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What’s the Most Dangerous Drug on the Market?

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Since the dawn of civilization, humans have had an insatiable appetite for altering their consciousness. From the ancient Sumerians writing about beer to the shamanic use of psychedelics in the Americas, our relationship with drugs is as old as humanity itself. It’s woven so deeply into the fabric of human society that virtually every major religion and legal system has attempted to regulate, control, or outright ban various substances.

For the past century, governments worldwide have been chasing the pipe dream of a “drug-free society.” The War on Drugs, launched in the 1970s, promised to rid the world of the scourge of drug abuse. Yet, here we are fifty years later, with more drugs, more potent substances, and more problems than ever before.

History has taught us an undeniable lesson: prohibition doesn’t work. As long as there’s demand, supply will always find a way. The only real achievements of prohibition have been to enrich criminal organizations and grant governments unprecedented powers over their citizens’ personal choices. From Al Capone during alcohol prohibition to modern-day cartels, we’ve seen this story play out time and time again.

But what if I told you that the most dangerous drug isn’t what you think it is? If you stopped random people on the street and asked them to name the most harmful substance, you’d likely hear responses like “heroin,” “crack,” or “meth.” However, a fascinating study by Professor David Nutt and his colleagues reveals a far different reality.

Today, we’ll dive into this groundbreaking research that challenged conventional wisdom about drug dangers. We’ll explore why current drug scheduling might be completely backward, and how legalization, rather than prohibition, could actually make drug use safer through proper regulation and quality control.

The results might surprise you – and they certainly surprised many in the scientific and political communities when they were first published. Let’s take a closer look at what the data really tells us about drug dangers in our society.

When it comes to drug research and policy, few names carry as much weight as Professor David Nutt. As a neuropsychopharmacologist specializing in the research of drugs affecting the brain, including addiction, anxiety, and sleep, Nutt has dedicated his career to understanding how various substances impact human health and society.

His credentials are impeccable: Fellow of the Royal College of Physicians, Royal College of Psychiatrists, and the Academy of Medical Sciences. He’s held prestigious positions at Imperial College London, the University of Bristol, and the University of Oxford. As a former chairman of the UK’s Advisory Council on the Misuse of Drugs (ACMD), he was literally the government’s top drug advisor – until controversy struck.

In 2009, Nutt was famously dismissed from his position by Home Secretary Alan Johnson for speaking scientific truth to power. His offense? Publishing research showing that alcohol and tobacco were more harmful than many illegal drugs, including LSD, ecstasy, and cannabis. Johnson claimed Nutt had “crossed the line from science to policy,” essentially admitting that evidence-based research took a backseat to political agendas.

The dismissal sparked outrage in the scientific community. Multiple ACMD members resigned in protest, including Dr. Les King and Marion Walker. Even the government’s own Chief Scientific Adviser, John Beddington, sided with Nutt, stating “the scientific evidence is absolutely clear cut. I would agree with it.”

Rather than back down, Nutt doubled down on his commitment to evidence-based drug policy by founding Drug Science, an independent scientific committee providing objective information about drugs. His dedication to scientific truth earned him the 2013 John Maddox Prize for “promoting sound science and evidence on a matter of public interest, whilst facing difficulty or hostility in doing so.”

The controversy highlighted a crucial point: drug policy should be based on scientific evidence, not political convenience. As Nutt himself wrote in The Lancet: “The repeated claims by Gordon Brown’s government that it had scientific evidence that trumped that of the ACMD and the acknowledgment that it was only interested in scientific evidence that supported its political aims was a cynical misuse of scientific evidence.”

Needless to say, David Nutt is someone who knows his stuff. His groundbreaking research into drug harms provides us with an unbiased, evidence-based assessment of how different substances affect both individuals and society. When we look at his findings, we’re not seeing political spin or moral panic – we’re seeing cold, hard data analyzed by one of the world’s foremost experts in the field.

Now, let’s take a look at what his research actually revealed about drug dangers in our society…

Professor Nutt’s groundbreaking study, published in The Lancet, aimed to create an evidence-based ranking of drug harms in the UK. Unlike previous approaches that relied on political assumptions or moral panic, Nutt and his team developed a comprehensive multicriteria decision analysis (MCDA) to evaluate 20 different drugs based on 16 specific harm criteria.

The methodology was rigorous. Nine criteria focused on direct harm to the user, including mortality, physical damage, and addiction potential. The remaining seven examined broader societal impacts like crime, economic costs, and family disruption. Each criterion was weighted to reflect its relative importance, allowing for a nuanced understanding of both personal and societal harms.

The results were shocking – and flew in the face of conventional drug classification systems. Alcohol emerged as the most harmful drug overall, scoring a staggering 72 out of 100 points. This was significantly higher than heroin (55) and crack cocaine (54), two substances generally considered among the most dangerous. When looking specifically at harm to others, alcohol’s dominance was even more pronounced, scoring nearly three times higher than crack cocaine.

What makes this finding particularly striking is the legal status of these substances. Alcohol, despite being the most harmful drug by a significant margin, remains widely available and culturally celebrated. Meanwhile, less harmful substances like psychedelics (LSD scored 7, mushrooms scored 6) are classified as Schedule I drugs, carrying severe legal penalties for possession or use.

Nutt’s recommendations based on these findings were clear: our drug laws need serious revision. The current classification system, he argued, bears little relationship to actual drug harms. Instead of basing drug policy on scientific evidence, we’ve created a system that criminalizes less harmful substances while normalizing the use of more dangerous ones.

Perhaps most importantly, Nutt’s research highlighted that harm reduction strategies should focus more on alcohol than currently illegal drugs. As he pointed out, if we’re genuinely interested in reducing drug-related harm to society, we should be more concerned about Friday night at the pub than about someone taking mushrooms in their living room.

The implications are profound. We’ve built entire legal and social frameworks around drug classifications that don’t reflect reality. Billions are spent enforcing laws against substances that, according to the data, pose relatively minimal risks to society. Meanwhile, alcohol – a drug that causes massive social harm through violence, health impacts, and family disruption – remains virtually unquestioned as a cornerstone of social life.

Now, with this understanding of Professor Nutt’s work, we must ask ourselves: isn’t it time to renegotiate our societal relationship with mind-altering substances? Can we justify maintaining the current system when it’s so clearly at odds with scientific evidence? As we’ll explore next, perhaps the path forward lies not in doubling down on failed prohibition policies, but in developing a more rational, evidence-based approach to drug regulation…

There’s a profound irony in our society’s relationship with drugs: one of the substances classified as Schedule I – DMT – is produced naturally in our own bodies. As Terence McKenna famously quipped, “Everybody’s holding.” This endogenous psychedelic, dubbed “the spirit molecule,” isn’t just some recreational chemical – recent research suggests it may be fundamental to our perception of reality itself. Rather than simply causing hallucinations, DMT might actually help stabilize our baseline consciousness, with additional doses allowing us to “break through” these perceptual barriers.

But this isn’t about DMT specifically. It’s about the absurdity of criminalizing a substance our bodies naturally produce while celebrating alcohol – a drug that, according to Professor Nutt’s research, causes more societal harm than heroin or crack cocaine. You can’t watch a football game without being bombarded by beer commercials, yet people sit in prison cells for possessing substances that are demonstrably less harmful.

As we approach another presidential election, both candidates have suddenly discovered their support for cannabis reform, despite long histories of opposition. But why stop at cannabis? Nutt’s research shows that psychedelics like LSD and psilocybin mushrooms pose even less risk to society than marijuana. We’ve spent half a century fighting to legalize one relatively benign plant while maintaining prohibition on substances that could potentially revolutionize mental health treatment.

The evidence is clear: legalization works. Even without full nationwide legalization, cannabis use among youth has declined in states with legal markets. Why? Because regulated markets require ID checks, while drug dealers don’t care about age verification. Legal markets also ensure product quality, generate tax revenue, and create legitimate jobs – all while undermining criminal enterprises.

When Professor Nutt presented scientific evidence challenging the established narrative about drug dangers, he wasn’t celebrated for his rigorous research – he was fired. This tells us everything we need to know about the real motivations behind drug prohibition. It was never about public health or safety; it was about control and profit.

The pharmaceutical industry has effectively captured the entire drug market, turning prohibition into their private monopoly. They’ve spent decades funding politicians, shaping media narratives, and influencing medical education. The result? A system where dangerous but profitable drugs are pushed through legal channels while safer alternatives remain criminalized.

The true danger isn’t any particular substance – it’s the unholy alliance between Big Pharma and government power. Perhaps Professor Nutt’s harm assessment missed the most addictive and destructive drug of all: Power. It’s the one substance corporate executives and politicians can’t seem to get enough of, and their addiction has shaped drug policy for generations.

It’s time to admit that the “war on drugs” was never about protecting public health – it was about protecting profits and power. The science is clear. The evidence is overwhelming. The only question that remains is: how many more lives must be ruined before we finally embrace a rational, evidence-based approach to drug policy?

 

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Colorado Could Become a Global Hub for Marijuana Genetics

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Ability to source marijuana genetic material from outside Colorado

Senate Bill 23-271, which went into effect in early 2024, aims to enhance Colorado’s marijuana industry. A key provision allows licensed marijuana cultivators to source “genetic material” from approved entities in other jurisdictions. Genetic material is defined as material used to propagate cannabis plants, including:

  • Immature plants and small plant fragments with ≤0.3% D9 THC on a dry weight basis;
  • Cannabis seeds, which grow into marijuana; and
  • Tissue cultures.

This law significantly expands sourcing options for Colorado cultivators, including opportunities, both domestic and international. Colorado cultivators can now bring in popular OG strains from around the world.

The anticipated marketing frenzy, however, hasn’t fully materialized. The answer lies in the complexity of transporting genetics across state and international lines.

That’s where we come in. With years of experience advising clients on compliant cross-border transportation, we understand the nuances in the law. Below is a high-level overview of the challenges involved. If you or your clients are ready to make an impact in Colorado’s market, please reach out to me or my team— we’d be happy to assist.

Marijuana genetics: are they hemp or marijuana?

This question – the Schrödinger’s Cat of the cannabis industry – is both simple and complex. In short, under federal law, marijuana genetics appear to be hemp. However, they are neither strictly hemp nor marijuana until a state makes that determination. In fact, in some states they may be both marijuana and hemp.

  • “Marihuana” (referred to in this blog post as “marijuana”) is defined in the Controlled Substances Act (“CSA”), as “all parts of the plant Cannabis sativa L., whether growing or not; the seeds thereof; the resin extracted from any part of such plant; and every compound, manufacture, salt, derivative, mixture, or preparation of such plant, its seeds or resin.”
  • Marijuana does not include “hemp” as defined in the Agricultural Improvement Act of 2018 (the “2018 Farm Bill”).
  • Hemp is defined as the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 THC concentration of not more than 0.3 percent on a dry weight basis.

In January 2022, the DEA issued a letter stating that cannabis seeds and other genetic material with ≤0.3% D9 THC meet the definition of hemp and aren’t controlled substances. Importantly, the DEA further clarified in a December 2022 letter that if the cannabis seed germinates into material exceeding 0.3% THC, then “that material” falls within CSA control. DEA’s use of “that material” rather than specifying the seed used to grow “that material” further supports that DEA, at least for now, does not view marijuana genetics (testing at ≤0.3% THC on a dry weight basis) as marijuana.

While these DEA letters aren’t legally binding, they suggest that marijuana genetics, when testing at ≤0.3% D9 THC, are considered hemp under federal law.

State complexities with marijuana and hemp genetics

Since marijuana genetics are currently treated as hemp under federal law, they can move across U.S. state and international lines. However, the 2018 Farm Bill allows states to impose stricter laws.

Some states, like neighboring Arizona, define marijuana genetics as material that will only grow into hemp. Others, like Arkansas, do not expressly exempt “hemp” form the definition of “marijuana,” creating a situation where the genetics are both hemp and marijuana. And States like Mississippi and Minnesota prohibit the sale of cannabis sativa seeds all together.

Understanding both federal and state laws is critical to ensuring a compliant transfer into Colorado. If the exporting state defines the genetics as hemp and permits exports, cultivators can likely import them into Colorado. If the exporting state does not define marijuana genetics as hemp, then selling or transporting marijuana genetics could lead to criminal violations under a state’s marijuana laws.

International considerations

An international import of marijuana genetics must comply with both state, federal, and international laws. As long as the export meets USDA and Customs requirements, federal law typically won’t pose an issue. However, it’s essential to consider the laws of the exporting country, and importing US state, ensuring that the genetics are classified as hemp by both governments. Otherwise, the transport may not only violate a US state’s laws, but also international law.

Conclusion

Licensed Colorado cultivators seeking unique marijuana strains from outside the state—whether from California, Oregon, or countries like Colombia and Jamaica—must navigate both federal and state laws. Harris Sliwoski has extensive experience helping operators transfer cannabis genetics. With our new Denver office, we are ready to assist Colorado cultivators with global genetics imports. A “Tour de Cannabis” anyone?



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America’s Constitutional Conundrum: Guns and Ganja

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Of Guns and Ganja: America’s Constitutional Conundrum

 

If there’s one thing America is famous for, it’s guns – and lots of ’em! In the land of the free and home of the brave, firearms aren’t just a right, they’re practically a national pastime. With over 400 million firearms floating around a nation of 330 million people, it’s safe to say that guns are as American as apple pie and baseball.

But you know what else Americans love? Drugs. The US remains the world’s largest drug market, with an particularly passionate affair with cannabis. Mary Jane has come a long way since the “Just Say No” propaganda of the D.A.R.E. days. Now, millions of Americans legally light up in their home states, transforming from “criminals” to “consumers” faster than you can say “tax revenue.”

Here’s where things get sticky though. Despite the Biden administration’s vague promises of reform, cannabis remains stubbornly classified as a Schedule I substance at the federal level. This creates a peculiar predicament for freedom-loving Americans who appreciate both their Second Amendment rights and their evening toke.

You see, there’s this obscure interpretation of federal law that says if you consume cannabis – even legally in your state – you’re technically not allowed to own firearms. Let that sink in for a moment: in a country with more guns than people, where cannabis is legally sold in most states, you’re forced to choose between your constitutional right to bear arms and your state-sanctioned right to consume a plant.

As you might imagine, telling Americans they can’t have their guns AND their ganja isn’t exactly going over well. It’s a uniquely American saga that pits state rights against federal law, personal freedom against bureaucratic overreach, and common sense against, well… whatever you’d call this situation.

Let’s dive into this bizarre legal battleground where constitutional rights and cannabis collide.

As America’s cannabis landscape evolves, we’re witnessing a fascinating legal tug-of-war between state sovereignty and federal authority. The latest battleground? The constitutional rights of cannabis consumers to bear arms.

In a groundbreaking decision, the U.S. Court of Appeals for the Fifth Circuit recently reaffirmed that banning occasional marijuana users from owning firearms is unconstitutional. The case, known as U.S. v. Daniels, centers around a man who was sentenced to four years in prison after police found trace amounts of cannabis and firearms during a routine traffic stop. Talk about wrong place, wrong time!

The federal government, particularly under the Biden administration, has been performing some impressive mental gymnastics to justify their position. Their argument? Cannabis users with guns “endanger public safety,” “pose a greater risk of suicide,” and are more likely to commit crimes “to fund their drug habit.” They’ve even argued that cannabis consumers are “unlikely to store their weapons properly.” I guess they never met my ex-military uncle who meticulously organizes his gun safe while enjoying his evening edible.

But here’s where it gets really interesting. The Department of Justice claims the restriction is perfectly constitutional because it aligns with the nation’s history of disarming “dangerous” individuals. They’re essentially putting cannabis users in the same category as folks with domestic violence restraining orders. As someone who’s spent considerable time around both cannabis users and domestic abusers (professionally, of course), I can tell you there’s a slight difference in temperament.

The courts, however, aren’t buying it. As the Fifth Circuit pointed out, the government failed to prove that Daniels was “presently or even regularly intoxicated at the time of arrest.” They noted that even if the government had proven frequent intoxication, they offered “no Founding-era law or practice of disarming ordinary citizens ‘even if their intoxication was routine.'”

The ruling doesn’t completely invalidate the federal statute (known as § 922(g)(3)), but it does expose its shaky constitutional foundation. As the court stated, “This is not a windfall for defendants charged under § 922(g)(3),” but rather a recognition that the government’s enforcement approach is fundamentally flawed.

Meanwhile, the National Rifle Association (NRA) – not exactly known for their progressive stance on substances – acknowledges the absurdity of the situation. They point out that “marijuana use is no longer limited to the domain of indigenous religious customs or youth-oriented counterculture and now includes a wide variety of people who use it for medicinal or recreational reasons.” When even the NRA is suggesting your gun control measure might be a bit extreme, you know something’s amiss.

The result of all this legal wrangling? A patchwork of confusion where state-legal cannabis users must choose between their Second Amendment rights and their medicine or recreational preference. It’s a prime example of how federal prohibition creates more problems than it solves, forcing otherwise law-abiding citizens to become unwitting criminals simply for exercising multiple legal rights simultaneously.

Welcome to America, folks, where you can have your guns or your ganja, but apparently not both – at least until the courts finish sorting out this constitutional cannabis conundrum.

Let me be blunt – we’re caught in a classic American political pretzel. The Biden administration dangles the carrot of rescheduling cannabis to Schedule III, making vague promises that sound good on the campaign trail but do little to address the fundamental issues plaguing cannabis consumers, including their right to bear arms.

While some celebrate these baby steps toward reform, I’ve been around this block enough times to know that rescheduling is like putting a Band-Aid on a bullet wound. It might stop some bleeding, but it doesn’t address the underlying trauma. The gun rights issue is just one of many complications that arise from cannabis’s continued inclusion in the Controlled Substances Act (CSA).

Here’s the uncomfortable truth: there’s only one real solution, and it runs straight through the halls of Congress. The same body that created this mess with the CSA in 1971 is the only one with the power to truly fix it. Congress needs to completely remove cannabis from the CSA – not reschedule it, not modify its status, but fully deschedule it.

Think about it. Rescheduling to Schedule III would still leave cannabis in a weird legal limbo. Sure, it might make research easier and give Big Pharma more room to play, but what about the millions of Americans who use cannabis medicinally or recreationally in their state-legal markets? They’d still be federal criminals, still banned from purchasing firearms, still caught in the crossfire between state and federal law.

The only path forward is complete removal from the CSA, coupled with a federal framework that respects state markets while establishing basic national standards. This would resolve the gun rights issue overnight – no more choosing between your Second Amendment rights and your medicine or recreational preference.

Would I love to see Congress completely overhaul the CSA? Absolutely. The entire scheduling system is based on outdated science and political theater rather than actual harm reduction principles. But let’s be realistic – that’s about as likely as finding bipartisan agreement on… well, anything these days.

Instead, we need to focus on what’s achievable: complete cannabis descheduling. This isn’t just about guns and ganja – it’s about fixing a broken system that’s created countless legal paradoxes and unnecessary criminal penalties. It’s about acknowledging that the emperor has no clothes, that cannabis prohibition has failed, and that it’s time to move forward with a sensible federal policy.

Until Congress acts, we’ll continue to see these legal battles play out in courts across the country, watching judges try to reconcile constitutional rights with outdated federal drug laws. It’s a waste of judicial resources, taxpayer money, and most importantly, it’s a waste of Americans’ time and freedom.

The solution is clear. The only question is: how many more Americans need to get caught in this legal crossfire before Congress finally does its job?

 

Inspiration:

https://www.marijuanamoment.net/federal-court-reaffirms-that-ban-

on-gun-ownership-for-people-who-occasionally-use-marijuana-is-unconstitutional/

https://www.marijuanamoment.net/nra-says-federal-ban-on-

marijuana-amid-state-level-legalization-has-created-confusing-legal-landscape-for-gun-owners/

 

CANNABIS AND GUN RIGHTS, READ ON…

CANNABIS USERS GUNS RIGHT

WHY CAN’T MMJ PATIENTS OWN GUNS, AGAIN? READ THIS!



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MLK Day 2025: Cannabis and Civil Rights

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It’s MLK Day once again.

I’ve been writing an MLK Day post on this blog for eight consecutive years. The theme of my posts is that cannabis is a civil rights issue, and that Dr. King would have advocated for ending prohibition based on that fact.

Each year, I have demonstrated with facts (upon facts upon facts) that the War on Drugs continues in insidious ways. In, 2023, which is the most recent year that FBI data is available, law enforcement officials made over 200,000 arrests for marijuana-related convictions. Those 200,000 arrests constitute roughly 25% of all drug-related arrests.

Sadly, arrests of black people constituted 29% of all drug arrests in 2023, although only 13.6% of Americans are black.

Heading into MLK Day weekend, President Biden announced that he is commuting the sentences of nearly 2,500 people convicted of non-violent drug offenses. The focus was predominantly on individuals “who received lengthy sentences based on discredited distinctions between crack and powder cocaine…”, as opposed to cannabis-related crimes. According to the Last Prisoner Project, “the total number of those incarcerated for cannabis who received commutations is not knows, but nine LPP constituents will be free.”

For all that Biden promised as to cannabis, it’s the least we could have asked. Under the new Trump administration, attention will quickly return to the frustrating marijuana rescheduling process. If cannabis ends up on Schedule III, criminal penalties for traffickers may soften, but make no mistake: possessing and distributing cannabis will still be a federal crime.

At the state level, where most arrest occur, progress has slowed in the last few years. Out here where I live in Oregon, with our 800 cannabis stores, it’s astonishing to think of 200,000 annual cannabis arrests– most for simple possession, no less.

There is a lot of work to do. Here are a short list of organizations if you’d like to get involved:

For prior posts in this series:



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