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Autistic life quality rose in rare study of customized cannabis treatments

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An individually tailored cannabis regimen may ease symptoms of autism, according to an August study published by Frontiers in Psychiatry. The researchers studied 20 autistic patients who followed a customized regimen of either CBD oil, THC oil, or a combination thereof. While the study was small, autistic patients saw marked reduced symptoms, and a better quality of life for both themselves and their families. 

The challenges of autism

Autism spectrum disorders could have multiple causes, but they encompass a host of conditions that impact 1 in 36 people and can affect patients in a variety of ways from mild to debilitating. Usually characterized by social difficulties, sensory issues, and repetitive behaviors, autism can also come with a high level of co-morbid conditions, like intellectual disabilities, emotional regulation challenges, and seizure conditions.

While these symptoms and their linked conditions vary from one autistic person to another, they can make life challenging for both autistic patients and their families. Unfortunately, there are few treatments available to address these needs.  

quality of life for autistic patients improved in 95% of cases, and their families’ lives improved in 83% of cases.

Can cannabinoids ease autism symptoms? 

Some researchers and advocates have long suggested cannabis as a potential therapy for autism, in part because autistic patients have been found to have lower levels of endocannabinoids. This could suggest an impairment in the endocannabinoid system, a cell signaling system that cannabis can stimulate. 

Previous studies have found cannabis can reduce the severity of autism symptoms. Unfortunately, the benefits and number of patients helped by cannabis have varied drastically between studies. That being said, the manifestations of autism, and the chemical composition of cannabis treatments, can both also vary drastically. 

This lack of clarity led the authors of the recent Frontiers in Psychiatry study to investigate whether cannabis treatments that had been specifically tailored to an individual might prove more consistently effective. 

Related

Why isn’t the endocannabinoid system taught in medical schools?

Unique dosing for unique individuals

The Frontiers in Psychiatry researchers, who are from Brazil, took on the challenge by designing a 20-person study where each patient was titrated up to their ideal dose of cannabis extract. 

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Starting with a small dose of full-spectrum CBD extract, they regularly adjusted each patient’s regimen in response to their symptoms. As they progressed, some patients found that slowly adding in THC improved results, until the researchers landed on a custom balance of THC and CBD. When the researchers identified an ideal dose and ratio of CBD to THC for each patient, they stayed on that regimen for six months. 

After six months of customized cannabis treatment, the patients’ caregivers took a survey on the impact cannabis made in the patient’s life, and the lives of their families. The survey covered a variety of domains relevant to autism and its symptoms.

Cannabis improves autistic quality of life

The results of the survey showed that caretakers felt that cannabis generally improved all of the analyzed symptom categories. Still, the particulars varied between individuals.

Overall, quality of life for autistic patients, however, improved in 95% of cases, and their families’ lives improved in 83% of cases.

Many caretakers reported improvements in domains like seizures (84%), meltdowns (76%), discomfort in noisy or crowded places (72%), aggressiveness toward others (67%), eating non-foods (63%), excessive appetite (62%) and making screams and random sounds (54%).

Cannabis also regularly improved communication-related abilities—85% of caretakers reported that their autistic loved one was more receptive to direct verbal communication. Furthermore, 75% reported visual contact and attention to conversation improved. Meanwhile, verbal communication improved for 50% of patients. 

Is cannabis the first treatment that helps intellectual performance?

Cannabis gets tagged for making healthy adults a little spacey and mellow. However, intellectual and cognitive performance (which is sometimes impaired in autistic patients due to co-morbid intellectual disorders) also improved in 57% of cases in the study. The authors highlighted this striking finding, as no other medication is known to improve this particular co-morbid condition.

Still, a few patients did experience worsening of specific symptoms, such as difficulty in making visual contact, attention to verbal communication, meltdowns, and aggressiveness to self or others.  Like any drug, cannabis is not a magic bullet, and two of the 20 patients experienced an overall worsening of symptoms, yet 19 of the 20 autistic patients reported an overall improvement in quality of life. 

More studies are needed

While promising, this study is limited by its small size and open, unblinded design. As a result, much larger studies are needed to confirm that these results would carry over to most autistic patients. Because patients and caregivers knew they were receiving cannabis, it’s also possible that the placebo effect could have swayed some of the results.

Still, the study suggests that larger, double-blind studies are warranted and may give us more insight into how cannabis impacts autistic patients. Additionally, it sheds light on how different patients might respond better to different doses and ratios of CBD to THC—and how to approach this challenge clinically. This insight could shift how future research on autism and cannabis is carried out, and yield more accurate results about its potential benefits. Complexity abounds among both autism sufferers and botanical cannabis formulations.

One clear barrier limits cannabis research on autism—the US federal government.

One clear barrier limits cannabis research on autism—the US federal government. America is the main source of medical research funds in the world and the country considers marijuana a Schedule 1 drug with no medical uses and a high potential for abuse. In 2023, President Biden ordered the Dept of Health and Human Services to review rescheduling marijuana and advise the DEA on its recommendation. We’ll see. 

If you are considering using cannabis for autism, keep in mind that it can be contraindicated with some medications and conditions. Always consult with a cannabinoid-specialized doctor first. 



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A Family’s Guide to Nurturing and Supporting Your Autistic Child

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Sensory tools like fidget toys, noise-canceling headphones, and weighted vests help with emotional regulation throughout the day. They can be especially beneficial in reducing overstimulation during activities like school, eating, or socializing. It’s a good idea to consult with an occupational therapist to find the right sensory tools for your child.



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Study: Early cannabis use in pregnancy doesn’t predict autism

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Cannabis use during pregnancy has been increasing in the US, and many people may be wondering what impacts this trend could have on children. Some previous research has pointed towards the possibility that prenatal cannabis exposure could increase the likelihood of having autistic children. But a recent study—one of the largest ever conducted on cannabis and autism—found that cannabis exposure in early pregnancy did not lead to higher odds of an autism diagnosis.

What is autism?

Autism is classified as a developmental disorder. It impacts how individuals interact with others, communicate, learn, and experience life. One in 36 Americans are diagnosed with autism; symptoms usually appear during the first two years of a person’s life. Autism is also a spectrum condition—it encompasses a wide variety of different symptoms that an individual might experience, and different levels of health care support may be needed.

Some of the challenges that autistic people might face include having a style of communication that non-autistic people have trouble understanding, having sensory issues because of heightened or reduced sensory perception, and having more repetitive or restricted patterns of behavior than non-autistic peers.

Related

Minnesota OKs Medical Marijuana for Autism, Sleep Apnea

While medical literature classifies autism as a disorder, many autistic advocates point out that many of the “symptoms” of autism are not inherently problematic or disordered; they simply clash with non-autistic expectations, leaving autistic people marginalized. 

Previous research on cannabis exposure and autism

The recent study, conducted by researchers from Kaiser Permanente and UC San Francisco, evaluated whether cannabis use in early pregnancy could increase the likelihood of a woman giving birth to an autistic child. Autism has been linked to a variety of potential environmental causes, but most research points towards genetics as the primary cause.  

One study, published in 2020, did find an association between prenatal cannabis use and autism, leading to questions about whether cannabis use could cause autism. However, otherstudies found no associations. Unfortunately, those studies utilized self-reporting methods, which may have skewed the results due to a potential underreporting of cannabis use. 

Researchers in the recent Kaiser / UCSF used more rigorous methods to determine whether prenatal cannabis use caused higher rates of autism in children.

Studying prenatal cannabis and autism

This recent study was one of the largest ever done on the topic (it included 178,948 pregnancies), but it also utilized a more robust data set for cannabis use and autism.

This recent study was one of the largest ever done on the topic (it included 178,948 pregnancies), but it also utilized a more robust data set for cannabis use and autism. The study incorporated information from Kaiser Permanente Northern California’s integrated health-care system, which universally screens pregnant individuals for cannabis use—via both self-reporting and a urine toxicology test. Kaiser also routinely screens and assesses children for autism.

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The researchers also included related factors in their analysis like sociodemographic data, the additional medications and substances that a mother consumes, and general health conditions.

Prenatal cannabis use not associated with autism

While an initial analysis appeared to indicate an association between autism and prenatal cannabis use, the association disappeared after adjusting for factors like sociodemographic characteristics and the medical conditions of the mother.

This lack of association suggests that mothers who use cannabis during pregnancy are more likely to have autistic children—not because of the cannabis itself, but because of other factors that also increase likelihood of cannabis use. 

While the researchers don’t identify those specific factors, these results shouldn’t be that surprising: For one, Autism has high hereditary rates. Furthermore, cannabis is sometimes used as an effective treatment for symptoms of autism. Separate studies have noted that autistic individuals tend to have lower levels of endocannabinoids in their bodies, which could suggest an impairment of the endocannabinoid system. 

Mothers with autism—or other conditions tied to the same genes as autism—are more likely to both use cannabis and have autistic children; this correlation may help explain the initial results of the study. Still, only more research will offer conclusive answers to these questions. 

Limitations and future research

This study used a strong methodology, with a large and diverse data set. Still, it was limited by the fact that cannabis use was only measured in early pregnancy. Future studies should measure cannabis use throughout pregnancy, and ideally include information like the methods and dosing of the cannabis itself.

While this study suggests prenatal cannabis use is not associated with autism, the authors nonetheless caution that there is evidence that cannabis can impact development in other ways and should be avoided during pregnancy. 



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Positive Medical News About Marijuana And Moms

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Federally funded medical research reveals marijuana not tied to autism.

Drinking, smoking and consuming marijuana while pregnant is never recommended. Over the course of history, woman have consumed liquor, especially during the period when clean water was hard to find, but child mortality was high. With advances in medicine, it has been discovered some activities, like drinking and smoking cigarettes, can cause harm to the baby. No one is saying expectant women should have booze, buds, or cigarettes. But early on, when a woman doesn’t know she is expecting, she might have engaged in these habits

RELATED: Science Says Medical Marijuana Improves Quality Of Life

One of the concerns circling around cannabis is how it can affect a baby’s development.  While more research needs to be done, two new studies have been published in the Journal of the American Medical Association (JAMA) which provides some good news. The first study  focused on discovering if maternal cannabis use during early pregnancy associated with risk of child autism spectrum disorder (ASD).

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This  study included 178 948 mother-child combinations. The children were born between 2011 and 2019 to pregnant Kaiser Permanente Northern California members screened for prenatal cannabis use during pregnancy. Statistical analysis was conducted February 2023 to March 2024. The findings suggest maternal cannabis use during early pregnancy was not associated with child ASD, but additional research should be conducted to replicate the findings.

Another study released this week found maternal cannabis use during early pregnancy was not associated with speech and language disorders, global delay, or motor delay. The investigation into marijuana and childhood development and included 119 976 pregnancies among 106 240 unique pregnant individuals.

RELATED: Couples Using Cannabis Can Increase Intimacy

A reason for the study is with legal marijuana increased, this is increased discussion around it being a cause of developmental development among babies. But  documented associations between maternal prenatal cannabis use and adverse birth outcomes, including preterm birth and low birthweight have not be in a study. There has been little research assessing the association of maternal prenatal cannabis use and childhood developmental outcomes, this study was done to provide a scientific fact around the information.

More research needs to be done, and like alcohol and cigarettes which are harmful for the body, not one is saying it is good to use why expecting, but it is good to have information grounded in facts.



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