Cannabis News
Is Oral THC a New Breakthrough for Fibromyalgia Patients?
According to the Centers for Disease Control and Prevention, fibromyalgia is a severe illness marked by overall body discomfort, sleep difficulties, tiredness, and emotional anguish. People with fibromyalgia constantly display abnormal pain perception processing. In the United States, this illness affects roughly 4 million grown-ups or about 2 of the adult population. When it comes to effective treatment options, this complicated disease constantly presents difficulties, leaving patients looking for other means of battling their condition.
Growing interest has been shown lately in the implicit use of oral THC remedies for fibromyalgia patients. THC, known colloquially as tetrahydrocannabinol, proudly takes its place among the diverse array of cannabinoids secreted by the cannabis plant. Revered for its distinct psychoactive properties, this wondrous compound has been espoused by experts who claim that harnessing the power of cannabis for medicinal purposes may unlock a trove of therapeutic benefits, extending its healing touch to an expansive gamut of ailments, including fibromyalgia.
State of Fibromyalgia Treatment
The current fibromyalgia treatment options focus on symptom management and constantly combine medication, cognitive behavioral therapy (CBT), and lifestyle changes. However, these approaches may not be effective for everyone, and some individuals experience unwanted side effects or incomplete relief. Given fibromyalgia sufferers’ difficulties, interest is growing in the study of complementary therapies such as oral THC. THC has shown potential in preliminary studies and anecdotal evidence for treating fibromyalgia symptoms like pain, exhaustion, and sleep difficulties.
Recent Studies on Oral THC Remedy
Proffers have surfaced suggesting that cannabis could be an indispensable remedial option for treating fibromyalgia. When we claw into the intricate chemical composition of cannabis, we encounter two crucial substances delta-9-tetrahydrocannabinol(THC) and cannabidiol(CBD). These substances have gained considerable attention for their therapeutic properties. Their effects are mediated through the type 1 cannabinoid receptor (CB1), which is expressed in the central nervous system, and the type 2 cannabinoid receptor (CB2), which is expressed in peripheral inflammatory cells.
The use of medical cannabis has been explored in a wide variety of diseases. Presently, the Food and Drug Administration( FDA) has approved the effectiveness of THC in easing nausea and puking caused by chemotherapy and stimulating appetite in cancer-related cases. Also, research has explored the implicit benefits of cannabis, particularly THC, in managing chronic pain disorders such as neuropathic pain and muscle spasticity associated with multiple sclerosis.
Considering the wide use of cannabis and its implicit efficacy in addressing different pain conditions, there is speculation that cannabis may be an effective treatment for fibromyalgia. Accordingly, the ideal of this review is to precisely examine the rearmost clinical data concerning the use of cannabis as a remedial approach for fibromyalgia.
According to newly released data, fibromyalgia patients suffering from pain and fatigue may find relief with oral THC remedies. According to a study conducted by German experts and published in the medical journal Schmerz, THC may be an effective medicinal alternative to the medications currently suggested in various therapy guidelines for people with fibromyalgia.
A sample of 120 fibromyalgia patients was examined in the study by German researchers, with 62 of them undergoing THC remedy. The study concentrated on patients undergoing multimodal, interdisciplinary therapy in the pain ward of a clinic, and they were examined based on the intensity of their pain, several psychometric parameters, and the number of analgesics they consumed while in the clinic. The findings showed that all patient groups saw significant improvements in pain intensity, depression, and general quality of life, with more pronounced changes shown among those receiving THC treatment. In addition, THC use resulted in dosage reductions or the cessation of analgesic drugs in five of the seven groups studied.
Following the legalization of medical cannabis in Germany in 2017, many qualitative studies have examined the effectiveness of medical cannabis, particularly THC, in treating fibromyalgia. This study aimed to dissect THC’s efficacy within an interdisciplinary multimodal pain therapy (IMPT) approach by examining its impact on pain and various psychometric variables.
The results of these studies aren’t solitary, as other researchers have also brought to light THC’s implicit effectiveness in treating fibromyalgia. A Brazilian study conducted in 2020 shed light on the remarkable benefits of THC oil, particularly a THC-rich whole plant extract, in abetting patients with fibromyalgia to manage their symptoms and elevate their overall quality of life.
To conduct this study, a group of 17 women diagnosed with fibromyalgia was named as participants to estimate the efficacy of cannabis oil. The chosen cannabis oil held a high amount of THC and was administered to the subjects for eight weeks. Initially, a single daily drop was the starting dose, with subsequent adaptations grounded on individual symptoms..
The participants were divided into two distinct groups, with one group receiving cannabis oil while the other group entered a placebo. Throughout the eight weeks, five visits were listed to administer the Fibromyalgia Impact Questionnaire (FIQ) both ahead and after the intervention. According to the experimenters,” the influence of the intervention on patients’ quality of life in the cannabis group was evident, leading to passions of well-being and advanced energy for everyday tasks. Attacks of pain also dropped. “
The low cost and well-tolerated nature of phytocannabinoids were stressed in this randomized controlled trial, suggesting that they can be added as a herbal drug option within the Brazilian public health system to reduce symptoms and enhance the health of fibromyalgia patients.
Since fibromyalgia has a wide range of effects on people, their families, communities, and the healthcare system, it is critical to look at alternative, reasonably priced, and well-tolerated therapeutic modalities. According to this study, using cannabis oil, especially a THC-rich whole plant extract, has the potential to help people with fibromyalgia manage their symptoms and improve their quality of life.
Conclusion
For fibromyalgia patients looking for symptom reduction, oral THC remedy is a feasible option. Although further exploration is demanded, early results indicate that THC may have the capability to reduce pain, improve mood, and enhance the general quality of life. Before considering alternative treatments, patients should speak with healthcare specialists, as with any medical decision.
We can open the door to more effective and personalized ways to treat this chronic illness by continuing to probe the possible advantages of oral THC remedies for fibromyalgia.
CANNABIS FOR FIBROMYALGIA, READ ON…
“How Long Does One Puff of Weed Stay in Your System?”… This topic can be difficult to answer since it is dependent on elements such as the size of the hit and what constitutes a “one hit.” If you take a large bong pull then cough, it might linger in your system for 5-7 days. A moderate dose from a joint can last 3-5 days, whereas a few hits from a vaporizer may last 1-3 days.
The length of time that marijuana stays in the body varies based on a number of factors, including metabolism, THC levels, frequency of use, and hydration.
Delta-9-tetrahydrocannabinol, or THC, is the primary psychoactive component of cannabis. THC and its metabolites, which remain in your body long after the effects have subsided, are detected by drug tests.
Since these metabolites are fat-soluble, they cling to bodily fat molecules. They could thus take a while to fully pass through your system, particularly if your body fat percentage is higher.
THC is absorbed by tissues and organs (including the brain, heart, and fat) and converted by the liver into chemicals such as 11-hydroxy-THC and carboxy-THC. Cannabis is eliminated in feces at a rate of around 65%, while urine accounts for 20%. The leftover amount might be kept within the body.
THC deposited in bodily tissues ultimately re-enters the circulation and is processed by the liver. For frequent users, THC accumulates in fatty tissues quicker than it can be removed, thus it may be detectable in drug tests for days or weeks following consumption.
The detection time varies according to the amount and frequency of cannabis usage. Higher dosages and regular usage result in longer detection times.
The type of drug test also affects detection windows. Blood and saliva tests typically detect cannabis metabolites for shorter periods, while urine and hair samples can reveal use for weeks or even months. In some cases, hair tests have detected cannabis use over 90 days after consumption.
Detection Windows for Various Cannabis Drug Tests
Urine Tests
Among all drug tests, urine testing is the most commonly used method for screening for drug use in an individual.
Detection times vary, but a 2017 review suggests the following windows for cannabis in urine after last use:
– Single-use (e.g., one joint): up to 3 days
– Moderate use (around 4 times a week): 5–7 days
– Chronic use (daily): 10–15 days
– Chronic heavy use (multiple times daily): over 30 days
Blood Tests
Blood tests generally detect recent cannabis use, typically within 2–12 hours after consumption. However, in cases of heavy use, cannabis has been detected up to 30 days later. Chronic heavy use can extend the detection period in the bloodstream.
Saliva Tests
THC can enter saliva through secondhand cannabis smoke, but THC metabolites are only present if you’ve personally smoked or ingested cannabis.
Saliva testing has a short detection window and can sometimes identify cannabis use on the same day. A 2020 review found that THC was detectable in the saliva of frequent users for up to 72 hours after use, and it may remain in saliva longer than in blood following recent use.
In areas where cannabis is illegal, saliva testing is often used for roadside screenings.
Hair Tests
Hair follicle tests can detect cannabis use for up to 90 days. After use, cannabinoids reach the hair follicles through small blood vessels and from sebum and sweat surrounding the hair.
Hair grows at approximately 0.5 inches per month, so a 1.5-inch segment of hair close to the scalp can reveal cannabis use over the past three months.
Factors Affecting THC and Metabolite Retention
The length of time THC and its metabolites stay in your system depends on various factors. Some, like body mass index (BMI) and metabolic rate, relate to individual body processing, not the drug itself.
Other factors are specific to cannabis use, including:
– Dosage: How much you consume
– Frequency: How often you use cannabis
– Method of consumption: Smoking, dabbing, edibles, or sublingual
– THC potency: Higher potency can extend detection time
Higher doses and more frequent use generally extend THC retention. Cannabis consumed orally may remain in the system slightly longer than smoked cannabis, and stronger cannabis strains, higher in THC, may also stay detectable for a longer period.
How Quickly Do the Effects of Cannabis Set In?
When smoking cannabis, effects appear almost immediately, while ingested cannabis may take 1–3 hours to peak.
The psychoactive component THC produces a “high” with common effects such as:
– Altered senses, including perception of time
– Mood changes
– Difficulty with thinking and problem-solving
– Impaired memory
Other short-term effects can include:
– Anxiety and confusion
– Decreased coordination
– Dry mouth and eyes
– Nausea or lightheadedness
– Trouble focusing
– Increased appetite
– Rapid heart rate
– Restlessness and sleepiness
In rare cases, high doses may lead to hallucinations, delusions, or acute psychosis.
Regular cannabis use may have additional mental and physical effects. While research is ongoing, cannabis use may increase the risk of:
– Cognitive issues like memory loss
– Cardiovascular problems including heart disease and stroke
– Respiratory illnesses such as bronchitis or lung infections
– Mood disorders like depression and anxiety
Cannabis use during pregnancy can negatively impact fetal growth and development.
Duration of Effects
Short-term effects generally taper off within 1–3 hours, but for chronic users, some long-term effects may last days, weeks, or even months. Certain effects may even be permanent.
Bottom Line
The amount of time that cannabis remains in your system following a single use varies greatly depending on individual characteristics such as body fat, metabolism, frequency of use, and mode of intake. Frequent users may maintain traces of THC for weeks, whereas infrequent users may test positive for as little as a few days. Hair tests can disclose usage for up to 90 days, while blood and saliva tests identify more recent use. Urine tests are the most popular and have varying detection durations. The duration that THC and its metabolites are detectable will ultimately depend on a number of factors, including dose, strength, and individual body chemistry.
PEE IN A CUP COMING UP, READ ON..
Is kratom addictive? Discover the potential for dependence on Kratom, the risks involved with its use, and how to approach its consumption responsibly.
From 2011 to 2017, over 1,800 calls to poison centers involved kratom in the U.S. This significant number highlights the concern regarding kratom addiction.
However, without Food and Drug Administration (FDA) oversight, and due to various consumption methods like teas and capsules, there are significant health risks. Safe use of kratom is now in question due to these issues.
Research debates how dependence develops, outlining signs like loss of control and withdrawal symptoms. These signs are seen in regular kratom users. Ironically, some people switch from drugs like heroin to kratom, looking for a legal alternative.
Understanding Kratom: Origins and Prevalence
Kratom comes from the Mitragyna speciosa tree in Southeast Asia. It can act like a stimulant or like opioids, based on how much you take. People use it in different ways, for a small energy boost or stronger effects at higher doses.
The legal status of kratom in the U.S. is complicated and changing. It’s a hot topic because some worry about its misuse. It’s still legal in several states. This shows how different places handle drug rules. The National Institute on Drug Abuse is looking into its medical benefits. But, the FDA hasn’t approved it for medical use yet. The DEA calls it a “drug of concern,” which means policies might change.
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From 2011 to 2017, poison control centers in the U.S. got over 1,800 reports about kratom. This shows it’s widely used and might pose health risks.
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Kratom’s main ingredients bind to opioid receptors very strongly, stronger than morphine even. This fact is key to understanding its effects.
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As more people use kratom, more are reporting serious health problems. These include liver and heart issues, and tough withdrawal symptoms, particularly in those already sick.
The statistics show mounting worries about kratom in the U.S. As its use grows, it’s becoming more important to health policies and laws. What happens next will depend on further research and legal decisions.
Is Kratom Addictive: Investigating the Substance’s Nature
The question of kratom’s addictiveness focuses on how it affects brain receptors and its long-term health implications. The ongoing debate highlights concerns about dependence and the risk of addiction. Scientists are closely looking at these issues.
How Kratom Works in the Brain
Kratom’s main alkaloids, mitragynine and 7-hydroxymitragynine, bind to the brain’s opioid receptors, similar to painkillers and narcotics. This connection suggests a potential risk of dependence. These alkaloids are key to kratom’s pain relief but also point to possible addiction concerns, especially with frequent, high-dose usage.
Patterns and Consequences of Long-term Use
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Using kratom often, especially in large doses, can increase the risk of dependence and intense withdrawal symptoms, similar to opioid withdrawal.
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Although some use it for pain or to improve mood, long-term kratom users might see serious health problems, like liver damage and mental health issues.
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Withdrawal symptoms, including irritability, nausea, and sleep problems, show kratom’s impact on one’s physical and mental health.
Assessment of Addiction Risks
Studies indicate a significant risk of addiction to kratom, especially with high doses or frequent use. Dependence develops as the body gets used to kratom, leading to tolerance and a need for more to feel its effects. Withdrawal symptoms emphasize this risk, as highlighted by health experts.
Physiological Effects: Kratom’s Impact on the Body
There is a lot of debate about the safety and use of kratom. This herbal extract comes from the Mitragyna speciosa plant. It has drawn attention for its possible harmful effects on the body. The FDA has issued many warnings about kratom, raising safety concerns.
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Kratom Adverse Effects: Kratom users have reported side effects like nausea, vomiting, and confusion. More serious issues include high blood pressure and liver damage. These problems highlight the risks of using kratom.
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Herbal Extract Safety: Some kratom products contain heavy metals and pathogens. These can cause severe health issues, including death. This shows the importance of safety in herbal products.
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FDA Warnings and Regulations: The FDA has linked kratom to over 35 deaths and warns against using it. They point out the lack of medical uses and the risk of addiction.
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Physiological Impact: Kratom’s effects depend on the dose and the user’s body. Yet, it can lead to dangerous outcomes like liver damage and seizures.
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Safety Concerns from Authorities: Federal agencies like the DEA are worried about kratom’s safety. Although not a controlled substance, monitoring suggests users should be careful.
Kratom might offer temporary relief for some ailments, but it comes with significant risks. The FDA’s warnings should make people think twice. If considering kratom, it’s crucial to talk to a doctor first. Experts stress the need for safety and caution with herbal extracts.
Conclusion
Kratom’s role in health and regulation is complex, with views and research findings widely varied. Some people use kratom for its claimed health benefits, but it’s a hot topic. Experts advise caution and suggest consulting a doctor before using kratom due to the unclear effects.
Clinical studies using scores like SOWS and COWS haven’t confirmed withdrawal symptoms from kratom. This adds to the debate, especially when some users report withdrawal. This makes kratom a controversial subject among different findings and user experiences.
When it comes to treating opioid addiction, kratom can be both helpful and harmful. Some have used it successfully to fight addiction. Yet, some states have banned it. This highlights the need for regulations and consistent product quality. It also raises questions about kratom’s legal status due to mixed actions by authorities.
The situation shows how complex kratom is in the realm of substance use and law. Without clear evidence supporting either its benefits or risks, it poses a challenge. More research is needed to guide regulations and health advice. For now, anyone thinking of using kratom should be careful, seek medical advice, and keep up with laws and health guidelines.
WHAT IS KRATOM ANYWAY? READ ON…
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