Had too much THC and need to reduce its effects? Generally, science and cannabis professionals say take some CBD, the non-psychoactive cannabinoid, to balance it out. But new research indicates that may not be a good idea. 

A recent study in Clinical Pharmacology & Therapeutics found that CBD can actually increase the psychoactive effects of cannabis. This news may surprise many, as CBD has been touted as a substance that can block or reduce the psychoactive aspects of too much THC. The theory goes that CBD, due to its unique engagement with endocannabinoid receptors, can block the activity of THC, the most abundant cannabinoid and main driver of cannabis’ psychoactive effects. 

Can CBD reverse your high? 

The idea that CBD can block THC’s effects comes from a 2006 study by cannabis researcher Dr. Ethan Russo. Russo’s theory made sense at the time, based on the data available; the study discusses the advantages of the entourage effect, and noted that in clinical trials, “CBD is demonstrated to antagonize some undesirable effects of THC including intoxication.”

But follow-up research has found mixed results in CBD’s efficacy for consistently reducing THC’s psychoactive effects. Some studies have found benefits to adding CBD to THC, such as reduced anxiety, paranoia and cognitive impairments, while others found CBD had no impact. 

This latest study shifts the conversation by providing the first piece of evidence that CBD might actually increase psychoactive effects from THC rather than blocking them. 

Can CBD increase THC’s pain relief?  

This study aimed to figure out whether adding CBD to THC would reduce psychoactive effects while still complementing its pain relieving abilities. The authors’ interests lay in how to make cannabis more accessible as a pain reliever, since many medical patients and recreational consumers seek out cannabis for pain management, but don’t want psychoactive effects for their day-to-day lives.

To examine the impacts of adding CBD, the researchers designed a randomized, double blind, placebo controlled clinical trial. Thirty-seven healthy, adult participants ages 18 to 45 took part in the trial. All were previous cannabis users, but had not used cannabis more than once per month in the 6 months prior to the experiment, or at all in the previous 3 weeks. 

At each test session, participants were given oral tablets with 9 mg of THC and either a placebo or varying levels of CBD, from 10 mg up to 450 mg. Then standardized tests were performed to determine the psychoactive and pain-relieving effects of the varying treatments, including measures for subjective effects like alertness, mood, depression, paranoia, anxiety, and just “feeling high.”

There were additional recordings of effects on cognition and motor function, like attention, stability, vigilance, and coordination. 

Large CBD doses can increase THC’s effects 

Surprisingly, the results show no reduction of psychoactive effects with higher levels of CBD. Instead, the highest dose of CBD (450mg) seemed to add to the psychoactive effects, with significantly higher scores on most measures. This enhanced psychoactive high was accompanied by elevated levels of THC and its metabolites in the participants’ blood.

This suggests that the increased psychoactivity may result from the way CBD can alter metabolization of certain drugs by inhibiting enzymes involved in metabolizing chemicals like THC. 

Interestingly, the lower doses of CBD (10mg and 30mg) made no significant impact at all. 

Sadly, none of the doses of CBD increased levels of pain relief. Still, researchers point out that this does not invalidate previous research supporting CBD’s pain relieving effects. The fact that the participants were healthy volunteers, rather than patients with chronic pain challenges, could explain why the CBD did not increase pain relief. In patient populations, we may see different results. 

Will adding CBD increase your high? 

While these results do not support the theory that adding CBD to THC can reduce a psychoactive high or increase pain relief, take the study with a grain of salt. Despite the double-blind and randomized study design, the sample size was still relatively small, and thus limiting how far we can generalize the results. 

But before you remove CBD from your cannabis routine (or add it in to make your high even stronger), it’s important to note that the study found increases in psychoactive effects only with very large doses of CBD. These doses are much higher than what most consumers normally use. The study doesn’t suggest that low doses are likely to significantly increase your high—but the authors say it’s possible.

To add to the complications, CBD can have biphasic effects, which means that it can have one effect at a low dose, but a different effect at a high dose. Given this, and previous research suggesting no impact, or a reduction of psychedelic effects with CBD, we still don’t have much evidence to suggest that typical doses of CBD could enhance a psychoactive high. 

Based on the totality of the research, it’s clear that CBD and THC might interact in a myriad of ways when it comes to psychoactivity. This study expands the possibilities, suggesting the interaction is even more complex than we originally thought. 

Sitting at the crossroads of THC and CBD – CBD helps with sleep and pain. Could it be right for you?

Marijuana is been proven a benefit to the medical world and the American Medical Association, Health and Human Services, the American College of Physicians and the Food and Drug administration all support increasing it’s reach and for more research.  It has been shown to be particularly helpful with chronic pain, nausea, and sleep. The cannabis plant provide a variety of cannabinols, including CBD, marijuana and CBN. But the medical question is CBN right for you? It sits at the crossroads between CBD and THC can be useful with health issues.

RELATED: Science Says Medical Marijuana Improves Quality Of Life

Like CBD and THC, CBN is among the 100+ molecules in the cannabis plant. When THC is heated and exposed to CO2 (oxygen), it converts to CBN. The compound is said to have a mild psychoactive effect, slightly more so than CBD but much less than THC. Specifically, it is said to have a sedating effect on most users and to have promising sleep aid applications, similar to melatonin (among other potential uses).

The marketing of CBN as a dietary supplement may be viable, provided that no unapproved health claims are made and could be nationally legal as long as they have a THC concentration of 0.3% or less. Unlike CBN and like THC, CBN is legal in some states, but not federally. The FDA likes to point out that the 2018 Farm Bill explicitly preserved FDA’s authority to regulate products containing cannabis or cannabis-derived compounds under the Food Drug & Cosmetic Act (“FDCA”) and section 351 of the Public Health Service Act. But the marketing of CBN as a dietary supplement may be viable nonetheless, provided that no unapproved health claims are made.

RELATED: What Is CBG And Is It Legal?

Unlike CBD, CBN not been approved as a drug, and FDA itself has acknowledged “parts of the cannabis plant that do not contain THC or CBD might fall outside the scope of the [drug exclusion rule].” As with CBG, if CBN is approved as a drug at some point down the line, it also seems likely that the drug exclusion rule would not apply: this is because the rule contains an exception for substances marketed as foods or dietary supplements prior to any FDA clinical investigation. People are already marketing CBN products as foods and dietary supplements.

But the question is still, is CBN right for you? With regards to sleep, it is can be a bit stronger than CBD alone. While melatonin is a known as a good over the counter sleep aid, it doesn’t work for everyone.

A clinical study looked into sleep improvements from 15 mg of CBD with or without 15 mg of CBN compared with 5 mg of melatonin. In the study, all groups reported improved sleep quality, and there were no significant differences between products. Since this study didn’t look at CBN alone, it isn’t a direct comparison. But it seems to indicate that products containing an equal amount of CBD and CBN are similarly effective to melatonin for sleep. And adding a CBD/CBN product to melatonin didn’t provide any added benefit.

RELATED: Science Says Medical Marijuana Improves Quality Of Life

CBN use showed relief in muscle and joint pain conditions with inflammation. Limited studies show The study also noted that pain relief was better when CBD and CBN were used together.

So CBN can be helpful if you need a little extra in over the counter help.

Research has also shown that cannabis contains terpenes, aromatic compounds that contribute to its therapeutic effects. For example, myrcene is known for its sedative properties, while limonene may help boost mood and reduce stress. The entourage effect, where these compounds work synergistically with cannabinoids, further enhances the plant’s medicinal potential. Understanding this complex interplay can help you choose cannabis products that best align with your specific wellness goals.