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The Effect of Cannabis on Metabolism

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Cannabis is often celebrated for its ability to increase the appetite and prevent wasting. However, new research suggests that the endocannabinoid system’s role in energy metabolism is more profound than we initially thought. This puts some cannabinoids in the limelight as potential treatment strategies for metabolic disorders like obesity and diabetes.

When it comes to cannabis and metabolism, we mostly hear about cannabis’ appetite-stimulating effects. However, the body of research continues to grow into the potential of cannabinoids to have an effect that’s quite the contrary. What we’re learning now is that there are a number of cannabinoids that affect metabolism in profound ways.

Cannabis, once the munchies-inducing herb that helped people from wasting away, is now being investigated for its potential to treat metabolic disorders such as obesity and diabetes mellitus. The primary cannabinoid in question is THCV, although CBD has also shown several effects on energy metabolism.

Let’s delve into this interesting avenue of cannabis research and its implications for future medical uses of cannabis.

Metabolism and the endocannabinoid system

The endocannabinoid system (ECS) is a molecular regulation system by which the body maintains balance in several different aspects. The endocannabinoid system is involved in regulating immunity, synaptic plasticity, cell signalling, central nervous system functioning and metabolism.

Recent research suggests that a dysfunctional endocannabinoid system disrupts the balance in energy metabolism and can lead to an accumulation of visceral fat (around the belly and waist). The inability of the body to properly use energy is what characterises metabolic disorders such as type 2 diabetes.

In particular, the CB1 receptor and its endogenous ligands, anandamide and 2-AG, are thought to be the most heavily involved aspects of the endocannabinoid system in energy metabolism. When the endocannabinoid system is functioning correctly, these pathways enhance energy storage, usage, and expenditure. When the endocannabinoid system is not, energy metabolism can be dysregulated and contribute to obesity, diabetes, and dyslipidaemia.

Constant activation of the ECS is associated with metabolic processes carried out in the hypothalamus and peripheral tissue in those with obesity. It’s therefore hypothesised that cannabinoid receptor antagonists could have a significant pharmacological effect on those with obesity and other related disorders such as diabetes. 

To put that into real-life context, THCV is one of the cannabinoid receptor antagonists capable of eliciting this effect. The implications of this are far-reaching as we discover just how much of a role the endocannabinoid system plays in one of the Western world’s most prevalent diseases: obesity.

How does THCV affect metabolism?

THCV isn’t an antagonist to the cannabinoid receptor itself. That means that it doesn’t block the cannabinoid receptor and prevent its cascade of events. Instead, THCV antagonises the ligands that bind to the CB1 receptor. This prevents the ligands from latching on and causing a cascade of events. 

In a rodent study conducted in 2020, researchers administered THCV to obese and type 2 diabetic rats. Administration of THCV decreased the appetite, increased satiety and up-regulated energy metabolism. Researchers concluded that THCV could be clinically useful in the treatment of obesity and type 2 diabetes.

In another rodent study from 2013, researchers administered THCV to obese mice and found that it improved insulin sensitivity. It also restored insulin signalling in liver cells and muscle fibres. The researchers did note that it didn’t seem to affect overall food consumption or body weight.

Finally, THCV is around 25% as psychoactive as its counterpart, THC. This makes it a potential candidate for therapy as it can be applied across several demographics. Although this cannabinoid is not abundantly present in cannabis, the understanding of its mechanisms suggests a way that cannabinoids can be used in treating metabolic disorders.

What does the research say about CBD, THC and weight loss?

When it comes to CBD, the cannabinoid receptor in question is CB2. It remains in question because the medical world still isn’t sure what the CB2’s involvement with weight loss is precisely and how its endogenous ligands affect weight gain and weight loss. 

In a 2011 study conducted on rats, CBD reduced weight gain. To assess the mechanism behind this, researchers administered AM630, a CB2 selective antagonist. This blocked the effects of CBD and led researchers to the hypothesis that the CB2 receptor is active in the process of weight gain and weight loss.

In another theory, researchers concluded that the downregulation of the CB1 receptor led to reduced BMI and reduced obesity. Interestingly, the researchers found that cannabis users (THC) had lower BMI’s but higher caloric intake than non-cannabis using people. They concluded that the long-lasting downregulation of the CB1 receptor reduces the storage of energy in adipose tissue and increases metabolic rates. 

The cannabis and weight loss paradox

This seems to be one of the scenarios where cannabinoids have very targeted, specific effects. Paradoxically, cannabis can simultaneously cause an increase in appetite as well as a reduction in obesity. The likely explanation is the highly targeted nature of each cannabinoid’s role in energy metabolism.

It is still not fully understood how cannabis affects metabolism because it’s unknown how the endocannabinoid system governs metabolism. At the same time, THCV shows potential for natural therapies in diabetes and obesity treatment. It’s an exceptionally pertinent issue as the Western world faces obesity epidemics and their associated health risks. 

How does cannabis affect your energy levels and appetite? Do different strains affect it differently? We’d love to hear your personal experiences in the comments.

  • Disclaimer:

    This article is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor or other licensed medical professional. Do not delay seeking medical advice or disregard medical advice due to something you have read on this website.



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The Importance of Leadership in Public Health Initiatives

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Have you ever wondered how health policies are developed or how public health campaigns are implemented? Behind every successful public health initiative is strong leadership. Leadership plays an instrumental role in shaping health outcomes, particularly in times of crisis, like during a pandemic or natural disaster. Effective leaders in public health drive the programs that promote wellness, prevent disease, and tackle health disparities in communities.

In this blog, we will share why leadership is so important in public health initiatives and how effective leadership can impact the health of entire populations. We will explore the essential qualities of good public health leaders, the challenges they face, and how they can make a lasting difference in their communities.

What is Public Health Leadership?

Public health leadership involves guiding and managing the health policies, programs, and services that aim to improve the well-being of communities. Leaders in this field are responsible for making critical decisions that affect how health resources are distributed, how health data is interpreted, and how communities respond to health issues. They work in a variety of settings, from government agencies to non-profit organizations and healthcare institutions, helping to improve the overall health of populations.

Good public health leadership is rooted in a deep understanding of health issues, a clear vision, and the ability to manage complex systems. These leaders must also work collaboratively with other professionals, including doctors, community leaders, and policymakers, to address public health challenges effectively.

The Role of Education in Developing Public Health Leaders

Education plays a major role in shaping the next generation of public health leaders. A strong educational foundation provides aspiring leaders with the tools and knowledge they need to succeed. One way to gain this essential knowledge is through a comprehensive master of public health online program. These degrees offer a flexible and comprehensive way for individuals to learn about health policy, epidemiology, health communication, and leadership skills while balancing work and personal commitments.

The online format of these programs provides convenience for those who may already be working in the field or have other responsibilities. Students can gain the necessary skills to lead in public health initiatives, whether they are interested in disease prevention, healthcare systems management, or global health. These programs often offer specialized courses in leadership development, helping students understand how to manage teams, make strategic decisions, and address the challenges that arise in public health projects.

Key Qualities of Effective Public Health Leaders

Effective public health leaders share several key qualities. These include:

  • Vision: Great leaders can see the bigger picture. They understand the long-term health goals of a community and work to implement strategies that will make a lasting impact.
  • Communication Skills: Public health leaders must be able to communicate clearly and effectively with a wide range of people, from government officials to the general public. Their ability to explain complex health issues in simple terms is essential to gaining support for public health initiatives.
  • Collaboration: Public health challenges often require teamwork. Leaders must work with other professionals and stakeholders to create coordinated responses and ensure that all voices are heard.
  • Adaptability: Health issues can change quickly. A good leader must be flexible and able to adjust strategies based on new information or emerging health threats.
  • Problem-Solving Abilities: Public health leaders must be able to think critically and creatively to solve complex health challenges. They need to analyze data, develop effective solutions, and implement those solutions in a way that reaches the people who need help.

The Impact of Leadership on Health Policies

Leadership directly influences public health policies, which in turn impact the health of entire populations. Strong public health leaders advocate for evidence-based policies that improve access to healthcare, reduce health disparities, and promote healthy lifestyles. They work with lawmakers to pass laws that provide better healthcare coverage, address environmental factors affecting health, and improve the overall health infrastructure of a community.

Leadership in public health is also crucial in times of crisis. During a health emergency, such as an outbreak of infectious disease, leaders must quickly assess the situation, make critical decisions, and direct resources where they are needed most. A well-prepared leader can minimize the impact of such crises by managing response efforts effectively.

Challenges Faced by Public Health Leaders

Public health leaders face many challenges in their roles. Some of the common challenges include:

  • Limited Resources: Many public health initiatives have limited funding and resources, making it difficult to implement programs that have widespread impact.
  • Cultural and Social Barriers: Leaders often have to overcome cultural and social barriers to engage communities and ensure that health initiatives reach everyone, particularly marginalized groups.
  • Political Influence: Public health policies are often influenced by political agendas, which can affect how programs are implemented and which populations receive attention.
  • Changing Health Needs: As health issues evolve, public health leaders must adapt their strategies. New diseases, health risks, and environmental changes require quick thinking and flexible approaches.

Despite these challenges, effective public health leadership can still make a significant difference in improving public health outcomes.

Public Health Leadership in Community Engagement

Public health leaders must be skilled in engaging with the communities they serve. Building trust and forming partnerships with local organizations, community leaders, and the public is essential for the success of health initiatives. When community members are involved in health programs, they are more likely to participate and support these initiatives.

Effective leaders work to understand the unique needs of different communities and tailor their programs to address those needs. They also educate the public about the importance of healthy behaviors and provide resources that help individuals make better health choices.

As the world continues to face evolving health challenges, the need for strong leadership in public health has never been clearer. Leaders who can guide initiatives, make tough decisions, and engage communities will be key in terms of shaping the future of healthcare. The question is, how will you contribute to this vital work? Whether you’re already in the field or just starting, the opportunity to make a meaningful impact is right in front of you. The path ahead is full of challenges, but with the right leadership, the potential for positive change is limitless.

rohit choudhary





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CDC calls for expanded bird flu testing after more dairy worker infections found in Colorado and Michigan

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Federal health officials on Thursday called for more testing of employees on farms with bird flu after a new study showed that some dairy workers had signs of infection, even when they didn’t report feeling sick.

Farmworkers in close contact with infected animals should be tested and offered treatment even if they show no symptoms, said Dr. Nirav Shah, principal director of the U.S. Centers for Disease Control and Prevention.

The new guidance comes after blood tests for 115 farmworkers in Michigan and Colorado showed that eight workers — or 7% — had antibodies that indicated previous infection with the virus known as Type A H5N1 influenza.

Read the rest of this story on TheKnow.DenverPost.com.



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Owner of troubled Aurora apartments faces state investigation related to conditions, consumer-protection laws

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The owners of several dilapidated apartment buildings in Aurora and Denver have faced a new threat in recent months: an investigation by the Colorado Attorney General’s Office on suspicion of violating the state’s safe-housing and consumer-protection laws.

The state office sent subpoenas to CBZ Management, one of its primary representatives and several of its subordinate companies in September, according to records obtained by The Denver Post. The subpoenas seek answers and records related to a swath of CBZ’s practices, including how it advertises its properties and whether tenants get the apartments they have toured; how the companies track and respond to maintenance requests and health code violations; how they handle security deposits; and how they screen tenants, among other questions.

CBZ Management’s buildings in Aurora have been the subject of extensive tenant and municipal complaints and have recently drawn international attention over allegations the properties were overtaken by gangs.

Read the rest of this story on TheKnow.DenverPost.com.



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