luke Allenbrand, Flora Farms’ crop leader, leads an integrated pest management program that focuses on prevention. “We don’t honestly deal with a lot of mites because of the IPM program, because of the predatory mites that we’ve put down as a precaution,” says Luke. “It allows us to have a much cleaner garden in the back half.” Preventative work keeps spray volumes relatively low because the curative side of the program rarely needs to be heavy.

“Actually, we are at the lowest number of these sprays that we have. The milliliters that we are using are numbers that do not exist to be a prevention,” says Luke. “But as soon as you see an uptick of those mites or anything, we bring it up to a therapeutic amount, which is still a small milliliter. And as long as you’re on a fast track with it, you see them disappear within 10 days.” The targets are spider mites, which feed on the plant’s THC and terpene production and degrade the flower.

© Flora Farms

Tested solutions
The three products used by the company are derived from agricultural and food use. “We actually apply about three insecticides that are very common around the agricultural and food grade of these products, using a suite of IPM, Venerate and Grandevo, insecticides that will deal with these mites,” says Luke. The application is intermittent rather than constant. “We usually use a 5-day spray cycle so we can have rest periods in between, so it’s not just a consistent density of that spray,” says Luke. He sees progress against mites in the gaps between the successions.

However, at some point, the spraying stops. “We finish the spray cycle by day 40. We usually don’t want to spray anywhere after day 40. At that point, you’re going to damage the product,” says Luke. “And at that point, we’ll put predatory mites in. It really helps us get to that final push point by day 59, 60 of that harvest. So we actually have a lot less of our spray in that late period. So it’s a much better tasting product.” Predatory mites take over the job of spraying, leaving nothing on the flower.

Biological control
Biological control has two forms. “We usually use them, they’re called crazy mites, and honestly, it’s crazy to see,” says Luke. “Actually, I’ve seen some of the ones in a close-up photo kill a bug, some of the cocoons actually drive away, and even attack the spider mites themselves. Very beneficial. Callias are also slow. They’re little bags that we hang on plants and they’re very beneficial to us.” Different predators work at different speeds, which is why the program runs more than one.

Missouri’s testing regime is the context in which growers operate. Each plant is tested for pest control chemicals and must pass before the product goes ahead. “Other crops and other black market shops or smoke shops in Missouri don’t have to worry about the testing we have to do,” Luke says. “Everything we use here is natural. Each of our pest management is a lot of essential oils that fight these mites. Everything we would put on a plant is food grade.” The test covers foreign chemicals, heavy metals, and anything else that an unregulated supply should never consider.

The whole arc is from biology to chemistry and back to biology. “We go from predatory mites to a food-grade spray regimen, and then back to predatory mites at the end. That way, these plants will have time to finish with no chemicals, nothing,” says Luke. “The rest of that life cycle, about 15 to 20 days, is the most natural it will have. No spraying at all during that, just to push predatory mites off that end, so there’s no residual mite damage on those plants.”

For more information:
Flower Farms
florafarmsmo.com

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California Bill To Legalize Marijuana Dispensary Drive-Thru Windows Advances In Senate After Clearing Full Assembly

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8 hours ago

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June 9, 2026

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It has been passed by a California Senate committee and passed by the Assembly bill that would allow marijuana dealers to offer car windows to serve customers.

The measure, which cleared the Senate Business, Careers and Economic Development Committee on a 7-3 vote Monday, says licensed cannabis retailers and micro-businesses with storefronts can sell marijuana products “in a motor vehicle to a customer in a drive-through located on the premises.”

Under Assemblywoman Gail Peller’s (D) AB 2697, cannabis businesses would need permission from the local jurisdictions in which they operate to add a drive-thru.

The sponsor told committee members before the final vote that the bill will “expand access to legal cannabis products while strengthening our ability to compete with the illegal market.”

Annie Aubrey of Chuck’s Wellness Center, a retailer in Placerville, testified that the legislation is “about improving access.”

“A large portion of our customers use cannabis as medicine, including seniors, veterans and people living with chronic conditions that affect mobility, the population that this regulated system seeks to serve,” he said. “For many, even simple tasks like getting out of a vehicle or navigating a retail space can be physically difficult or prohibitive…A drive-thru option removes that barrier, giving patients and consumers access to what they need in a way that’s dignified and consistent with their healthcare needs.”

Amy O’Gorman Jenkins of the California Cannabis Operators Association said the legislation will provide “operational flexibility” in a highly regulated system.

“It doesn’t expand who can access cannabis,” he said. “It allows retailers, with local approval, to serve existing patients and customers more efficiently.”

Jenkins also argued that this measure could improve security.

“Currently, road traction transactions are already allowed. This means that workers regularly have to leave a safe premises while transporting the product, and sometimes they have to deposit cash in parking lots,” he said. “AB 2697 provides an additional mechanism for obtaining product, but requires a fixed and secure transaction point, keeping employees inside and reducing exposure to theft.”

Pellerin, the bill’s sponsor, previously said that “California cannabis retailers lack a common and accessible transaction channel for consumers that so many other retailers in California offer, including fast food, pharmacies, banks and even liquor stores.”

“Cannabis consumers with mobility issues or other disabilities have limited options for obtaining cannabis without having to get out of their vehicles. And while home delivery is legal, there are restrictions on service areas,” he said. “Allowing cannabis sellers to add a secure ride option, if allowed by their local jurisdiction, will improve the consumer experience, increase the security of cannabis sellers and help expand California’s legal cannabis market.”

The California Association of Narcotics Officers opposes the proposal, however, as a representative, Ryan Sherman, testified that it would make it more difficult for dispensary workers to check the IDs of customers who are of legal age or to spot signs of current intoxication at drive-thru windows.

“This bill prioritizes speed of sale over public safety while undermining existing protections designed to prevent illegal sales and protect public safety,” he argued.

Under current policy during the COVID pandemic, dispensaries can already offer street pickup.

The invoice that moving forward in the legislature would mandate that auto sales “be made through a fixed panel security window with a security drawer or similar secure transfer mechanism that is part of a building located within the premises.”

—
It’s Marijuana Time tracking hundreds of cannabis, psychedelic and drug policy bills in state legislatures and Congress this year. Patreon supporters by pledging at least $25/month, you’ll get access to our interactive maps, charts, and audio calendars so you never miss a development.

Learn more about our marijuana bill tracking and become a Patreon supporter to gain access
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California regulators recently approved emergency rule changes to the state’s marijuana licensing process. to make it easier for companies to receive benefits In line with the Trump administration’s latest move to federally regulate medical cannabis.

While Gov. Gavin Newsom (D) recently He took credit for helping lead the state’s push to legalize marijuana and discussed his limited experience with cannabis use.

In October, however, Newsom vetoed a bill that would have It allowed micro-marijuana companies to ship medicinal cannabis directly to patients Through common carriers like FedEx and UPS, he said the proposal would be “too burdensome and complex to manage.”

Newsom signed a bill earlier this month streamlining research into marijuana and psychedelics.

In September, the governor also signed a measure pause on the recent tax increase on marijuana products.

Separately, the state attorney general says Indian tribes cannot independently participate in the marijuana trade with licensed cannabis businesses without obtaining their own commercial license from state officials.

California officials have recently been rewarded nearly $30 million in grants for marijuana-focused academic research projects.

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Concert Series Specials launched for state medical cannabis patients

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1 day ago

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June 8, 2026

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Post Dispensary, Kentucky’s first medical cannabis dispensary, is connecting with patients in Owensboro, Henderson, Bowling Green, Elizabethtown, Madisonville, Hopkinsville and surrounding areas by aligning unique specials with the region’s summer concert calendar. Located at 300 N Main St. in Beaver Dam, minutes from major highways connecting these vibrant cities.

This summer, The Post Dispensary is offering special pricing and incentives for Concert Series Events at the Beaver Dam Amphitheater, SPARKS in the Park 4th of July celebration and surrounding events, such as Owensboro’s ROMP Festival (June 24-27, 2026). Patients can stop by before or after shows for big savings.

“We’re more than just a booty,” said a dispensary representative. “From Owensboro’s world-class ROMP Festival to Beaver Dam’s Amphitheater events, we’re making it convenient and budget-friendly for patients in Owensboro, Henderson, Bowling Green, Elizabethtown, Hartford and beyond to combine our love of music with compassionate care and an affordable product.”

The Post Dispensary hosts regular Patient Guidance events on the second Saturday of every month. These units have professionals on hand to assess patients and issue written certificates at low cost, application support and expert consultations in a welcoming environment. The next Patient Drive aligns perfectly with summer travel patterns, making it easy for patients from Owensboro, Bowling Green, Elizabethtown, Madisonville, Henderson, Madisonville and surrounding towns to plan a trip to Beaver Dam that combines care with community and entertainment.

For more information:
Post-Dispensary
thepostdispensary.com/










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