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Can Minor Cannabinoids Found in the Cannabis Plant Help Fight Cancer?

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Can Minor Cannabinoids Help You Fight Cancer? Here’s What The Studies Say

 

Most of us already know about THC (tetrahydrocannabinol), the primary psychoactive in marijuana which gets you high.

 

Studies have shown that THC is responsible for getting you stoned, but it also has numerous medicinal benefits. In addition, we also know about CBD (cannabidiol), the relaxing cannabinoid which also happens to be the second most prominent active ingredient in weed. It’s found in such trace amounts in marijuana but CBD is abundant in hemp, and CBD’s powerful therapeutic properties have prompted manufacturers to learn how to produce it in a laboratory.

 

In addition, there are a couple hundred more other cannabinoids out there. It’s believed that there are a minimum of 60 cannabinoids that are unique to marijuana, while the rest can be found in other herbs, plants, vegetables, and even fruits. But do these cannabinoids that are far less popular than THC and CBD have any value at all?

 

Cannabinoids’ Potent Therapeutic Properties May Help Fight Cancer

 

There has been growing interest in researching the therapeutic potential and medical applications of minor cannabinoids over the last few years. That said, there are lots of ongoing studies that are working to uncover possible new uses for cannabinoids in medicine.

There have been studies on CBG (cannabigerol), which has been given the nickname, “mother of all cannabinoids” because it’s a precursor to THC, CBD, and other cannabinoids. CBG has been shown to be anti-inflammatory, neuroprotective, and antibacterial. CBC, or cannabichromene, is an anti-depressant, anti-viral, and anti-fungal. It also has the potential to promote neurogenesis. Other popular minor cannabinoids include CBN (cannabinol), THCV (tetrahydrocannabivarin), CBDV (cannabidivarin), and more.

 

Now, some studies show that cannabinoids may even have the potential to treat cancer. It’s unfortunate that given the numerous conventional treatments available for cancer, we still have not been able to completely treat cancer. Is Big Pharma hiding something? Only time can tell.

That said, it’s clear that the treatments available today leave much to be desired. Chemotherapy and radiation, the most common treatments recommended for cancer, don’t always work 100% of the time. They also have extreme side effects, including nausea, vomiting, hair loss, and loss of appetite, which greatly affect patients’ quality of life. It is certain that we need more breakthrough therapies for treating cancer – and the answers we’ve been seeking may be found in cannabis all along.

Studies On Cannabinoids And Cancer

 

A recent study, which was published in the medical journal called BioFactors, analyzed minor cannabinoids and their impact on multiple myeloma (MM), which is a rare cancer affecting plasma cells. When multiple myeloma strikes, it turns healthy cells into dangerously unhealthy cells which can wreak havoc on tissues, bones, and blood.

 

For the study, they looked at CBG, CBN, CBC, CBDV, and even CBN in an animal model. They were surprised to find these positive results: “Together, our results suggest that CBG, CBC, CBN, and CBDV can be promising anticancer agents for MM,” wrote the authors.  They added that the cannabinoids possess cytotoxic properties for multiple myeloma.

 

In addition, the researchers added that the cannabinoids possessed a “beneficial effect on the bone in terms of reduction of MM cells invasion toward the bone and bone resorption (mainly CBG and CBN).” Furthermore, they found that CBG, CBN, CBC, and CBDV “reduced the invasion of MM cells toward osteoblasts cells”, which are cells that create new bones and contribute growth to current bone tissue. It’s also interesting to note that CBN was found to be effective in reducing the tumor mass size.

 

Another study from 2020, which was financed by an American cannabis company called Cannabics Pharmaceuticals, was carried out by Israeli researchers to determine if CBG and CBC have feasible anti-tumor properties against gastrointestinal cancer cells and other types of cancer cells. The study was conducted in Cannabics Pharmaceuticals’ High Through-put Screening (HTS) facility located in Israel, and the HTS platform was used to look for the necrotic properties of these cannabinoids.

 

They found that CBG and CBC were both effective in significantly causing necrosis among cancer cells. “My working assumption is that these results show that a correlation may exist between a cannabinoid’s Topological Polar Surface Area (TPSA) value and its ability to induce anti-tumor activity, diminishing cancer cell’s viability rates. CBC and CBG, as neutral cannabinoids, were both found to have a TPSA value which allows the cannabinoid molecule to penetrate a cancer cell’s membrane, whereas their acidic form (CBCA and CBGA) do not,” explained Dr. Yaakov Waksman, who heads cannabinoid research for Cannabics Pharmaceuticals.

 

“Gastrointestinal cancers are amongst the leading and most wide-spread causes of cancer-related deaths worldwide. We are intrigued by the results we have obtained in the lab, and our aim is to consider placing an emphasis on this organ system, and to further explore the differential anti-tumor properties of cannabinoids,” added Dr. Eyal Ballan, the company’s co-founder and CTO. “We believe that these preliminary results vindicate our vision; which is to bring personalization into cannabinoid-based cancer treatments.”

 

 

Conclusion

 

These studies demonstrate the promising anti-cancer properties of minor cannabinoids in marijuana. Whether by inducing cell death or inhibiting tumor growth, these mechanisms by which various cannabinoids can help treat cancer and reduce the proliferation of cancer cells is important for helping save lives. Certainly, more studies on the benefits of minor cannabinoids for cancer cells are necessary to help us better understand its benefits and learn how to use it in medical and clinical settings.

 

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Another Setback for Recreational Marijuana in Florida…

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In the 2024 election, Florida’s Amendment 3, which sought to legalize recreational marijuana for adults aged 21 and over, garnered 55.9% support —falling short of the 60% supermajority required for constitutional amendments in the state. This outcome has left proponents of marijuana reform contemplating the next steps to achieve legalization.

 

Understanding the Defeat of Amendment 3

Amendment 3 aimed to permit adults to possess up to three ounces of marijuana and five grams of cannabis concentrate for personal use. It also proposed allowing existing Medical Marijuana Treatment Centers to sell marijuana to adults for recreational purposes.

Despite receiving a majority vote, the amendment did not meet Florida’s stringent 60% threshold for constitutional changes.

 

Several factors likely contributed to the amendment’s defeat. Governor Ron DeSantis led a robust campaign against the measure by utilizing state funds and significant donations, including $12 million from billionaire Ken Griffin, to fund opposition efforts. The opposition’s messaging focused on concerns about public safety, potential increases in crime, and the societal impact of legalizing recreational marijuana.

 

Legal Perspectives on the Outcome

Criminal attorney Joshua Padowitz, who has extensive experience in drug-related cases, both as prosecutor and defense attorney, offers insights into the implications of the amendment’s failure. “The defeat of Amendment 3 means that individuals in Florida will continue to face criminal penalties for possession of marijuana, even in small amounts,” Padowitz explains. “This perpetuates a flawed, unjust system where non-violent offenders are subjected to legal consequences that can have lasting effects on their lives.”

 

Padowitz astutely emphasizes the need for reform, stating, “The current legal framework appears to disproportionately affect minority communities and contributes to the overburdening of our criminal justice system. Legalizing recreational marijuana could alleviate some of these issues by reducing the number of individuals prosecuted and jailed for minor drug offenses. Here in Broward County, Florida, elected State Attorney Harold Pryor has boldly and commendably enacted a policy in his office to not prosecute most minor marijuana possession cases, which effectively discourages law enforcement from pursuing these types of arrests. Unfortunately, Pryor’s forward-thinking directive is not uniform throughout the State of Florida and it remains a criminal offense, subjecting a person to a deprivation of their liberty and a criminal record if convicted.”

 

Steps Forward for Advocates of Recreational Marijuana

Despite the setback, supporters of marijuana legalization in Florida are exploring various avenues to advance their cause:

  1. Legislative Advocacy: Engaging with state legislators to introduce and support bills that decriminalize or legalize marijuana. Building coalitions with lawmakers who recognize the benefits of legalization is crucial.

  2. Public Education Campaigns: Informing the public about the benefits of legalization, including economic growth, job creation, and the potential for tax revenue. Addressing concerns about public safety and health through evidence-based information can shift public opinion.

  3. Future Ballot Initiatives: Analyzing the shortcomings of Amendment 3 to craft a more comprehensive proposal for future elections. Gathering broader support and ensuring clear, concise language can improve the chances of meeting the 60% threshold.

  4. Legal Challenges: Exploring the possibility of challenging existing marijuana laws in court, arguing that they are unconstitutional, outdated, or do not reflect current societal norms and scientific understanding.

 

The Role of Medical Marijuana Providers

Companies like Trulieve, Florida’s largest medical marijuana operator, have been significant proponents of legalization efforts. Trulieve contributed nearly $145 million to the campaign supporting Amendment 3. Their involvement underscores the potential economic benefits of a legal recreational market.

 

However, the defeat of Amendment 3 has financial implications for these companies. Following the election, cannabis stocks experienced a sharp decline, reflecting investor disappointment. This economic impact may motivate continued advocacy from industry stakeholders.

 

Public Opinion and Future Prospects

Public support for marijuana legalization has been growing nationwide. A 2023 Gallup poll indicated that approximately 70% of Americans support legalizing marijuana. In Florida, the 55.9% support for Amendment 3 demonstrates a majority favoring legalization, even if it did not meet the required threshold.

 

Advocates can leverage this support by mobilizing grassroots campaigns, engaging in community outreach, and highlighting successful legalization efforts in other states. By addressing concerns and presenting a unified, well-organized front, proponents can work towards achieving legalization in future elections.

 

Concluding Thoughts

The defeat of Florida’s Amendment 3 in the 2024 election is certainly a major setback for proponents of recreational marijuana legalization. However, the majority support it received indicates a shifting perspective among Floridians. By learning from this experience and employing strategic advocacy, public education, and legislative efforts, supporters can continue to push for reform. As attorney Joshua Padowitz encouragingly  notes, “Change is often a gradual process, but with persistent effort and a focus on justice and equity, we can move towards a legal framework that reflects the will of the people and the realities of modern society.”

 



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Margin Compression Madness – $1,000 Fine for Selling Weed at Too Low of a Price?

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A cannabis store in Revelstoke, British Columbia, has been fined $1,000 for selling products at a 50% discount, violating provincial regulations. The Liquor and Cannabis Regulation Branch (LCRB) determined that the sale breached rules against selling cannabis below cost. The penalty was issued following a hearing in October, with the fine due by November 23, 2024. This incident highlights ongoing regulatory scrutiny in the cannabis industry as it navigates complex pricing laws.

 

The trouble began when Fresh Cannabis Co. Inc., operating as Cost Cannabis, advertised a massive sale on all products and accessories, slashing prices by half. This promotion caught the attention of the LCRB after a complaint was lodged on April 22, 2024. An inspector visited the store just days later to investigate whether the store was indeed selling cannabis below the minimum prices set by the government.

 

During the inspection on April 25, the inspector asked about four specific products, and staff confirmed that their sale prices were lower than their listed prices. However, when asked for documentation regarding their purchase prices, the store could not provide it at that moment. This lack of transparency raised further concerns.

 

After a thorough investigation that included requests for sales records and inventory lists, it became clear that Cost Cannabis was selling products below both the price they paid to the provincial distributor and the wholesale price. The LCRB’s ruling emphasized that such practices could lead to public safety issues, including over-consumption and loss of control among consumers.

 

Regulations surrounding cannabis sales in British Columbia

 

The regulations surrounding cannabis sales in British Columbia are designed to create a safe and stable market. The LCRB enforces rules that prevent retailers from selling cannabis at prices lower than what they paid to ensure fair competition and consumer safety. These measures aim to deter practices that could lead to over-service or over-consumption of cannabis products.

 

In this case, Dianne Flood, a delegate from the LCRB, noted that the store should have anticipated that a blanket promotion of 50% off would raise red flags for regulators. She pointed out that there was no evidence showing that Cost Cannabis had taken steps to prevent such violations from occurring.

 

 Cost Cannabis Defense

 

Faced with the fine, Cost Cannabis admitted to violating minimum pricing rules but argued that these regulations do not effectively prevent over-service or over-consumption. They contended that the persistent presence of an illicit market—where cannabis can be purchased at significantly lower prices—poses a greater risk of unsafe consumption than licensed retailers selling below minimum prices.

 

The store highlighted that many consumers still turn to unregulated sources for their cannabis needs because of price disparities. They claimed this underground market is often more likely to contribute to public safety issues due to potentially tainted products.

 

Despite their arguments, Flood concluded that the violation had been proven and imposed a $1,000 fine—the minimum penalty for such an infraction. She stated that first-time violations could result in either a monetary penalty or a short suspension of the business’s license.

 

 Broader Industry Implications

The incident involving Cost Cannabis in Revelstoke, British Columbia, raises significant questions about pricing strategies within the province’s legal cannabis market. As retailers navigate an increasingly competitive landscape, they must find a balance between competitive pricing and regulatory compliance while addressing consumer preferences influenced by a persistent illicit market.

 

  1. The Challenge of Compliance

 

The fine imposed on Cost Cannabis for selling products at a 50% discount highlights the stringent regulations governing cannabis pricing in British Columbia. Retailers are prohibited from selling cannabis below the price they paid to the government or below the wholesale price. This regulation aims to prevent practices that could lead to over-consumption and protect public safety. However, it also creates challenges for retailers who want to attract customers in a crowded market.

 

  1. Understanding Regulatory Frameworks: Retailers must have a clear understanding of the regulations that govern their pricing strategies. Compliance with minimum pricing laws is crucial not only to avoid penalties but also to maintain their licenses and reputations. Failure to comply can result in fines, as seen in this case, and can damage consumer trust.

 

  1. Strategic Pricing Models: Developing a strategic pricing model that aligns with both regulatory requirements and market expectations is essential. Retailers should conduct thorough market analyses to understand competitor pricing and consumer behavior. This understanding can help them position their products effectively while adhering to legal standards.

 

  1. The Impact of the Illicit Market

 

The ongoing presence of the illicit cannabis market complicates pricing strategies for legal retailers. Many consumers still turn to unregulated sources for cheaper products, which can undermine the efforts of licensed stores.

 

  1. Consumer Education: Educating consumers about the benefits of purchasing from licensed retailers is vital. Legal products are subject to safety regulations and quality controls that illegal products do not adhere to. Retailers can leverage this information in their marketing strategies to encourage consumers to choose legal options over cheaper illicit alternatives.

 

  1. Advocacy for Regulatory Change: Retailers may need to advocate for changes in regulations that could help level the playing field with the illicit market. This could include lobbying for adjustments in taxation or minimum pricing laws that allow licensed stores more flexibility in their pricing strategies.

 

 

  1. Long-term Sustainability and Market Dynamics

The fine against Cost Cannabis underscores broader issues related to sustainability and competition within the cannabis industry.

 

  1. Market Stability: Maintaining stable prices is essential for the long-term viability of the legal cannabis market. If retailers engage in aggressive discounting or undercutting each other, it could lead to unsustainable business practices that harm overall profitability.

 

  1. Innovation and Differentiation: To effectively compete against both legal and illegal markets, retailers must focus on innovation and differentiation rather than solely on price competition. Offering unique product lines, exceptional customer service, or creating engaging retail experiences can help draw consumers away from cheaper alternatives.

 

  1. Building Brand Loyalty: Establishing strong brand loyalty can mitigate the impact of price competition. Retailers who cultivate relationships with their customers through loyalty programs, community involvement, and personalized service may find that consumers are willing to pay a premium for trusted products.

 

Conclusion

The $1,000 fine imposed on Cost Cannabis serves as a reminder of the challenges faced by retailers operating within British Columbia’s legal cannabis framework. As they navigate competitive pressures and regulatory requirements, incidents like this underscore the importance of compliance with provincial laws designed to protect public health and safety.

As British Columbia continues refining its approach to cannabis regulation, ongoing dialogue among regulators, retailers, and consumers will be essential in fostering a sustainable marketplace. This incident not only highlights the complexities of operating within this industry but also emphasizes the need for all stakeholders to work collaboratively toward a safer and more equitable cannabis market in Canada.

 

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BIG PHARMA RACKS UP $82 BILLION IN FINES, ARE YOU SAFE?



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Latest Trump Weed Rumor – Trump Will Federally Deschedule and Decriminalize Cannabis, but Not Legalize It

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In a recent interview, former New Jersey Governor Chris Christie made headlines by asserting that President-elect Donald Trump will pursue significant reforms in federal policies regarding marijuana and cryptocurrency. As the nation grapples with evolving attitudes toward cannabis and the burgeoning digital currency market, Christie’s predictions have ignited discussions about the potential implications of such changes on both industries. This article delves into Christie’s insights, the current state of marijuana and cryptocurrency regulations, and the broader implications of these anticipated reforms.

 

The Current Landscape of Marijuana Legislation

 

Federal vs. State Laws

Marijuana remains classified as a Schedule I substance under the Controlled Substances Act (CSA), which places it in the same category as heroin and LSD. This classification has created a complex legal landscape where states have moved to legalize cannabis for medical and recreational use, while federal law continues to impose strict prohibitions. As of now, over 30 states have legalized marijuana in some form, leading to a burgeoning industry that generates billions in revenue.

 

Challenges Faced by the Cannabis Industry

 

Despite its legality in many states, the cannabis industry faces significant hurdles due to federal restrictions. These challenges include:

  • Banking Access: Many banks are hesitant to work with cannabis businesses due to fear of federal repercussions, forcing these businesses to operate largely in cash.

  • Taxation Issues: The IRS enforces Section 280E of the tax code, which prohibits businesses engaged in illegal activities from deducting normal business expenses, leading to disproportionately high tax burdens for cannabis companies.

  • Interstate Commerce: The lack of federal legalization prevents cannabis businesses from operating across state lines, limiting their growth potential.

 

Chris Christie’s Perspective on Marijuana Reform

 

Christie, a former presidential candidate known for his tough stance on drugs during his tenure as governor, has evolved his views on marijuana over the years. In his recent statements, he emphasized that Trump is likely to pursue descheduling cannabis, which would remove it from the Schedule I classification. This move would not only provide clarity for businesses operating in legal markets but also open avenues for banking and investment.

 

Christie highlighted that descheduling would allow for a more regulated market where safety standards could be established, thus protecting consumers. He believes that this approach aligns with a growing consensus among Americans who support legalization and recognize the potential benefits of cannabis use for both medical and recreational purposes.

 

The Future of Cryptocurrency Regulation = The Rise of Cryptocurrencies

 

Cryptocurrencies have surged in popularity over the past decade, with Bitcoin leading the charge as the first decentralized digital currency. The market has expanded to include thousands of alternative coins (altcoins), each with unique features and use cases. As cryptocurrencies gain traction among investors and consumers alike, regulatory scrutiny has intensified.

 

Current Regulatory Challenges

 

The cryptocurrency market faces several regulatory challenges that hinder its growth and adoption:

 

  • Lack of Clarity: Regulatory frameworks vary significantly across states and countries, creating confusion for investors and businesses.

  • Fraud and Scams: The rapid growth of cryptocurrencies has led to an increase in fraudulent schemes targeting unsuspecting investors.

  • Consumer Protection: Without clear regulations, consumers are often left vulnerable to risks associated with volatile markets.

 

Christie’s Vision for Crypto Regulation

 

Christie believes that under Trump’s leadership, there will be an effort to find a “sweet spot” for cryptocurrency regulation balancing innovation with consumer protection. He argues that overly stringent regulations could stifle growth in this emerging sector while too little oversight could expose consumers to significant risks.

 

In his view, a balanced regulatory framework would include:

 

1. Clear Definitions: Establishing clear definitions for different types of cryptocurrencies and tokens to differentiate between securities and utility tokens.

2. Consumer Protections: Implementing measures to protect investors from fraud while promoting transparency within the market.

3. Encouraging Innovation: Creating an environment conducive to innovation by allowing startups to thrive without excessive regulatory burdens.

 

Christie’s insights reflect a growing recognition among policymakers that cryptocurrencies are here to stay and that appropriate regulations are necessary to foster growth while safeguarding consumers.

 

Implications of Proposed Reforms

 

Economic Impact

 

The potential reforms proposed by Christie could have far-reaching economic implications:

 

  • Job Creation: Legalizing marijuana at the federal level could lead to significant job creation within the cannabis industry—from cultivation and production to retail sales.

  • Investment Opportunities: Descheduling cannabis would open up investment opportunities for institutional investors who have been hesitant due to federal restrictions.

  • Boosting Local Economies: Legal cannabis markets have proven beneficial for local economies through increased tax revenues and job creation.

 

Similarly, clear regulations around cryptocurrencies could stimulate investment in blockchain technology and related industries, fostering innovation and economic growth.

 

Social Justice Considerations

 

Both marijuana legalization and sensible cryptocurrency regulations have social justice implications:

 

  • Addressing Past Injustices: Legalizing marijuana could help rectify past injustices related to drug enforcement policies that disproportionately affected marginalized communities.

  • Financial Inclusion: Cryptocurrencies offer opportunities for financial inclusion for those underserved by traditional banking systems, particularly in low-income communities.

 

Political Landscape

 

The political landscape surrounding these issues is complex. While there is bipartisan support for marijuana reform among certain lawmakers, challenges remain in overcoming entrenched opposition. Similarly, cryptocurrency regulation has garnered attention from both sides of the aisle but requires collaboration to establish effective frameworks.

 

Conclusion

 

Chris Christie’s predictions about President-elect Donald Trump’s approach to federal marijuana descheduling and cryptocurrency regulation suggest a potential shift in U.S. policy that could significantly reshape both industries. As public opinion evolves on these issues, lawmakers have an opportunity to enact meaningful reforms that promote economic growth while ensuring consumer protection. The anticipated changes could foster a more robust cannabis industry that contributes positively to the economy and addresses social justice concerns, while clear regulatory frameworks for cryptocurrencies could encourage innovation and protect consumers in the digital economy. Stakeholders in both sectors are closely watching these developments, eager to see how potential reforms might impact their futures. While the realization of Christie’s predictions remains uncertain, it’s clear that the conversation around marijuana and cryptocurrency regulation is ongoing and far from settled.

 

TRUMP 2.0 ON CANNABIS REFORM, READ ON…

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