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CBD did not help people who got too high, study finds

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CBD news and products keep coming at us all hot and heavy, Leafly Nation. 

In the last 30 days, scientists found a common CBD claim didn’t hold up, but cannabidiol did help with opioid withdrawal. 

CBD’s mainstreaming also continued with a major sports deal. Plus, we found some new gummies, capsules, and tinctures we like—even one from Travis frickin’ Barker.

Leafly rounds up everything from the last month that’s fit to post about America’s second favorite pot molecule (after THC). Get up to speed with this essential rundown below.

Top CBD news of November

CBd did not lessen the impact of THC in this study series. (Courtesy Neuropsychopharmacology)
CBD did not lessen the impact of THC in this study series. (Courtesy Neuropsychopharmacology)

‘CBD Does Not Reduce Negative Effects of THC in Cannabis.’ “Overall, our advice to people wanting to avoid the negative effects of THC is to use less of it,” said Philip McGuire, the study’s senior author.” [Laboratory Equipment]

Anxiety went down, down, down on CBD in this study.
Anxiety went down, down, down on CBD in this study.

Clinical Trial: CBD Dosing Reduces Anxiety, Improves Cognitive Performance [NORML]

Cannabis, menopause, and the endocannabinoid system. “I’ve seen patients throughout most of the hormonal transitions. And I have seen cannabis be very, very helpful,” said Dr. Genester Wilson-King. [Project CBD]

Review: Data Suggests Role for CBD in Managing Opioid Withdrawal Symptoms. “Growing evidence suggests that CBD may have the potential to reduce anxiety, pain, and insomnia with also some signals for reducing craving, nausea, vomiting, muscle spasms, and blood pressure.” [NORML]

America's favorite pastime—baseball, and CBD marketing. (Courtesy Charlotte's Web)
America’s favorite pastime—baseball, and CBD marketing. (Courtesy Charlotte’s Web)

Major League Baseball became the first major sports league to ink a sponsorship deal with a CBD company last month. On October 12, Charlotte’s Web became “The Official CBD of Major League Baseball.” The partnership coincides with the launch of the CBD company’s Charlotte’s Web SPORT- Daily Edge tincture, a broad-spectrum product (meaning that the extract contains a range of cannabinoids from the hemp plant, but no THC).

“The CEO of edibles company Wana Brands is ponying up $3 million to further cannabis and psychedelic research at Johns Hopkins University (JHU).” [TheGrowthOp]

Legendary goth-metal band Type O Negative has jumped on the CBD train. #SureWhyNot. Their signature Blackberry No. 1 tincture—a cute reference to their spooky scary 1993 single “Black No. 1”—dropped last week, in collaboration with Texas-based Whole Organix

Ever find yourself jonesing for CBD-infused, booze-free wine? You’re also in luck. This summer, Health Advance Group launched its collection of 66° wines. Last week, the company announced its intent to expand rapidly across this grand land of ours. Soon, no connoisseur of CBD-infused, booze-free wine will go unsatiated.

Cannabidiol (CBD) infused beverages are worth $2.83B in 2021 [Digital Journal]

How do you know if your CBD is legit? [Forbes]

What are the health benefits of CBD coffee? [Medical News Today]

CBD Statistics: How Many People Uses It, Demographics, & More (2022 Data Update). “26% of Americans are using CBD in 2022; 64% of CBD users use CBD for pain.” [CFAH]

Cannabidiol (CBD) in Food [Alabama Public Health]

CBD products Leafly loved this month

Barker Organic Gummies

Travis Barker has a gummy for stage fright. (Courtesy Barker)
Travis Barker has a gummy for stage fright. (Courtesy Barker)

I’m feeling this! Lord knows that celebrities have overrun the CBD market with branded gummies, tinctures, and more. But we gotta hand it to Travis Barker, the generously-tattooed drummer of the (recently-reunited) Blink-182: His broad-spectrum gummies rise above much of the competition. While the citrus-y “Recovery” variety imparted a mildly plastic-y aftertaste, both the Green Apple Matcha “Maintenance” gummy (10 mg CBD and 10 mg CBG) and the effective “Sleep” (10 mg CBD and 10 mg CBN) gummy boasted a full-bodied taste, and a pleasantly dense chewiness.

Infinite Focus capsules

Sometimes we want to take our CBD in capsule form: No sugar, no flavors, no mess. I recently came across this exciting line of products from Colorado’s Infinite CBD. The Focus products—also available in gummy and tincture forms—contain 18mg of CBD isolate (meaning the extract does not contain any other cannabinoids and 2mg of CBG). Most notably, the Focus products also contain 25 mg each of 5-HTP, a compound that research suggests may boost serotonin levels and in turn help individuals suffering from depression or anxiety. 

R+R Medicinals tinctures

Get some rest and relaxation, soldier. R&R tincture.  (Courtesy R&R)
Get some rest and relaxation, soldier. R&R tincture. (Courtesy R&R)

The good folks at my local dispensary turned me on to this excellent Colorado brand. Their tinctures—made from a proprietary, certified organic strain of hemp—pack quite a punch: 2500 milligrams of CBD per one ounce bottle. That’s over 40 mg per dropper. (R+R offers lower-strength tinctures as well.) Bonus points: The R+R sweeties even throw in free shipping in the US. R+R sells their tinctures in both full-spectrum (up to 0.3% THC) and broad-spectrum varieties.

America’s best edibles for the holidays 2022

$45 / 200 mg CBD. Sold in CA and online nationwide. (Courtesy Rose LA)
$45 / 200 mg CBD. Sold in CA and online nationwide. (Courtesy Rose LA)

Our Leafly Danksgiving roundup tosses in some CBD edibles picks.

Other CBD reviews around the web

‘25 best CBD pills [Discover Magazine]

‘My favorite CBD products go on sale for Black Friday’ [Refinery29]

Related

What’s the difference between CBD and THC?

Better late than never, Congress just sent President Biden a cannabis research bill that’ll make it slightly easier to research THC and CBD. There’s tons of caveats, though. For example, scientists cannot study products actually in stores.

On November 1, Idaho will begin enforcing a ban of CBD and hemp products for pets. The policy has infuriated Idahoans, who, you know, want their pets to lead healthy, happy lives. I guess this is what they meant by “limited government?”

On October 21, Hong Kong officially outlawed CBD, putting it in the same category as heroin cocaine. In Hong Kong, that means up to seven years in prison. The policy will take effect in December.

CBD press releases and sponsored content

  • Rare Cannabinoid Company launches new delta-9 THC+CBC mood gummies [Leafly]
  • Take a dip in the Canna River [Leafly
  • These single-source CBD extracts let the plant shine [Leafly]
  • CBD for Weight Loss: Does It Really Work? 8 Brands We Recommend [Woman’s World]
  • 15 best CBD gummies for sex. [LA Weekly]

And that’s it for Leafly’s monthly novel CBD news roundup. It’s busy out there. We’ll keep an eye on the topic and see you next month for more.

Did CBD ever help you with being too high? Leave a comment below.

Max Savage Levenson's Bio Image

Max Savage Levenson

Max Savage Levenson likely has the lowest cannabis tolerance of any writer on the cannabis beat. He also writes about music for Pitchfork, Bandcamp and other bespectacled folk. He co-hosts The Hash podcast. His dream interview is Tyler the Creator.

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Cannabis Has Unique Benefits For People With Bipolar Disorder, Finds New Research

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Around 46 million people around the world struggle with the symptoms of bipolar disorder. Also known as manic depression, bipolar disorder can disrupt daily life, affecting relationships and ability to work.

There are three kinds of bipolar disorder: bipolar I, with symptoms including manic episodes that can last at least a week and may even require admission to the hospital; bipolar II is characterized by patterns of manic and depressive episodes, particularly elevated moods that make patients more agitated and energetic; and cyclothymic disorder, with symptoms including a rapid cycling of high and low mood swings, going from excessively energetic and happy to depressive in a switch.

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Photo by Maskot/Getty Images

Psychotherapy and medications are recommended for the treatment of bipolar disorder. Pharmaceutical medications are conventionally seen as necessary to help regulate moods. However, many patients don’t find relief from symptoms from pharmaceutical medications especially its effects take a while, and they usually come with side effects.

Cannabis is a safer, more natural alternative that can help patients with bipolar disorder.

brand new study, that sought to understand how cannabis affected cognitive and goal-directed behaviors among people with bipolar disorder, reveals that marijuana may have “uniquely beneficial effects” for this condition. Researchers, who presented the findings at the Neuroscience 2022 conference, specifically found that cannabis was effective in improving cognitive function while helping reduce risky decision making, which is common among individuals with bipolar disorder.

The researchers also suggest that cannabis reduces the dopaminergic activity in the brain to help suppress its symptoms.

“Chronic cannabis use may have uniquely beneficial effects in people with BD. Previous studies suggest that some people with BD have increased dopaminergic activity due to a reduced dopamine transporter expression,” they concluded. “Chronic cannabis use has been shown to reduce dopamine release, thus chronic cannabis use may result in a return to dopamine homeostasis in people with BD and consequently normalizing their deficits in goal directed behaviors. We are engaged in additional studies that explore this potential,” wrote the authors.

Other Studies

There have been similar findings in other older studies.

According a 2018 clinical trial data, researchers found that cannabis consumption is linked to improvement in clinical symptoms of bipolar disorder. It also doesn’t negatively impact cognitive performance, they shared. Researchers from Harvard Medical School, McLean Hospital, and Tufts University analyzed the impact of cannabis on cognitive function and moods among patients who have been diagnosed with bipolar disorder. This marked the first clinical trial to ever be conducted with the goal of analyzing how marijuana affects neuropsychological performance and mood.

RELATED: Does CBD Help With Social Anxiety? What The Latest Medical Studies Say

They found that cannabis use resulted in reduced scores for depression, anger, and tension. It was also associated with increased vigor. However, patients who consumed marijuana also showed no significant changes in cognitive performance compared to subjects who abstained.

“The current study highlights preliminary evidence that patients with BPD who regularly smoked marijuana reported at least a short-term clinical symptom alleviation following marijuana use, indicating potential mood-stabilizing properties of marijuana in at least a subset of patients with BPD,” they concluded.

ADHD anxeity
Photo by SIphotography/Getty Images

A significant portion of the population do not even know they have bipolar disorder. They do, however, experience mild symptoms of mood swings and other symptoms of dysregulated moods. For them, cannabis can also help.

2020 review from researchers at the University of New Mexico involving the analysis of real-life information taken from the Releaf App found that cannabis was effective in treating the symptoms of depression. “One of the more interesting findings from this study, is that cannabis flower with relatively high levels of tetrahydrocannabinol or THC is particularly associated with immediate reductions in the intensity of depressive feelings,” explains researcher Jacob Miguel Vigil.

“With no end to the depression epidemic in sight, and given the limitations and potential severe negative side effects of conventional antidepressant medications, there is a real need for people to be able to treat mood disturbances with natural, safe, and effective medications, and the cannabis plant checks off all three boxes,” he added.

RELATED: New Study Backs Claims That Cannabis Can Reduce Anxiety And Depression

Boosting the endocannabinoid system with the use of cannabinoid-based products has been shown to positively impact the neuroendocrine, neurotransmission, and neuroimmune systems. These systems are all greatly affected by those who suffer from depression and other mood disorders such as bipolar disorder.

In a 2006 study out of Montreal, researchers found that increasing the amount of endocannabinoids produced by the brain is effective in improving one’s mood. Investigators from the McGill University Health Center revealed that using the synthetic URB579 agent resulted in “potent anti-depressant-like effects” in animal models because it was successful in preventing cannabinoids from degrading.

It was the first study to ever prove that something external can help boost cannabinoids and overall mood.

RELATED: Indica Or Sativa: Which Is Best To Treat Anxiety?

According to lead researcher Gabriella Gobbi, “This is the first time it has been shown that a drug that increases cannabinoids in the brain can improve your mood,” she said.

Additionally, a 2020 report from BMC Psychiatry found that whole plant cannabis and plant-based cannabinoids are effective in improving moods and sleep while reducing anxiety and psychotic disorders.

Conclusion

While the body of research on cannabis for bipolar disorders is fairly young, the studies and anecdotal evidence is promising. If you or a loved one struggle with bipolar disorder and want to use cannabis or CBD products, be sure to do so with the guidance of your physician.

This article originally appeared on Cannabis.net and has been reposted with permission.



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Does CBD Modulate THC? No, Says Study – Cannabis | Weed | Marijuana

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Does CBD modulate the effects of THC? No, says a new study.

For years, both experience and research have indicated that CBD has a mitigating effect when consumed with THC.

For example, budtenders suggest a THC-strain balanced with CBD for new consumers to avoid overwhelming them.

When an experienced stoner has eaten an edible or taken some oil and feels too high – they use CBD to take the edge off.

But a recent study suggests this is all placebo.

How Could CBD Modulate THC?

CBD Modulate THC

More extensive studies will conclusively determine if CBD modulates THC. But for now, we’ll have to rely on conflicting research and anecdotal experiences.

CBD and THC have drastically different effects. THC stands for tetrahydrocannabinol, the most famous of all cannabis compounds. THC binds to our cannabinoid receptors to produce the “high” feeling.

CBD, on the other hand, doesn’t directly bind to our cannabinoid receptors. It is more like a psychedelic in that it targets the serotonin 5-HT1A receptors, which we find primarily in our stomach.

CBD also prolongs the life span of our endogenous cannabinoids: anandamide (AEA) and 2-arachidonoylglyerol (2-AG).

These endogenous cannabinoids bind to our cannabinoid receptors. Researchers figure that because CBD inhibits the breakdown of anandamide in the cannabinoid one receptor, THC can’t fully bind and thus has a muted effect.

Research performed under double-blind, placebo-controlled conditions suggested CBD can reduce the unpleasant effects of THC.

Other research disputes this. But what about this new study?

Does CBD Modulate THC? No, Says Study

psychosis

According to the latest study no, CBD does not modulate the effects of THC. Published in the journal Neuropsychopharmacologythis randomized, double-blind cross-over trial was thorough.

Researchers recruited 46 healthy volunteers ranging from 21 to 50 years old. They’d used cannabis before but not more than once per week during the previous year. Researchers asked them to inhale cannabis vapour containing 10mg of THC combined with different levels of CBD. 

So per experiment, they consumed a 10:0 ratio, then a balanced 10:10 ratio, followed by 10:20, and then 10:30. In other words, by the last experiment, participants were inhaling more CBD per milligram than THC. 

After each experiment, the researchers asked the participants to complete a set of tasks. Researchers measured “psychotic symptoms,” including “cognitive, subjective, pleasurable, pharmacological and physiological effects.”

For example, THC is associated with delayed verbal recall. The study said CBD did not improve those scores.

The study concludes, “There was no evidence of CBD modulating the effects of THC on other cognitive, psychotic, subjective, pleasurable, and physiological measures.”

Even going further to suggest, “This should be considered in health policy and safety decisions about medicinal and recreational cannabis.”

Yet, did this study conclusively determine these results? Even the authors admit their research can only go so far without a placebo-controlled group.

To suggest that “no evidence that CBD protects against the acute adverse effects of cannabis,” while other double-blind clinical trials have shown otherwise, indicates more to the story.

Building a CBD Tolerance 

CBD Modulate THC

This latest study suggested that CBD does not modulate the effects of THC in the short term. But what about the long term?

Cannabis connoisseurs know about tolerance. If you smoke weed daily, you build up a tolerance to THC. You can take a few days off and let your cannabinoid receptors reset. When you return to the herb, you’ll feel the effects more with less.

CBD might work the opposite way. It may promote receptor sensitivity, meaning you need less over time.

CBD may also reestablish homeostatic levels (bringing balance to your endocannabinoid system). So while it may give the impression it’s not doing anything, CBD is working with your system without producing the “psychotic symptoms,” of THC. 

At least one study suggests the longer you use CBD, the lower dosages you’ll need. Which is another way of saying: you need to build up some CBD in your system before it can work. 

With that in mind, how accurate was this new study? A short-term look at people inhaling THC-CBD vapour after a year of virtually no consumption?

And no placebo-controlled group, to boot.

Yet, these researchers want their inconclusive opinions “considered in health policy and safety decisions” about cannabis.

The Problem With the “CBD Doesn’t Modulate THC” Study

Langara College grant

Of course, the apparent problem with this “CBD doesn’t modulate THC” study is its short-term aspect, the lack of a placebo group, and the cannabis delivery method.

Cannabis is a complex plant, and if you consume THC or CBD through edibles, the body will process the cannabinoids differently.

Same for plant extracts. Were the volunteers of this study taking THC and CBD isolates in vape format? Or were these full-spectrum products containing other cannabinoids like CBG and CBN?

What would result if a participant ate 10mg of CBD edibles for two weeks straight and then smoked a one-gram joint with 25% THC? And what if we paired them with a participant who didn’t consume CBD two weeks prior? 

This is why more research is needed before inconclusive results should be “considered” in government policy. 

But the big problem with the “CBD doesn’t modulate THC” study comes down to bias.

The study says, “Cannabis users may reduce harms when using a higher CBD:THC ratio, due to the reduced THC exposure rather than the presence of CBD.”

Throughout the paper, the researchers engage in a priori extremism by labelling THC “harmful” without further discussion. It’s one of the biases built into the study. And we saw it earlier by referring to THC’s effects as “psychotic symptoms.”

But what evidence links cannabis, particularly the effects of THC, to “psychotic symptoms?”

When we consume THC, we don’t become “psychotic.” We get high. We become stoned. The fact that they didn’t use a neutral, scientific term to describe THC’s effects brings the entire paper into question.

Not to mention, English and Australian universities funded this study. Two countries not exactly known for their legal recreational cannabis markets. (Even their medical program is strictly controlled and absurdly risk-averse).

Furthermore, we have conclusive, double-blind, placebo-controlled studies that prove that CBD reduces anxiety. And since higher concentrations of THC cause anxiety in some people, it’s no surprise we have past studies indicating that CBD modulates the effects of THC. 

What Did This Study Prove?

CBD Modulate THC

The problem with this “CBD doesn’t modulate THC” study is its bias and limited scope. They created a category of “psychotic symptoms.” Then they tested this theory on a small group of participants in the short term without any placebo-controlled group.

It may be that CBD isn’t the modulating agent we think it is. Further studies may validate the conclusions of this study. 

But further research is needed. Governments destroyed nutrition science in the 20th century by accepting half-baked theories and biased research as proven facts.

With cannabis legalization sweeping the world, we cannot allow the same thing to happen to cannabinoid-based therapies. 





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Why Cannabis Users Have Better Orgasms & Overall Sexual Function, According To Study

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By Nina Zdinjak

Young marijuana enthusiasts and alcohol consumers have better orgasms and overall sexual function than those who abstain, according to a study undertaken in Spain, reported Marijuana Moment.

Researchers from the University of Almeria were inspired to tackle the controversy swirling around numerous previous studies that looked at the impact of cannabis and alcohol on sexual functioning, which disclosed both positive and negative effects. And so, Spanish researchers created a new observational study that concluded: “Sexual function in young people who use cannabis and alcohol more frequently was shown to be better than in those who do not use either.”

sex
Photo by ChristopherBernard/Getty Images

Study Details – Reduction In Anxiety And Shame 

For six months, researchers examined 185 females and 89 males between the ages of 18 to 30 who were either regular cannabis or alcohol users or non-users. The research excluded those who were using opiates or MDMA and those suffering from health conditions like depression and diabetes, as these are known to produce a negative impact on sexual performance.

“Sexual function is improved in young people who are high-risk cannabis consumers with a moderate risk of alcohol use, resulting in increased desire, arousal, and orgasm,” revealed the study, which was published in late December 2021 in the journal Healthcare. “This improvement is usually associated with a reduction in anxiety and shame, which facilitates sexual relationships.”

RELATED: Study: Cannabis Can Help Alleviate Insomnia In Those Suffering From Depression & Anxiety

Cannabis consumers had better scores than non-consumers when it came to both the overall sexual functioning scale and subscales of arousal and orgasm. In addition, frequent cannabis users also had better functioning and arousal scores than those who consumed weed moderately.

There was no significant difference in scores between men and women.

“Our findings indicate that young people who use cannabis frequently, regardless of gender, have better overall sexual function,” according to the Spanish study.

What About Alcohol? Depends On The Amount

Surprisingly, alcohol use showed no notable differences in either overall sex function or any of the subscales examined. There were, however important differences based on levels of alcohol consumption, with heavy drinkers having higher scores on the total sexual function and arousal subscale, compared to those who did not consume booze at all.

marijuana alcohol
Photo by Matthew Micah Wright/Getty Images

“The findings of this study revealed a higher score in sexual function, as well as arousal and orgasm, in subjects at risk of having cannabis-related problems and risk of addiction associated with alcohol consumption,” noted the study.

RELATED: Most Americans Don’t Think Weed Is Dangerous, But They’re Split On Whether It Does This

The researchers reported that they did not focus on the detection and consequences of heavy drinking and/or marijuana use such as the tendency to engage in less safe sex due to them being under the influence of either substance.

In conclusion, considering that these and similar results are often associated with less anxiety and shame in individuals who consume marijuana or alcohol, the study suggested that future sex education methods provide strategies that help people reduce shame and anxiety without placing them at risk of developing potential marijuana and alcohol dependency.

This article originally appeared on Benzinga and has been reposted with permission.



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