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Cannabigerol (CBG): Before CBD and THC

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Cannabis in its full spectrum is an elaborate map that two components in isolation cannot give justice to. A map consisting of an interconnected system. The discovery and explosion of CBD’s endless potential is young relative to its infamously intoxicating counterpart, THC. Beyond the wellness buzz is yet another medicinal treasure cove – Cannabigerol.

Introducing CBG

Minor domains in cannabis’ intricate structure now deserve attention.

In Canada, Whistler Medical Marijuana Corp carries its own unique THC:CBG strain, Shiatsu Kush, available to British Columbia ACMPR patients. A profile of 6-8% THC and 5-7% CBG make this an exceptionally unique chemovar.

GW Pharmaceuticals, the developers of Sativex and Epidiolex have patents for CBG formulations, but no released products, as of July 2019.

Whereas in the United States and Europe, a select few companies do have hemp-derived CBG isolates available.

Others are working to breed stable seed lines of CBG, or hunting hemp varieties for a breed that is viable for producing extracts.

Cannabigerol
Bluebird Botanicals.

Before THC

Acidic cannabigerol is also known as CBGa. This is the first cannabinoid to blossom within cannabis’s chemistry. It typically appears in minute concentrations and cannot be easily captured due to it rapidly transitioning into either THCa, CBDa, and/or CBCa. Which route it will take depends on individual growth environments including, but not limited to, acidity, light, and heat. Each strains genetic influence on its own composition plays a perpetually important role, too. Growers manipulate these traits to achieve their desired result.

Developing cannabigerol dominant cannabis and hemp varieties has been an ongoing feat for a few producers now. ‘Pheno hunting’, breeding, utilizing a two week shorter grow cycle, or lower temperatures with a higher PH are all strategies these growers have implemented. Efforts have also been made in halting certain enzymes that promote cannabinoid metamorphosis, a biological process known as isomerization.

Cannabigerol

What is “acidic” cannabigerol?

The letter “a” stands for an extra “acid,” a basic carboxylic acid. With the extra little attachment, the cannabinoid is too big to pass through your blood-brain-barrier. The unstable acidic addition breaks away after you apply heat during smoking, vaporizing, or cooking. Active cannabinoids small enough to enter your brain stay intact during a process more commonly referred to as decarboxylation.

Skipping CBD

Liberty Cut Cookies by Liberty Farms is known to carry little to no CBD next to ~22% THC, while still holding onto approximately 3% CBG.

In a majority of strains, CBGa turns into CBDa before becoming THCa. Breeds with rare, still underappreciated genetics, do not have a CBD path. Genetics and ultimately enzymes exist in these rare varieties that can quickly turn cannabigerol directly into tetrahydrocannabinol. Certain Phenotypes of GSC, for example, can carry this unusual trait.

A quick glance into a vast medicine cabinet

Moving through Cannabigerol’s cabinet we find varying evidence for many medicinal properties; important to explore as a multifaceted anti-inflammatory, antioxidant, neuroprotective and regenerative aid, antibacterial, and an endocannaninoid system regulator.

All suggesting widespread therapeutic potential for:

  • Cancer
  • Huntington’s Disease
  • MS
  • Glaucoma
  • Immune dysfunction
  • Pain
  • Muscle spasms
  • IBD
  • Bladder dysfunctions
  • Antiemetic
  • PTSD
  • Anxiety
  • Psoriasis
  • Cachexia
  • MRSA

As well as many anti-inflammatory and neurodegenerative diseases.

This list of effects is certainly worth exploring to understand how each compliment and compares to CBD.

Beyond an Introduction

Cannabis studies are constant. Research is becoming blissfully unrestricted for licensed production and science communities. In the future, we can discuss, in confidence, the wonderful effects currently established on mice. Through these studies, certain strains, and limited product test releases a vague understanding of Cannabigerol’s effects are brought into the light.

Science will dwell deeper in their search. For now, we can travel across what information has already been presented. Follow along Cannabis Life Networks’ new series to find out exactly what Cannabigerol is.

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CBG Mania: What Are the Best Ways To Use And Consume CBG?

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Cannabigerol (CBG) is quickly becoming one of the most popular cannabinoid products these days. More than just a buzzword, CBG exists in the hemp plant as a precursor to CBD as well as THC. Also known as the mother of all cannabinoids, it can only be found in the plant’s blooming phase before the cannabinoids are converted into CBD or THC. However, due to the short blooming timeframe of the hemp cannabis plant, it can be challenging to find products that are rich in CBG.

When CBG is still in its precursor form, better known as cannabigerolic acid (CBGA), it doesn’t produce any psychoactive effects. Once it converts to CBG form, its original properties go through a transformation although there are also other properties that remain the same. Pure CBG can naturally be found in small concentrations that are usually less than 1% in the hemp plant so it took a while for researchers to take it seriously and study it.

Now, we have farmers and scientists that are devoting more time to genetic studies on CBG. There are now more hemp cultivars that have a higher CBG content, allowing everyday people like you and me to benefit from its therapeutic benefits.

Benefits of CBG

Just like CBD, CBG isn’t intoxicating so you can consume it without worrying about getting high. It’s a beneficial cannabinoid for treating stress, anxiety, and pain. Studies show it also has antibacterial activity.

Researchers have found that it has potent anti-inflammatory properties but a word of caution: it’s best not to mix CBG intake with THC or CBD since they have different effects on the body.

Dosage

As of the time of writing, there is no standard dosage instructions for CBG.

However, we can follow the standards that have been determined for CBD and THC. There are many personal factors that affect finding the right dose for you, which includes your overall baseline health, age, weight, underlying conditions, and your previous experience with cannabis, if any. Just like with cannabis, we always recommend starting small and going slow.

RELATED: OSU Study Finds CBGA And CBDA Block COVID-19 Virus

When shopping for CBG products, manufacturers will indicate either in percentage or MG form the quantity of CBG. If a manufacturer doesn’t indicate this information, you can check their website or any lab results. Manufacturers may already have a recommended starting dose which you can start with, then work your way up gradually until you have found the quantity necessary for achieving your desired effect.

Gradually consuming CBG will help you get used to the cannabinoid. Start with 2.5 to 5mg of CBG as the smallest dose while you begin working your way up. While there are no fatal side effects for taking too much CBG, consuming an excess may lead to diarrhea, nausea, or vomiting until the cannabinoid has fully left your system although this may take 3-5 hours. However, everyone will react to it differently just like with other cannabinoids.

Generally speaking, CBG has shown to be well-tolerated and its effects are mild. Always remember to follow the recommended dose indicated by the manufacturer or brand.

Consumption

There are many ways you can consume CBG. Here are some products to look for:

CBG Isolate: Similar to other isolate products on the market, CBG isolate ensures you get the purest form possible. This is ideal for individuals who want to create edibles infused with CBG, or simply medicate with CBG without the properties of other products.

RELATED: How Effective Is CBG For Pain Relief?

Isolate can be consumed orally or infused with a carrier oil to make a tincture. If you intend to consume the isolate on its own, just put a drop or two (depending on its dose and the effects you’re after) underneath your tongue, where you can leave it for a minute before swallowing.

CBG Oil: When starting out with a new cannabinoid product, consuming it via oil is one of the easiest ways to control dosage. Simply put a few drops under your tongue, then hold it for 30-60 seconds so that the cannabinoid receptors located in this part of your mouth can more efficiently absorb it. This is an efficient way to get the most out of CBG.

THC oil
Photo by Rocky89/Getty Images

Moreover, CBG oil can also be added into food and drink. Many people enjoy adding CBG oil into coffee, shakes, smoothies, salads, baked goods, and salad dressings the way you would with other condiments. Keep in mind that it may not have a desirable flavor though adding it to other food and drink can hide the flavor.

RELATED: What Is CBG And Is It Legal?

Vaporizer: Vape CBG oil is also available, which are compatible with vape pens and vaporizers. Vaping cannabis products including CBG has been one of the most popular ways to consume cannabis since they are easy to do and more discreet compared to smoking flower because it produces very little smoke. Additionally, consuming it this way takes it directly to the lungs where it will reach the bloodstream almost immediately, so you can feel its effects straight away.

Flower: Hemp flower with higher-than-average amounts of CBG can also be found in the market. It’s much less concentrated compared to oils or isolate, and you are also getting the benefits of other cannabinoids when you smoke it via flower. Some CBG strains you can try include:

Conclusion

There are many reasons people are trying CBG these days. It’s an excellent form of cannabinoid that has multiple health benefits, including supporting overall health and well-being. Given that there are numerous ways that you can consume it, there’s no reason you shouldn’t be trying CBG today.

This article originally appeared on Cannabis.net and has been reposted with permission.



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Study Says… CBG For Glowing Skin

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With all the new cannabinoids coming out, and the cannabis properties being studied, it’s easy to get lost in it all. We already know a lot about THC and CBD, but what about CBG? And what’s the new research pointing to CBG for skin health? Here’s a look at minor cannabinoid CBG, and the low down on how this compound can be used to keep your skin glowing.

CBG is the new word in skin care, with new research pointing to tons of benefits like hydrated skin, less inflammation and redness, and a way to lessen blemishes. If you’re trying to keep your skin looking young, CBG might be the best way to do it. We cover everything in the cannabis industry, and work hard to bring you the best news out there. Make sure to subscribe to the THC Weekly Newsletter to keep up to date on everything going on, and to check out exclusive deals on flowers, vapes, edibles, and many other products! We’ve also got great offers on cannabinoid products, like HHC-O, Delta 8Delta 9 THCDelta-10 THCTHCOTHCVTHCP HHC. Find them in our “Best-of” lists, and enjoy!


What is CBG?

CBG (cannabigerol) is a cannabinoid of the cannabis plant, much like THC and CBD. Whereas THC and CBD occur in much higher amounts, CBG is a minor cannabinoid, only showing up as about 1% of the plant. CBG exists because of the decarboxylation of cannabigerolic acid, the precursor molecule to CBG. Most CBG gets converted to THC, CBD, or other cannabinoids during growth.

This does have one important implication. Though CBG is a naturally occurring cannabinoid, (unlike delta-10 THC or THC-O-A), it doesn’t occur in large enough amounts to be able to extract it from the plant and use for products. Manufacturing products requires a good bit of a raw material, and in this case, the plant itself cannot provide enough. So any CBG products out there can only exist by synthesizing the CBG.

Only a little research has been done on CBG thus far, but as the cannabis plant gains more and more traction, each little piece of it is being examined. This past month, the first research on CBG for skin care benefits was published, which we’ll get to in a minute. It can surely be expected that more research will be out on this compound soon enough, as its thought to play a role in many things, like stimulating the appetite, as an anti-inflammatory agent, for antibacterial properties, as an antioxidant, and with neuroprotective attributes. It is not psychoactive, and it’s chemical formula is C21H32O2.

CBG skin

In terms of legality, CBG isn’t specifically mentioned by a UN scheduling treaty. If it’s derived from marijuana (high-THC cannabis) it’s illegal, however, if derived from hemp (low-THC cannabis) it is legal. It should be remembered, that the need to synthesize it means that anything used for products will not be hemp-derived, but synthetically derived, and therefore not covered under the 2018 Farm Bill, which legalizes hemp products if they’re actually derived from hemp.

CBG can be bought in many forms. It can be an oil, a distillate, an isolate, as a high CBG flower, in vape carts, and in edibles like gummies. It can also be found in creams and other skin care products.

Research says CBG is great for the skin

Published January 13th, 2022, this study sheds a bit more light on CBG for the skin: In Vitro and Clinical Evaluation of Cannabigerol (CBG) Produced via Yeast Biosynthesis: A Cannabinoid with a Broad Range of Anti-Inflammatory and Skin Health-Boosting Properties. One of the findings of the study is that CBG has shown to regulate more genes than CBD, which include several related to skin health.

When skin cells were triggered to produce a cytokine reaction and show oxidative stress, it was shown that “CBG and CBD reduce reactive oxygen species levels in HDFs better than vitamin C.” CBG went a step further, inhibiting pro-inflammatory cytokine releases from inflammatory inducers like ultraviolet A (UVA), ultraviolet B (UVB), chemical, and C. acnes, much of the time more potently than CBD.

Study investigators used 20 subjects, who were given a 0.1% CBG serum, or placebo, which was put on the skin for two weeks after the skin was irritated by sodium lauryl sulfate (found in nearly every hair washing product). The CBG serum caused a statistically significant improvement over the placebo for transepidermal water loss, and reduction in redness.

The study went on to say, “While CBD and CBG modulate many targets at the gene level, the data presented here demonstrate that CBG has greater potency in modulating specific cutaneous targets.” They explained why this might be, saying, “CBG has previously been reported to act as a partial agonist for both CB1 and CB2, while CBD does not bind to CB2, but may affect CB1 receptor activity via an indirect method. Thus, we can speculate that CBG’s ability to modulate both cannabinoid receptors may lead to its improved activity and efficacy in skin.”

cannabis skin care

The study authors concluded: “We demonstrate for the first time that minor cannabinoid CBG, when applied topically, clinically promotes skin health by reducing the appearance of redness and improving barrier function better than a placebo. Based on the data presented here, CBG is an attractive new candidate for dermatological use, outperforming its more well-known derivative, CBD, in several in vitro studies.”

As a note, this study was not done using CBG directly extracted from the plant, but instead used synthetic CBG which was “prepared via biosynthesis using yeast strain CEN.PK2-1D.”

How does all this make CBG good for your skin?

Studies can get very technical, and sometimes we just want to know what it means for us as consumers. Since CBG has antioxidant properties, this implies it deals well with free radicles, which are a reason for premature aging. It has anti-inflammatory properties that can help bring down puffiness and redness in the skin, as well as antibacterial and antifungal properties that can help keep skin clear of infections.

This means CBG can calm down inflamed skin, reduce blemishes, clear out pores, balance sebum in the skin, and help with cellular turnover. Since CBG can help cells retain moisture, it can keep your skin looking and feeling hydrated. This also helps maintain a youthful appearance as drying skin is a part of aging. This ability to retain moisture helps the skin to show aging signs at a much slower pace, as well as helping it retain its glow.

Apart from these benefits for the skin, CBG is thought to enhance the function of the neurotransmitter anandamide, which effects feelings of pleasure, motivation, appetite regulation, sleep, and pain sensation. From previous research, CBG is also associated with bringing down inflammation from inflammatory bowel disease; reducing intraocular pressure in people who suffer from glaucoma; slowing down cancer cell growth, and possibly being a treatment for Huntington’s disease.

What CBG products for the skin exist?

Plenty of companies are getting in on the CBG game, offering products infused with just CBG, or a cannabinoid combination. In the future it can be expected that many more options will be available containing CBG. For now, here are a few possibilities for those interested in improving their skin’s health.

CBG flowers

Mask Skin Care offers a line of CBG infused products like Under Eye Patches ($8), Face Masks ($16), Anti-Aging Masks ($16), and Spotless Masks ($16) to help with blemishes and oily skin. The products are not tested on animals, have a USDA organic certification, and contain no toxic chemicals. Using natural extracts, this company produces products that help condition skin, and keep it at its finest. Interested buyers can check out the ‘Where to buy’ section to find retailers in their area.

Kanabigerol also has a whole line of CBG products. The company offers products like a Cosmetic Universal Ointment (€ 26.90/$30.77), Revitalizing Face Cream (€ 49.90/$57.08), Silky Cleansing Gel (€ 38.90/$44.49), and Skin Oil (€ 29.90/$34.20). All of these products are infused with 4% CBG. I did not see anything on the website about being cruelty-free, or being chemical free, and some products do contain Vaseline, which is mineral oil, and a byproduct of the oil industry.

The company Happy Dance also offers a CBG option with its Soul Revival CBD+CBG Hand Cream ($20), which is great for keeping your hands from getting too dry, what with constant handwashing, and exposure to the elements. This hand cream is made without formaldehyde, parabens, phthalates, propylene glycol, sulfates, synthetic dyes, or synthetic fragrances.

For those who want to use a pure oil on their skin, Pharma Hemp has CBG Drops (€44.90/$51.37). According to the company, these drops are produced using a raw extract made through an alcohol extraction, diluted with MCT oil. The oil contains a high amount of CBG along with other cannabinoids like CBD, and compounds like terpenes. It comes in three strengths: 5%, 10% (€84.90/$97.11), and 15% (€124.90/142.88).

Conclusion

Cannabis oil has many benefits from its many cannabinoids and terpenes within. Whereas a whole plant extract can certainly do some good, so can cannabinoids on their own. With more coming out every day about the benefits of CBG for the skin, the beauty industry is certainly taking notes, and incorporating this naturally-occurring cannabinoid into products.

Hello readers! Welcome to CBDtesters.co, your #1 internet location for the most relevant and important cannabis and psychedelics-related news of interest today. Check us out regularly to stay up-to-date on the constantly-moving universe of legal drugs and industrial hemp, and make sure to subscribe to The THC Weekly Newsletter, so you’re never late on getting the news.

DisclaimerHi, I’m a researcher and writer. I’m not a doctor, lawyer, or businessperson. All information in my articles is sourced and referenced, and all opinions stated are mine. I am not giving anyone advice, and though I am more than happy to discuss topics, should someone have a further question or concern, they should seek guidance from a relevant professional.





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How Effective Is CBG For Pain Relief?

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Pain is a common symptom in almost all diseases in the world. Since the dawn of civilization, medical workers have looked for ways to effectively manage pain, and have been successful in finding some. But, the quest is still on for better treatments to relieve pains.

The widespread acceptance of cannabis, as well as the new legislation supporting the plant’s use, has paved a way for scientists to discover what compounds make cannabis an effective therapeutic. Now, the world has learned that most cannabinoids are responsible for the medical abilities of cannabis.

The recent clinical studies and experiments being carried out on cannabis plants have revealed that one of its minor cannabinoids can be a better and more effective treatment for pain. This compound is cannabigerol (CBG).

What Is CBG And Why Is Everyone Comparing It To CBD?
Photo by Lukas Dvorak/EyeEm/Getty Images

Compared to tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabigerol is a fairly ignored compound. There is a lesser demand for it and like other minor cannabinoids, phytochemicals, and terpenes, very little research has been carried out on it.

To meet the demand for THC and CBD cannabis products, breeders have pushed aside the notion of trying to improve the other compounds that make up the plant. Growers are also focused on primarily cultivating cannabis plants for their THC and CBD contents.

Studies have shown that CBG may be a better treatment to provide pain relief, calm and balance in medical marijuana patients. But, just how effective can this compound be?

What Is Cannabigerol (CBG)?

Cannabigerol, commonly called CBG, is a minor cannabinoid that is non-psychoactive. It can be found in large concentrations in High-CBD and Low-THC cannabis strains like hemp.

The distinction between CBG and other minor cannabinoids is that cannabigerol is the main producer of THC and CBD. This may sound confusing, but the explanation is that all cannabinoids were formed from their acidic precursors. In this case, CBGA (the acidic precursor of CBG) is produced in extreme amounts in cannabis plants, however, as the plant matures, most of it is converted to THCA and CBDA (both are acidic precursors of THC and CBD respectively). A very little amount of CBGA is converted to CBG. For this very reason, CBG is commonly referred to as the mother of all cannabinoids.

RELATED: What Is CBG And Is It Legal?

Like other cannabinoids, CBG binds with the cannabinoid receptors in the brain to elicit therapeutic responses. Rather than induce a psychoactive reaction in the user like THC does, CBG works instead to reduce the psychoactive effects brought about by THC. For example, when a cannabis user consumes products with higher levels of THC, it works to ease the induced paranoia or stress.

THC marijuana
Photo by Catherine Falls Commercial/Getty Images

Scientists claim that cannabigerol has the capabilities to fight pain, nausea, inflammation, and even has anti-cancerous properties. Clinical studies show that the compound was effective against glaucoma, as it was observed to significantly lower intraocular eye pressure associated with the condition. With CBG, conditions like Crohn’s disease, inflammatory bowel disease, and cancer can be managed effectively.

Effects of Cannabigerol

This rare cannabinoid has shown potential in treating a host of symptoms and disease conditions. Some of the symptoms it has shown effective in providing relief include

  • Pain
  • Inflammation
  • Oxidative stress
  • Anxiety
  • Stress

Cannabigerol and Pain

As stated earlier, cannabigerol is a rare and versatile cannabinoid that has the potential of managing a bunch of ailments, and a handful of studies have been published to corroborate these claims. When ingested, CBG is immediately broken down in the body to THC, CBD, and CBD compounds.

Exploring the Relationship Between Cannabigerol and Pain

A recent experiment studies the connection between chronic pain and cannabigerol. Patients who identify as frequency consumers of high-CBG products volunteered in numbers for the survey/study.

The researchers reported that this was the first clinical study in the use of cannabigerol. The survey documented the effectiveness of high-CBG cannabis in treating depression, chronic pain, anxiety, and insomnia. Over half of the volunteers reported that the drug was more efficenting than traditional pharmacotherapy. They also noted that there was a mild adverse effect that occurred. In addition to this, some respondents claim they had issues trying to withdraw from the products.

RELATED: What You Need To Know About The Healing Benefits Of Marijuana’s CBG

At the end of the survey, the researchers established that high-CBD cannabis and by-products are available in some dispensaries and are being sold in high numbers by cannabis patients. They also added that there is a need for more controlled trials of CBG-based cannabis medications to be precisely studied. More tests and research will assess the efficacy and safety of using CBG to treat symptoms like pain and stress. Researchers will also be able to establish a standard dosage for administration as well as the therapeutic implications of using the drug.

study people who purchase recreational marijuana are also looking for pain relief and sleep
Photo by Seth Ryan/EyeEm/Getty Images

CBG or THC: Which Is a Better Pain Reliever?

It is still too early to conclude on the best pain reliever. But, studies are being done to determine which is.

In the early 2000s, multiple clinical kinds of research were carried out to test the effectiveness of THC in relieving pain. Several of these studies reported that THC has more anti-inflammatory qualities than regular aspirin and hydrocortisone. It was also found to not pose the same risks of bleeding as observed in NSAIDs.

RELATED: These Are The Next Big Cannabinoids To Go Mainstream

The downside of THC is that it is a psychoactive drug, and as such might make it difficult for patients to adapt without the risk of addiction.

On the other hand, CBG and CBD which are non-intoxicating cannabis components may be better options. A 2017 study observed that CBG has even more potent anesthetic quantities than THC. Another study which was published in the 1970s, referenced in this 2008 research, stated that CBG could be used for conditions like chronic pain and anxiety disorders.

Conclusion

Cannabigerol shows great promise as a potential analgesic to manage pain in some medical conditions. Before it can be approved for clinical use, long-term clinical studies have to be carried out to fully observe the potentials of the compound. There are at least a dozen other minor cannabinoids that have also shown therapeutic potential. Some of them are CBC, THCV, and CBN. This shows that cannabinoids research has to progress from this limiting infant stage.

This article originally appeared on Cannabis.net and has been reposted with permission.



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