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Would You Take Weed and Magic Mushrooms Together in One Pill?

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Researchers Aim To Combine Psilocybin and Cannabis Into Single Medical Treatment

According to a product patent from the renowned marijuana laboratory, CaaMTech, substantial strides have been made in developing a comprehensive treatment that combines cannabinoids and psilocybin for treating both physical and mental health concerns.

 

Located in Issaquah, Washington, less than 20 miles southeast of Seattle, CaaMTech is aggressively researching the interactions between these two chemicals as well as the potential effects on physical and mental health.

 

The initial stages of their enhanced psilocybin-cannabinoid product development are presently underway.

 

This patent advancement comes at a time when genetic data on cannabis and psilocybin is becoming more widely available, opening up possibilities for investigating novel ways these two substances might interact, potentially leading to the development of novel commercial products.

 

For instance, the use of cannabis and psilocybin together has shown to be effective in shrinking tumors in patients with breast cancer, as was the case in the case of a 49-year-old woman.

 

Researchers concluded as a result of this discovery that there is growing anecdotal and empirical evidence that supports the therapeutic effects of cannabinoids and psychedelics in preventing the growth of tumors and acting as palliative medicine to ease the pain and emotional distress brought on by cancer and chemotherapy.

 

Incorporating psilocybin with a minor cannabinoid like cannabichromene (CBC), abundant in the cannabis plant, may help researchers create a comprehensive treatment for inflammation and severe mental health issues.

 

The president and CEO of the Canadian cannabis business Hexo Corp., Charlie Bowman, reaffirmed the viability of this strategy by saying, “That most certainly can be done.” He added that while CBC is difficult to produce and expensive to synthesise, it may be combined with psilocybin mushrooms to provide a more cost-effective alternative to a broader spectrum of clients. Making a water-soluble version of CBC and mixing it with mushrooms could result in one possible way to consume it: as tea.

 

Cannabis-assisted psychedelic treatment is currently being used at the Center for Medicinal Mindfulness in Boulder, Colorado. It is run by Daniel McQueen, author of “Psychedelic Cannabis” and executive director. This entails facilitating private cannabis and ketamine psychedelic experiences under medical supervision, including classes, personalised coaching, guided meditation sessions, and community support.

 

McQueen concurred that creating a psilocybin-cannabis tablet or other combo substance is possible. He did point out, though, that cannabis by itself can already generate psychedelic states; other psychedelics are not required. We frequently use cannabis as a psychedelic for the same reasons that people seek out psilocybin and other medications, he went on to say.

 

Imagine a three-hour DMT-level psychedelic experience with MDMA’s emotional support and the capacity to retain your sense of autonomy, he continued. In this instance, McQueen was alluding to the hallucinogen dimethyltryptamine, demonstrating how psychedelic cannabis may be able to produce a comparable experience.

 

This is the range of potential being investigated with psychedelic marijuana.

 

Different Hurdles to the Combination

 

There are many difficulties in creating a combination of chemicals that must be overcome.

 

Different brain receptors are affected differently by psychedelics and cannabis. While cannabinoids like THC largely bind to the CB1 receptor, CBC and THC mostly bind to the CB2 receptor. However, psychedelics like psilocybin bind to the 5-HT2A serotonin receptors predominantly.

 

The cannabinoid CBD, however, may also interact with serotonin receptors, according to a study. Interestingly, serotonin and a CB2 cannabinoid receptor can work together to accomplish things neither receptor can do independently.

 

For instance, ischemia in neonatal pigs was the subject of a 2022 study by Spanish researchers who discovered that CBD activates a serotonin receptor with neuroprotective properties. The study suggests that a large portion of the neuroprotective effects of CBD are likely due to the stimulation of the 5-HT1A receptor, one of the three serotonin receptors to which psilocybin interacts.

 

Medical and Curative Implications

 

The medical marijuana community is growing more and more enthused as they become aware of the potential of the combo substance.

 

For instance, patients with breast cancer have shown a substantial tumor reduction when cannabis and psychedelics are combined.

 

Researchers at the University of Miami are also investigating a single pill containing CBD and psilocybin as a potential treatment for traumatic brain damage and PTSD.

 

In addition, a new survey-based study reveals that using cannabis and psychedelics together may increase the therapeutic advantages of doing so, indicating possible receptor target overlap.

 

According to the Centre for Psychedelic Research at Imperial College London, concurrent cannabis usage may intensify the positive psychological benefits connected with psychedelics. Based on survey responses from 321 participants from 40 different nations, the researchers concluded by comparing the subjective effects of psychedelics and cannabis, such as euphoria, changed time perception, increased sensory perception, and improved associative thinking.

 

Although the molecular mechanisms behind the synergistic effects of cannabis and psychedelics were not investigated in the current investigation, the findings strongly support their presence.

 

Although serotonergic psychedelics and cannabis have different modes of action, the Imperial researchers say that recent research has suggested that there may be some receptor target overlap between these two drug classes.

 

Similarities between cannabis and psychedelics

 

Research is still being done on the fascinating connection between cannabis and psychedelics; some results point to possible overlaps.

 

For example, recently found cannabinoids have shown the capacity to provide a stronger and more psychedelic experience, perhaps making them acceptable for psychedelic-assisted treatment without additional psychedelics.

 

THC-O, sometimes called THC acetate ester, is an example of a synthetic cannabinoid produced through chemical synthesis. Due to its powerful and intoxicating properties, this substance is relatively new and has attracted interest. Consumer reports indicate that THC-O produces more psychedelic or spiritual psychoactivity than other cannabinoids.

 

THCP, a recently discovered cannabinoid, has the potential to be 33 times more potent than THC. However, the specific effects of THCP on humans, including its potential to surpass psychedelics in potency and therapeutic applications, remain unknown. Nevertheless, ongoing research suggests that THCP could be a significant component in certain cannabis strains. Further studies are necessary to comprehend the properties and implications of this promising cannabinoid fully.

 

According to a 2019 study by Italian researchers, THCP should be added to the list of key phytocannabinoids to properly evaluate the pharmacological effects of cannabis extracts given to patients. According to the researchers, the finding of this powerful phytocannabinoid with THC-like qualities may shed light on some pharmacological characteristics that cannot all be attributable to delta-9 THC.

 

Additionally, research is being done to create psychedelics with antidepressant properties without causing hallucinations. The University of North Carolina School of Medicine’s Dr Bryan Roth and his research group have created a substance that, when administered to mice, targets the same brain regions as psychedelic drugs, producing long-lasting antidepressant effects without the psychedelic side effects.

 

Dr Roth is still dubious about the viability of a molecule that combines psychedelics and cannabis, though. He argues that while psychedelics boost activity in some neurons, cannabis usually lowers neuronal activity throughout the brain. As a result, these chemicals’ effects are vastly dissimilar.

 

Bottom Line

 

There is significant interest in investigating the use of cannabis and psychedelics together for therapeutic and medical purposes, according to ongoing research and breakthroughs. The possible advantages include treating inflammation and mental health conditions, decreasing tumors, and comforting relief. Despite the difficulties in developing a combination chemical, researchers are upbeat about the viability and affordability of such a medicine. Even though psychedelics and cannabis interact with brain receptors differently, data points to possible overlap, which supports the idea that mixing these drugs may have synergistic effects. More study is necessary to comprehend the molecular pathways completely and appreciate the medical ramifications of this combination.

 

WEED AND SHROOMS, READ ON…

DEA ON GROWING MUSHROOMS AND WEED

THE DEA WANTS YOU TO GROW SHROOMS AND WEED FOR RESEARCH!



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America’s Constitutional Conundrum: Guns and Ganja

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Of Guns and Ganja: America’s Constitutional Conundrum

 

If there’s one thing America is famous for, it’s guns – and lots of ’em! In the land of the free and home of the brave, firearms aren’t just a right, they’re practically a national pastime. With over 400 million firearms floating around a nation of 330 million people, it’s safe to say that guns are as American as apple pie and baseball.

But you know what else Americans love? Drugs. The US remains the world’s largest drug market, with an particularly passionate affair with cannabis. Mary Jane has come a long way since the “Just Say No” propaganda of the D.A.R.E. days. Now, millions of Americans legally light up in their home states, transforming from “criminals” to “consumers” faster than you can say “tax revenue.”

Here’s where things get sticky though. Despite the Biden administration’s vague promises of reform, cannabis remains stubbornly classified as a Schedule I substance at the federal level. This creates a peculiar predicament for freedom-loving Americans who appreciate both their Second Amendment rights and their evening toke.

You see, there’s this obscure interpretation of federal law that says if you consume cannabis – even legally in your state – you’re technically not allowed to own firearms. Let that sink in for a moment: in a country with more guns than people, where cannabis is legally sold in most states, you’re forced to choose between your constitutional right to bear arms and your state-sanctioned right to consume a plant.

As you might imagine, telling Americans they can’t have their guns AND their ganja isn’t exactly going over well. It’s a uniquely American saga that pits state rights against federal law, personal freedom against bureaucratic overreach, and common sense against, well… whatever you’d call this situation.

Let’s dive into this bizarre legal battleground where constitutional rights and cannabis collide.

As America’s cannabis landscape evolves, we’re witnessing a fascinating legal tug-of-war between state sovereignty and federal authority. The latest battleground? The constitutional rights of cannabis consumers to bear arms.

In a groundbreaking decision, the U.S. Court of Appeals for the Fifth Circuit recently reaffirmed that banning occasional marijuana users from owning firearms is unconstitutional. The case, known as U.S. v. Daniels, centers around a man who was sentenced to four years in prison after police found trace amounts of cannabis and firearms during a routine traffic stop. Talk about wrong place, wrong time!

The federal government, particularly under the Biden administration, has been performing some impressive mental gymnastics to justify their position. Their argument? Cannabis users with guns “endanger public safety,” “pose a greater risk of suicide,” and are more likely to commit crimes “to fund their drug habit.” They’ve even argued that cannabis consumers are “unlikely to store their weapons properly.” I guess they never met my ex-military uncle who meticulously organizes his gun safe while enjoying his evening edible.

But here’s where it gets really interesting. The Department of Justice claims the restriction is perfectly constitutional because it aligns with the nation’s history of disarming “dangerous” individuals. They’re essentially putting cannabis users in the same category as folks with domestic violence restraining orders. As someone who’s spent considerable time around both cannabis users and domestic abusers (professionally, of course), I can tell you there’s a slight difference in temperament.

The courts, however, aren’t buying it. As the Fifth Circuit pointed out, the government failed to prove that Daniels was “presently or even regularly intoxicated at the time of arrest.” They noted that even if the government had proven frequent intoxication, they offered “no Founding-era law or practice of disarming ordinary citizens ‘even if their intoxication was routine.'”

The ruling doesn’t completely invalidate the federal statute (known as § 922(g)(3)), but it does expose its shaky constitutional foundation. As the court stated, “This is not a windfall for defendants charged under § 922(g)(3),” but rather a recognition that the government’s enforcement approach is fundamentally flawed.

Meanwhile, the National Rifle Association (NRA) – not exactly known for their progressive stance on substances – acknowledges the absurdity of the situation. They point out that “marijuana use is no longer limited to the domain of indigenous religious customs or youth-oriented counterculture and now includes a wide variety of people who use it for medicinal or recreational reasons.” When even the NRA is suggesting your gun control measure might be a bit extreme, you know something’s amiss.

The result of all this legal wrangling? A patchwork of confusion where state-legal cannabis users must choose between their Second Amendment rights and their medicine or recreational preference. It’s a prime example of how federal prohibition creates more problems than it solves, forcing otherwise law-abiding citizens to become unwitting criminals simply for exercising multiple legal rights simultaneously.

Welcome to America, folks, where you can have your guns or your ganja, but apparently not both – at least until the courts finish sorting out this constitutional cannabis conundrum.

Let me be blunt – we’re caught in a classic American political pretzel. The Biden administration dangles the carrot of rescheduling cannabis to Schedule III, making vague promises that sound good on the campaign trail but do little to address the fundamental issues plaguing cannabis consumers, including their right to bear arms.

While some celebrate these baby steps toward reform, I’ve been around this block enough times to know that rescheduling is like putting a Band-Aid on a bullet wound. It might stop some bleeding, but it doesn’t address the underlying trauma. The gun rights issue is just one of many complications that arise from cannabis’s continued inclusion in the Controlled Substances Act (CSA).

Here’s the uncomfortable truth: there’s only one real solution, and it runs straight through the halls of Congress. The same body that created this mess with the CSA in 1971 is the only one with the power to truly fix it. Congress needs to completely remove cannabis from the CSA – not reschedule it, not modify its status, but fully deschedule it.

Think about it. Rescheduling to Schedule III would still leave cannabis in a weird legal limbo. Sure, it might make research easier and give Big Pharma more room to play, but what about the millions of Americans who use cannabis medicinally or recreationally in their state-legal markets? They’d still be federal criminals, still banned from purchasing firearms, still caught in the crossfire between state and federal law.

The only path forward is complete removal from the CSA, coupled with a federal framework that respects state markets while establishing basic national standards. This would resolve the gun rights issue overnight – no more choosing between your Second Amendment rights and your medicine or recreational preference.

Would I love to see Congress completely overhaul the CSA? Absolutely. The entire scheduling system is based on outdated science and political theater rather than actual harm reduction principles. But let’s be realistic – that’s about as likely as finding bipartisan agreement on… well, anything these days.

Instead, we need to focus on what’s achievable: complete cannabis descheduling. This isn’t just about guns and ganja – it’s about fixing a broken system that’s created countless legal paradoxes and unnecessary criminal penalties. It’s about acknowledging that the emperor has no clothes, that cannabis prohibition has failed, and that it’s time to move forward with a sensible federal policy.

Until Congress acts, we’ll continue to see these legal battles play out in courts across the country, watching judges try to reconcile constitutional rights with outdated federal drug laws. It’s a waste of judicial resources, taxpayer money, and most importantly, it’s a waste of Americans’ time and freedom.

The solution is clear. The only question is: how many more Americans need to get caught in this legal crossfire before Congress finally does its job?

 

Inspiration:

https://www.marijuanamoment.net/federal-court-reaffirms-that-ban-

on-gun-ownership-for-people-who-occasionally-use-marijuana-is-unconstitutional/

https://www.marijuanamoment.net/nra-says-federal-ban-on-

marijuana-amid-state-level-legalization-has-created-confusing-legal-landscape-for-gun-owners/

 

CANNABIS AND GUN RIGHTS, READ ON…

CANNABIS USERS GUNS RIGHT

WHY CAN’T MMJ PATIENTS OWN GUNS, AGAIN? READ THIS!



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MLK Day 2025: Cannabis and Civil Rights

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It’s MLK Day once again.

I’ve been writing an MLK Day post on this blog for eight consecutive years. The theme of my posts is that cannabis is a civil rights issue, and that Dr. King would have advocated for ending prohibition based on that fact.

Each year, I have demonstrated with facts (upon facts upon facts) that the War on Drugs continues in insidious ways. In, 2023, which is the most recent year that FBI data is available, law enforcement officials made over 200,000 arrests for marijuana-related convictions. Those 200,000 arrests constitute roughly 25% of all drug-related arrests.

Sadly, arrests of black people constituted 29% of all drug arrests in 2023, although only 13.6% of Americans are black.

Heading into MLK Day weekend, President Biden announced that he is commuting the sentences of nearly 2,500 people convicted of non-violent drug offenses. The focus was predominantly on individuals “who received lengthy sentences based on discredited distinctions between crack and powder cocaine…”, as opposed to cannabis-related crimes. According to the Last Prisoner Project, “the total number of those incarcerated for cannabis who received commutations is not knows, but nine LPP constituents will be free.”

For all that Biden promised as to cannabis, it’s the least we could have asked. Under the new Trump administration, attention will quickly return to the frustrating marijuana rescheduling process. If cannabis ends up on Schedule III, criminal penalties for traffickers may soften, but make no mistake: possessing and distributing cannabis will still be a federal crime.

At the state level, where most arrest occur, progress has slowed in the last few years. Out here where I live in Oregon, with our 800 cannabis stores, it’s astonishing to think of 200,000 annual cannabis arrests– most for simple possession, no less.

There is a lot of work to do. Here are a short list of organizations if you’d like to get involved:

For prior posts in this series:



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No Smoking, No Vaping – What’s the Safest Way to Consume Cannabis Based on Your Genetics and Science?

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The Safest Way To Consume Cannabis For Health, According To Science and Genetics

 

Marijuana legalization continues to help thousands of people.

Most especially those who need marijuana to treat conditions in a safer, more natural, and more cost-effective manner compared to pricey, addictive, and dangerous pharmaceutical medications. That said, not all weed is made the same: depending on where you get your weed, some of it may be grown using pesticides, which can be bad for your health especially when smoked. So yes, it does matter what kind of weed you’re smoking and where you got it from.

In addition, not all methods of consumption are also the same. Many consumers, particularly extremely health-conscious individuals, prefer not to smoke weed. Smoking weed that’s been grown with pesticides can also be dangerous for one’s health. It’s especially not recommended if you are immunocompromised,

 

That’s why a growing number of consumers prefer to explore the variety of other consumption methods available these days, such as edibles, tinctures, beverages, and cannabis oil to name a few.

Now, the results of a new study have just been published, suggesting that cannabis oil extracts may be the safest way to consume weed. Researchers studied MCT oils that contained high concentrations of CBD with some THC.

 

“Several studies have found damage to various chromosomal associated with cannabinoid use,” said the researchers. “Considering numerous studies demonstrating the genotoxicity of cannabis, it is noteworthy that many of these investigations have focused on individuals who consume cannabis through smoking or in cigarette form, normally rich in THC,” they said.

 

The researchers specifically found that extracts of cannabis sativa don’t exhibit genotoxic or mutagenic potential in doses that are commonly used by patients to manage anxiety, pain, epilepsy, and other conditions. “Although the current literature on cannabis sativa extract remains inconsistent, most evidence suggests that these extracts are safe for cells and DNA under both acute and chronic experimental conditions, even at high doses, in studies involving both male and female animals,” wrote the researchers.

 

Some consumers were alarmed recently when studies, albeit weak in nature, were published, which suggested that cannabis smoke had the potential to be genotoxic. That said, it still isn’t recommended for individuals who may be immunocompromised but there is no strong evidence that cannabis can indeed cause genetic mutations.

 

Since oral consumption of cannabis oil bypasses the respiratory system and allows patients a more accurate way to dose, it’s become the preferred method of consumption for many medical cannabis patients. Whether you’re young or old, the safety profile of cannabis oil has been proven; this is especially true if you wish to avoid respiratory harm.

 

The Role Of Quality Cannabis In Health

 

As cannabis consumers, there are many ways you can ensure that you’re medicating with clean, safe cannabis that’s free from dangerous contaminants. Pesticides aren’t the only contaminants to be aware of; street cannabis sold by dealers can be laced with toxic additives and even fatal ingredients, such as in the notorious case of the tainted THC vapes containing Vitamin E acetate. Other undesirable ingredients to take note of include residual solvents and heavy metals.

 

It’s also your role as a consumer to do research about the quality of cannabis you buy. Of course, it makes sense to only buy from licensed cannabis dispensaries since they can easily supply laboratory-tested cannabis products. From edibles to oils, flowers and more, licensed dispensaries can provide products that have a Certificate of Analysis or COA, which can either be printed on the packaging itself, accessed online, or via a QR code. A cannabis product with a COA can give you peace of mind that the product meets stringent testing and quality standards.

 

In addition, you can also seek out certified organic cannabis products. Of course, the fact that cannabis still isn’t federally legal means that there is nothing similar to a USDA Organic certification for weed, though some manufacturers make it easier for consumers these days to know if they are buying organic or not. For example, if you live in California, you can look for Clean Green Certified or OCal (weed that has been grown in standard that are comparable to organic).

 

 

Conclusion


If you are older or have pre-existing medical conditions, the best way to medicate with marijuana is by taking cannabis oil orally. It’s also extremely versatile, since it can be used to treat an array of conditions ranging from nausea to chronic pain, headaches, muscle pain, and so much more. While it may have reduced bioavailability compared to smoking, cannabis oil extracts do provide fairly quick relief for several conditions.

 

Smoking weed in any form, whether by flower, vape oil, or concentrates, should be avoided or limited altogether. There are also other potential consumption methods that are safer and more suitable for the immunocompromised, such as sprays, edibles, and topicals.

 

It also helps to carefully consider the type of cannabinoids you are consuming. For patients that need to medicate during the daytime, CBD or high-CBD products are always preferred. One must be careful with THC especially if you are older, operate machinery, or have no previous experience with psychoactive drugs. Always start with the lowest dose possible, and work your way to a higher dose slowly.

 

SAFEST WAY TO USE WEED, READ ON…

SAFEST WAY TO USE WEED

AMERICANS DON’T KNOW THE SAFEST WAYS TO USE WEED!



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