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A Single Dose Of Psilocybin Can Lead To ‘Rapid’ And ‘Long-Lasting’ Improvements In Depression, Study Indicates
A single dose of psilocybin, combined with therapy sessions, significantly improved depression symptoms within days and lasted for months, according to a first study published by the Swedish Medical Association.
Researchers from the Karolinska Institutet and the Stockholm Brain Stimulation Clinic conducted a phase 2 randomized clinical trial with 35 participants with moderate-to-severe depression who received a 25-milligram dose of psilocybin or placebo niacin.
For the study, published last week in JAMA Psychiatry, patients also underwent five psychotherapy sessions to complete either the psychedelic experience or a placebo.
The psilocybin cohort showed, on average, clinically observable improvements at day 8 compared to the placebo group.
“This finding means that psilocybin may be an alternative to standard treatments when symptom relief is important,” the paper says.
“A single dose of psilocybin was associated with rapid antidepressant effects.”
By the sixth week of the trial, 53 percent of the psilocybin cohort was considered to be in remission from depression, while only 6 percent of the placebo group said so.
However, the researchers found that the overall effect faded after a year.
“Our results suggest that psilocybin may provide rapid and clinically meaningful improvements in depression and may serve as an alternative to standard treatment when symptom reduction is important.” analyze Author Hampus Yngwe said in a press release.
“However, the long-term effects are uncertain. Repeated treatments may be needed to prevent relapse,” he said. “This needs to be investigated in larger studies.”
“Our findings indicate that psilocybin may be a valuable addition to current treatments due to its rapid onset and relatively long-lasting effects, although the duration may not be as long as previous uncontrolled studies suggest. Therefore, repeated dosing or maintenance therapy may be needed to prevent relapse.”
Johan Lundberg, professor of neuroscience at the Karolinska Institute, add “It is important to emphasize that the treatment is not without risk and that some patients need additional support.”
This is the first randomized, double-blind study in Sweden investigating psilocybin for depression. The researchers received funding from the Swedish Research Council and Norrsken Mind.
However, this is hardly the only research to suggest that a single dose of psychedelic therapy can have lasting effects in the treatment of a variety of mental health conditions.
For example, another study recently published by the American Medical Association (AMA) found this A dose of psilocybin, an integrated psychotherapy, appears to be a “safe and effective” treatment option. for people with cocaine use disorders (CUD).
That study was published about two months after the AMA released another study that found this A single dose of psilocybin combined with therapy “significantly increased long-term abstinence.” compared to nicotine patches from cigarettes. This indicates that psychedelics “have potential in the treatment of tobacco use disorder,” the researchers said.
As psychedelic policy reform progresses in the United States legislature and Congress, Americans have shown increasing interest in exploring the therapeutic potential of substances such as psilocybin. To that point, a RAND Corporation study recently found that nearly 10 million American adults microdosed psychedelic drugs such as psilocybin, LSD, or MDMA. in 2025
A scientific review published by the AMA last year Psilocybin use has “surged” in the US in recent years amid the decriminalization movement and given the “promising results of clinical trials” regarding its therapeutic potential. But the document also noted that current federal laws present a “significant barrier” to researchers better understanding the true impacts of the psychedelic substance.
Meanwhile, another study last year found that psilocybin assisted psychotherapy “It showed significant reductions in alcohol consumption and high rates of smoking cessation” and has the potential to reduce opioid addiction.
On the other hand, in 2024, two more investigations – including the contributions of a top federal drug official.studied psychedelics and alcohol use disorder (AUD)..
One found that a single dose of psilocybin was “safe and effective in reducing alcohol consumption in AUD patients,” and the other concluded that classic psychedelics such as psilocybin and LSD “have demonstrated potential to treat drug addiction, particularly AUD.”
That year, the National Institute of Health also announced the same It would put $2.4 million toward studies on the use of psychedelics to treat methamphetamine use disorders.– The funding comes as federal health officials report a sharp increase in deaths from methamphetamine and other psychostimulants in recent years, with fatal overdoses from the substances increasing nearly fivefold between 2015 and 2022.
In 2023, the National Institute on Drug Abuse (NIDA) announced that a $1.5 million in funding rounds to further study psychedelics and addiction.
Meanwhile, the Trump administration has Steps have recently been taken to explore the therapeutic potential of psychedelics such as ibogainewhich has been touted as a potentially life-saving treatment option for people with serious mental health conditions such as post-traumatic stress disorder (PTSD) and substance use disorder.
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Other studies have also suggested that psychedelics could hopefully unlock new avenues for treating addiction. A first study carried out in 2023 shed some new light. Psychedelic-assisted therapy works for people with alcohol use disorder.
In 2024, the National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health (NIH), He identified the treatment of alcohol use disorder as one of the possible benefits of psilocybinalthough the substance remains a Schedule I controlled substance under US law.
The agency highlighted a 2022 study that “suggests that psilocybin may be helpful for alcohol use disorders.” The study found that people in psilocybin-assisted therapy had fewer drinking days than the control group over 32 weeks, and the NCCIH said it “suggests that psilocybin may be helpful for alcohol use disorders.”
user photo Dick Culbert.
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Post Dispensary, Kentucky’s first medical cannabis dispensary, is connecting with patients in Owensboro, Henderson, Bowling Green, Elizabethtown, Madisonville, Hopkinsville and surrounding areas by aligning unique specials with the region’s summer concert calendar. Located at 300 N Main St. in Beaver Dam, minutes from major highways connecting these vibrant cities.
This summer, The Post Dispensary is offering special pricing and incentives for Concert Series Events at the Beaver Dam Amphitheater, SPARKS in the Park 4th of July celebration and surrounding events, such as Owensboro’s ROMP Festival (June 24-27, 2026). Patients can stop by before or after shows for big savings.
“We’re more than just a booty,” said a dispensary representative. “From Owensboro’s world-class ROMP Festival to Beaver Dam’s Amphitheater events, we’re making it convenient and budget-friendly for patients in Owensboro, Henderson, Bowling Green, Elizabethtown, Hartford and beyond to combine our love of music with compassionate care and an affordable product.”
The Post Dispensary hosts regular Patient Guidance events on the second Saturday of every month. These units have professionals on hand to assess patients and issue written certificates at low cost, application support and expert consultations in a welcoming environment. The next Patient Drive aligns perfectly with summer travel patterns, making it easy for patients from Owensboro, Bowling Green, Elizabethtown, Madisonville, Henderson, Madisonville and surrounding towns to plan a trip to Beaver Dam that combines care with community and entertainment.
For more information:
Post-Dispensary
thepostdispensary.com/
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German imports of medical cannabis flowers fell to 50.5 tonnes in the first quarter of 2026, down from 60.8 tonnes in the previous quarter, the decline from the first quarter of 2024. According to a new EU and UK market update from Whitney Economics.
The drop lands against a year that went backwards. Germany took in more than 2025 tonnes of the product in 2025, more than double the 72,850 kilograms recorded in 2024, and import volumes have risen every year since 2018, when the figure remained below 4,500 kilograms. The first quarter number continues to match the high pace of 2025, which is why the report treats it as an early sign of stabilization rather than a turnaround.
Prices
The volume has not created a stable price. A gram of cannabis in a German pharmacy is approaching 4 euros, while a gram on the illegal market is around 8 euros, reversing the usual relationship between regulated and unregulated supply. The wholesale price is around 2 euros per gram, roughly half the retail price at the pharmacy. Pharmacy prices breached 3.99 euros in November 2025, and the report puts the overall compression close to 25% in two and a half years.
Germany legalized ownership in 2024 and restricted sales to pharmaceutical and telemedicine providers. Two access roads run parallel. Medical cannabis is mainly prescribed through private prescriptions, and recreational cannabis is available through membership of a cannabis association, with 400 licensed cultivation associations across the country, although the exact count varies by source. It is the medical segment that drives market growth, not the recreational segment.
Growth is based on telemedicine
Patients fill out an online questionnaire, receive a prescription from an affiliated physician, and in many cases have their order filled through an integrated pharmacy partner, with delivery within days and, in some cities, within hours. Between 600,000 and 700,000 self-employed consumers are supported by the telemedicine industry, compared to 200,000 to 300,000 medical patients supported by pharmacies. Total imports are now sufficient to supply between 900,000 and one million consumers.
© Philiprowe | Dreamstime
Market exposure
Critics argue that commercial interests risk overshadowing the medical nature of the system, and treatment does not always meet the required standard of control. Legislative initiatives that would tighten the framework are already on the table, including mandatory in-person inquiries and a ban on distribution of mail requests. The likely result of both measures is a significant decline in demand for medical cannabis flowers. Many telemedicine companies are preparing for the opportunity by building networks with local doctors and pharmacies.
Where patients and consumers would go if medical access is curtailed is an open question, as the recreational market lacks a real alternative for patients and cannabis clubs continue to face licensing hurdles at the state level.
Part of the difficulty in reading the market is that import figures say less than they seem. More cannabis is entering the country than ever before, but how much is reaching consumers and what the actual demand is is unclear. Without a nationwide data framework, the market functions as a black box, and excess supply and actual demand are difficult to measure with great precision. Supply has tended to expand faster than the market can absorb, with no forecast to confirm mature demand, and prices have adjusted downward as a result.
Germany has had a signal effect across Europe since the start of its reform, although its model has drawn criticism, with the mixing of medical and recreational consumption a recurring complaint. Countries that have traditionally taken a conservative line, France among them, have gone to a more formalized medical field, under stricter conditions and without adopting the medical flower like Germany.
For more information:
Whitney Economics
Beau Whitney
(503) 724-3084
www.whitneyeconomics.com
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