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All Natural Cannabis Pesticides Made from….Cannabis?

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cannabinoid pesticides

A recent study conducted by researchers at Cornell University revealed the potential use of cannabinoids from hemp as a foundation for natural pesticides. Published in the October issue of Horticulture Research, the research, led by Larry Smart, a plant breeder and professor at Cornell’s AgriTech’s College of Agriculture and Life Sciences, demonstrated that higher concentrations of cannabinoids in hemp leaves correlated with reduced damage from pests.

 

Funded by the New York State Department of Agriculture and Markets through Empire State Development, the study focused on Trichoplusia ni larvae, showing that when feeding on leaves with higher cannabinoid concentrations, the larvae consumed less leaf area and experienced stunted growth. To eliminate confounding factors, artificial insect diets were amended with cannabinoids in physiologically relevant concentrations, specifically isolating CBDA and CBGA.

 

The results indicated that as cannabinoid concentration increased, larvae exhibited lower rates of survival and reduced growth, supporting the hypothesis that cannabinoids play a defensive role against chewing herbivores. Notably, the study did not explore the use of THCA as a pesticide due to federal restrictions on high THCA plants within the Cornell program.

 

This discovery holds significance as it marks a potential initial step towards the development of natural pesticides applicable to non-edible plants. Larry Smart emphasized the defensive nature of cannabinoids, particularly their accumulation in female flowers to protect seeds. However, he noted that comprehensive experimental results establishing a direct link between cannabinoid accumulation and harmful effects on insects have been lacking.

 

George Stack, the paper’s first author and a postdoctoral researcher in Smart’s lab expressed excitement about the potential use of cannabinoids as pesticides but acknowledged regulatory barriers due to the compounds’ pharmacological activity. Further research is deemed necessary to identify the pests against which cannabinoids would be most effective.

 

How Higher Cannabinoid Concentrations in Hemp Leaves Deter Pests

 

In the intricate dance between plants and pests, Cornell University’s recent study has spotlighted a compelling revelation: the potent defense mechanism housed within the higher concentrations of cannabinoids found in hemp leaves. Researchers, spearheaded by Larry Smart, have illuminated a natural deterrent against pests, notably demonstrated through reduced damage inflicted by Trichoplusia ni larvae.

 

The study’s focal point lies in deciphering the correlation between elevated cannabinoid levels and the resilience of hemp plants against pests. As Trichoplusia ni larvae fed on leaves boasting higher cannabinoid concentrations, the observed outcomes revealed a remarkable phenomenon: diminished consumption of leaf area and stunted growth. These findings provide a glimpse into the intricate dynamics of plant-insect interactions, suggesting that cannabinoids play a pivotal role in repelling herbivores.

 

This subheading explores the intricate details of the study’s first major revelation, shedding light on how nature’s own arsenal of cannabinoids acts as a formidable defense mechanism for hemp plants, offering insights that could revolutionize pest management strategies in agriculture.

 

A Precise Approach to Isolating CBDA and CBGA

 

The journey into understanding the potential of cannabinoids as natural pesticides takes us deep into the controlled realms of artificial insect diets and meticulously crafted conditions. In this section, we unravel the intricacies of the methodology employed by Cornell University researchers to isolate CBDA and CBGA, two key cannabinoids, and eliminate any confounding factors that might cloud the study’s precision.

 

To ensure accurate observations and reliable results, the researchers amended artificial insect diets with cannabinoids in concentrations that mirror physiological relevance. This deliberate approach allowed them to dissect the specific impact of CBDA and CBGA, shedding light on their individual roles in deterring pests. By isolating these cannabinoids, the study not only bolsters the validity of its findings but also opens the door to a nuanced understanding of how different components within hemp contribute to its defense mechanisms.

 

This subheading navigates through the scientific rigor applied in the study, emphasizing the controlled conditions that facilitated a focused exploration of the effects of CBDA and CBGA. It underscores the importance of this precision in revealing the potential of cannabinoids as a groundbreaking tool in the development of natural pesticides.

 

Implications for Pesticide Development

 

Embarking on the promising journey of harnessing cannabinoids as natural pesticides, researchers at Cornell University encountered significant regulatory barriers that shape the landscape of this pioneering exploration. This section delves into the intricate challenges faced by the Cornell program, particularly the federal restrictions that curtailed the examination of THCA as a potential pesticide. The complex interplay of regulations highlights the need for a careful balance between scientific innovation and compliance with existing frameworks.

 

The significance of this discovery extends beyond the confines of the laboratory, marking a potential initial step towards the development of natural pesticides for non-edible plants. Larry Smart, the leading force behind the study, emphasizes the defensive nature of cannabinoids, particularly their accumulation in female flowers to protect seeds. Yet, he notes a gap in comprehensive experimental results establishing a direct link between cannabinoid accumulation and harmful effects on insects, underscoring the intricate web of relationships waiting to be unraveled.

 

George Stack, the paper’s first author and a postdoctoral researcher, adds a pragmatic layer to the excitement surrounding cannabinoids as pesticides. While acknowledging the potential, Stack highlights the regulatory barriers stemming from the pharmacological activity of these compounds. This recognition underscores the necessity for further studies to not only identify the pests against which cannabinoids would be most effective but also to navigate the regulatory landscape and ensure the safe and effective deployment of these natural pesticides. The future of this field hinges not only on scientific advancements but also on strategic maneuvering within regulatory frameworks, shaping the path towards sustainable and innovative pest management solutions.

 

Bottom Line

 

In essence, Cornell University’s research on the potential use of hemp-derived cannabinoids as natural pesticides not only sheds light on the intricate dynamics between plants and pests but also underscores the significance of precision in scientific methodology. While unveiling the defensive capabilities of cannabinoids presents a promising step toward sustainable pest management, the regulatory hurdles and the need for further research, as emphasized by Larry Smart and George Stack, remind us that realizing this potential requires careful navigation and continued scientific exploration. The bottom line is a call for a balanced approach, recognizing the transformative possibilities while acknowledging the complexities that lie ahead in deploying cannabinoids as innovative tools in agriculture.

 

CONTAIMINATED WEED, YOU BET, READ ON…

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US Court Rules Delta-8 THC Derived from Hemp is 100% Legal, Slamming the DEA in Embarrassing Court Case

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supreme cour ruling on delta-8 thc from hemp

In a groundbreaking decision, the U.S. Court of Appeals for the Ninth Circuit has ruled that Delta-8 tetrahydrocannabinol (Delta-8 THC) derived from legal hemp sources is not classified as a controlled substance under federal law, directly contradicting the Drug Enforcement Administration’s (DEA) position that all synthetically derived tetrahydrocannabinols, including Delta-8 THC, fall under Schedule I controlled substances. This landmark ruling emerged from a case brought forward by several key players in the hemp industry who challenged the DEA’s interpretation of the 2018 Farm Bill, which legalized hemp and its derivatives. The court’s decision not only rejects the DEA’s restrictive stance but also provides much-needed clarity regarding the legal status of Delta-8 THC, allowing for its continued production and sale from legally sourced hemp. This ruling is significant as it has the potential to reshape the regulatory landscape for cannabinoids, encouraging further exploration and commercialization of hemp-derived products while also highlighting the ongoing tensions between federal regulations and the rapidly evolving hemp industry.

 

 Delta-8 THC: A Naturally Occurring Cannabinoid

Delta-8 tetrahydrocannabinol (Delta-8 THC) is a naturally occurring cannabinoid found in trace amounts in hemp and cannabis plants that shares a similar molecular structure to Delta-9 THC, the primary psychoactive compound in marijuana, but is known to produce significantly milder intoxicating effects; the 2018 Farm Bill’s legalization of hemp and its derivatives containing no more than 0.3% Delta-9 THC on a dry weight basis created a legal gray area for Delta-8 THC, which has proliferated in the form of various products derived from legal hemp sources and sold in a largely unregulated market, as they are not explicitly classified as controlled substances by the Drug Enforcement Administration (DEA) despite the agency’s stance that all synthetically derived tetrahydrocannabinols should be treated as Schedule I drugs regardless of their origin or potency, a position that has been challenged by hemp industry players arguing that Delta-8 THC from legal hemp should be exempt from the same restrictions as Delta-9 THC.

 

 The DEA’s Stance and Industry Challenges

The Drug Enforcement Administration (DEA) has taken a firm stance that all synthetically derived tetrahydrocannabinols, including Delta-8 THC, are classified as Schedule I controlled substances under the Controlled Substances Act (CSA), regardless of their source or concentration. This position has faced considerable resistance from various stakeholders within the hemp industry, who argue that Delta-8 THC derived from legal hemp should not be subjected to the same stringent restrictions as Delta-9 THC, the primary psychoactive compound in marijuana. Proponents contend that the 2018 Farm Bill, which legalized hemp and its derivatives, should extend to include Delta-8 THC, allowing it to be treated as a legal product when sourced from hemp that contains less than 0.3% Delta-9 THC. They emphasize that while Delta-8 THC may occur naturally in small amounts in hemp, the majority of Delta-8 products on the market are produced through a chemical conversion process from CBD, which the DEA argues renders them synthetic and thus illegal. This conflict has led to ongoing legal challenges, with some courts ruling in favor of the hemp industry, asserting that Delta-8 THC should not be classified as a controlled substance when derived from legal hemp. As the debate continues, the tension between the DEA’s regulatory framework and the evolving hemp market raises critical questions about the future of cannabinoid regulation in the United States.

 

 The Court’s Ruling and Its Implications

 

The U.S. Court of Appeals for the Ninth Circuit ruled that Delta-8 THC derived from legal hemp sources is not controlled substance.

  • The court found the DEA’s interpretation of the law was “arbitrary and capricious” and lacked a reasoned explanation.

  • This ruling effectively removes Delta-8 THC from the DEA’s list of controlled substances, provided it is derived from hemp containing less than 0.3% Delta-9 THC.

  • The decision provides legal protection for businesses and consumers involved in Delta-8 THC products derived from legal hemp sources.

 

 

Opportunities for the Hemp and Cannabis Industries

The recent court ruling represents a significant victory for the hemp and cannabis industries, paving the way for new possibilities in product development and research.

  • Therapeutic Potential: Delta-8 THC has been recognized for its potential therapeutic benefits, which could attract more consumers seeking alternative treatments.

  • Increased Investment: The legalization of Delta-8 THC may lead to heightened investment and innovation within the sector, encouraging the development of new products and formulations.

  • Regulatory Concerns: Despite the positive implications, the ruling also raises important concerns regarding the regulation and quality control of Delta-8 THC products, necessitating careful oversight.

  • Need for Standards: As the market for Delta-8 THC expands, there will be a pressing need for clear guidelines and standards to ensure consumer safety and product consistency, helping to build trust in these emerging products.

Broader Implications for Cannabis Legalization

The court’s ruling underscores the ongoing conflict between federal and state laws concerning the regulation of cannabis and its derivatives.

  • Increasing State Legalization: As more states advance toward the legalization of both recreational and medical marijuana, the pressure on the federal government to revise its policies and align them with shifting public opinion is likely to intensify.

  • Step Forward for Delta-8 THC: The ruling regarding Delta-8 THC may be viewed as a positive development in the broader context of cannabis legalization, yet significant challenges remain.

  • Path to Comprehensive Legalization: There is still a considerable distance to cover before achieving comprehensive federal legalization of cannabis, highlighting the complexities of navigating cannabis policy in the United States.

 

Conclusion

 

The court’s ruling underscores the ongoing conflict between federal and state laws concerning the regulation of cannabis and its derivatives. As more states advance toward the legalization of both recreational and medical marijuana, the pressure on the federal government to revise its policies and align them with shifting public opinion is likely to intensify. The ruling regarding Delta-8 THC may be viewed as a positive development in the broader context of cannabis legalization; however, significant challenges remain, and there is still a considerable distance to cover before achieving comprehensive federal legalization of cannabis, highlighting the complexities of navigating cannabis policy in the United States.

 

DELTA-8 THC IS LEGAL, READ MORE…

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What Is It, Why You Should Care, and How Cannabis Helps

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metabolic syndrome

Metabolic syndrome is an umbrella term referring to several conditions that negatively impact how the body metabolizes carbohydrates, fats, and proteins.


It occurs when there are unusual, abnormal chemical processes in the body which affect otherwise healthy metabolic functions. The primary symptoms of metabolic syndrome include abdominal fat, high blood pressure, high blood sugar, high triglycerides, and low levels of LDL (good) cholesterol. These conditions all greatly increase the risk of stroke, coronary heart disease, diabetes, and other severe health issues that are difficult or near impossible to reverse.

 

The most telling symptom, though, is a large waist circumference – and you don’t need to take any kind of medical test to tell you this because it’s completely visible.


That’s why prevention is key when it comes to metabolic syndrome. However, the choices you make on a daily basis in your lifestyle can determine your risk for metabolic syndrome of not. We know that an unhealthy diet that is high in sugar, salt, and processed food can contribute to the symptoms of metabolic syndrome. A sedentary lifestyle, obesity, poor sleep hygiene, and exposure to chronic stress can also make the risk much worse. Smoking tobacco and alcohol are even worse – don’t even think about it.


But cannabis? That can actually help!

What Studies Say

 

A recent study that was published in the American Journal of Open Medicine found that young adults with a habit of consuming cannabis had a significantly lower prevalence of metabolic syndrome. For the study, investigators from the University of Miami analyzed a cohort of almost 4,000 individuals whose ages ranged from 18 to 25. They specifically zoned in on the young adults’ cannabis use.

 

They found that current cannabis users were 42% less likely to have metabolic syndrome. They also found that Non-Hispanic Blacks, who were consuming more weed than the other subjects, were found to be the least likely of all to have metabolic syndrome. “Current cannabis users had a lower prevalence of MetS, predominantly noted among NHB (non-Hispanic Blacks], the group with the highest prevalence of current cannabis use,” said the study’s authors. “Future prospective studies are warranted to examine the role of specific cannabinoids on MetS by race/ethnicity,” they said.

 

A Smaller Waist Circumference: Why You Should Pay Attention, And How Weed Can Help

 

Having a large waist circumference or a visibly fatty belly has been associated with numerous health conditions. Of course, this includes a heightened risk of metabolic disease. It also increases the risk of inflammation, type 2 diabetes, cardiovascular disease incidence, and cancer among others.

That is why it’s critical to pay attention to the size of your stomach. A smaller waist means you have a smaller amount of visceral fat, which is necessary for better health and an improved quality of life.

There are many steps you can take to reduce your visceral fat. These include:

 

  • Sticking to a low carbohydrate and low sugar diet

  • Having a diet high in good protein sources

  • Reduce consumption of trans fat and saturated fats

  • Engage in strength training and cardiovascular exercises

  • Manage stress effectively

 

Last but not the least: did you know that consuming cannabis has been shown to be associated with smaller waistlines and a reduced risk for obesity?

In 2020, a study out of Quebec in Canada revealed that cannabis consumption was linked to a smaller waist and reduced triglyceride levels. For this study, the investigator in Canada analyzed subjects who either never consumed marijuana in the past, used it sometime in the past but had no recent use, had some infrequent use, or consume it infrequently. They specifically measured the participants’ waist circumference and triglycerides.

 

They found out that the subjects who consumed certain marijuana strains for metabolic syndrome for at least 4 days per week were found to have smaller waistlines as well as less triglycerides compared to the other participants in the study.

 

Another study from 2015, also out of Quebec, was conducted by researchers from the Conference of Quebec University Health Centers. They analyzed cannabis consumption patterns of 786 Arctic aboriginal adults, the Inuits. The investigators also analyzed their body mass index to search for any links between cannabis use and BMI.

They found that study participants who consumed marijuana within the last year were more likely to have a lower body mass index, as well as reduced fasting insulin and better insulin resistance (using the HOMA-IR indicator) compared to those who did not.

“In this large cross-sectional adult survey with high prevalence of both substance use and obesity, cannabis use in the past year was associated with lower BMI, lower percentage fat mass, lower fasting insulin, and HOMA-IR,” said the researchers. In other words, they observed a relationship between cannabis use and BMI that led them to conclude that cannabis and cannabinoid use can help consumers reduce the likelihood of obesity and diabetes.

 

Meanwhile, an older study from 2013 also had similar results. Research data from The American Journal of Medicine taken from more than 4,600 patients yielded interesting findings. Almost 45% of patients never consumed marijuana in their lives, while 43% of them smoked in the past though no longer do currently. And 12% of them were regular cannabis users.

Researchers discovered that cannabis users who consumed marijuana within the past month had 16% less fasting insulin levels compared to those who never consumed weed. In addition, they even add reduced HOMA-IR levels and higher high-density lipoprotein. Furthermore, the investigators found that regular cannabis users who usually consume more calories, they also had lower BMI’s.

 

Conclusion

 

Staying fit and healthy is much more than vanity: science and medical research makes it clear that there is a strong link between obesity and body mass index, to overall health and wellness. Metabolic syndrome further emphasizes the importance of keeping one’s BMI normal, and based on these studies, that’s something cannabis can help with. Integrating responsible cannabis use into your lifestyle is one tool out of many that can help you stay healthy and reduce the risks of developing metabolic syndrome.

 

MORE ON METABOLIC SYNDROME AND WEED, READ ON…

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More Bad News for Intoxicating Hemp (California, Missouri, New Jersey)

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Last week, I wrote a post entitled “Loper Comes For the DEA. Will it Matter Though?” In that post, I discussed a brand new federal Fourth Circuit Court of Appeals case that concluded that hemp derivatives like THC-O are not controlled substances. The hemp community has largely celebrated this as a win, even though as I wrote in that post and back in July, none of this really matters if Congress bans intoxicating hemp products – which looks like it will happen.

On the heels of the Fourth Circuit case, a few things happened that don’t make life easier for people who want intoxicating hemp products.

Probably the most significant of the bad news, the California Department of Public Health (CDPH) issued emergency regulations to ban a series of intoxicating hemp products. A lot has been written about these regulations, but it’s worth pointing out that California’s hemp law (AB-45) was already not very favorable to smokable hemp products.

For example, AB-45 already prohibits smokable hemp products. And more notably, it defines THC to include THCA and “any tetrahydrocannabinol, including, but not limited to, Delta-8-tetrahydrocannabinol, Delta-9-tetrahydrocannabinol, and Delta-10-tetrahydrocannabinol, however derived”. In other words, all of the various things that are defined as THC – and there are many – must already not exceed 0.3% in the aggregate. This means that a host of products were already de facto banned in the state.

While, to be sure, the new emergency regulations take things farther, I think it would be inaccurate to describe this as a “sea change” in how hemp products are regulated in the state. What remains to be seen is whether CDPH or other agencies ramp up enforcement in any meaningful way. It’s California, so my guess is no.

California’s not the only state taking aim at intoxicating hemp products. Just the other day, Missouri’s Attorney General created a new task force to crack down on intoxicating hemp products. New Jersey’s Governor also signed a bill cracking down on intoxicating hemp products.

All this just adds to the long list of states and municipalities that had been going after unregulated intoxicating hemp products prior to the Fourth Circuit’s decision – often for violations of state or local law which are unlikely to be impacted by the federal case. And of course, if Congress gets around to banning intoxicating hemp products, that will likely be the last straw for many of these products.



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