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Is CBN The Fountain Of Youth? Here’s What A Recent Study Found

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It turns out that one of the ways your brain cells can remain sharp over time is with a steady dose of CBD. Some days back, the brilliant scientists at Salk revealed this fantastic discovery. They said that CBN, a minor and relatively unknown cannabinoid, has the potential to protect brain cells from the adverse impact of aging.

Research on medical cannabis has been going on for many decades. For the most of this duration, scientists have focused more on the therapeutic properties of major cannabinoid compounds (i.e. THC and CBD). Minor cannabinoids like cannabinol (CBN), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), acid (CBNA), cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), cannabigerol (CBG), and acid (THCA) have been given less attention. We’ve begun to observe an influx of research into these minor compounds.

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Scientists say that these minor cannabinoids have more to offer medically. New researchers are investigating how these compounds are broken down and their interactions with the endocannabinoid system, emphasizing their effects on the brain.

Cannabinol and the Human Brain

Cannabinol has a similar molecular structure to THC, the major difference being that it is not psychoactive. The non-psychoactive property of the compound has caused it to be less regulated by federal agencies. The Salk researchers were pleased to announce their latest influential studies, which have established that cannabinol (CBN) positively impacts the brain. In the last decade, scientists around the world have tried to investigate the medical potential of CBN. However, the federal prohibition of the cannabis plant has limited these studies.

The primary pathway to the death of cells is through oxidative injuries. This is usually followed by neurologic disorders in aged people. This new study describes how cannabinol can shield brain cells, also called nerve cells, from the damaging effects of this pathway. The findings of this trial have been published in the online Free Radical Biology and Medicine journal. The detailed report implies that cannabinol could be an effective drug to treat or manage age-induced neurodegenerative diseases like Alzheimer’s. Scientists suggest that CBN has a high potential for protecting nerve cells as a person ages.

Salk Study Research

Professor Pamela Maher, senior author and head of Salk’s Cellular Neurobiology Laboratory, said her team had discovered the anti-neurodegenerative effects of cannabinol. She mentioned that her team studied how the cannabinoid shields nerve cells from oxidative stress and death, which are major contributors to the onset of dementia and Alzheimer’s diseases.

According to Neuroscience News, Maher and her team of brilliant researchers believe this discovery would lead to the development of new drugs and treatment plans to treat various neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s. Maher’s lab had studied the use of cannabinol in the past, and this recent investigation was done to build on the first discoveries. In the preliminary research, the team found out about the protective properties of CBN on the brain and how CBN could be used to derive drugs for neurological diseases.

RELATED: Is CBN Going To Give Melatonin A Run For Its Money?

This recent study focused more on how CBN functions in the body. During this study, Salk scientists took into account the oxytosis and ferroptosis processes, a major contributing factor to aging and diseased brain cells. The oxytosis, or ferroptosis process occurs in aging brains. The mechanism is induced by the gradual loss of glutathione, an antioxidant, as a person ages. It results in prominent damage or death to neural cells through lip oxidation. The trial began by administering CBN to nerve cells to observe how they limit oxidative action. The scientists then proceeded to propose a different mechanism to induce oxidative damage.

Study Observations  

Following testing healthy and damaged brain cells with cannabinol, the following observations were made. The report stated that the administered cannabinol protected the nerve cells. They also observed that the mitochondria, a cell’s powerhouse, were protected from oxidative damage.

The mitochondria in healthy cells were compared with those in damaged cells. Maher and her team found that the mitochondria in the damaged cell appeared to be folded up in a round shape to shield it from more damage. These scrunched-up powerhouses are frequently noticed within the brain cells of Alzheimer’s and Parkinson’s patients.

Treating Dementia With Cannabis: What Patients And Caregivers Should Know
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On the other hand, the healthy cells appropriately housed functioning mitochondria. The powerhouse in these cells remained in its regular, non-folded form.

Maher wrote that her team successfully showed that cannabinol could contribute to maintaining mitochondria in nerve cells. She added that the protective effects of CBN urged the proper functioning of the powerhouse.

More Information

Zhinin Liang, co-author and postdoctoral fellow, says that smoke evidence shows that cannabinol is safe for human and animal consumption. This can be linked to the absence of psychotropic effects after CBN is consumed. The researcher said that CBN works on specific cells in the body while delivering therapeutic effects.

Maher also noted that her team’s findings reveal implications for other neurodegenerative diseases connected to glutathione loss. The dysfunction of a nerve cell’s powerhouse results in further damage to nearby tissues. The potential of CBN to heal and maintain functions in a powerhouse suggests that it could also be used to treat other parts of the body besides the brain. This opens the floor for further research beyond the context of neurodegenerative conditions. The next agenda item for the team is to reproduce the above study in a preclinical mouse model.

RELATED: CBD Might Not Cause You To Fail a Drug Test, But CBN Might

Other researchers that contributed to the success of this study include Brendan Duggan from the University of California, Antonio Currais, David Schubert, Devin Kepchiaz, and David Soriano-Castell Salk. The Paul F. Glenn Center for Biology of Aging Research at Salk, the Shikey Foundation, the University of California, The Bundy Foundation, and the National Health Institute provided funding.

Bottom Line

Salk’s CBN research points out the need for more investigations into lesser-studied cannabinoids. Most of these minor cannabinoids have shown little therapeutic potential in the limited levels of research done.

Some of the therapeutic benefits possessed by CBN, as suggested by anecdotal evidence, include pain relief, stress relief, and anti-inflammatory effects. This buttresses Maher’s point that further comprehensive research must be done.

This article originally appeared on Cannabis.net and has been reposted with permission.



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How Marijuana Affects Us Differently As We Age

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If you use cannabis regularly or have casually enjoyed it for many years, you may have noticed it affects you differently today than it did 5, 10 or even 20 years ago. A lot of this change may have to do with factors like tolerance, the weed itself or even life experience.

After all, once we get used to a substance it doesn’t quite feel the same as it once did, and it takes more of the substance to feel the similar effects. But there could be something else contributing to this change you feel. Your age might be one of the reasons that cannabis affects you differently today than it did when you were younger. 

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Marijuana use has increased significantly in the older demographics in the last several years. According to a 2020 study published in the JAMA Network, “Marijuana use in the prior year among people over 65 had jumped 75 percent from 2015 to 2018, from 2.4 percent of that group to 4.2 percent. By 2019, use had reached 5 percent.” With this steady increase in older folks getting high, it is more pertinent than ever to understand if and how marijuana use affects people differently based on age.

Cannabis use is only now starting to be widely studied and tested. It will take years of data and more cannabis decriminalization before we get the more nuanced answers to how marijuana affects us as we age. But while much more research must be done, with the limited research available, scientists are uncovering some very interesting findings – and some might even surprise you.

For one, there is memory and mental capacity to consider. You might think that as we get older, marijuana might mess with our memory and cognition more than it once did. After all, as we age, our minds aren’t exactly what they used to be. But this might not be the case when it comes to marijuana use. According to a 2021 study titled “Are the Acute Effects of THC Different in Aging Adults,” the results, and previous reports, actually differ from what you might think. 

“Consistent with some reports in the preclinical literature, the findings suggest that older adults may be less sensitive to the effects of THC on cognitive and affective measures.” In other words, older users tended to keep their wits about them just fine (if not better) than younger adults. In the end, their findings suggest that “THC has an adverse impact on aspects of cognition in younger adults and that young adults are more susceptible to phenotypes of THC dependence.”

Vaping In Teens Continues To Increase And Could Have Long Lasting Impact
Photo by Toan Nguyen via Unsplash

When it comes to cannabis and age, the curious results are not limited to just seniors and more “seasoned” cannabis users. There are also some studies that compare mature adult usage to adolescent cannabis usage. According to a 2019 study that examined age-related differences regarding cannabis use, adolescents showed a slightly more resilient memory than older users. “Human adolescents exhibited less impairment in memory post-intoxication than adults,” according to the study.

RELATED: Can Cannabis Keep Your Brain Young?

But while the younger users may have had less impairment, they found that younger users tended to crave cannabis more. “Craving and inhibitory control may not decrease as much after cannabis intoxication in adolescents compared to adults.” The authors also noted these trends were most noticeable among “very heavy and dependent users.”

More research is required in order to uncover more concrete evidence within these trends. Marijuana affects everyone differently, and the user’s age is a not-often researched, but clearly significant variable when it comes to THC and how we react to it.

RELATED: Smoking Weed Vs. Edibles: Which Is Better For Your Brain?

Now, more than ever, this type of research is important. After all, more and more seniors (and adults in general) are reaching for cannabis instead of other substances. Even retailers are getting in on the trend. “Major retailers offer dispensary discounts of 10 to 20 percent on ‘Silver Sundays’ or ‘Senior Appreciation Days,’” according to the New York Times.

With seniors becoming a crucial part of the retail market, it seems high time we understand the different ways marijuana impacts us as we age.



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CBD Slows The Aging Process Says Study, So When Should You Start Taking It?

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Realizing that you’re getting old can be a tough process. For some, it comes with cracks and pains with even the slightest movements. For others, it’s the sign of wrinkles where taut skin once was, and the lack of energy. We all want to age as gracefully as possible, but it’s harder than it sounds. After all, how do we fight gravity and time?

While there’s no way to prevent getting old completely, there are certain things we can improve within our lifestyle to ensure that getting older is somewhat less painful on our bodies, minds, and overall appearance. Integrating cannabidiol (CBD) is one of them.

CBD is one of the hundreds of compounds within the cannabis plant which has powerful health benefits. It doesn’t give you any kind of a high or a buzz, making it safe to consume any time of the day even when you need to drive or get things done. Cannabidiol products are everywhere these days: it can be taken in pill, oil, topical, tincture, and edible form to enjoy its health and anti-aging benefits. CBN is also a cannabinoid that has shown anti-aging properties in humans as well!

Whether you’re 20, 25, 30, or even 40, it’s never too early to start using CBD to prevent the detrimental effects of aging. Here’s why.

CBD
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CBD Protects the Brain From Neurodegenerative Disease

Mental neurodegenerative disorders that cause gradual death of neurons and other parts of the brain over time. As a result, this causes memory loss, agitation, anxiety, and depression. Some of the most common neurodegenerative disorders include dementia, Alzheimer’s, and Parkinson’s Disease.

Millions of aging people worldwide struggle with neurodegenerative disease as they get older. According to experts, 1 in every 10 people around the age of 65 will develop neurodegenerative disease. However, cannabidiol has been shown to help.

The most common neurodegenerative disease is Alzheimer’s; its symptoms are memory loss, aggression, and agitation. This is why it isn’t just the people with the disease that struggle — their loved ones do, too. A 2019 study shows promise for CBD’s ability to suppress the causes of Alzheimer’s disease, though this study showed that it was more effective when paired with THC.

RELATED: Is Dark CBD The Newest Trend In Cannabis Products?

There are also studies demonstrating the efficacy of CBD in treating the aggression caused by dementia. The researchers said that using CBD oil was “mostly safe, with no significant differences in the occurrence of adverse events.”

In addition, studies show that CBD has neuroprotective properties in the brain; it has been found to help reduce inflammation and oxidative stress, both of which contribute to the risk of neurodegenerative disease. Taking CBD early on can help slow down the effects of aging in the brain.

CBD Combats Free Radicals

We are exposed to free radicals in our daily lives. The most notorious sources of free radicals are industrial chemicals, pollutants, the ozone, x-rays, and cigarette smoke among others. Chronic exposure to these unstable atoms contribute to premature aging, sickness, and several diseases.

The best way to combat the side effects of free radical exposure is through antioxidants. These substances prevent oxidation, which is a chemical reaction that occurs within the body, producing more free radicals. Antioxidants also promote electron production within free radicals to stabilize these unstable molecules and prevent their detrimental effects within the human body.

RELATED: The #1 Difference Between Cannabis Oil And CBD Oil

Chemically speaking, the cannabidiol structure contains free oxygen atoms which are then donated to free radicals. In doing so, it neutralizes them. Furthermore, studies show that CBD works in the same way as other antioxidants: by interrupting free radical chain reactions.

Given the many other health benefits of CBD, this is definitely one of the best antioxidants out there.

Not All CBD Topicals Are Treated Equal
Photo by Sora Shimazaki from Pexels

CBD Fights Inflammation In the Skin

Exposure to free radicals, the sun, inflammatory compounds in our diet, pollutants, and chemicals combined with aging can all promote premature aging in the skin. This results in wrinkles as well as skin disorders including rashes, red patches, psoriasis, eczema, and so much more.

study from 2017 demonstrates how CBD protects the skin because of its antioxidant properties which speed up the aging process. In addition, another study revealed that CBD reduces the inflammatory action of sebocytes, ensuring healthy skin texture while another study demonstrates how CBD helps reduce redness, pain, and swelling to minimize irritation from psoriasis and eczema. It can also help reduce dryness experienced by dehydrated skin.

It’s no wonder why so many cannabis companies are creating CBD-infused skincare and anti-aging products and they’re flying off the shelves!

CBD Provides Natural Relief From Stress

Constantly being stressed is one of the quickest ways to age — and it will show in your skin, health, and mental well-being. Whether it’s stress from work, parenthood, or life in general, all kinds of stress is bad for your health and contributes to premature aging.

Instead of coping with stress in unhealthy ways, you can already supplement with CBD, which works in different ways to help the body cope with the stress response. Studies show that CBD engages with the 5-HT1A receptor to decrease symptoms of stress such as increased heart rate, anxiety, heightened blood pressure, and fear expression. It can also help you get deeper, longer sleep — one of the best ways to help your body recover through deep healing.

This article originally appeared on Cannabis.net and has been reposted with permission.



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Is CBD Good For Your Skin?

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This article originally appeared on Jointly and has been reposted with permission.

Did you know CBD can be great for your skin? CBD, the non-intoxicating compound found in cannabis, can be combined with coconut oil or other fats to create CBD oil or CBD balm that you can use on your skin. CBD oil serves as the foundation for a variety of beauty and skin products. Due to the anti-inflammatory action of CBD, studies show it can be of great use in managing skin issues such as:

  • Acne
  • Dryness and itching from inflammation
  • Bug bites
  • Aging and wrinkles
cbd cream dark eye circles
Photo by VladimirFLoyd / Getty Images

RELATED: What Newbies Should Know About CBD Skincare Products

In this article, we’re going to explore the benefits of incorporating CBD into your skin care regimen and discuss how these skin conditions can benefit from the wondrous healing powers of CBD.

How CBD Works to Banish Acne Blemishes

Acne is a common, but frustrating, skin condition. Luckily, research shows that CBD contains numerous anti-inflammatory compounds that may reduce oil and combat microbes, leading to decreased zits and flare-ups. One of the primary contributors to a skin breakout is excessive oil production by the sebaceous glands. These sebocytes (oil-making skin cells) create sebum, an oily, waxy protective substance that makes skin supple, soft, and smooth (under normal conditions). Painful and inflamed acne blemishes occur when sebum production is off-balance.

RELATED: What Is The Functionality Of CBD In Skincare Products?

2014 study found that CBD is beneficial in decreasing sebum production in those suffering from overactive sebaceous glands, thus improving acne and overall skin smoothness and appearance. Interestingly, another study published in 2016 concluded that due to the anti-bacterial and anti-fungal properties of cannabis, CBD could benefit various other processes that play a role in acne breakouts. Additionally, CBD may help reduce the appearance of acne scars. A 2019 study indicates CBD may help reduce the appearance of acne scars and spots, in addition to bringing active breakouts to a halt.

CBD For Itchy Skin

Dry and itchy skin can be quite unpleasant. Thankfully, a 2019 study indicates that CBD oil-based products can help soothe skin irritation and itchy skin. The study concludes that CBD may be remarkably beneficial in treating dryness, itching, and flaking by intercepting triggers for those symptoms.

RELATED: Can Marijuana Or CBD Help Acne?

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Photo by Lumin via Unsplash

How CBD Can Soothe Itchy Bug Bites

Nothing can spoil an outdoor adventure faster than itchy bug bites. When a mosquito bites you, it produces an inflammatory response accompanied by redness, swelling, and intense itching. The anti-inflammatory effect of CBD can target the skin’s endocannabinoid system and aid in the reduction of those troublesome symptoms, decreasing or stopping the itch associated with bug bites.

How CBD Can Help Decelerate the Aging Process

We aren’t claiming CBD is the fountain of youth, but a 2017 study indicates it may be beneficial to add CBD to your anti-aging routine. The study highlighted the antioxidant properties of CBD. Oxidative stress is unavoidable, but excessive oxidative stress accelerates the aging process. Fortunately, CBD has potent antioxidant and anti-inflammatory effects that may help stave off the breakdown of skin collagen, which leads to wrinkles and inevitable aging of the skin.

CBD may be incredibly useful in managing common troublesome skin conditions that contribute to itching, breakouts, and aging.

Use the Jointly App to Get More Out of Cannabis

Have you started your cannabis wellness journey? Jointly is a new cannabis wellness app that helps you discover purposeful cannabis consumption so you can achieve your wellness goals with cannabis and CBD. On the Jointly app, you can find new cannabis products, rate products based on how well they helped you achieve your goals, and track and optimize 15 factors that can impact your cannabis experience. These 15 factors include your dose, the environment in which you consume cannabiswho you are with when you ingesthow hydrated you arethe quality of your diethow much sleep you got last night, and more. Download the Jointly app on the App Store or the Google Play Store to get started on your cannabis wellness journey.

Sam is an award-winning screenwriter of “Are You Glad I’m Here” on Amazon Prime. His passions include helping people understand purposeful cannabis consumption.  He is the content Director at Jointly, a cannabis wellness company powered by a proprietary data platform to help people reach their full potential. The company was created on the premise that purposeful cannabis consumption is the key to unlocking a better you.



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