Cannabis

Marijuana Shows Promise In Sickle Cell Disease Treatment

Published

1 year ago

October 18, 2023

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Exact projections remain unknown, but the Centers for Disease Control and Prevention (CDC) report that between 70,000 to 100,000 Americans have sickle cell disease. The disease causes a deficit in red blood cells and blocks blood flow throughout the body. This can result in chronic pain with patients typically prescribed opioids, despite potential side effect like addiction, constipation, and respiratory depression.

But a new study published in JAMA Network Open finds that cannabis could provide an alternative or adjunctive treatment to sickle cell patients. The research, co-led by UC Irvine researcher Kalpna Gupta and UC San Francisco’s Dr. Donald Abrams, represents the first double-blind, placebo-controlled, randomized clinical trial to explore marijuana as a potential pain relief for sickle cell.

“These trial results show that vaporized cannabis appears to be generally safe,” Gupta said. “They also suggest that sickle cell patients may be able to mitigate their pain with cannabis—and that cannabis might help society address the public health crisis related to opioids.”

Here's How You Can Disinfect Cannabis Packaging — Photo by Iryna Veklich/Getty Images

The trial recruited 23 participants with sickle cell-disease-related pain. They either inhaled a cannabis vaporizer with equal parts THC and CBD or a placebo over two five-day inpatient sessions. Researchers then recorded how pain still affected the general activities, sleep patterns, walking, and general mood of participants.

Those who inhaled cannabis reported general improvements in pain, with the effectiveness of the plant increasing over time. Subjects reported less and less pain interference in walking and sleeping and their moods also improved. However, Gupta noted the difference between the cannabis group and placebo group when it came to measuring pain were not statistically significant. But from the results she saw, Gupta still pushed for more research.

“Pain causes many people to turn to cannabis and is, in fact, the top reason that people cite for seeking cannabis from dispensaries,” said Gupta. “We don’t know if all forms of cannabis products will have a similar effect on chronic pain. Vaporized cannabis, which we employed, may be safer than other forms because lower amounts reach the body’s circulation. This trial opens the door for testing different forms of medical cannabis to treat chronic pain.”

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AARP

How Cannabis Can Help With Dysmenorrhea

Published

5 days ago

November 9, 2024

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Millions suffer, but relief could be here thanks to science and a simple plant. Here is how cannabis can help with dysmenorrhea.

It is an uncomfortable topic to discuss, but the painful truth is a majority of women will suffer it at some point and finding relief is invaluable. Around 80% of women experience period pain at some stage in their lifetime. Dysmenorrhea is the medical term for pain or discomfort during menstruation. It is a common gynecologic problem, but the pain can range from dull cramps to indescribable agony. Here is how cannabis can help with dysmenorrhea.

Medicinal cannabis has emerged as a potential treatment option for dysmenorrhea, offering hope for the tens of millions of women who suffer from menstrual pain. Current medical management options primarily consisting of over-the-counter pain relievers and hormonal contraceptives. The effectiveness of these treatments vary greatly.

The endocannabinoid system plays a role in uterine function and pain perception. Cannabinoid receptors CB1R and CB2R, as well as TRPV receptors, have been identified in human myometrial tissue. Tetrahydrocannabinol (THC), a primary component of cannabis, can act as a cannabinoid agonist, potentially triggering myometrial relaxation and easing menstrual pain.

The potential benefits of cannabis for dysmenorrhea includes pain relief, improved sleep quality, and reduced reliance on pharmaceutical pain relievers. While research specifically on cannabis for dysmenorrhea is growing, studies on chronic pain provide some insights:

A systematic review of 18 randomized controlled trials found that synthetic cannabis products with high THC-to-CBD ratios may offer moderate improvement in pain severity.
A meta-analysis of 32 trials showed that medical cannabis or cannabinoids resulted in small to very small improvements in pain relief, physical functioning, and sleep quality among chronic pain patients.

There is significant interest in using cannabis for gynecologic pain management:

A survey found that 61.2% of women who had never used cannabis and 90.0% of those who had were willing to try it for gynecologic pain.
After cannabis legalization in Canada, current cannabis use increased from 13.3% to 21.5% among women with self-reported moderate-to-severe pelvic pain.

With th American Medical Association, American College of Physicians and even AARP recognizing the medical benefits of cannabis, it is critical more research is funded. Millions of women may be in pain needlessly due to untreated dysmenorrhea.

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Cannabinoids

Staying Trim During The Holidays With Marijuana THCV

Published

6 days ago

November 9, 2024

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The holidays are fun and full of family, activities, and food. But does marijuana have a natural secret weapon to help you at least not gain weight this season?

The holidays are here – turkeys, pie, and family favorites. Along with Christmas cookies, holiday cocktails, everything adds up and starts to make a difference in how clothes fit. On average, people gain between 1-2 pounds in November and December. Some studies suggest people gain more, with an average of 2–5 pounds. But is marijuana’s THCV your natural holiday weight loss plan. While Ozempic has been the wonder drug of weight loss, cannabis a natural plant used for thousands of years in medicine. Why not use to look good also? Here is some information and also advice on how much to take and how it works.

The most famous cannabinoids are THC or CBD. Legal to over 50% of the country and used by millions across the country. While they are the most commonly used cannabinoids, the cannabis plant contains many other medically beneficial cannabinoids including THCV. Although THCV (Tetrahydrocannabivarin) is similar to THC, it contains its own unique benefits.

Research points to THCV’s ability to block the body’s rewarding sensations while eating different foods. If you’re looking to keep your food cravings at bay or prevent the munchies, check out strains high in THCV, which will suppress your appetite, especially during the holidays.

It has also been found that THCV in its purest form can calm the unreasonable urge to overeat while also reducing hunger cravings. Thus, consumption of THCV can be beneficial for those who struggle with weight gain and/or food craving. Since THCV can help curb one’s appetite, researchers believe there’s a potential for THCV helping people fight obesity and other related health issues.

It is important to manage the dosage. Start with a low dose of 5-7.5mg of THCV for appetite suppression effects. Options for taking THCV include gummies, tinctures, vapes, or THCV-rich cannabis strains Take THCV in the morning to help with focus and energy. Start on teh weekend so you can make sure it works in a way which is comfortable. Consume it with food to increase absorption.

Gummies and tincture/oils are the easiest ways to consume to manage the dosage. Start with half a gummy or 1 full gummy (typically 10mg) and adjust based on your response. You can increase to 2 gummies per day if needed. For tinctures, start with half a dropper or less and adjust as needed. Take THCV about an hour before you normally start feeling hungry

THCV should be part of a healthy routine including exercise and proper rest. Research on cannabis continues, to using THCV is not a long term solution, consider it for the holidays. As usual, take to your health professional to make sure it doesn’t interact poorly with any prescribed medications. Start low and grow so you can pay attention how your body and mind reacts.

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alcohol

Science Says Cannabis Can Be Making Us Healthier

Published

6 days ago

November 8, 2024

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As it it becomes available to more people, there is a positive health change going on according to data.

Cannabis is becoming more mainstream and and the side effects are doing even better than expected. It seems the availability of legal marijuana is helping with the health of the general population. Studies in California, Canada and the now New Zealand have shown the upside of legalization. While cannabis has been used for health benefits for millions of years, reduction in more harmful intoxication products is another important wellness trend.

Alcohol consumption is associated with significant health risks, including liver damage, cardiovascular issues, and certain cancers. In contrast, marijuana has not been linked to the same level of severe physical health consequences. The Centers for Disease Control and Prevention (CDC) reports that over 36,000 annual U.S. deaths are attributed to chronic alcohol use, while there is no comparable category for marijuana-related deaths. Alcohol is also much more addictive than marijuana, causing long term physical and mental issues.

A study from New Zealand has found some interesting trends regarding the relationship between marijuana legalization and the consumption of alcohol and opioids.

heart cannabis — Photo by megaflopp/Getty Images

Following the legalization of marijuana in New Zealand, researchers observed a notable decline in alcohol consumption:

There was a 6-9% decrease in the frequency of binge drinking among adults aged 21 and older.
The study found no significant impact on underage drinking rates among those aged 12-20.

This suggests for adults, marijuana may be serving as a substitute for alcohol in some cases, particularly when it comes to heavy drinking episodes.

The relationship between marijuana legalization and opioid use appears more complex:

There was no clear evidence of marijuana legalization directly reducing opioid use or abuse.
However, some research indicates that people who use cannabis are more likely to initiate opioid use, with an odds ratio of 2.76 compared to non-cannabis users.
The likelihood of transitioning from opioid use to opioid use disorders among cannabis users was found to be 2.52 times higher than non-cannabis users.

The study also revealed some additional findings regarding substance use patterns:

Marijuana use increased by 16% among adults aged 21 and older following legalization.
There was a 5-6% increase in marijuana use initiation among adolescents and young adults aged 12-20. This would be go with the greater North American trend of California sober and Gen Z drifting away from alcohol and more into marijuana.
No significant changes were observed in the use of hard drugs like cocaine or heroin in any age group.

These findings suggest while marijuana legalization may lead to decreased alcohol consumption among adults, it does not necessarily translate to reduced use of other substances, particularly opioids. The relationship between cannabis use and other substance use behaviors is complex and multifaceted. Time and more research should yield more benefits.

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