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Tripping Fish Reveal How Psychedelics Work

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Researchers at the Weizmann Institute of Science have developed a method using zebrafish to study the effects of psychedelics. These tripping fish gave us insights into how these substances influence the brain and behavior, potentially leading to improved treatments for depression and anxiety.

Unveiling the Mechanisms of Psychedelics through Tripping Fish

Introduction to the Study

Scientists at the Weizmann Institute of Science are using zebrafish to explore how psychedelics like psilocybin affect brain function and behavior. This research aims to uncover mechanisms that could lead to better psychiatric treatments.

Methodology and Techniques

The team, led by Dr. Takashi Kawashima, combines optical microscopy, image analysis, and artificial intelligence to observe the effects of psychedelics on zebrafish. The transparency of zebrafish larvae allows researchers to monitor neural activity and behavior in real-time.

Key Findings

The study found that zebrafish exposed to psilocybin exhibited reduced stress responses and increased exploratory behavior. These effects are linked to specific neural activation patterns, providing insights into how psychedelics influence serotonin-related brain functions.

From the research: “Psychedelics affect serotonin receptors much faster than common antidepressants and appear to act in a more targeted manner”

Potential Therapeutic Applications

Understanding how psychedelics target serotonin receptors can inform the development of new treatments for depression, anxiety, PTSD, and other mood-related disorders. This research supports the potential for psychedelics to act faster and more precisely than traditional antidepressants.

Why This Is Important

This research demonstrates a novel approach to studying psychedelics, potentially leading to safer and more effective psychiatric treatments. It also underscores the importance of exploring non-human models to gain deeper insights into complex brain functions.

Possible Implications

  1. New Drug Development: Identification of new compounds targeting serotonin receptors.
  2. Enhanced Therapies: Improved treatments for mood disorders with fewer side effects.
  3. Regulatory Advances: Increased support for psychedelic research and therapeutic use.
  4. Scientific Understanding: Greater knowledge of brain chemistry and neural pathways.

What to Follow

  • Clinical Trials: Upcoming studies on the therapeutic use of psychedelics.
  • Regulatory Changes: Shifts in policies supporting psychedelic research.
  • Technological Advances: Innovations in imaging and AI for neuroscience.

Tripping Fish and Psychedelics – Conclusion

The Weizmann Institute’s use of zebrafish to study psychedelics provides valuable insights into their effects on the brain. This research could pave the way for new psychiatric treatments, offering hope for those with treatment-resistant conditions.

Source: Weizmann Institute of Science



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Global Cannabidiol Market (CBD) Poised for $23.4 Billion by 2031

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The global cannabidiol market (CBD) is set to undergo a dramatic expansion, with projections estimating the market value will grow from USD 8.12 billion in 2024 to USD 23.41 billion by 2031. This represents a compound annual growth rate (CAGR) of 16.3% over the forecast period. The rise in demand for CBD products, coupled with increasing legalization worldwide, and the growing acceptance of CBD in both the health and wellness sectors, are the primary drivers of this growth.

Why the Cannabidiol Market Will Surge 16.3% by 2031Market Drivers and Dynamics

The global Cannabidiol market is witnessing growth across multiple fronts, with several factors playing a crucial role:

Legalization and Regulatory Evolution

Legalization in North America, Europe, and parts of Asia-Pacific has provided the foundation for CBD’s widespread adoption. The 2018 U.S. Farm Bill, which legalized hemp-derived CBD with less than 0.3% THC, has accelerated market growth in North America, accounting for a 40.2% market share in 2024​. Europe is expected to follow suit as more countries, including Germany and the UK, adjust their regulations around medical CBD, contributing to rapid market expansion.

In Asia-Pacific, countries like China, Japan, and India are showing interest in hemp-derived CBD, contributing to the region’s position as the fastest-growing market. The increasing recognition of CBD’s health benefits has led to expanding domestic production and a regulatory shift toward greater acceptance​.

Increasing Demand for Natural Health and Wellness Products

The rising trend toward natural, plant-based health solutions is a major driver of CBD demand. Consumers are increasingly seeking alternatives to traditional pharmaceuticals for managing conditions like chronic pain, anxiety, and sleep disorders. CBD products are perceived as safer, non-addictive options compared to opioids and benzodiazepines, which has contributed to their growing popularity.

CBD is also being adopted in the sports and fitness sectors, with athletes and active individuals using it for its anti-inflammatory and pain-relieving properties. This crossover into wellness and fitness markets is expected to fuel continued growth, particularly for CBD oils, topicals, and edibles.

Medical and Therapeutic Applications

CBD’s use in medical treatments is a key segment driving growth. The pharmaceutical industry is increasingly incorporating CBD into medications, with FDA-approved products like Epidiolex used to treat epilepsy. CBD’s role in treating conditions like schizophrenia, multiple sclerosis, chronic pain, and even cancer symptoms has opened up significant opportunities for expansion in the medical cannabis market​.

Research continues to explore CBD’s potential in treating opioid addiction, neurological disorders, and mental health conditions, making the medical sector one of the most promising growth avenues​.

Market Segmentation: Product and Application Insights

The cannabidiol market is diverse, with products catering to a wide range of consumer needs. The market can be segmented by product type, application, and region:

By Product Type

  • CBD Oil: Accounting for the largest market share, CBD oil is favored for its bioavailability and versatility. It can be administered sublingually, added to food and drinks, or used topically.
  • Topicals: CBD topicals, such as creams and balms, are gaining popularity for their effectiveness in treating localized pain, skin conditions, and inflammation​.
  • Edibles and Beverages: The growing popularity of CBD-infused food and drinks is particularly strong in North America and Europe. This segment appeals to a broader consumer base looking for convenient and discreet consumption methods​.

By Application

  • Medical Use: Medical CBD applications, particularly in managing chronic pain, neurological disorders, and epilepsy, are a major growth driver. This segment is expected to continue expanding as research confirms more therapeutic benefits​.
  • Wellness and Personal Use: The wellness market has seen significant growth, with consumers using CBD for stress relief, sleep improvement, and general well-being. CBD-infused skincare and beauty products are also becoming increasingly popular.

Regional Insights: Market Growth Across Continents

North America

The North American market dominates the global CBD landscape, driven by favorable regulations and strong consumer demand. The U.S. remains the largest market, with major players like CV Sciences and Charlotte’s Web leading the industry. Canada has also seen significant growth due to nationwide legalization of cannabis.

2. Europe

Europe is projected to witness steady growth as countries such as Germany, the UK, and France develop more favorable regulatory frameworks. Increased demand for CBD in pharmaceuticals and wellness products will fuel market growth.

Asia-Pacific

The Asia-Pacific region is set to emerge as the fastest-growing market due to its vast population and increasing demand for hemp-derived CBD products. China and Japan, in particular, are investing in domestic hemp production, positioning themselves as key players in the CBD supply chain​.

Global Cannabidiol Market (CBD) Poised for $23.4 Billion by 2031
Global Cannabidiol Market (CBD) Poised for $23.4 Billion by 2031

Challenges and Opportunities in the Cannabidiol Market

Despite the promising growth trajectory, the cannabidiol market faces several challenges:

1. Regulatory Uncertainty

The lack of uniform global regulations creates barriers to entry for manufacturers and complicates international trade. In countries where cannabis remains illegal or heavily regulated, businesses face hurdles in scaling operations and distributing products across borders.

2. Quality and Safety Concerns

As demand for CBD products grows, ensuring product quality and safety becomes increasingly important. The rise of counterfeit and contaminated products in unregulated markets can undermine consumer trust, emphasizing the need for clear regulations and third-party testing.

3. Product Innovation and Differentiation

With intense competition in the market, companies are focusing on product innovation to stand out. Developing new forms of CBD delivery, such as CBD inhalers, transdermal patches, and suppositories, will create opportunities for differentiation and attract niche markets​.

Conclusion

The global CBD market is set for extraordinary growth through 2031, driven by expanding legalization, increasing consumer interest in natural health products, and advancements in medical applications. With a projected CAGR of 16.3%, the market presents significant opportunities for businesses and investors. However, companies must navigate regulatory complexities and ensure product quality to achieve long-term success.



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Cannabis in Germany 2024: Why 60% Still Use Illegal Sources?

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As the legalization of medical cannabis advances, the 2024 Cannabis Barometer from Bloomwell reveals critical insights into the cannabis landscape in Germany. The survey, which involved over 1,000 participants, shows that although 94.4% of respondents use cannabis for health reasons, nearly 60% still resort to illegal sources. Additionally, social stigma and limited access to cannabis-trained doctors remain significant barriers. Despite regulatory improvements, patients continue to face challenges in obtaining safe and legal cannabis.

The State of Cannabis in Germany: Key Findings from the 2024 Survey:

Widespread Use for Medical Purposes
A staggering 94.4% of respondents reported using cannabis to address health concerns such as chronic pain, stress, and sleep disorders. This underscores the importance of cannabis as a therapeutic option, with many users seeking to reduce reliance on traditional pharmaceuticals. For instance, 20% of patients reported being able to reduce or eliminate other medications due to cannabis use.

Continued Reliance on Illegal Sources
Despite legal advances, the majority of cannabis users still purchase from illegal markets, citing cost barriers and difficulties in accessing medical cannabis. Only 10% of participants obtained cannabis solely through legal channels, and more than 26% had purchased contaminated or low-quality cannabis on the black market, raising serious health concerns.

Stigma and Misunderstanding
Many respondents feel socially stigmatized due to their cannabis use, with 77% reporting negative societal attitudes. This stigma contributes to the persistence of illegal cannabis use, as patients fear being judged by healthcare providers and society. Interestingly, the survey dispels the notion that cannabis is primarily used by men; women accounted for 41% of users.

Telemedicine as a Solution
Access to cannabis-friendly doctors remains a hurdle, with 92% of respondents supporting the use of telemedicine as a safer, more convenient way to receive treatment. The demand for digital health services has skyrocketed, with patients eager for a streamlined process of receiving prescriptions and delivery from pharmacies.

Regional and Demographic Trends
The survey highlighted regional variations in cannabis use, with North Rhine-Westphalia and Bavaria showing the highest rates of consumption. Additionally, the data revealed that cannabis use is not restricted to younger people; 28% of users were between the ages of 31-40, and another 28% were aged 22-30.

    Challenges in Accessing Legal Cannabis

    Germany’s medical cannabis system, despite legal improvements, has failed to keep pace with patient demand. A significant portion of patients are still without access to physicians knowledgeable in cannabis therapies, forcing many to turn to illegal sources. This gap in healthcare is further exacerbated by doctors’ reluctance to prescribe cannabis due to lingering stigmas and a lack of education about its medical uses.

    Patients who rely on medical cannabis also face economic barriers. The survey revealed that a large number of users simply cannot afford the high cost of legally prescribed cannabis, which is often not fully covered by insurance. This drives many to the black market, despite concerns over quality and safety.

    Cannabis in Germany 2024
    Cannabis in Germany 2024

    Addressing Stigma and Misinformation

    Stigma remains one of the largest hurdles for medical cannabis patients in Germany. According to the survey, 77% of patients feel judged by society for their cannabis use, even though the vast majority use it for legitimate medical reasons. This negative perception often prevents patients from discussing their cannabis use with doctors, which can lead to unsafe consumption practices or ineffective treatment plans.

    Addressing stigma will require a multi-faceted approach, including public education campaigns to inform the public about the legitimate medical uses of cannabis and its potential to improve quality of life. The medical community also needs to be more proactive in normalizing cannabis treatments, offering patients a stigma-free environment to discuss their needs.

    The Growing Role of Telemedicine

    Telemedicine presents a promising solution to many of the access issues facing medical cannabis patients in Germany. With 92% of respondents supporting telemedicine for cannabis prescriptions, there is a clear demand for more flexible, patient-friendly healthcare solutions. Telemedicine can bridge the gap for those living in areas where cannabis-friendly doctors are scarce, offering consultations and prescriptions through digital platforms.

    Moreover, telemedicine aligns with the modern patient’s preference for convenience and privacy, making it an attractive option for those seeking cannabis treatments without the fear of social judgment.

    Policy Recommendations and the Path Forward

    The Cannabis Barometer data highlights several key areas where policy improvements are needed:

    1. Increase Education for Healthcare Providers: More doctors need comprehensive training on cannabis therapies to better meet the growing demand. This will reduce the number of patients turning to illegal sources.
    2. Tackle Stigma through Public Campaigns: Education campaigns targeting both the public and the medical community can help reduce the stigma surrounding cannabis use, encouraging safer and more transparent patient-doctor communication.
    3. Improve Access through Telemedicine: Telemedicine should be further integrated into the healthcare system, especially in rural areas where access to cannabis-friendly physicians is limited.
    4. Ensure Affordability of Legal Cannabis: Financial barriers to accessing medical cannabis need to be addressed, possibly through better insurance coverage or government subsidies to prevent patients from resorting to the black market.

    Conclusion

    The 2024 Cannabis Barometer survey sheds light on the complex landscape of medical cannabis use in Germany. While legalization has paved the way for improved access, significant barriers remain in the form of stigma, high costs, and limited healthcare access. Addressing these issues through policy reform, public education, and expanding telemedicine will be crucial in ensuring that cannabis can be safely and effectively used by the people who need it most.



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Ganja Tourism

Inside The Thai Retreat With Cannabis-Infused Wellness Treatments That Target Insomnia And More

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US cannabis edibles brand KANHA partnered with an award-winning luxury beachfront hotel on Thailand’s Koh Samui Island, The Beach Samui. This partnership introduces a range of cannabis-infused treatments, aiming to enhance the guest experience and offer something unique within wellness tourism.

https://www.benzinga.com/markets/asia/24/09/40832311/inside-the-thai-retreat-with-cannabis-infused-wellness-treatments-that-target-insomnia-and-more



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