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Cannabis Causes a 34% Increase in Coronary Artery Disease (CAD)

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Reginald Examines the Heart of the Study…

Study claims daily cannabis smoke linked with 34% increase in CAD chances

 

As more and more states legalize cannabis, the once-taboo plant is making its way into the mainstream. Whether you use it for recreational or medical purposes, you’ve likely heard some of the conflicting information about its effects on the human body. Some people swear by it, claiming that it helps with everything from anxiety to chronic pain, while others caution against it, citing its potential to harm the lungs and impair cognitive function. So what’s the truth?

 

Well, the truth is that it’s complicated. Cannabis is a complex plant with hundreds of different chemical compounds, each of which can interact with the human body in different ways. This means that each individual’s experience with cannabis is unique, with some people finding it calming and others finding it stimulating. And with more and more people admitting to using cannabis, researchers are finally able to collect more data on its consumption and effects.

 

However, as a forever skeptic, I know it’s important to approach these studies with a healthy dose of skepticism. After all, we’ve seen time and time again how statistics can be manipulated to highlight certain preferred results. 

 

That’s why in this article, I’ll be taking a closer look at the latest study that claims daily cannabis use increases the chances of coronary artery disease (CAD) by 34%. I’ll examine the methods used by researchers to arrive at this conclusion and discuss what it means for those who use cannabis regularly.

 

But don’t worry, I’m not here to scare you away from cannabis altogether. In fact, I believe that education is the key to making informed decisions about its use. That’s why I’ll also be providing “Good Heart Health tips” at the end of the article, so you can continue to enjoy your cannabis while taking care of your heart. Because let’s face it, if you’re going to indulge, you might as well do it in a way that’s good for you. 

 

So sit back, relax, and let’s explore the complex world of cannabis and its potential impact on our bodies.

 

A Closer Look at the Claims of the Study

 

The American College of Cardiology released a study which suggests that daily cannabis use increases the likelihood of developing coronary artery disease (CAD) by one-third, compared to those who have never used the drug. 

 

The study analyzed health data from 175,000 people and found that daily marijuana users were 34% more likely to develop CAD than those who had never used the drug. The research team utilized Mendelian randomization, a genetics-based approach, to identify a causal relationship between cannabis use disorder and CAD risk, using data from an independent genetics consortium.

 

Cannabis use disorder is a psychiatric disorder involving frequent marijuana use and dependency – but we also know that the DSM is a bit exaggerated. 

 

After adjusting for age, sex, and major cardiovascular risk factors, the results indicated that daily cannabis users were 34% more likely to have CAD than those who have never used marijuana. 

 

The study suggests that it is important for people to be aware of the risks associated with cannabis use and inform their doctors if they use cannabis so that clinicians can take appropriate steps to monitor their heart health.

 

The datasets used in this study did not differentiate between various forms of cannabis use, such as smoking or consuming edibles or other forms. 

 

Therefore, it is crucial to examine the health implications of these different forms of cannabis consumption in future studies. 


 

Core Points:

 

  • Daily cannabis use increases the likelihood of developing coronary artery disease (CAD) by one-third.

  • Daily marijuana users were found to be 34% more likely to develop CAD than those who have never used the drug.

  • Mendelian randomization, a genetics-based approach, was utilized to identify a causal relationship between cannabis use disorder and CAD risk.

  • It is important to be aware of the risks associated with cannabis use and inform doctors of cannabis use when monitoring heart conditions.

  • Further research is needed to understand the health implications of different forms of cannabis consumption.

 

How to Lie with Statistics

 

When it comes to interpreting data, there are a lot of common mistakes researchers can make. I’m talking about errors that can turn your findings from trustworthy to just another sensational headline.

 

One mistake researchers often make is overgeneralizing the results. You can’t just assume that the results of a study on 175,000 people are representative of the entire population. That’s like saying you can judge the taste of a cake by only trying a single crumb. Plus, the study only analyzed data from the All of Us Research Program, which may not be representative of cannabis users as a whole.

 

Another mistake is assuming causation from correlation. Just because there’s a correlation between daily cannabis use and CAD, it doesn’t mean that one causes the other. There could be other factors at play, like lifestyle habits or genetic predisposition, that contribute to the development of CAD.

 

But hey, let’s give credit where credit is due. The study analyzed a massive sample size and used a genetics-based approach to establish a causal relationship between cannabis use disorder and CAD risk. That sounds pretty legit, right?

 

However, there’s a catch. We don’t have direct access to examine the datasets ourselves, so we have to trust the researchers’ analysis and interpretation of the data. It’s like trusting a cook who says the food is delicious, but you can’t taste it yourself.

 

So how can we protect ourselves from potentially skewed results? First, we need transparency in scientific research. Researchers need to be upfront about their methods and analysis, and they should report all results, not just the ones that support their hypothesis.

 

Second, peer review and replication of studies are essential. We need other researchers to review and critique the study to identify potential biases and limitations that could affect the results. It’s like a group of judges at a baking competition. They all have different tastes and opinions, but together they can identify the best cake.

 

Interpreting scientific research can be like walking through a minefield. There are a lot of potential biases and limitations to consider, and we have to trust the researchers’ analysis of the data. 

 

However, by demanding transparency and peer review, we can better ensure the accuracy and reliability of the results. 

 

So next time you see a sensational headline about the latest scientific study, remember to approach it with a healthy dose of skepticism and a craving for more information – unlike the mainstream media that regurgitated the same article. 

 

The Media as a Variable to Control

 

The media can be both a blessing and a curse. On the one hand, they can help disseminate important information quickly and effectively. On the other hand, they can also contribute to the spread of misinformation and bias. Take, for example, the recent media frenzy around the study linking daily cannabis use to an increased risk of coronary artery disease (CAD). As soon as the study was released, it seemed like every news outlet was publishing the same story, complete with the same quotes and statistics. This mass replication of the story gave the impression that the study was valid and reliable.

 

However, as we discussed earlier, there are several potential issues with the study that could compromise its validity. For one, it hasn’t been peer-reviewed yet, so we don’t know if other experts in the field would agree with its conclusions. Additionally, there could be unconscious biases in the way the data was collected, analyzed, and interpreted. And let’s not forget the potential for deliberate manipulation of the data, whether by the researchers themselves or by external parties.

 

But with the media amplifying the story and presenting it as fact, many people are now convinced that daily cannabis use is a serious threat to their heart health. They might not even be aware of the potential flaws in the study or the fact that it hasn’t undergone rigorous peer-review. This is a problem because the media can also be a variable that we need to consider when conducting cannabis research. Journalists might have their own unconscious biases or agendas that influence the way they report on studies. They might also be more inclined to cover studies that have attention-grabbing headlines, rather than studies that are more methodologically sound.

 

It’s important to remember that just because a story is widely covered in the media doesn’t necessarily mean it’s true or accurate. We need to approach media coverage with a critical eye and consider the potential biases and flaws in the studies being reported on. Until the study linking daily cannabis use to CAD undergoes peer-review and further scrutiny, we can’t take it as law.

 

This isn’t to say that we shouldn’t also take these findings seriously. Quite the opposite, if you have a history of heart disease – you may want to be aware of these facts. We still find that the majority of cannabis users don’t suffer from these issues, however, it’s good to be informed. 

 

Good Heart Health Practices

 

Taking care of our heart is crucial to living a healthy and fulfilling life. In addition to being aware of the potential risks associated with cannabis use, there are many other steps we can take to promote good heart health.

 

First and foremost, maintaining a healthy and balanced diet can make a significant impact on our heart health. Eating a variety of nutrient-dense foods, including fruits, vegetables, whole grains, lean proteins, and healthy fats can help reduce the risk of heart disease.

 

Regular exercise is also key to good heart health. Even moderate physical activity, such as brisk walking or cycling, can help lower blood pressure, reduce inflammation, and strengthen the heart muscle.

 

Managing stress through relaxation techniques such as meditation, deep breathing, or yoga can also help reduce the risk of heart disease.

 

Avoiding or quitting smoking is one of the most effective ways to lower the risk of heart disease. Smoking damages the heart and blood vessels, and even secondhand smoke can be harmful to heart health.

 

Monitoring blood pressure, cholesterol, and blood sugar levels is also important for maintaining good heart health. Regular check-ups with a healthcare provider can help catch potential issues early and prevent serious heart problems down the line.

 

In summary, here are some key practices to promote good heart health:

 

  • Maintain a healthy and balanced diet

  • Engage in regular physical activity

  • Manage stress through relaxation techniques

  • Avoid or quit smoking

  • Monitor blood pressure, cholesterol, and blood sugar levels

 

Now go toke up you stoner! 

 

CANNABIS AND HEART DISEASE, READ ON…

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California Appeals Court Rejects Marijuana Grow Permit, Citing Federal Illegality

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In a landmark decision that highlights the tension between state and federal cannabis laws, a California appellate court ruled on October 29th that property owners can refuse to allow the transportation of cannabis across their land via easements, even when the cannabis operation is approved by local authorities.

The Second District Court of Appeal’s unanimous decision draws attention to private property rights in a context where cannabis remains federally illegal, but state law allows licensed cultivation, distribution and sale. Presiding Justice Albert Gilbert stated, “No matter how much California voters and the Legislature might try, cannabis cultivation and transportation are illegal in California as long as it remains illegal under federal law.” JCCrandall LLC v. County of Santa Barbara, Case No. B333201, 2024 WL 4599304, Oct. 29, 2024.

Unless the California Supreme Court grants review – which I would not rule out – the decision empowers private property owners to refuse to contract with cannabis businesses, and restricts local government from approving cannabis operations that implicate the property rights of neighbors who object.

The case at hand

The dispute centered around a cannabis cultivation operation in Santa Barbara County, where JCCrandall LLC challenged a conditional use permit granted by the County to its neighbor, Santa Rita Holdings Inc. The critical issue was that Santa Rita Holdings could only access its 2.5-acre cannabis farm via an unpaved road crossing JCCrandall’s property through a pre-existing easement. JCCrandall grows oats and barley.

JCCrandall’s primary concern? It raised a number of complaints with the Santa Barbara County Supervisors about truck traffic and night operations, which did not gain traction, but in the Court of Appeal JCCrandall focused on what it claimed was potential liability associated with having federally illegal substances transported across its property, even though County regulators found that the Santa Rita operation was fully compliant with state and local laws.

Key legal findings

The appellate court’s decision hinged on several crucial points:

  1. Property Rights: The court emphasized that “the right to exclude others is the essence of the right of property ownership” and classified it as a fundamental vested right.
  2. Federal Supremacy: The panel determined that allowing cannabis transportation across private property “defies the Supremacy Clause” of the U.S. Constitution.
  3. State vs. Federal Law: While cannabis might be legal under California law, the court ruled that federal law’s prohibition takes precedence in this context.

California cannabis industry implications

Legal experts suggest this ruling could have far-reaching consequences for California’s cannabis industry. Section 1550.5(b) of the California Civil Code makes contracts within California involving cannabis lawful and enforceable, and Santa Rita Holdings bet the ranch on that argument. But the Court of Appeal held that the statute could not compel a landowner to allow cannabis to travel across its property on a pre-existing easement. Licensed operators may find it harder to do business because neighbors who have property rights affected by a cannabis business can object, and, under the JCCrandall ruling, local government must yield to those objections.

An example might be a cannabis dispensary that depends on access to its parking lot via an easement or is located in a shopping center where other lessees have rights to object to tenants notwithstanding the approval of the landlord. In cultivation, many cannabis farms depend on vehicular access through easements because they are remote and do not always have direct access to public thoroughfares, or they depend on water sourced from other properties pursuant to agreements made by prior owners who grew traditional crops. These neighbors might not need to show any negative impact on their property, but can argue that they could be found complicit in federally illegal activities.

I think the most problematic language in the JCCrandall ruling is the following, which might draw the attention of the California Supreme Court and cause it to grant review: “For as long as an easement is enjoyed, its mode and manner of use shall remain substantially the same as it was at the time the easement was created. The County argues the easement was used for agricultural purposes. But there is a vast difference between legal and illegal agricultural purposes.” (Emphasis added.) If California has determined that cannabis cultivation is legal – as it has – and state courts routinely enforce contracts involving cannabis, it is a pretty bold step to declare the use of a lawful pre-existing easement illegal simply because the agricultural crop is cannabis and take away easement access from Santa Rita.

Looking ahead

This decision creates new challenges for cannabis businesses in California, and will result in more disputes among neighbors. While the Biden administration has shown signs of easing federal marijuana restrictions, this ruling demonstrates that the federal-state law conflict continues to create significant legal hurdles for the cannabis industry.

California court decisions also can be persuasive authority in other states, so we might see similar litigation (and decisions) elsewhere in the country where cannabis has been legalized.

The case serves as a reminder that despite California’s progressive stance on cannabis, federal prohibition continues to cast a long shadow over the industry’s operations and development. As the cannabis landscape continues to evolve, this ruling may prompt businesses to reassess their property arrangements and local governments will certainly have to reconsider their permitting processes to give more careful consideration to objections by neighbors who claim that their property rights are implicated by cannabis operations.

Note: This post was first published earlier this month on the Alger ADR Blog.



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Autoimmune Conditions Are Rising Fast in American Medicine, Can Cannabis Help?

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Why Are Autoimmune Conditions On The Rise? And How Cannabis Can Help

 

Autoimmune diseases refer to a group of medical conditions that occur as a result of the immune system attacking your own tissues.

 

In a normal human body, the immune system is responsible for protecting the body by producing antibodies that prevent toxins, cancer cells, and viruses from harming the body. However, when one is struck by an autoimmune disorder, the immune system is no longer able to distinguish the difference between dangerous cells and healthy cells. As a result, the healthy cells are attacked, too.

Today, we know of around 100 different kinds of autoimmune conditions. Some of the most common examples of autoimmune conditions include rheumatoid arthritis (RA), lupus, inflammatory bowel disease, celiac disease, Type 1 diabetes, multiple sclerosis (MS), and the Guillain-Barre syndrome (GBS) to name a few. Others include Graves’ disease, Hashimoto’s thyroiditis, psoriasis, and vasculitis.

 

According to the National Health Council, around 50 million Americans are affected by autoimmune diseases today. This is a conservative estimate, considering that several autoimmune conditions are tricky to treat and so many people go undiagnosed for long periods of time. It’s worrisome to note that there are more people developing autoimmune diseases these days, many of which have reached levels comparable to epidemics.

 

But cannabis can help!

 

How Cannabis Can Help Curb And Manage Autoimmune Diseases

 

Not one single cause is responsible for the alarming growth of autoimmune diseases, though there are several factors at play. While there isn’t just one cause we can point at, it’s certain the reasons lie in our environment. After all, human genetics haven’t changed significantly yet the chemicals, toxins, and pollutants in our food and everyday items have risen dramatically.

 

In addition, people are getting less sleep than ever; stress rates are through the roof, and people are constantly worried. There is a clear link between psychological stress and physical health as well as immunity, which is why it isn’t unusual – it’s even common – to see many autoimmune disease cases flare up after people experience severe stress caused by grief, an accident, job loss, or the death of a loved one. These highly stressful and traumatic conditions wreak havoc on the body’s immune response, causing inflammation all over the body.

 

Conventional treatments prescribed to treat autoimmune conditions are focused on taming inflammation; these usually include steroids but also some non-steroidal drugs. These drugs often come with unwanted side effects, but research has shown that cannabis can work with the endocannabinoid system through THC and CBD, as well as other cannabinoids, to simulate similar results. In one study for example, we can see the clear association of the endocannabinoid system for neurodegenerative and inflammatory processes seen in Multiple Sclerosis and Amyotrophic Lateral Sclerosis.


There has also been an increasing number of studies proving the efficacy of cannabis for treating several autoimmune conditions.

 

Cannabis For Multiple Sclerosis

 

Multiple sclerosis is one of the autoimmune conditions where a growing number of studies have come out supporting the therapeutic benefits of cannabis for. In a 2024 study, patients with multiple sclerosis reported several improvements in quality of life after using cannabis-based medical products (CBMPs). For the study, British investigators analyzed the impact of cannabis based medicinal products made from either oil or extracts in 141 patients who were enrolled in the UK Medical Cannabis Registry.

 

The researchers then analyzed the changes in patient outcomes after a month, then three and 6 months after. According to the patients themselves, they were able to sustain improvements in their mental and physical health after marijuana therapy.

 

“This case series demonstrates a potential association between the initiation of CBMPs and improved patient reported outcomes in sleep, anxiety, and general HRQoL [health-related quality of life] measures, over six months,” said the study authors. “Additional measures for HRQoL, including various physical and mental health subdomains, also exhibit improvements up to six months when compared to baseline,” the authors concluded.

 

In another study from 2023, patients with multiple sclerosis reported significant improvements in symptoms after cannabis use. For the study, researchers from the Dent Neurologic Institute in Buffalo, New York, analyzed the medical records of 141 patients with multiple sclerosis, who were also legally authorized to consume medical marijuana products. They then analyzed data from the patients after one up to 4 follow-up sessions after the initial session of cannabis therapy. Sixty-five percent of patients consumed 1:1 THC:CBD tinctures.

 

According to the authors: “The results of this study indicate that use of MC [medical cannabis] to alleviate symptoms of MS is largely efficacious, with improvement in pain (72 percent of patients), muscle spasticity (48 percent of patients), and sleep disturbance (40 percent of patients) frequently reported.”

 

“More than half of opioid users at baseline were able to either discontinue or decrease their opioid use after starting MC. The mean daily MME [morphine milligram equivalents] was significantly reduced from the initial visit (51 mg) to the last follow-up visit (40 mg). This is consistent with previous literature showing that MC legalization is associated with decreased opioid use and that MC use is associated with decreased opioid use in patients with chronic pain. These findings indicate that MC may represent an alternative analgesic to opioids for some patients,” they wrote. 

 

Anecdotal Evidence

 

While more studies are needed to determine cannabis’ effect on other autoimmune conditions such as rheumatoid arthritis, we can rely on anecdotal evidence. In 2020, data from the medical journal, Rheumatology, revealed that patients who have this condition, along with those who have lupus and fibromyalgia, consume cannabis.

 

In fact, it was reported that marijuana was extremely common especially for patients with fibromyalgia. “In this meta-analysis, we found that one in six patients suffering from rheumatologic disease actively consumes cannabis, reducing pain reduction… A favorable effect of cannabis on pain in our meta-analysis reinforces the idea that cannabis could be used for analgesic purposes,” the authors concluded.

 

Conclusion

Cannabis is a safe and natural way to help prevent and treat the symptoms of autoimmune disease. It targets inflammation at its root, and is a proven natural way to help cope with stress, pain, insomnia, and inflammation all while protecting the brain. However, it’s important to ensure you medicate with clean, organic sources of marijuana.

 

AUTOIMMUNE AND CANNABIS, READ ON…

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Hemp and the New Senate Farm Bill

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The U.S. Senate’s version of the Farm Bill finally landed this week. They’re calling it the Rural Prosperity and Food Security Act of 2024 (the “Senate bill”). The Senate bill follows on the House’s proposal, called the Farm, Food and National Security Act of 2024 (the “House bill”), offered in May. Neither the Senate bill nor the House bill would preempt state or Indian law regarding hemp or the regulation of hemp products. This means states and tribes will retain a lot of latitude in regulating hemp and hemp-derived products– which gets people fired up.

Aside from giving states some runway, the Senate bill and the House bill differ in key respects regarding hemp. Therefore, these august bodies must confer and reconcile their sundry proposals. That could happen in 2024, but seems more likely in 2025 when the new Congress convenes. As of this week, though, we finally have a framework.

The Senate Bill re-defines “hemp” and defines “industrial hemp”

Section 10016 of the Senate bill (“Hemp Production”) amends the definition of “hemp.” Hemp was defined in the 2018 Farm Bill and removed from the federal Controlled Substances Act (CSA), taking us on a truly wild ride. See: What Happened to Hemp? (“What Happened”). The Senate bill also gives us a definition for “industrial hemp.” Here are those definitions, with points of emphasis in bold:

(1) Hemp. The term “hemp” means (A) the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 total tetrahydrocannabinol concentration (including tetrahydrocannabinolic acid) of not more than 0.3 percent on a dry weight basis; and (B) industrial hemp.

(3) Industrial Hemp. The term “industrial hemp” means the plant Cannabis sativa L. if the harvested material (A) is only (i) the stalks of that plant, fiber produced from those stalks, or any other manufactured product, derivative, mixture, or preparation of those stalks (except cannabinoid resin extracted from those stalks); (ii) whole grain, oil, cake, nut, hull, or any other compound, manufactured product, derivative, mixture, or preparation of the seeds of that plant (except cannabinoid resin extracted from the seeds of that plant); or (iii) viable seeds of that plant produced solely for production or manufacture of any material described in clause (i) or (ii); and (B) will not be used in the manufacturing or synthesis of natural or synthetic cannabinoid products.

The new regime

Again, the definitional stuff in bold is what I want to emphasize.

First, the Senate bill keeps the THC threshold at 0.3 percent, which is an arbitrary number we’ve been advocating against for years. The Senate bill mirrors the House bill in this respect, though, so we are stuck with this, unless Ron Paul gets his way.

Second, the Senate bill keeps the 2018 Farm Bill’s total THC standard, including THCA. The House bill does this too. This was fairly predictable: in What Happened, I wrote that we could “expect the total THC standard to remain, which means that actual Delta-9 THC won’t be the only metric for calculating THC content.”

We’ve also explained on this blog that the 2018 Farm Bill and USDA rules mandate total THC testing on pre-harvest hemp batches, but do not mandate such testing on post-harvest hemp or hemp products. The Senate bill doesn’t change this paradigm, which means the “loophole” for gas station weed remains open. This proposal is a big win for opponents of the House bill’s “Miller Amendment,” which would narrow the definition of “hemp” to exclude intoxicating hemp-derived substances.

Third, the Senate bill introduces a new definition and framework for industrial hemp. The House bill does this too, albeit slightly differently. The idea here is to invite farmers to grow hemp for fiber and grain purposes, while freeing them from regulatory burdens with the Department of Agriculture and criminal exposure with the Department of Justice. More specifically, for “industrial hemp” growers, the Senate bill:

  • removes background check requirements;
  • instates “relaxed regulatory requirements” for sampling and inspection methodologies (which will need to be adopted by rule); and
  • develops a certified seed program. 

The Senate bill also makes any hemp producer ineligible to grow hemp for five years if that producer, “with a culpable mental state greater than negligence, produces a crop of hemp that is inconsistent with that license.”(Hint: use the seed program.) The proof standard here seems like it could be an issue, and even if anyone has been adjudicated as growing marijuana under the guise of hemp, Farm Bill ineligibility seems like a far-off concern.

Bottom line

The big takeaway for me is that the Senate bill leaves the door open for intoxicating hemp products, whereas the Miller Amendment to the House bill does not. Something’s gotta give. And it needs to happen soon, because we’re already long overdue. As I explained in a webinar last week, the Farm Bill deals with the nation’s entire food supply, not just hemp. Therefore, this is not like with the SAFE Banking Act, where we have a proposed law specific to cannabis that may or may not ever pass. The Farm Bill must pass, and soon.

Stay tuned and we’ll keep you updated on any major happenings. For more on this topic, check out our massive hemp and CBD archive, or these specific, recent posts:



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