Cannabis News
Does Weed Make You Antisocial or More Social?
Humans and their brains and minds are intricately molded and typically operate within an ongoing interplay with others. This need for interpersonal connection extends beyond our immediate circles, encompassing not only our families and close friends but also extending to various levels of our social interactions.
While research has suggested that marijuana can offer relief to patients experiencing loneliness and depression, it’s crucial to clarify that this doesn’t translate to cannabis turning individuals into social butterflies. In fact, a recent study has uncovered quite the opposite effect: regular marijuana use may lead to reduced sociability compared to non-users.
This research, featured in the Journal Nature, was spearheaded by Giovanni Marsicano at NeuroCentre Magendie in Bordeaux, France. Marsicano and his team aimed to deepen our comprehension of cannabinoid receptors and their interactions with marijuana compounds. Prior studies had predominantly located cannabinoid receptors on the cell membrane.
However, in 2012, Marsicano’s team made a significant breakthrough, discovering that certain receptors also exist within mitochondria, the cellular powerhouses responsible for providing energy. Bordering the mitochondria’s membrane are small, star-shaped cells known as astrocytes. As explained by the study’s authors, these astrocytes play a pivotal role in absorbing glucose from the bloodstream to fuel the brain, facilitating neuronal activity and behavioral responses.
With this discovery, Marsicano and his team wondered: if these astrocytes harbor cannabinoid receptors, how do they interact with marijuana?
“We were keen to unravel the significance of these specific cannabinoid receptors in astrocytes and understand the implications for brain function and behavior when exposed to cannabis,” said Marsicano, underscoring the significance of astrocytes and energy utilization in brain functioning.
When THC, the psychoactive cannabinoid found in cannabis, was administered to mice, it initiated a series of molecular processes. Among these processes was the glucose metabolism disruption in astrocytes, impairing their ability to convert glucose into energy. Without this added energy supply, scientists observed decreased social interactions among the animals for up to 24 hours following THC administration.
Marsicano emphasized the findings: “Our study is the first to demonstrate that the reduced sociability sometimes associated with cannabis use results from altered glucose metabolism in the brain. It also paves the way for further research to explore therapeutic solutions for mitigating some of the behavioral issues arising from cannabis exposure. Furthermore, it sheds light on the direct impact of astrocyte energy metabolism on behavior.”
The Cannabis Paradox: Loneliness Relief vs. Reduced Sociability
In the realm of marijuana use, a paradox has emerged. While cannabis has been suggested to alleviate feelings of loneliness and depression, a groundbreaking study has illuminated a more complex picture. This study, conducted by Giovanni Marsicano and his team at NeuroCentre Magendie in Bordeaux, France, sought to shed light on the intricate relationship between cannabis consumption and social behavior. Contrary to the initial assumptions, their findings unveiled a paradoxical twist: habitual marijuana use might lead to reduced sociability, standing in contrast to the notion that it serves as a social salve.
The findings of the study cast doubt on the widespread belief that marijuana improves social skills. It’s significant to note that while marijuana use may provide some people with momentary respite from feelings of isolation or despair, the long-term effects on social connections seem to vary. This paradox highlights the requirement for a more complex comprehension of how cannabis influences our social lives. We must delve further into the processes at work inside the complicated chemistry of the brain when exposed to cannabinoids like THC in order to untangle this intricate web.
Beyond mere conjecture, the implications of this problem could alter how society views cannabis usage, particularly among those who use it for therapeutic or recreational purposes. Everyone should be aware of the subtleties of how marijuana affects social behavior. Still, lawmakers and healthcare experts should be especially aware of these issues as they work to create acceptable marijuana usage policies and recommendations.
Towards Therapeutic Solutions: Addressing Behavioral Issues from Cannabis Exposure
The groundbreaking study led by Giovanni Marsicano and his team, which explored the intricate relationship between cannabis use and social behavior, has significant implications for addressing the behavioral consequences of cannabis exposure. As we confront the paradox of marijuana offering relief from loneliness and depression while potentially reducing sociability, it becomes imperative to chart a path toward therapeutic solutions.
One of this research’s most promising aspects is its potential for developing targeted interventions. By identifying that the decline in sociability linked to cannabis use results from altered glucose metabolism in the brain, researchers have opened the door to novel therapeutic avenues. Scientists and medical professionals can now explore strategies to modulate this metabolic process, potentially mitigating the behavioral challenges that arise from cannabis exposure.
This discovery further highlights the significance of individualized approaches to cannabis use. Cannabis does not affect everyone the same way, and variables, including dosage, frequency of use, and individual variations in brain chemistry, may greatly impact how marijuana impacts sociability. Interventions tailored based on these variables may be more effective and assist people in making more educated decisions about their cannabis usage.
In essence, this study serves as a critical building block for future studies aimed at unraveling the complexity of cannabis’s behavioral effects and creating specialized treatments for any potential problems. It serves as a reminder that as our knowledge of cannabis expands, we have the chance to improve our methods for using it and, ultimately, the well-being of people who use it for diverse purposes.
Bottom Line
The study led by Giovanni Marsicano has shed light on the complex relationship between chronic marijuana use and sociability, revealing a paradox where cannabis, while offering temporary relief from loneliness and depression, may lead to reduced sociability in the long term. This finding calls for a nuanced understanding of cannabis’s impact on social behavior and opens doors to potential therapeutic solutions targeting altered glucose metabolism. It underscores the significance of personalized approaches to cannabis use, acknowledging the role of dosage, frequency, and individual brain chemistry. This research serves as a critical building block, shaping our comprehension of cannabis’s behavioral effects and offering valuable insights for policymakers, healthcare professionals, and individuals navigating the multifaceted landscape of cannabis use while striving to safeguard overall well-being.
CANNABIS TO BE MORE SOCIAL, READ ON…
“How Long Does One Puff of Weed Stay in Your System?”… This topic can be difficult to answer since it is dependent on elements such as the size of the hit and what constitutes a “one hit.” If you take a large bong pull then cough, it might linger in your system for 5-7 days. A moderate dose from a joint can last 3-5 days, whereas a few hits from a vaporizer may last 1-3 days.
The length of time that marijuana stays in the body varies based on a number of factors, including metabolism, THC levels, frequency of use, and hydration.
Delta-9-tetrahydrocannabinol, or THC, is the primary psychoactive component of cannabis. THC and its metabolites, which remain in your body long after the effects have subsided, are detected by drug tests.
Since these metabolites are fat-soluble, they cling to bodily fat molecules. They could thus take a while to fully pass through your system, particularly if your body fat percentage is higher.
THC is absorbed by tissues and organs (including the brain, heart, and fat) and converted by the liver into chemicals such as 11-hydroxy-THC and carboxy-THC. Cannabis is eliminated in feces at a rate of around 65%, while urine accounts for 20%. The leftover amount might be kept within the body.
THC deposited in bodily tissues ultimately re-enters the circulation and is processed by the liver. For frequent users, THC accumulates in fatty tissues quicker than it can be removed, thus it may be detectable in drug tests for days or weeks following consumption.
The detection time varies according to the amount and frequency of cannabis usage. Higher dosages and regular usage result in longer detection times.
The type of drug test also affects detection windows. Blood and saliva tests typically detect cannabis metabolites for shorter periods, while urine and hair samples can reveal use for weeks or even months. In some cases, hair tests have detected cannabis use over 90 days after consumption.
Detection Windows for Various Cannabis Drug Tests
Urine Tests
Among all drug tests, urine testing is the most commonly used method for screening for drug use in an individual.
Detection times vary, but a 2017 review suggests the following windows for cannabis in urine after last use:
– Single-use (e.g., one joint): up to 3 days
– Moderate use (around 4 times a week): 5–7 days
– Chronic use (daily): 10–15 days
– Chronic heavy use (multiple times daily): over 30 days
Blood Tests
Blood tests generally detect recent cannabis use, typically within 2–12 hours after consumption. However, in cases of heavy use, cannabis has been detected up to 30 days later. Chronic heavy use can extend the detection period in the bloodstream.
Saliva Tests
THC can enter saliva through secondhand cannabis smoke, but THC metabolites are only present if you’ve personally smoked or ingested cannabis.
Saliva testing has a short detection window and can sometimes identify cannabis use on the same day. A 2020 review found that THC was detectable in the saliva of frequent users for up to 72 hours after use, and it may remain in saliva longer than in blood following recent use.
In areas where cannabis is illegal, saliva testing is often used for roadside screenings.
Hair Tests
Hair follicle tests can detect cannabis use for up to 90 days. After use, cannabinoids reach the hair follicles through small blood vessels and from sebum and sweat surrounding the hair.
Hair grows at approximately 0.5 inches per month, so a 1.5-inch segment of hair close to the scalp can reveal cannabis use over the past three months.
Factors Affecting THC and Metabolite Retention
The length of time THC and its metabolites stay in your system depends on various factors. Some, like body mass index (BMI) and metabolic rate, relate to individual body processing, not the drug itself.
Other factors are specific to cannabis use, including:
– Dosage: How much you consume
– Frequency: How often you use cannabis
– Method of consumption: Smoking, dabbing, edibles, or sublingual
– THC potency: Higher potency can extend detection time
Higher doses and more frequent use generally extend THC retention. Cannabis consumed orally may remain in the system slightly longer than smoked cannabis, and stronger cannabis strains, higher in THC, may also stay detectable for a longer period.
How Quickly Do the Effects of Cannabis Set In?
When smoking cannabis, effects appear almost immediately, while ingested cannabis may take 1–3 hours to peak.
The psychoactive component THC produces a “high” with common effects such as:
– Altered senses, including perception of time
– Mood changes
– Difficulty with thinking and problem-solving
– Impaired memory
Other short-term effects can include:
– Anxiety and confusion
– Decreased coordination
– Dry mouth and eyes
– Nausea or lightheadedness
– Trouble focusing
– Increased appetite
– Rapid heart rate
– Restlessness and sleepiness
In rare cases, high doses may lead to hallucinations, delusions, or acute psychosis.
Regular cannabis use may have additional mental and physical effects. While research is ongoing, cannabis use may increase the risk of:
– Cognitive issues like memory loss
– Cardiovascular problems including heart disease and stroke
– Respiratory illnesses such as bronchitis or lung infections
– Mood disorders like depression and anxiety
Cannabis use during pregnancy can negatively impact fetal growth and development.
Duration of Effects
Short-term effects generally taper off within 1–3 hours, but for chronic users, some long-term effects may last days, weeks, or even months. Certain effects may even be permanent.
Bottom Line
The amount of time that cannabis remains in your system following a single use varies greatly depending on individual characteristics such as body fat, metabolism, frequency of use, and mode of intake. Frequent users may maintain traces of THC for weeks, whereas infrequent users may test positive for as little as a few days. Hair tests can disclose usage for up to 90 days, while blood and saliva tests identify more recent use. Urine tests are the most popular and have varying detection durations. The duration that THC and its metabolites are detectable will ultimately depend on a number of factors, including dose, strength, and individual body chemistry.
PEE IN A CUP COMING UP, READ ON..
Is kratom addictive? Discover the potential for dependence on Kratom, the risks involved with its use, and how to approach its consumption responsibly.
From 2011 to 2017, over 1,800 calls to poison centers involved kratom in the U.S. This significant number highlights the concern regarding kratom addiction.
However, without Food and Drug Administration (FDA) oversight, and due to various consumption methods like teas and capsules, there are significant health risks. Safe use of kratom is now in question due to these issues.
Research debates how dependence develops, outlining signs like loss of control and withdrawal symptoms. These signs are seen in regular kratom users. Ironically, some people switch from drugs like heroin to kratom, looking for a legal alternative.
Understanding Kratom: Origins and Prevalence
Kratom comes from the Mitragyna speciosa tree in Southeast Asia. It can act like a stimulant or like opioids, based on how much you take. People use it in different ways, for a small energy boost or stronger effects at higher doses.
The legal status of kratom in the U.S. is complicated and changing. It’s a hot topic because some worry about its misuse. It’s still legal in several states. This shows how different places handle drug rules. The National Institute on Drug Abuse is looking into its medical benefits. But, the FDA hasn’t approved it for medical use yet. The DEA calls it a “drug of concern,” which means policies might change.
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From 2011 to 2017, poison control centers in the U.S. got over 1,800 reports about kratom. This shows it’s widely used and might pose health risks.
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Kratom’s main ingredients bind to opioid receptors very strongly, stronger than morphine even. This fact is key to understanding its effects.
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As more people use kratom, more are reporting serious health problems. These include liver and heart issues, and tough withdrawal symptoms, particularly in those already sick.
The statistics show mounting worries about kratom in the U.S. As its use grows, it’s becoming more important to health policies and laws. What happens next will depend on further research and legal decisions.
Is Kratom Addictive: Investigating the Substance’s Nature
The question of kratom’s addictiveness focuses on how it affects brain receptors and its long-term health implications. The ongoing debate highlights concerns about dependence and the risk of addiction. Scientists are closely looking at these issues.
How Kratom Works in the Brain
Kratom’s main alkaloids, mitragynine and 7-hydroxymitragynine, bind to the brain’s opioid receptors, similar to painkillers and narcotics. This connection suggests a potential risk of dependence. These alkaloids are key to kratom’s pain relief but also point to possible addiction concerns, especially with frequent, high-dose usage.
Patterns and Consequences of Long-term Use
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Using kratom often, especially in large doses, can increase the risk of dependence and intense withdrawal symptoms, similar to opioid withdrawal.
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Although some use it for pain or to improve mood, long-term kratom users might see serious health problems, like liver damage and mental health issues.
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Withdrawal symptoms, including irritability, nausea, and sleep problems, show kratom’s impact on one’s physical and mental health.
Assessment of Addiction Risks
Studies indicate a significant risk of addiction to kratom, especially with high doses or frequent use. Dependence develops as the body gets used to kratom, leading to tolerance and a need for more to feel its effects. Withdrawal symptoms emphasize this risk, as highlighted by health experts.
Physiological Effects: Kratom’s Impact on the Body
There is a lot of debate about the safety and use of kratom. This herbal extract comes from the Mitragyna speciosa plant. It has drawn attention for its possible harmful effects on the body. The FDA has issued many warnings about kratom, raising safety concerns.
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Kratom Adverse Effects: Kratom users have reported side effects like nausea, vomiting, and confusion. More serious issues include high blood pressure and liver damage. These problems highlight the risks of using kratom.
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Herbal Extract Safety: Some kratom products contain heavy metals and pathogens. These can cause severe health issues, including death. This shows the importance of safety in herbal products.
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FDA Warnings and Regulations: The FDA has linked kratom to over 35 deaths and warns against using it. They point out the lack of medical uses and the risk of addiction.
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Physiological Impact: Kratom’s effects depend on the dose and the user’s body. Yet, it can lead to dangerous outcomes like liver damage and seizures.
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Safety Concerns from Authorities: Federal agencies like the DEA are worried about kratom’s safety. Although not a controlled substance, monitoring suggests users should be careful.
Kratom might offer temporary relief for some ailments, but it comes with significant risks. The FDA’s warnings should make people think twice. If considering kratom, it’s crucial to talk to a doctor first. Experts stress the need for safety and caution with herbal extracts.
Conclusion
Kratom’s role in health and regulation is complex, with views and research findings widely varied. Some people use kratom for its claimed health benefits, but it’s a hot topic. Experts advise caution and suggest consulting a doctor before using kratom due to the unclear effects.
Clinical studies using scores like SOWS and COWS haven’t confirmed withdrawal symptoms from kratom. This adds to the debate, especially when some users report withdrawal. This makes kratom a controversial subject among different findings and user experiences.
When it comes to treating opioid addiction, kratom can be both helpful and harmful. Some have used it successfully to fight addiction. Yet, some states have banned it. This highlights the need for regulations and consistent product quality. It also raises questions about kratom’s legal status due to mixed actions by authorities.
The situation shows how complex kratom is in the realm of substance use and law. Without clear evidence supporting either its benefits or risks, it poses a challenge. More research is needed to guide regulations and health advice. For now, anyone thinking of using kratom should be careful, seek medical advice, and keep up with laws and health guidelines.
WHAT IS KRATOM ANYWAY? READ ON…
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