Featured

Non-hallucinogenic Neuroplastogens Enter First-in-Human Trials

Published

1 year ago

January 17, 2024

admin

For years, researchers have been looking for ways to harness the medical benefits of psychedelics, but without the hallucinations. Some neuroscientists even believe that the drugs’ mental-health benefits don’t come from tripping at all. Now, for the first time, researchers have developed psychedelic-inspired drugs that to bring on neuroplastic effects without producing a trip – a new breed of neuroplastogens.

Neuroplasticity explained

Neural plasticity describes the brain’s ability to change, adapt, and form new connections in response to various stimuli. It’s a vital aspect of healthy brain function, and as such, essential to the way we humans function in our day-to-day lives. Situations in which the brain demonstrates neuroplasticity include learning a new skill such a subject in school or a new language, practicing music, memorizing directions in a new city, and working on puzzles and memory games. It can also occur when a person loses a sense, such as hearing or sight, and their other senses start to overcompensate for the lost one.

Many neurological and psychiatric ailments stem from a lack of neuroplasticity in the brain, which leads to poorly adaptive behavioral responses. Anxiety, depression, and substance abuse are common in people whose brains are unable to strengthen these beneficial circuits. Developing and maintaining neuroplasticity is crucial in promoting recovery from these brain and mood disorders that a large percentage of the adult population struggle with.

Juvenile brains exhibit remarkable neuroplasticity, with both the ability to learn new things as well as the brain being able to quickly mend damaged circuits. But as we grow older, our brains become less plastic and we’re more prone to getting stuck in negative thought and behavioral patterns. This is why external intervention, often in the form of hallucinogenic drugs, is sometimes necessary to repair those broken connections and pathways.

The science of neuroplastogens

Neuroplastogens, also known as psychoplastogens, are a group of small-molecule drugs that are capable of producing rapid and long-lasting effects on both neural structure and function. Many are so potent that they are known to produce the desired therapeutic effects after only a single session. As such, neuroplastogens are quickly becoming the go-to option for treating these neurological disorders.

Typically, hallucinogenic drugs like psilocybin and LSD, or dissociatives like ketamine and MDMA, are the gold-standard when it comes to improving neuroplasticity. Recently approved second-generation psychedelics like Spravato and COMP360 work via the same mechanisms. And as incredible as these substances may be, the problem is that not all patients have the time or desire for a psychedelic trip.

A huge number of prospective consumers would prefer to reap the therapeutic benefits of these drugs, without the high. Not to mention, for reasons of liability, when doctors prescribe hallucinogens, the patient needs to be strictly monitored for the duration of their trip, which adds another layer of complexity (as well as higher costs) to the treatment process involving these drugs.

Source link

allergies

Cannabis Can Help A Sore Throat

Published

11 hours ago

April 2, 2025

admin

There is a buzz about sore throats today. While they are most common in colder months, spring allergies bring the pain also. This is often due to postnasal drip, which is when mucus from the nose and sinuses drains down the back of the throat, causing irritation and a scratchy feeling. Overuse of the voice, like talking loudly or singing for long periods, can tire out and strain the muscles in your throat, causing them to feel sore. The good news is cannabis can help a sore throat.

RELATED: How Hemp Helps You Sleep

For those seeking natural alternatives to manage cold symptoms, cannabis is emerging as a promising option for throat irritation. Increasing research at medical center specifically targeting sore throats shows early insights. The data suggests cannabinoids and terpenes could offer symptom relief through their unique properties.

medical marijuana — Photo by Esther Kelleter / EyeEm/Getty Images

Cannabis contains compounds like THC and CBD, which studies indicate possess anti-inflammatory properties that may reduce throat swelling and irritation. Terpenes such as eucalyptol—found in some strains—are traditionally associated with decongestant effects, potentially easing respiratory discomfort. These components work synergistically to calm inflamed tissues, though their direct impact on sore throats requires further clinical validation.

Smoking cannabis while ill remains controversial due to potential throat irritation from heat and smoke. Instead, experts recommend gentler options:

Edibles/lozenges: THC or CBD-infused products bypass inhalation, delivering localized relief without aggravating the throat.
Cannabis tea: Warm beverages with cannabis extracts may soothe scratchy throats while providing hydration.
Tinctures: Sublingual CBD oils allow precise dosing and avoid respiratory irritation.

Beyond direct throat relief, cannabis may improve overall wellness during illness. THC’s appetite-stimulating properties can combat reduced hunger, while its relaxing effects might promote restorative sleep. CBD’s muscle-relaxing qualities could help alleviate the body aches often accompanying colds.

While preliminary findings are encouraging, users should consult healthcare providers before combining cannabis with conventional cold medications due to potential interactions. Starting with low-dose CBD products may offer benefits without psychoactive effects. As legalization expands, more targeted research is expected to clarify cannabis’s role in respiratory health.

Innovative cannabis formulations—from throat-calming lozenges to anti-inflammatory teas—are redefining how we approach minor ailments. For those navigating cold season, these plant-based solutions present a compelling fusion of traditional herbal wisdom and modern cannabinoid science

Source link

Cannabis

White House Finally Comments On Marijuana Industry

Published

1 day ago

April 1, 2025

admin

Part of the cannabis industry supported the new president, betting he was going to move and move quickly on cannabis – the White House finally commented.

The cannabis industry has been a boon for consumers, medical patients, veterans and legal states, but for the thousands of mom and pop businesses is has been a roller coaster. With a huge demand, it would seem to be easy money, but the federal, tax, and banking restrictions have made it difficult to grow and expand. Part of the industry were all for the new administration assuming they would support positive change, but many in the new cabinet and the House Speaker Mike Johnson are foes. Now the White House finally comments on marijuana industry…and it doesn’t show a clear path.

The administration’s current stance on marijuana reform is marked by inaction, despite campaign promises and earlier signals of support for cannabis-related reforms. A White House official recently confirmed that “no action is being considered at this time” regarding marijuana policy, leaving advocates and industry stakeholders uncertain about the administration’s priorities.

During his campaign, the resident expressed support for rescheduling marijuana under the Controlled Substances Act (CSA), which would move it from Schedule I to Schedule III, easing restrictions on medical use and enabling cannabis businesses to access banking and tax benefits. However, since taking office, no concrete steps have been taken to advance this initiative. A DEA hearing on rescheduling, initially planned for January 2025, was postponed due to procedural appeals and remains unscheduled.

The president has also voiced support for state autonomy in cannabis policy and endorsed state-level legalization initiatives, such as Florida’s failed 2024 ballot measure for recreational marijuana. While this reflects a more favorable stance compared to his first term, his administration has yet to prioritize federal reforms like the SAFE Banking Act, which would facilitate banking services for cannabis businesses. Efforts to include such measures in a government funding bill late last year were unsuccessful.

The delay in federal action has significant implications for the cannabis industry. Rescheduling marijuana could alleviate financial burdens by eliminating restrictions under IRS Code Section 280E and promoting medical research. However, the stalled process leaves businesses navigating regulatory uncertainties and limited financial access.

While stakeholders continue lobbying for reform, the administration appears focused on other priorities such as immigration and foreign policy. Advocates hope the President will leverage his influence to advance cannabis reform, but for now, the issue remains sidelined. Until then the industry struggles and waits.

Source link

april fools

The History Behind April Fool’s Day

Published

2 days ago

April 1, 2025

admin

Love it or hate it – April Fool’s Day is here to stay…and here is the history behind this unique tradition

From Britain to India, it is a popular day of pranks, laughs and silliness. From Google to Burger King has participated and some people spend endless hours planning the perfect joke. But what is the history behind April Fool’s Day? It is celebrated annually on April 1, is a global tradition marked by pranks and jokes. Despite its widespread popularity, the origins of this playful holiday remain uncertain, with several theories tracing its roots to different historical events and cultural practices.

Both April Fools’ Day and Día de Los Inocentes mark days when people play practical jokes on one another. April Fools’ Day is primarily celebrated in English-speaking countries, while Día de Los Inocentes is more widely marked in Spanish-speaking countries. A key way Día de Los Inocentes differs from April Fools’ Day is it celebrated on December 28th every year

Some of the most famous April Fool’s pranks include The Swiss Spaghetti Harvest, where the BBC broadcast a segment showing peasants harvesting spaghetti from trees in Switzerland. Another notable prank was when radio station KGB-FM in San Diego announced that the Space Shuttle was landing at a local airport, drawing over 1,000 people. Google has also been known for its annual April Fool’s jokes, such as the “Hyper Text Coffee Pot Control Protocol”. Additionally, brands like Pornhub have participated with humorous site name changes, such as “Cornhub” and “Hornhub”

One popular theory links April Fool’s Day to the adoption of the Gregorian calendar in 1582, initiated by Pope Gregory XIII. Before this change, many European countries followed the Julian calendar, where the new year began around late March or early April. Those who continued celebrating the old New Year date were mocked as “April fools,” giving rise to the holiday’s name and customs.

A Burger Kind April Fool's prank....

Another theory suggests that April Fool’s Day may have originated from ancient spring festivals such as Rome’s Hilaria or India’s Holi. Hilaria, celebrated in late March, involved games, disguises, and mockery of neighbors, while Holi featured playful pranks and joyous festivities marking the arrival of spring.

The first definitive reference to April Fool’s Day comes from a 1561 Flemish poem by Eduard de Dene. In this humorous tale, a nobleman sends his servant on absurd errands for nonexistent items, a prank still known as a “fool’s errand.” This poem solidifies April Fool’s Day as an established tradition by the late Middle Ages.

In France, the day became known as poisson d’avril (“April fish”), where children would pin paper fish on unsuspecting friends’ backs. This tradition symbolizes gullibility, likening victims to young fish easily caught.

By the 18th century, April Fool’s Day had spread across Europe and North America. In Scotland, it evolved into “Gowkie Day,” where people were sent on wild goose chases. The following day, “Tailie Day,” involved pranks like pinning “kick me” signs on others. Media outlets also began participating in the holiday by publishing fake headlines and stories—a tradition that continues today.

While the exact origin remains debated, April Fool’s Day thrives as an opportunity for lighthearted fun worldwide. Its enduring appeal lies in its ability to bring laughter and mischief into everyday life, transcending cultural boundaries and historical uncertainties.

Source link