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Patient Zero for Untreatable Depression Begins Groundbreaking Psychedelics Therapy

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In a phase 2b clinical trial, Beckley Psytech has started treating the first subject for BPL-003, an intranasal synthetic formulation of the psychedelic chemical 5-MeO-DMT intended for patients with treatment-resistant depression.

 

With FDA clearance for investigational new medication status in February, this groundbreaking research represents the biggest controlled examination into the potential of 5-MeO-DMT, involving 40 locations throughout Australia, Europe, and the US.

 

The trial, employing a randomized, quadruple-masked design, seeks to identify optimal dosages of BPL-003, complemented by psychological support, in 225 individuals grappling with moderate to severe treatment-resistant depression, compared to a placebo group.

 

Efficacy will be gauged using the Montgomery-Asberg Depression Rating Scale at various intervals throughout the trial, with all participants receiving psychological support before, during, and after dosing. An open-label extension is slated for select sites eight weeks post-initial dosing to evaluate sustained effects following a second dose.

 

Anticipated findings from this phase 2b endeavor, projected by late 2024, will augment insights gleaned from the ongoing phase 2a exploration of BPL-003, as highlighted by the company.

 

Cosmo Feilding Mellen, CEO of Beckley Psytech, expressed confidence in the compound, citing promising safety and pharmacokinetic data. He emphasized its capacity to induce brief yet profound subjective experiences correlating with therapeutic benefits, underscoring the company’s eagerness to advance BPL-003 through the clinical development pipeline.

 

Unprecedented Research Scope

 

An important turning point in the field of psychedelic research, especially in the area of mental health therapy, was reached with the start of Beckley Psytech’s phase 2b clinical experiment. The large-scale nature of this experiment highlights an important development in our knowledge of the therapeutic potential of psychedelic substances, with a particular emphasis on 5-MeO-DMT for patients suffering from depression that does not respond to conventional therapy. This experiment, which spans 40 sites throughout Australia, Europe, and the US, is the biggest controlled investigation into the possible effectiveness of 5-MeO-DMT, in contrast to earlier research. This wide outreach guarantees a varied pool of participants and improves the trial’s outcomes dependability and generalizability.

 

A rising awareness among scientists of the need for novel strategies to tackle the widespread problems associated with treatment-resistant depression is reflected in the decision to launch such an extensive research project. Researchers want to increase the number of therapy choices available for those who have not reacted well to traditional medications by investigating the therapeutic benefits of 5-MeO-DMT in a rigorous clinical environment. The trial’s multi-site design also makes it easier for clinicians and researchers in various areas to collaborate, which promotes a group effort to further our understanding of psychedelic-assisted treatment.

 

The size of this phase 2b experiment not only emphasizes the significance of its findings, but also demonstrates Beckley Psytech’s dedication to pushing the limits of psychedelic research. Through strategic alliances and diligent preparation, the firm has proved its commitment to performing high-quality clinical studies that meet rigorous scientific criteria while investigating novel treatment approaches. This innovative method not only aids the area of mental health treatment, but also helps to de-stigmatize psychedelics by demonstrating their ability to treat significant psychiatric illnesses safely and responsibly.

 

The experiment is expected to yield valuable insights that might influence future research, clinical recommendations, and regulatory choices related to the use of psychedelic substances in mental health therapy. This is because the trial is expected to proceed and data will accrue. Psychedelic-assisted therapy is being promoted as a possible therapeutic option for the intricate problems associated with treatment-resistant depression, thanks to the combined efforts of researchers, physicians, and study participants.

 

Trial Design and Objectives

 

BPL-003’s phase 2b clinical trial has been carefully designed to assess the drug’s potential as a therapy for people with depression who are not responding to conventional treatments. The experiment uses a quadruple-masked, randomized design to reduce biases and guarantee the validity and dependability of the results. This methodological rigor bolsters the foundation for well-informed decision-making on developing BPL-003 and increases the legitimacy of the study’s findings.

 

Central to the trial’s objectives is the identification of optimal dosages of BPL-003 that can effectively alleviate symptoms of moderate to severe treatment-resistant depression. By employing a range of doses and comparing them against a placebo group, researchers seek to discern the therapeutic window within which BPL-003 demonstrates the greatest efficacy while minimizing adverse effects. This dose-finding aspect of the trial is crucial for informing subsequent clinical studies and eventual therapeutic use.

 

The experiment incorporates psychological support as an additional therapeutic component in addition to dose optimization. All patients get thorough psychological care before, during, and following medication since it is acknowledged that depression is a complex condition with psychosocial components that may influence treatment outcomes. To promote complete healing and recovery, this holistic approach emphasizes the need to address not only the biology but also the psychological and emotional elements of depression.

 

Furthermore, the trial’s design includes strong metrics for measuring effectiveness, particularly using the Montgomery-Asberg Depression Rating Scale at several points throughout the research. This validated method enables researchers to systematically assess changes in depression symptoms and track the therapeutic benefits of BPL-003 over time. The trial uses standardized evaluation techniques to improve the consistency and comparability of outcomes across multiple research sites, increasing the reliability and generalizability of the findings.

 

Evaluation Methods and Milestones

 

A wide range of evaluation techniques and milestones are included in the phase 2b clinical study to assess BPL-003’s effectiveness in treating depression that is resistant to therapy. The Montgomery-Asberg Depression Rating Scale, a reliable instrument for gauging depression symptoms and treatment response, is a key component of this evaluation. Researchers can systematically monitor changes in participants’ depressed symptoms and evaluate the therapeutic efficacy of BPL-003 in comparison to placebo by giving this scale to participants at different intervals during the experiment.

 

The study underlines the need to provide psychological support to all participants before, during, and after dosing. This integrated approach stresses the need to meet the holistic needs of patients receiving therapy while also recognizing the complex interplay between biological, psychological, and social factors in depression. The study’s purpose is to improve treatment outcomes and participants’ overall well-being by offering comprehensive psychological support, such as counseling and therapeutic sessions, during the experiment.

 

Furthermore, the trial includes an open-label extension phase at select sites, scheduled eight weeks post-initial dosing, to evaluate the sustained effects of BPL-003 following a second dose. This extension phase allows researchers to assess the durability of treatment response and investigate the potential for long-term therapeutic benefits. By extending the observation period beyond the initial dosing phase, the trial aims to provide insights into the maintenance of treatment effects over time and inform recommendations for the optimal dosing regimen of BPL-003 in clinical practice.

 

Bottom Line

 

Beckley Psytech’s phase 2b clinical trial of BPL-003 for treatment-resistant depression marks a significant milestone in psychedelic research. With its expansive scope, rigorous trial design, and emphasis on comprehensive evaluation methods, the study holds promise for advancing our understanding of psychedelic-assisted therapy. As the trial progresses and data accumulates, it is poised to provide valuable insights that could influence future treatment approaches and regulatory decisions in the field of mental health.

 

MUSHROOMS TO END DEPRESSION, READ ON…

MUSHROOMS FOR DEPRESSION

UK STUDY SAYS MUSHROOMS ARE BEST DRUG TO FIGHT DEPRESSION!



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Cannabis and the Authoritarian State

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Cannabis and the Authoritarian State

Cannabis has been legal for longer than it has been illegal. Let that sink in for a minute. For thousands of years, humans cultivated and consumed cannabis freely across civilizations and continents. It wasn’t until the early 1900s that we witnessed a massive push to drive hemp and cannabis into the black market, primarily due to industrial competition from petrochemicals, pharmaceuticals, and other industrial applications.

What makes cannabis so threatening to powerful interests? For starters, hemp and cannabis are highly versatile crops with over 50,000 different uses, from medicine to textiles to fuel. Even more remarkable is how this plant is hardwired to work with the human body through our endocannabinoid system—a biological network we didn’t even discover until the 1990s.

Perhaps most threatening of all is that cannabis is insanely easy to grow. This means that if the plant helps you with a particular physical ailment, you have the ability to grow your own medicine indefinitely. No insurance premiums, no wait lists, no pharmaceutical middlemen—just you cultivating your own healing directly from the earth.

Authoritarians do not like this, not one bit. When people can meet their own needs independently, power structures lose their grip. When citizens can think differently without permission, control systems begin to fail. So today, we’re going to look at the interesting relationship between authoritarianism and cannabis, and how this humble plant plays a key role in keeping you free.

We’ve already established the versatility of cannabis, but there’s another element that those old D.A.R.E. PSAs inadvertently reveal about what authoritarians think about cannabis. I’m talking, of course, about “behavior.” You see, in an authoritarian system, you and I are but cogs in the machine. We’re the expendables who should be proud to work ourselves to death for our “fearless leaders.”

This is precisely why certain ideas, philosophies, religions, movements, books, and substances are typically banned in authoritarian regimes. Take North Korea as an example: everything from the type of television citizens watch to the music they hear is a tightly spun spell designed to keep the populace in check. While they don’t have explicit laws against hemp (they actually grow it industrially), smoking psychoactive cannabis is strictly forbidden.

Contrast this with places like Malaysia, where you can get up to 5 years for possessing just 20 grams of cannabis, and even face the death penalty depending on the situation. These authoritarians don’t play around when it comes to cannabis because they know it affects the behavior of their populace in ways they can’t control.

The question becomes: what behavior do they fear so much that cannabis produces within the individual?

The answer is a critical mind. People who consume cannabis often begin to question their own belief systems. Most regular users undergo some transformation in their values and perspectives. Cannabis has a unique way of helping people see beyond cultural programming and think outside established paradigms. It can make the familiar strange and the strange familiar—a psychological state that’s antithetical to authoritarian control.

This independent thinking runs counter to the narrative of authoritarians who wish to maintain a tight grip on social consciousness. If even 10% of a population begins to pivot in their behavior within a regime, it can have massive ripple effects. Just look at cannabis in the US—it went from being demonized to being embraced by the majority in less than 80 years, despite massive propaganda efforts.

For authoritarians, psychoactive cannabis isn’t primarily a threat to public health and wellbeing—it’s a threat to the health and wellbeing of authoritarianism itself. When people start thinking differently, they start living differently. When they start living differently, they start demanding different. And that’s the beginning of the end for any system built on unquestioning obedience.

Beyond the threat to thought control, there’s another reason why drugs in general remain illegal: the state can use prohibition as a weapon against the populace. This isn’t conspiracy theory—it’s documented history.

Take Nixon’s war on drugs. His domestic policy chief, John Ehrlichman, later admitted: “We knew we couldn’t make it illegal to be either against the war or black, but by getting the public to associate the hippies with marijuana and blacks with heroin, and then criminalizing both heavily, we could disrupt those communities.” Nixon essentially placed cannabis on the Controlled Substances Act because he needed an excuse to shut down anti-war protests and target Black communities.

Since hippies and anti-war protesters were smoking “freedom grass,” making it illegal would circumvent their freedom of speech and freedom of assembly, and more importantly—turn free citizens into state property. It’s a win-win if you’re an authoritarian looking to silence dissent.

Then there’s the whole “boogeyman” complex that prohibition creates. We’re told “drug dealers” are roaming the streets preying on innocents, giving them “marihuanas” so they can do vile things. What the government conveniently leaves out is how the banks these “dealers” use to launder their money remain untouched. They don’t mention the shadier dealings of law enforcement either—like running guns into Mexico (eventually leading to the death of one of their own), or spraying poison on crops, killing and hospitalizing people because, you know…”Drugs are bad!”

Authoritarians cannot let go of the value that keeping the most widely used illicit substance in the world illegal provides them. This explains why the US hasn’t federally legalized cannabis despite nearly 80% of Americans supporting some form of legalization. It’s not because they don’t have enough research or that they’re genuinely concerned about public health—it’s because prohibition gives them all the privileges of violating constitutional rights while siphoning money into their coffers.

Drug prohibition creates a perpetual enemy that can never be defeated, allowing endless justification for surveillance, militarized police, asset forfeiture, and expansion of state power. What authoritarian could resist such a convenient tool?

Cannabis is a plant. You can’t make nature illegal—it’s counter to the human experience. When governments attempt to criminalize a naturally occurring organism that humans have cultivated and used for thousands of years, they reveal the absurdity of their position and the limits of their authority.

While the United States isn’t a full-on authoritarian state (yet), the truth is that many authoritarian elements have played out over the years. You only need to look as far as the war on drugs to see how the state utilizes prohibition as a weapon to their advantage. From no-knock raids to civil asset forfeiture to mass incarceration, drug laws have erected a parallel legal system where constitutional protections often don’t apply.

The fundamental truth is that cannabis is not only versatile and medicinal, it gives you back your autonomy in multiple ways. It helps you think for yourself. It allows you to grow your own medicine. It connects you with a plant that humans have used ceremonially, medicinally, and industrially throughout our history. And this autonomy is something authoritarians cannot stand—free individuals who know how to think beyond the narratives they’re fed.

Cannabis doesn’t just get you high—it offers a perspective from which the absurdities of prohibition become glaringly obvious. Perhaps this is why, as state after state legalizes, we’re witnessing the slow but steady unraveling of one of the most enduring authoritarian policies in American history.

So if you count yourself among those who value freedom of thought and bodily autonomy, who believe that nature doesn’t require government permission, and who understand that true liberty includes the right to explore your own consciousness—well, maybe it’s time to toke one up for freedom!

 

LEGALIZING CANNABIS IS NOT ENOUGH, READ ON..

LEAGLIZATION OF CANNABIS

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Stop Using Bat Poop to Fertilize Your Weed Plants Immediately, Here is Why…

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Don’t Fertilize Your Weed with Bat Poop

 

Fertilization is a critical step for growing healthy marijuana plants.

They help provide essential nutrients for marijuana in various stages of growth, while promoting plant growth. There are dozens of different fertilizers to choose from in the market; growers can choose based on budget, nutrients needed, location, season, and much more. But not all fertilizers are made equally – of course, some are of better quality than others.

That said, there are some rather unusual fertilizers that can be used on plants. These may include, but are not limited to: coffee, milk, grass clippings, banana peels, fish tank water, potato water, and even urine! Yes, it does sound strange, but to gardening enthusiasts, there is nutritional value to be found in each of these things, which can make them suitable fertilizers depending on the circumstances.

For example, grass clippings make excellent mulch and can provide potassium, nitrogen, and phosphorus. Urine is a potent source of nitrogen as well as phosphorus. Banana peels are rich in calcium, which is excellent for promoting root growth while helping supply oxygen to the soil.

But what about bat poop? Also known as guano, bat poop has been said to work as a plant fertilizer because it’s rich in nitrogen, potassium, phosphorus, and other nutrients. Unfortunately, using bat poop as a plant fertilizer can also be dangerous. So if you don’t really know what you are doing, bat poop as a fertilizer can be extremely risky.

Bat Poop Fertilizer Kills 2 NY Men

On December 2024, news of two men hailing from Rochester, New York, dying went viral.

The cause of death was dangerous fungus, in the bat poop that they were using to fertilize their marijuana plants. Both men grew their own marijuana plants for medical consumption, but unfortunately developed histoplasmosis after breathing toxic fungal spores from the guano.

One of the men was aged 59 years old; he bought bat poop online to use as fertilizer for his plants. Meanwhile, the other was a 64-year-old male who found guano in his attic, then decided to use it to fertilize his cannabis plants. They both developed similar symptoms, including chronic coughs, fever, severe weight loss, and respiratory failure. The case was also discussed in the Open Forum Infectious Diseases medical journal.

Is there a safe way to use bat poop as fertilizer? If you ask me, I truly can’t understand why one would use guano as fertilizer when there are so many other proven safe alternatives out there that are simply not as risky. According to the University of Washington, one must always wear a dust mask each time you open a bag containing soil amendments. That’s because a mask will greatly decrease the chances of breathing in fungal spores, which could be potentially dangerous. They also go on to explain that yes, guano is indeed used as fertilizer for its valuable nitrogen content but it still isn’t without its own risks, particularly of developing Histoplasma – the same condition that killed the two men.

Make Your Own Safe Fertilizers At Home

There are many other safe, affordable – and even free – fertilizers you can feed your marijuana plants with. It doesn’t have to cost a fortune nor does it have to be risky to your health.

Check out these easy, low-cost, DIY fertilizers for weed:

 

  • Coffee grounds are abundant in nitrogen, which makes it perfect for the vegetative stage of marijuana plants. They are also a fantastic source of organic materials and green waste, which contain other vital nutrients. When the coffee grounds decompose, they create soil aggregates that improve soil aeration and its water retention capabilities.

 

Mix around 2 grams of coffee ground for every liter of soil. Measuring its pH levels is also helpful, since you want it to be between 6 to 6.5

 

  • Crushed eggshells are a great way to ensure no eggshells go to waste. It’s rich in calcium plus other minerals that are effective in improving overall plant structure, health, and growth. In fact, so many gardeners and farmers commonly use crushed eggshells to help boost plant growth – and it will work just as well for marijuana plants.

 

They’re really easy to use, too! Just mix eggshells into the soil, or steep them into water then pour into the soil for a calcium-packed feed.

 

  • Banana tea or water is rich in potassium and magnesium, making it perfect as a feed during the marijuana plant’s flowering stage. You can use banana peels differently: with 3 to 5 banana peels, soak it in water for 2 days. Then you can use the water on your plants, and even leave the banana peels as compost for your garden.

 

  • Wood ash from your fireplace or other sources is a great source of phosphorus and potassium. Simply sprinkle some wood ash over marijuana during the final flower phase. Just use 1 or 2 grams of ash for every liter of substrate. Be careful not to use too much wood ash, or it can make the soil too alkaline.

 

  • Animal manure, such as those from cows, rabbits, or horses, make excellent organic fertilizers. Just be sure that they’re composed properly so that you avoid introducing weed seeds, or pathogens.

 

These low-cost fertilizers are also natural and effective. There’s no reason for you to turn to bat poop as fertilizer, even if you’re in a bind.


Conclusion

Guano or bat poop is a poor choice of fertilizer if you don’t know what you are doing. It’s risky and potentially dangerous – just not worth it. Instead, fertilize your marijuana plants with these options mentioned.

 

BEST POOP FOR CANNABIS PLANTS, KEEP READING…

BEST POOP FOR CANNABIS PLANTS

WHAT IS THE BEST POOP FOR USING ON CANNABIS PLANTS?



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Getting THC Edibles in Your Edible Arrangement?

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Edible Arrangements Leans into Intoxicating Hemp Products: A Strategic Expansion

 

Edible Arrangements, a brand renowned for its vibrant fruit bouquets and sweet treats, is embarking on a bold new venture into the hemp and THC-infused edibles market. Through its parent company, Edible Brands, the company has launched Edibles.com, an e-commerce platform offering a variety of hemp-based products such as THC-infused beverages, gummies, and snacks. This strategic move taps into the burgeoning demand for cannabis-related wellness products and reflects a deliberate expansion beyond traditional offerings.

 

Introduction to Edible Arrangements and Its New Venture

 

Edible Arrangements was founded in 1999 by Tariq Farid, who envisioned a unique way to gift fresh fruit arrangements that were both visually appealing and delicious. Over the years, the company has grown to become a global brand with hundreds of locations across the United States and internationally. However, the company’s latest initiative marks a significant departure from its traditional fruit-based offerings, signaling a broader strategic shift towards becoming a comprehensive food, health, and wellness company.

 

The New Venture: Edibles.com

 

Edibles.com debuted on March 20, 2025, starting operations in Texas with ambitious plans to expand rapidly across Southeastern states like Florida and Georgia. The platform is designed to cater to consumers aged 21 and older, providing low-dose THC products that comply with the 2018 Farm Bill, which legalized hemp containing less than 0.3% THC by dry weight. Select products will also be available for nationwide shipping where legally permitted, leveraging the company’s existing logistics infrastructure.

 

Product Lineup

 

The initial product lineup includes a range of THC-infused beverages, gummies, and snacks. These products are designed to appeal to both seasoned cannabis users and newcomers looking for low-dose, accessible options. The company emphasizes the importance of quality and safety, ensuring that all products undergo rigorous testing to meet high standards of purity and potency.

 

Strategic Alignment and Market Potential

 

The move into the infused edibles market aligns with Edible Brands’ vision of becoming a broader food, health, and wellness company. CEO Somia Farid Silber highlighted that the infused edibles market is a fast-growing sector with high consumer demand for safe and reliable products. The company is leveraging its extensive franchise network to deliver these items while planning to open brick-and-mortar stores under the Incredible Edibles brand.

 

Market Trends and Consumer Demand

 

The cannabis industry, particularly the segment focused on hemp and THC-infused products, has seen exponential growth in recent years. This growth is driven by increasing consumer interest in wellness and recreational products, as well as evolving legal landscapes that have opened up new markets. Edible Arrangements is positioning itself to capitalize on this trend by offering products that cater to both health-conscious consumers and those seeking unique gifting options.

 

Challenges and Opportunities

 

While this expansion offers significant growth potential, it also comes with challenges such as navigating varying state regulations and ensuring product safety and quality. The company aims to address these issues through robust infrastructure and consumer advocacy. Thomas Winstanley, a cannabis industry veteran leading Edibles.com, emphasized the company’s unique position to drive innovation in this emerging market.

 

Regulatory Challenges

 

One of the primary challenges facing Edible Arrangements is the complex regulatory environment surrounding cannabis products. Laws regarding the sale and distribution of THC-infused products vary significantly from state to state, requiring the company to adapt its operations to comply with local regulations. This includes ensuring that products meet specific THC content limits and are marketed responsibly.

 

Quality Control and Safety

 

Another critical challenge is maintaining high standards of quality and safety across all products. Edible Arrangements is investing heavily in testing and quality assurance processes to ensure that all products meet stringent safety standards. This includes partnering with reputable suppliers and implementing rigorous testing protocols to verify the potency and purity of all THC-infused items.

 

Consumer Education and Advocacy

 

As part of its strategy, Edible Arrangements is also focusing on consumer education and advocacy. The company recognizes that many consumers are new to cannabis products and may have questions about usage, dosage, and safety. To address this, Edibles.com will provide comprehensive product information, dosage guidelines, and resources for consumers to learn more about the benefits and risks associated with THC-infused products.

 

Marketing Strategy

 

Edible Arrangements plans to leverage its existing brand recognition and customer loyalty to promote its new line of hemp-based products. The company will utilize social media, email marketing, and targeted advertising to reach its target audience. Additionally, partnerships with influencers and cannabis industry experts will help build credibility and drive awareness about the brand’s entry into this new market.

 

Future Expansion Plans

 

In the coming months, Edible Arrangements plans to expand its operations beyond Texas, targeting key markets in the Southeast. The company is also exploring opportunities to open physical stores under the Incredible Edibles brand, which will offer a curated selection of THC-infused products alongside traditional Edible Arrangements items.

 

Incredible Edibles Stores

 

The Incredible Edibles stores will serve as a unique retail experience, combining the company’s traditional fruit arrangements with its new line of hemp-based products. This format will allow customers to explore and purchase THC-infused items in a welcoming and educational environment. The stores will also host workshops and events focused on cannabis education and wellness, further enhancing the brand’s position as a leader in this emerging market.

 

Conclusion

Edible Arrangements’ foray into the hemp and THC-infused edibles market marks a significant strategic shift for the company. By leveraging its brand recognition and logistical capabilities, Edible Arrangements is poised to become a major player in this rapidly growing sector. While challenges exist, the company’s commitment to quality, safety, and consumer education positions it well for success in this new venture.

As the cannabis industry continues to evolve, Edible Arrangements’ entry into this market underscores the broader trend of mainstream brands embracing cannabis-related products. This move not only expands the company’s offerings but also reflects a broader cultural shift towards greater acceptance and normalization of cannabis use.

 

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