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True or False – Women Are More Sensitive to THC Than Men?

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women more senstive to thc

Introduction

Recent research suggests that women may be more sensitive to the effects of tetrahydrocannabinol (THC), the main psychoactive compound in cannabis. Studies have found that females exhibit greater sensitivity to the pain-relieving qualities of THC and develop tolerance to its effects more quickly than males.

Sex Differences in Sensitivity

  1. Increased Sensitivity in Females: Multiple studies have found that women exhibit increased sensitivity to the pain-relieving and subjective effects of THC. A study by Rebecca Craft and colleagues at Washington State University discovered that female rats were at least 30% more sensitive than males to the pain-relieving qualities of THC.

  1. Dose Adjustments: Researchers adjusted the doses for female rats to be 30% lower than those for males, but the females still developed more tolerance to THC after just 10 days of treatment.

  2. Hormonal Influence: This heightened sensitivity may be due in part to fluctuations in female sex hormones. Craft explained that females show a “very clear spike in drug sensitivity right when they are ovulating, right when their estrogen levels have peaked and are coming down.”

  3. Human Studies

  • A study by Cooper and Haney found that among frequent cannabis users, women reported greater abuse-related subjective effects like feeling “good” and wanting to “take again” after smoking cannabis compared to men.

  • Another study discovered that in occasional cannabis users, women experienced stronger positive subjective effects like feeling “good” and “like the drug” at a low oral THC dose (5 mg), while men had stronger effects at a higher dose (15 mg).

 Anxiety and Adverse Effects

  1. Higher Anxiety Risk: The greater sensitivity of women to the effects of THC may put them at higher risk for adverse events, particularly anxiety. A study by Klumpers and colleagues found that 45% of infrequent female cannabis users discontinued a study due to anxiety after inhaling purified THC vapor, compared to 0% of males.

  2. Panic Attacks: Survey data also suggests that women are twice as likely as men to report cannabis-induced panic attacks or anxiety.

  3. Mechanisms of Action:

  • Animal studies have found that THC administration into the amygdala, a brain region involved in anxiety, increased anxiety in male rats, an effect blocked by a CB1 receptor antagonist. This suggests that the functional status of CB1 receptors in the amygdala may underlie the dose-related increase in anxiety-related effects of THC in females compared to males.

  • Implications for Therapeutic Use: The heightened sensitivity of women to THC’s negative effects, such as anxiety and paranoia, is an important consideration given the growing interest in therapeutic cannabis use. As more people turn to cannabis for medical purposes, understanding these sex differences is crucial to ensure safe and effective treatment.

 

Withdrawal and Dependence

  1. Vulnerability to Dependence: As cannabis use becomes more prevalent, understanding the unique challenges women face regarding withdrawal and dependence is crucial. Research indicates that women may be more susceptible to cannabis dependence and experience more severe withdrawal symptoms than men. This section delves into the various aspects of withdrawal and dependence, highlighting the telescoping effect, withdrawal symptoms, and the unique “munchies” phenomenon.

  2. The Telescoping Effect refers to the phenomenon where women tend to progress from initial cannabis use to dependence at a faster rate than men, experiencing a shorter interval between onset of use and development of cannabis use disorder. This accelerated progression may be influenced by hormonal fluctuations, social and environmental factors, and increased vulnerability to the effects of cannabis.

  3. Withdrawal Symptoms: Women tend to experience more severe withdrawal symptoms when abstaining from cannabis compared to men, which can include increased irritability, anxiety, and depression. This disparity may be attributed to hormonal differences, as fluctuations in estrogen levels can affect the brain’s response to cannabis withdrawal. Additionally, women may be more likely to experience physical symptoms such as headaches, nausea, and fatigue during withdrawal. Overall, the severity of withdrawal symptoms can make it more challenging for women to quit or reduce cannabis use, highlighting the need for gender-specific support and treatment strategies.

  4. Munchies Effect: Interestingly, the increased appetite caused by THC is the only effect where males show more sensitivity than females.

 

Implications for Medical and Recreational Use

  1. Public Health Considerations: As cannabis use becomes more widespread, understanding the sex differences in its effects is crucial. The higher sensitivity of women to the negative effects of THC, like anxiety and paranoia, is an important consideration given the growing interest in therapeutic cannabis use.

  2. Targeted Interventions: In the context of recreational use, the unique challenges women face with THC use have important implications for public health policies and treatment approaches. Women may require lower doses of THC to achieve desired effects, which could lead to unintended overconsumption and adverse outcomes. Additionally, the heightened risk of dependence and withdrawal symptoms in women highlights the need for targeted interventions and support services.

  3. Future Research Directions: Researchers are now studying how the effects of cannabidiol (CBD), another compound found in cannabis, can counter some of THC’s negative side effects. Future studies should investigate the interaction between sex, cannabis use frequency, and the effects of THC to provide a more comprehensive understanding of this important issue.

 

Limitations and Future Research Directions

  1. Inconsistent Findings: It’s important to note that not all studies have found sex differences in the subjective effects of THC. An earlier study in frequent cannabis smokers reported no differences between men and women in subjective effects after oral THC administration. Another study found that in participants with a wide range of cannabis use frequencies, women exhibited smaller increases in heart rate, took longer to detect drug effects, and experienced shorter durations of effects when smoking cannabis compared to men.

  2. Complexity of THC’s Impact: These inconsistent findings underscore the complexity of THC’s impact and the need for further research. Future studies should explore the potential therapeutic applications of CBD in mitigating the negative effects of THC, particularly in women.

 Conclusion

In conclusion, women face unique challenges with THC use due to their heightened sensitivity to the drug’s effects. These challenges include greater sensitivity to the pain-relieving and subjective effects of THC, faster development of tolerance, increased risk of anxiety and adverse events, and vulnerability to dependence and withdrawal symptoms.

 

As cannabis legalization continues to spread and therapeutic use grows, understanding these sex differences is crucial for informing public health policies, treatment approaches, and harm reduction strategies. By acknowledging the unique needs and experiences of women, we can ensure that the benefits of cannabis are accessible while minimizing the risks.

 

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US Court Rules Delta-8 THC Derived from Hemp is 100% Legal, Slamming the DEA in Embarrassing Court Case

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supreme cour ruling on delta-8 thc from hemp

In a groundbreaking decision, the U.S. Court of Appeals for the Ninth Circuit has ruled that Delta-8 tetrahydrocannabinol (Delta-8 THC) derived from legal hemp sources is not classified as a controlled substance under federal law, directly contradicting the Drug Enforcement Administration’s (DEA) position that all synthetically derived tetrahydrocannabinols, including Delta-8 THC, fall under Schedule I controlled substances. This landmark ruling emerged from a case brought forward by several key players in the hemp industry who challenged the DEA’s interpretation of the 2018 Farm Bill, which legalized hemp and its derivatives. The court’s decision not only rejects the DEA’s restrictive stance but also provides much-needed clarity regarding the legal status of Delta-8 THC, allowing for its continued production and sale from legally sourced hemp. This ruling is significant as it has the potential to reshape the regulatory landscape for cannabinoids, encouraging further exploration and commercialization of hemp-derived products while also highlighting the ongoing tensions between federal regulations and the rapidly evolving hemp industry.

 

 Delta-8 THC: A Naturally Occurring Cannabinoid

Delta-8 tetrahydrocannabinol (Delta-8 THC) is a naturally occurring cannabinoid found in trace amounts in hemp and cannabis plants that shares a similar molecular structure to Delta-9 THC, the primary psychoactive compound in marijuana, but is known to produce significantly milder intoxicating effects; the 2018 Farm Bill’s legalization of hemp and its derivatives containing no more than 0.3% Delta-9 THC on a dry weight basis created a legal gray area for Delta-8 THC, which has proliferated in the form of various products derived from legal hemp sources and sold in a largely unregulated market, as they are not explicitly classified as controlled substances by the Drug Enforcement Administration (DEA) despite the agency’s stance that all synthetically derived tetrahydrocannabinols should be treated as Schedule I drugs regardless of their origin or potency, a position that has been challenged by hemp industry players arguing that Delta-8 THC from legal hemp should be exempt from the same restrictions as Delta-9 THC.

 

 The DEA’s Stance and Industry Challenges

The Drug Enforcement Administration (DEA) has taken a firm stance that all synthetically derived tetrahydrocannabinols, including Delta-8 THC, are classified as Schedule I controlled substances under the Controlled Substances Act (CSA), regardless of their source or concentration. This position has faced considerable resistance from various stakeholders within the hemp industry, who argue that Delta-8 THC derived from legal hemp should not be subjected to the same stringent restrictions as Delta-9 THC, the primary psychoactive compound in marijuana. Proponents contend that the 2018 Farm Bill, which legalized hemp and its derivatives, should extend to include Delta-8 THC, allowing it to be treated as a legal product when sourced from hemp that contains less than 0.3% Delta-9 THC. They emphasize that while Delta-8 THC may occur naturally in small amounts in hemp, the majority of Delta-8 products on the market are produced through a chemical conversion process from CBD, which the DEA argues renders them synthetic and thus illegal. This conflict has led to ongoing legal challenges, with some courts ruling in favor of the hemp industry, asserting that Delta-8 THC should not be classified as a controlled substance when derived from legal hemp. As the debate continues, the tension between the DEA’s regulatory framework and the evolving hemp market raises critical questions about the future of cannabinoid regulation in the United States.

 

 The Court’s Ruling and Its Implications

 

The U.S. Court of Appeals for the Ninth Circuit ruled that Delta-8 THC derived from legal hemp sources is not controlled substance.

  • The court found the DEA’s interpretation of the law was “arbitrary and capricious” and lacked a reasoned explanation.

  • This ruling effectively removes Delta-8 THC from the DEA’s list of controlled substances, provided it is derived from hemp containing less than 0.3% Delta-9 THC.

  • The decision provides legal protection for businesses and consumers involved in Delta-8 THC products derived from legal hemp sources.

 

 

Opportunities for the Hemp and Cannabis Industries

The recent court ruling represents a significant victory for the hemp and cannabis industries, paving the way for new possibilities in product development and research.

  • Therapeutic Potential: Delta-8 THC has been recognized for its potential therapeutic benefits, which could attract more consumers seeking alternative treatments.

  • Increased Investment: The legalization of Delta-8 THC may lead to heightened investment and innovation within the sector, encouraging the development of new products and formulations.

  • Regulatory Concerns: Despite the positive implications, the ruling also raises important concerns regarding the regulation and quality control of Delta-8 THC products, necessitating careful oversight.

  • Need for Standards: As the market for Delta-8 THC expands, there will be a pressing need for clear guidelines and standards to ensure consumer safety and product consistency, helping to build trust in these emerging products.

Broader Implications for Cannabis Legalization

The court’s ruling underscores the ongoing conflict between federal and state laws concerning the regulation of cannabis and its derivatives.

  • Increasing State Legalization: As more states advance toward the legalization of both recreational and medical marijuana, the pressure on the federal government to revise its policies and align them with shifting public opinion is likely to intensify.

  • Step Forward for Delta-8 THC: The ruling regarding Delta-8 THC may be viewed as a positive development in the broader context of cannabis legalization, yet significant challenges remain.

  • Path to Comprehensive Legalization: There is still a considerable distance to cover before achieving comprehensive federal legalization of cannabis, highlighting the complexities of navigating cannabis policy in the United States.

 

Conclusion

 

The court’s ruling underscores the ongoing conflict between federal and state laws concerning the regulation of cannabis and its derivatives. As more states advance toward the legalization of both recreational and medical marijuana, the pressure on the federal government to revise its policies and align them with shifting public opinion is likely to intensify. The ruling regarding Delta-8 THC may be viewed as a positive development in the broader context of cannabis legalization; however, significant challenges remain, and there is still a considerable distance to cover before achieving comprehensive federal legalization of cannabis, highlighting the complexities of navigating cannabis policy in the United States.

 

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What Is It, Why You Should Care, and How Cannabis Helps

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metabolic syndrome

Metabolic syndrome is an umbrella term referring to several conditions that negatively impact how the body metabolizes carbohydrates, fats, and proteins.


It occurs when there are unusual, abnormal chemical processes in the body which affect otherwise healthy metabolic functions. The primary symptoms of metabolic syndrome include abdominal fat, high blood pressure, high blood sugar, high triglycerides, and low levels of LDL (good) cholesterol. These conditions all greatly increase the risk of stroke, coronary heart disease, diabetes, and other severe health issues that are difficult or near impossible to reverse.

 

The most telling symptom, though, is a large waist circumference – and you don’t need to take any kind of medical test to tell you this because it’s completely visible.


That’s why prevention is key when it comes to metabolic syndrome. However, the choices you make on a daily basis in your lifestyle can determine your risk for metabolic syndrome of not. We know that an unhealthy diet that is high in sugar, salt, and processed food can contribute to the symptoms of metabolic syndrome. A sedentary lifestyle, obesity, poor sleep hygiene, and exposure to chronic stress can also make the risk much worse. Smoking tobacco and alcohol are even worse – don’t even think about it.


But cannabis? That can actually help!

What Studies Say

 

A recent study that was published in the American Journal of Open Medicine found that young adults with a habit of consuming cannabis had a significantly lower prevalence of metabolic syndrome. For the study, investigators from the University of Miami analyzed a cohort of almost 4,000 individuals whose ages ranged from 18 to 25. They specifically zoned in on the young adults’ cannabis use.

 

They found that current cannabis users were 42% less likely to have metabolic syndrome. They also found that Non-Hispanic Blacks, who were consuming more weed than the other subjects, were found to be the least likely of all to have metabolic syndrome. “Current cannabis users had a lower prevalence of MetS, predominantly noted among NHB (non-Hispanic Blacks], the group with the highest prevalence of current cannabis use,” said the study’s authors. “Future prospective studies are warranted to examine the role of specific cannabinoids on MetS by race/ethnicity,” they said.

 

A Smaller Waist Circumference: Why You Should Pay Attention, And How Weed Can Help

 

Having a large waist circumference or a visibly fatty belly has been associated with numerous health conditions. Of course, this includes a heightened risk of metabolic disease. It also increases the risk of inflammation, type 2 diabetes, cardiovascular disease incidence, and cancer among others.

That is why it’s critical to pay attention to the size of your stomach. A smaller waist means you have a smaller amount of visceral fat, which is necessary for better health and an improved quality of life.

There are many steps you can take to reduce your visceral fat. These include:

 

  • Sticking to a low carbohydrate and low sugar diet

  • Having a diet high in good protein sources

  • Reduce consumption of trans fat and saturated fats

  • Engage in strength training and cardiovascular exercises

  • Manage stress effectively

 

Last but not the least: did you know that consuming cannabis has been shown to be associated with smaller waistlines and a reduced risk for obesity?

In 2020, a study out of Quebec in Canada revealed that cannabis consumption was linked to a smaller waist and reduced triglyceride levels. For this study, the investigator in Canada analyzed subjects who either never consumed marijuana in the past, used it sometime in the past but had no recent use, had some infrequent use, or consume it infrequently. They specifically measured the participants’ waist circumference and triglycerides.

 

They found out that the subjects who consumed certain marijuana strains for metabolic syndrome for at least 4 days per week were found to have smaller waistlines as well as less triglycerides compared to the other participants in the study.

 

Another study from 2015, also out of Quebec, was conducted by researchers from the Conference of Quebec University Health Centers. They analyzed cannabis consumption patterns of 786 Arctic aboriginal adults, the Inuits. The investigators also analyzed their body mass index to search for any links between cannabis use and BMI.

They found that study participants who consumed marijuana within the last year were more likely to have a lower body mass index, as well as reduced fasting insulin and better insulin resistance (using the HOMA-IR indicator) compared to those who did not.

“In this large cross-sectional adult survey with high prevalence of both substance use and obesity, cannabis use in the past year was associated with lower BMI, lower percentage fat mass, lower fasting insulin, and HOMA-IR,” said the researchers. In other words, they observed a relationship between cannabis use and BMI that led them to conclude that cannabis and cannabinoid use can help consumers reduce the likelihood of obesity and diabetes.

 

Meanwhile, an older study from 2013 also had similar results. Research data from The American Journal of Medicine taken from more than 4,600 patients yielded interesting findings. Almost 45% of patients never consumed marijuana in their lives, while 43% of them smoked in the past though no longer do currently. And 12% of them were regular cannabis users.

Researchers discovered that cannabis users who consumed marijuana within the past month had 16% less fasting insulin levels compared to those who never consumed weed. In addition, they even add reduced HOMA-IR levels and higher high-density lipoprotein. Furthermore, the investigators found that regular cannabis users who usually consume more calories, they also had lower BMI’s.

 

Conclusion

 

Staying fit and healthy is much more than vanity: science and medical research makes it clear that there is a strong link between obesity and body mass index, to overall health and wellness. Metabolic syndrome further emphasizes the importance of keeping one’s BMI normal, and based on these studies, that’s something cannabis can help with. Integrating responsible cannabis use into your lifestyle is one tool out of many that can help you stay healthy and reduce the risks of developing metabolic syndrome.

 

MORE ON METABOLIC SYNDROME AND WEED, READ ON…

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More Bad News for Intoxicating Hemp (California, Missouri, New Jersey)

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Last week, I wrote a post entitled “Loper Comes For the DEA. Will it Matter Though?” In that post, I discussed a brand new federal Fourth Circuit Court of Appeals case that concluded that hemp derivatives like THC-O are not controlled substances. The hemp community has largely celebrated this as a win, even though as I wrote in that post and back in July, none of this really matters if Congress bans intoxicating hemp products – which looks like it will happen.

On the heels of the Fourth Circuit case, a few things happened that don’t make life easier for people who want intoxicating hemp products.

Probably the most significant of the bad news, the California Department of Public Health (CDPH) issued emergency regulations to ban a series of intoxicating hemp products. A lot has been written about these regulations, but it’s worth pointing out that California’s hemp law (AB-45) was already not very favorable to smokable hemp products.

For example, AB-45 already prohibits smokable hemp products. And more notably, it defines THC to include THCA and “any tetrahydrocannabinol, including, but not limited to, Delta-8-tetrahydrocannabinol, Delta-9-tetrahydrocannabinol, and Delta-10-tetrahydrocannabinol, however derived”. In other words, all of the various things that are defined as THC – and there are many – must already not exceed 0.3% in the aggregate. This means that a host of products were already de facto banned in the state.

While, to be sure, the new emergency regulations take things farther, I think it would be inaccurate to describe this as a “sea change” in how hemp products are regulated in the state. What remains to be seen is whether CDPH or other agencies ramp up enforcement in any meaningful way. It’s California, so my guess is no.

California’s not the only state taking aim at intoxicating hemp products. Just the other day, Missouri’s Attorney General created a new task force to crack down on intoxicating hemp products. New Jersey’s Governor also signed a bill cracking down on intoxicating hemp products.

All this just adds to the long list of states and municipalities that had been going after unregulated intoxicating hemp products prior to the Fourth Circuit’s decision – often for violations of state or local law which are unlikely to be impacted by the federal case. And of course, if Congress gets around to banning intoxicating hemp products, that will likely be the last straw for many of these products.



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