A recent study published by Johns Hopkins University researchers comparing psilocybin to nicotine patches found that participants given a single dose of the psychedelic were six times more likely to abstain from smoking than those given the patch, according to a NPR report.
The study, a randomized trial of 82 smokers, was published this week in JAMA Network. The researchers noted that after a six-month follow-up, about 40% of participants given a psilocybin treatment had quit smoking, while only about 10% of those given the patch had stopped.
The researchers also noted that abstinence rates among those given the psychedelic “were higher than typical treatments, suggesting promise for smoking cessation.”
The study’s lead author and a professor of psychiatry at Johns Hopkins, Matthew Johnson, told NPR he was “surprised by the sheer size of the effect.”
Participants who took psilocybin were given a high dose, according to the report. Additionally, there was no placebo with the test, so everyone given psilocybin was aware they were taking the drug, which the researchers noted could bias the results.


