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Non-hallucinogenic Neuroplastogens Enter First-in-Human Trials 

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For years, researchers have been looking for ways to harness the medical benefits of psychedelics, but without the hallucinations. Some neuroscientists even believe that the drugs’ mental-health benefits don’t come from tripping at all. Now, for the first time, researchers have developed psychedelic-inspired drugs that to bring on neuroplastic effects without producing a trip – a new breed of neuroplastogens. 

Neuroplasticity explained 

Neural plasticity describes the brain’s ability to change, adapt, and form new connections in response to various stimuli. It’s a vital aspect of healthy brain function, and as such, essential to the way we humans function in our day-to-day lives. Situations in which the brain demonstrates neuroplasticity include learning a new skill such a subject in school or a new language, practicing music, memorizing directions in a new city, and working on puzzles and memory games. It can also occur when a person loses a sense, such as hearing or sight, and their other senses start to overcompensate for the lost one.  

Many neurological and psychiatric ailments stem from a lack of neuroplasticity in the brain, which leads to poorly adaptive behavioral responses. Anxiety, depression, and substance abuse are common in people whose brains are unable to strengthen these beneficial circuits. Developing and maintaining neuroplasticity is crucial in promoting recovery from these brain and mood disorders that a large percentage of the adult population struggle with.  

Juvenile brains exhibit remarkable neuroplasticity, with both the ability to learn new things as well as the brain being able to quickly mend damaged circuits. But as we grow older, our brains become less plastic and we’re more prone to getting stuck in negative thought and behavioral patterns. This is why external intervention, often in the form of hallucinogenic drugs, is sometimes necessary to repair those broken connections and pathways.  

The science of neuroplastogens 

Neuroplastogens, also known as psychoplastogens, are a group of small-molecule drugs that are capable of producing rapid and long-lasting effects on both neural structure and function. Many are so potent that they are known to produce the desired therapeutic effects after only a single session. As such, neuroplastogens are quickly becoming the go-to option for treating these neurological disorders.  

Typically, hallucinogenic drugs like psilocybin and LSD, or dissociatives like ketamine and MDMA, are the gold-standard when it comes to improving neuroplasticity. Recently approved second-generation psychedelics like Spravato and COMP360 work via the same mechanisms. And as incredible as these substances may be, the problem is that not all patients have the time or desire for a psychedelic trip.  

A huge number of prospective consumers would prefer to reap the therapeutic benefits of these drugs, without the high. Not to mention, for reasons of liability, when doctors prescribe hallucinogens, the patient needs to be strictly monitored for the duration of their trip, which adds another layer of complexity (as well as higher costs) to the treatment process involving these drugs.  

That being said, there is a growing demand for neuroplastogens that are capable of promoting circuit-based plasticity in specific locations of the brain, without unwanted side effects (hallucinations). To meet this unfulfilled need, researchers are exploring the different ways that psychedelics can rewire key areas of the brain, should the psychedelic properties be excluded.  

For example, several studies show that ketamine can improve overall mood in humans, even if it’s administered when patients are unconscious. This means that patients who missed out on knowingly feeling ketamine’s dissociative effects, because they were not awake for them, still felt happier and less anxious after their operations – which suggests that you don’t need to consciously experience the high in order to benefit medicinally from the drugs.  

How do they work? 

Just like standard psychedelic drugs, these non-hallucinogenic neuroplastogens stimulate the same serotonin receptors, mainly 5-HT2A. When activated, the brain then produces a compound known as brain-derived neurotropic factor (BDNF), which functions as a sort of “brain fertilizer”, that promotes neural growth and survival. While activation of 5-HT2A is often associated with sensory hallucinations, this is not always the case. Different drugs bind to and activate receptors in a variety of ways, which results in very different effects. The focus of non-hallucinogenic psychoplastogens is to activate 5-HT2A serotonin receptors in a way that does not induce a trip.  

Some of these trip-free psychedelics are relatively new, like one that was synthesized two years ago (study published January 2022) by a team of Chinese researchers. The drug works by imitating the mechanisms of lisuride, an analog of LSD, as well as psilocin, the compound that our bodies convert psilocybin from mushrooms into. The drug does not have a name yet, just a serial number, IHCH-7113, and it’s currently undergoing animal trials.  

Per the study: “Here, we present structures of 5-HT2AR complexed with the psychedelic drugs psilocin (the active metabolite of psilocybin) and d-lysergic acid diethylamide (LSD), as well as the endogenous neurotransmitter serotonin and the nonhallucinogenic psychedelic analog lisuride. Serotonin and psilocin display a second binding mode in addition to the canonical mode, which enabled the design of the psychedelic IHCH-7113 (a substructure of antipsychotic lumateperone) and several 5-HT2AR β-arrestin–biased agonists that displayed antidepressant-like activity in mice but without hallucinogenic effects.” 

Other non-hallucinogenic neuroplastogens, although not widely used, have existed for decades. For example, a compound known as 2-Br-LSD (an analog of LSD), was first synthesized in 1957 by Albert Hofmann, the Swiss chemist who created LSD. Renewed interest in this compound has led to new studies, which found that 2-Br-LSD can effectively relieve anxious and depressive behavior in mice, but without twitching and other actions that are common when hallucinations occur. Now, several decades after its initial discovery, a Canadian company, Betterlife Pharma, is planning on conducting the first in-human trials using this trip-free psychedelic. 

Are hallucinations just the side-effect? Or something more? 

For those of us who truly believe in the healing power of psychedelics, hearing people who have likely never used them talk about how much better these drugs would be without hallucinations… well, it can be pretty annoying, to say the least. Many people who have participated in a psychedelic trip describe it as one of the most meaningful and educational experiences of their lives. Not to mention, several studies on psilocybin concluded that the intensity of the trip had a direct correlation on the magnitude and longevity of the therapeutic effects.  

Now let’s circle back to those studies about ketamine. Despite people feeling happier after ketamine administration even when they didn’t trip out, there are some questions there that remain unanswered. Comparatively, would the antidepressant effects have been stronger had they felt the hallucinogenic effects? How long did the positive effects last after their surgeries, in contrast to patients who experience the drugs in their full scope?  

And what about microdosing? Those who take subtherapeutic doses of psychedelic drugs claim to experience many of the neurological benefits – better mood, enhanced creativity, improved focus, and so on – even though the doses they are taking are so low they don’t feel a “high” or experience any sensory hallucinations. However, there are few studies to back up these sentiments, and some people don’t do well with small doses. I personally get very anxious and uneasy when I take low doses of psilocybin, compared to happy, positive highs when I use larger doses.  

So, while technically, yes, the hallucinations are a side effect, anyone who has used psychedelics in a meaningful and serious way can attest to the fact that visuals and other sensory feelings are informative and eye-opening in an extremely powerful way. Are they everything these products have to offer? No. Can people benefit from using these drugs without tripping? Absolutely. But are they missing out on a very important piece of the puzzle? Probably so.  

Final thoughts 

Like most aspects of this industry, more studies need to be done in order to determine how much we are really missing when we remove the trip from psychedelics. Non-hallucinogenic neuroplastogens certainly have an important place in wellness and pharma, as they will expose an entirely new population of mental health patients to the benefits of psychoplastogenic drugs. But which will reign superior? New age neuroplastogens with no hallucinogenic side effects? Or classic entheogens that help transport your senses and your entire being to transcendent new heights? Only time and more research will tell.  

Hello readers. We’re happy to have you with us at Cannadelics.com; a news source here to bring you the best in independent reporting for the growing cannabis and hallucinogen fields. Join us frequently to stay on top of everything, and subscribe to our Cannadelics Weekly Newsletter, for updates straight to your email. Check out some awesome promos for cannabis buds, smoking devices and equipment like vapes, edibles, cannabinoid compounds, amanita mushroom products, and a whole bunch more. Let’s all get stoned together!



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How To Tell If Your Weed Is Bad

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A myth about cannabis is it is grown in healthy, organic atmospheres – which is frankly not true. Here is how spot bad weed.

Like corn, avocados and watermelons, cannabis is sometimes hard to tell if you got the right one.  Peaches, apples, and tomatoes are easy with a squeeze, but other plants are more of challenge. Impurities are pretty common and not all growing habitats are healthy – including indoor. While 50+% of the country has access to legal weed, illicit weed still is a big part of the market, especially in states which don’t allow weed and New York which has over 1,500 unlicensed stories selling who knows what.

RELATED: Why You Should Smell Your Weed Before Buying

Figuring out if your weed is good involves seeing, touching, and smelling your buds to check for contaminants. The more you use, the more you will be able to understand quickly. Here is how to tell if you weed is bad.

marijuana
Photo by Kindel Media via Pexels

Visual Inspection

This can be done using the naked eye or a microscope. If the cannabis flowers are covered with too much shiny, crystalline substance, something could be afoot. During the harvest process, shake out buds and view the drop-off substances. Some impurities  might see include grains, crystals, or powders. If you cannot identify some of these substances, it might be good to take a pass.

RELATED: Why You Should Smell Your Weed Before Buying

Inspect by Feeling

Visual is one one or even the first step.  Pick up a bud to determine whether or not it crumbles or quickly dries out.

Smell and Taste Inspection

Before lighting up, take a whiff to get a better read. Although this only works if you’re familiar with what it should smells and tastes like. If you catch a hint or taste of chemicals or other unnatural substances, then you may have contaminated buds.

marijuana odor terpenes
Photo by LightFieldStudios/Getty Images

Inspect the Combusted Weed

When lighting rolled-up buds, check if it gives up sparks when inhaled. Also, check what the flame looks like immediately and after the weed is lit. If you hear a crackling sound when you drag on the buds, it is very possible the buds are contaminated.

Also, check the flavor and smell given of the weed; if an abnormal order is detected, stop inhaling.

Inspect The Leftovers

This is the last process. If the previous inspections did not give off any weird results, there’s still a need to observe the ash left behind. A non contaminated bud will leave dark gray ash, which is obviously dry and soft to touch. If you see jet black, hard or greasy ash, then your buds contain one or more contaminants.

Cannabis is often exposed, directly or indirectly, to contaminants. Common culprits include sugar, sand, fertilizer, hairspray, and industrial pesticides or fertilizers.

Sand is one of the natural residues that can slip past the inspection of even the most experienced cannabis connoisseurs. Sand is an unavoidable material in agricultural operations, so there’s a high chance it contaminates the products by accident. Some unscrupulous growers tend to add sand on purpose to their products because it gives the buds a shinier and heavier look. It is always advisable to shake out your buds and sift through the ground ones before packaging.

Usually in large grown operations, fertilizer can put consumers at risk of developing life-threatening ailments if inhaled. Many chemicals are used for credible reasons, such as protecting crops and maximizing growth. However,  the consumption of these hazardous chemicals over time can result in diseases such as neurotoxicity and asthma.

Other cannabis Contaminants to watch out for including fungus, mold and talc.

marijuana flower
Photo by Ben Harding/Getty Images

If you ever find yourself with contaminated cannabis buds or products, the severity of contamination determines whether or not you’ll have to dispose of them. Some contaminated buds can be cleansed with the proper materials. However, if you have no time to do this yourself, it’s best to throw them out.

It is always best to purchase from a licensed, legal store as products are more closely inspected and have more oversight to ensure consumer safety.

RELATED: Is Sticky Weed A Good Or Bad Sign?

The main objective of recognizing cannabis bud impurities is to ensure purer and smoother-hitting buds without taking in something harmful. Carefully check through your homegrown and purchased cannabis bids at all times, if not for anything, but stay safe.



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Key Things To Know About Synthetic Marijuana

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As 50%+ of the US has legal weed available, synthetic marijuana is still around.  Here is what you need to know about it

Marijuana has become increasing legal in the US, but it has not stopped the use of K-2, or spice. Created to provide similar reactions as weed, it has some significant drawbacks to natural cannabis. Often to be made to look like weed, it is not and the dangers are much higher. Here are the key things to know about synthetic marijuana.

RELATED: Why Big Pharma Loves The Power Of Synthetic Cannabinoids

Synthetic Marijuana Claims Third Victim In Illinois
Photo by Jorge Alberto Mendoza Mariscal/Getty Images

What is it?

Synthetic marijuana/fake weed/Spice/K-2 is a blended product. Containing shredded plant material and chemicals made in a lab, manufacturers spray chemicals onto the shredded plant material to make it look like marijuana.  In reality, it is a group of manmade chemicals producing a “high” mimicking some of the effects of THC. Natural THC organically binds to the body’s cannabinoids, producing strong effects which can be euphoric and relaxing. Synthetic marijuana tries to do the same, but sometimes binds to the body’s endocannabinoid system in unpredictable ways. particularly since no one really knows what’s in these products.

Why is it dangerous?

Aside from its unpredictability, synthetic marijuana tends to bind more tightly to the body’s endocannabinoid system, creating a stronger relationship that’s harder to shake off. Side effects associated with synthetic weed are dramatic and dire, unlike the ones associated with regular marijuana use. According to the Cleveland Clinic, they include heart attacks, organ failure, seizures, psychosis, stroke, violent behavior, hypertension, and more. Researchers believe synthetic marijuana can make it more likely for people to suffer from psychiatric conditions, among them bipolar disorder, schizophrenia, anxiety, and depression. About a quarter (28%) of synthetic cannabinoid users experienced central nervous system depression or coma—when brain and spinal cord functions slow down and impair breathing, heart rate, and cognitive processes.

Men Who Vape Are More Likely To Have This Condition Than Non-Vapers
Photo by Itay Kabalo via Unsplash

RELATED: ‘Synthetic Marijuana’ Is A Dangerous Misnomer That People Need To Stop Using

Who’s at risk?

According to the Centers for Disease Control and Prevention (CDC), people between the ages of 20-30 are more likely to be exposed to synthetic cannabis, with men being more likely than women to try it out. Users tend to have already tried out cannabis or are regular cannabis consumers.



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Naps Done Right Can Make a Huge Difference

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Weekends are made for naps, but done right they can make your week better also!

The body is a machine which needs fuel, maintenance and downtime.  Around 30% of people don’t get enough night sleep during the week, which can cause problems during the waking hours. There has been a stigma around napping as being lazy, but often those “judging” are not giving their own body enough time to rest, refocus and beenergized for the challenges of day to day life.  Data shows it is good for you and naps done right can make a huge difference.

RELATED: Does Hitting The Snooze Button Help Or Hinder Sleep

Everyone is different and bodies need certain things to function, enough rest is one. Healthy sleep is one of the American Heart Association’s Life’s Essential 8, their guide for improving and maintaining health.  Naps can reduced fatigue, increased alertness, improve your mood and performance, and help with memory.  But there are some guidelines…don’t sleep too long, don’t nap to close to your bedtime, and the following key lessons.

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Figure out the right nap for the moment

The National Sleep Foundation shares there are three kinds of naps, each with their own patterns and effects. Planned napping, emergency napping and habitual napping. The first is when people sleep before they get tired, the second is when they nap because they’re exhausted and they have to, and the third is when they make a habit out of daily naps. Find the option that works best for you and you needs.

Naps should be short.

Productive naps are between 10-20 or so minutes. While we think of the more sleep the better, this is a case of a little goes a long way. Studies show a 10 minute nap can make people feel rested and prepared for the rest of their day. In fact, sleeping for over 30 minutes can disrupt in nightly sleeping patterns, which can alter your nights and productivity. Set an alarm for your naps, keeping them to a defined time, especially if you’re napping habitually and are not catching up on missed sleep.

Tired At Home GIF - Find & Share on GIPHY

Once awake, start moving

Weekends can be made for lounging around and being lazy. Spend all day in bed or lounging in the couch and end up sleeping on and off.  But hese sessions can result in blurry days where the hours fly by and you end up feeling exhausted. It results in having trouble sleeping at night and not being rested. Days like these disrupt your circadian rhythms. Naps work best when they’re planned, with some activity and movement before and after.

Develop a schedule

Going to sleep at the same time every night provides plenty of positive results, helping you maintain a schedule and develop better sleeping habits. It’s the same with naps. “The brain prefers to anticipate something, not react to it. A nap is no different, which is why a scheduled nap always works better over the long haul when compared to a random nap.” This schedule shouldn’t force you to nap everyday, instead, it should help you nap more easily and feel more rested. Hope you can use the tips to make the most out of naps.



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