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Cannabis vs. Hemp: Decoding the Key Differences and Similarities

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Cannabis vs. Hemp: Decoding the Key Differences and Similarities

Cannabis, hemp, marijuana — the plant with the Latin name cannabis sativa and its derivatives have so many names that confusion almost seems bound to arise. Luckily, Jorge Olson, co-founder and Chief Marketing Officer of two publicly traded companies, Hempacco (HPCO) and Green Globe International (GGII), helps decode what’s what when it comes to this pointed leaf.

 

“Cannabis is the same as marijuana, but that term has a discriminatory history,” Olson explains. “Cannabis is wonderful. Hemp, however, is the most wonderful plant in the world.”

 

The amount of THC makes all the difference 

 

Delta Extrax

Cannabis and hemp are both essentially the same plant. One major difference divides the two: the amount of tetrahydrocannabinol (THC) is more than 0.3 percent in cannabis, whereas hemp has equal to or less than that amount.

 

Since THC is psychoactive, cannabis delivers that famous “high.” Most products derived from hemp do not, although there are some exceptions. For instance, high concentrations of Delta-8, a cannabinoid extracted from hemp, can. Unlike cannabis, however, Delta-8 is legal nationwide in the US. 

 

“Delta-8 is also cheaper than cannabis,” Olson asserts. “You pay a quarter of the price and get the same effect, although Delta-8 is a nicer high, in my opinion. There’s no paranoia or fear, it can help you doze off and get rest, and is widely available — you can buy it at a liquor store.”

 

Hemp and its derivatives — such as CBD and, yes, Delta-8 — are legal nationwide in the US. THC, on the other hand, is illegal on the federal level, but some states have legalized it for medical and/or recreational use.

 

The way hemp is taxed is also different from cannabis. Customers are only responsible for normal sales taxes on hemp products, while cannabis is often subject to higher taxes, like alcohol or cigarettes. 

 

“The special tax on cannabis skyrockets all the way up to 40 percent in some states,” Olson explains. For this reason, hemp products tend to be much less expensive.

 

Controlling the amount of THC

 

Since the amount of THC is what distinguishes hemp from cannabis, producers and distributors of hemp products must carefully test every batch to ensure it doesn’t have too much of this cannabinoid. Olson and his team not only have farmers test every harvest they send to their facilities, but also do their own testing to double-check each shipment. While they can comply with the law by diluting hemp that comes in a little too hot, they return harvests that are too high.

 

“It’s a persistent problem for the whole industry,” he says. “If your products have too much THC, the FBI can raid your facility, and the FDA can remove your products from store shelves.”

 

According to Olson, scientists are currently mapping the genome for hemp, looking for ways to control the amount of THC in hemp and produce it more reliably, as well as unleash its massive therapeutic potential.

 

“We hardly know anything about hemp yet,” he says. “So far, about 140 cannabinoids have been identified. But we are still in our infancy of studying their possible purposes.”

 

Hemp: The most wonderful plant in the world

 

Despite the newness of this field, studies have already hinted at hemp’s incredible potential. “We know that CBD is a natural anti-inflammatory,” Olson says. “Numerous clinical studies have suggested it can relieve pain. Some people just roll CBD on their joints, and that’s enough to ease their arthritis. CBD can also restore movement in hands for people who want to continue playing musical instruments as they age. One of CBD’s largest impacts is stopping seizures in children.”

 

Indeed, researchers from New York University’s Grossman School of Medicine recently explained that CBD blocks an overactive molecule in the brain that can trigger seizures. In this way, CBD helps treat epilepsy in children when other methods fail.

 

Another cannabinoid called cannabigerol shows great promise in reducing depression and anxiety, ameliorating chronic pain, and even breast cancer. This compound is found in greater concentrations in young plants than in mature ones.

 

The most precious plant on the planet

 

In the end, cannabis is just one use of the hemp plant, and THC is just one cannabinoid out of more than 140. Cannabis sativa presents a treasure chest of untapped potential.

 

“Hemp is a spectacular plant we’re just starting to discover,” Olson says. “Imagine the benefits all these compounds can provide.”

 

The hemp plant grows so profusely, cannabis has often been called “weed.” But given all its therapeutic applications, this “weed” may actually be the most precious plant on the planet.



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New Blueberry weed strains are about to make a wave

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Recently, we told you about strains to watch for 2025 and it got us thinking: Blueberry has come back into vogue. 

Blueberry first debuted in the ‘90s with DJ Short’s Blueberry, and really epitomized that era. Blueberry led to Blue Dream—a top-selling hybrid to this day. Now, Blueberry is back like ripped jeans and Nirvana T-shirts.

We reached out to some breeders, growers, and brands to see if they’re feeling the vibes. Here are some examples of why we think the Pantone for pot this year emits a brilliant shade of blue.

Blueberry Sugar—Blockhead Seeds

(Grape Cream Cake 2.1 x Blueberry Frosting)

Blueberry Sugar updates that candy-gas we all love. (Courtesy Blockhead Seeds)

Firstly, we checked in with Blockhead Seeds, breeder of Leafly Strain of the Year 2024 Super Boof (aka Blockberry), who told us about a gem they came up with using some Blueberry Frosting pollen from Party Time Farms in Santa Cruz, CA. The recipe for the male part of this consists of (Blueberry Cookies x Wedding Crasher). Blockhead told us the terps on these plants smell like a perfect blend of candy blueberries and gas. This Blueberry Sugar tastes so good, Blockhead also crossed it with their Halle Berry and the Block Berry.

Related

How to order weed delivery online with Leafly

Blueberry Caviar—Ridgeline Farms 

(LANTZ x Grape Gas)

Blueberry Caviar has an abnormally loud, dank blueberry smell. (Photo by Ginja Club; courtesy Ridgeline Farms)

Secondly, Ridgeline Farms bred their award-winning LANTZ strain with a few different big time fan favorites this last year. Now, they take another swing for the fences by crossing the formula of (Green Lantern x Ridgeline Runtz) with the super popular Compound Genetics strain Grape Gas (Grape Pie x Jet Fuel Gelato). Blueberry Caviar grows into big, purple buds with a crazy loud Blueberry candy smell that Ridgeline’s Jason Gellman told us is, “so insane they almost seem fake. When I break the bud up the smell is like a dessert that I can’t get enough of.” One of our 12 hot strains to watch in 2025.

Blueberry Cherry—Exotic Genetics

(Cherry Bang Bang x Blueberry Bang Bang)

Blueberry Cherry. (Courtesy Exotic Genetix)

Meanwhile, Exotic Genetics dropped this as part of their Blueberry Bang Bang seed collection and fans on Discord are already showing beautiful examples of the plants, looking to stock up on packs, and talking about the flavor of tart berries and gas or cream. Blueberry Cherry comes from Cherry Bang Bang x Blueberry Bang Bang—(Cherry Cosmo x Red Runtz) x (Blueberry x Cherry Bang Bang—essentially BBB back onto the Cosmo/Runtz combo. Another thing that makes this exciting: Red Runtz comes from Red Pop, a trending flavor we’ll hear more of in 2025. See also: Exotic Genetix Bluezy.

Blueberry Pancakes—Humboldt Seed Company

(Slurricane x PPD)

Blueberry Pancakes. (Courtesy Humboldt Seed Co)
Blueberry Pancakes. (Courtesy Humboldt Seed Co)

You’re probably familiar with Humboldt Seed Co.’s easy-to-grow all-star Blueberry Muffin strain. This takes things to the next level. Part of the 2023 seed drop, and the result of a three-generation search with Monterey County’s Wave Rider Nursery, this strips out the muffin and goes straight for the blueberry. HSC’s co-founder Ben Lind described the aroma as being outrageously sweet, “like blueberry faygo with a tiny hit of gas at the back end.” Moreover, we’re seeing home and commercial growers all over the country, producing their plants, putting up reviews, and emphatically giving this a big thumbs up.

DJ Short’s Blueberry

blueberry marijuana strain
Behold the Blueberry, one of the Garden State’s favorites. (Leafly)

Finally, we can’t finish off this list without giving a moment to the strain that undeniably launched a thousand ships. Winner of the 2000 Cannabis Cup, released in 1981 and still being used in gardens around the world. Legendary breeder DJ Short wrote that he created this iconic strain by breeding together a Highland Thai called Juicy Fruit Thai, a Chocolate Thai x Oaxacan Gold called Purple Thai, and an Afghani. Considered the big bang for blueberry terps, DJ Short’s Blueberry can be found in the building blocks of countless strains that boast Blue in the flavor or aroma. Not long ago, Short released a batch of Blueberry f5 onto the market. Could this be part of why we’re seeing this oncoming wave? 

Affiliate picks

Blueberry Cherries—Cookies Seed Bank

Oregon ’85 Blueberry X (Cherry Pie X Planet Purple)

On sale now.

Epsilon F1—Royal Queen Seeds

(Blue Dream x Blueberry x Amnesia Lemon Haze x Black Domina)

Buy now.

Blue Zushi—Premium Seeds

(Kush Mints and Zkittlez)

Buy now.

Placa Blava—Terphogz

(Blueberry Thin Mint x Zuava)

Buy now.

These products are independently selected by Leafly editors. If you buy through the links below, we may earn a small commission.


In conclusion—don’t snooze on these new blues.





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Can Cannabis Provide Some Relief From Chronic Pain

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Chronic pain can be life changing – from the pain to zapped energy. But can cannabis make a difference?

An estimated 20% of adults in the US and roughly 8 million Canadians experience chronic pain. This condition is defined as pain that lasts for more than three months. It can lead to insomnia and fatigue. If can impact many other parts of life, including mood and the ability to move and body functions. It can also lead to changes in the brain and nervous system, which can make the pain worse and harder to manage. But can cannabis provide some relief from chronic pain?

RELATED: The Most Popular Marijuana Flavors

Medical cannabis (MC) and cannabidiol (CBD) have show promise in managing chronic pain, though efficacy varies by condition and formulation. Research indicates cannabinoids may reduce pain severity by 30–50% compared to placebo, particularly in neuropathic and inflammatory conditions. A 2023 systematic review of 15 studies found CBD alone or combined with tetrahydrocannabinol (THC) reduced pain by 42–66%.

Can Cannabis Provide Some Relief From Chronic Pain

Cannabinoids interact with the body’s endocannabinoid system, modulating pain signaling and inflammation:

  • THC binds to CB1 receptors in the central nervous system, altering pain perception.
  • CBD enhances anandamide (a natural pain-regulating compound) and activates glycine receptors, potentially reducing localized inflammation.
  • Combined THC:CBD formulations (e.g., nabiximols) often show superior pain relief compared to single cannabinoids, with CBD mitigating THC’s psychoactive effects.

Clinical Evidence by Condition

  • Neuropathic pain: THC:CBD sprays reduced pain scores in multiple sclerosis and spinal injury patients.
  • Arthritis/fibromyalgia: Topical CBD improved peripheral neuropathy, while oral formulations alleviated fibromyalgia pain in 30% of patients.
  • Chronic back/neck pain: Preliminary trials suggest vaporized cannabis may rival oxycodone’s efficacy.

The good news is studies report 18–29% of patients achieve ≥30% pain reduction with cannabinoids vs. 14–26% on placebo. Effective CBD doses range widely (2.5–1,500 mg/day), and prolonged use may alter drug metabolism. So trend carefully with both CBD and THC. Remember, only THC:CBD combos like nabiximols are FDA-approved for specific conditions; most CBD products remain unregulated.

RELATED: This Natural Cannabinoid Makes You Feel Happy

CBD alone shows fewer side effects (fatigue, diarrhea) than THC-containing products. Notably, real-world data associate medical cannabis with 60% reduced opioid use in chronic pain patients, though long-term safety data remain limited.

While cannabinoids offer a potential alternative for refractory chronic pain, optimal use requires personalized dosing and further high-quality trials targeting specific pain subtypes. Current evidence supports cautious integration into multimodal pain regimens, particularly when conventional therapies fail. Always talk with your health professional when adding something new to your pain management regime.



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Can Medical Cannabis Help Support Immune Health?

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The immune system plays a vital role in defending the body against infections, including viruses like COVID-19. When the body is exposed to a pathogen, the immune system activates defense mechanisms to fight it off. COVID-19 specifically targets the respiratory system, but it can also affect other parts of the body, leading to a wide range of symptoms, including fever, cough, fatigue, and loss of taste or smell. In some cases, COVID-19 can trigger an overactive immune response, leading to inflammation, organ damage, and even severe complications.



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