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Cannabidiol in Epilepsy Treatment: Understanding CBD’s Role

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By: Juan Sebastian Chaves Gil

The therapeutic use of cannabidiol (CBD) is a subject of controversy. While its application to treat various conditions such as anxiety, stress, insomnia, or certain chronic pains is on the rise, scientific and clinical evidence regarding the effects of this component of cannabis remains limited. In 2017, the World Health Organization (WHO) concluded that CBD has only been proven effective in some types of epilepsy after clinical trials, as research for other diseases is less advanced.

Several studies have shown the positive effects of cannabidiol in the treatment of refractory epilepsies, those that do not respond to conventional antiepileptic medications. However, neurologist Ángel Aledo Serrano warns about the need for caution and the importance of using it under the prescription and supervision of a neurologist.

There is a positive perception of CBD due to its natural origin, but Dr. Aledo emphasizes that it is crucial to adjust expectations, as it is not a universal remedy or healthier than other medications just because it comes from a plant.

In Spain, the only scientifically endorsed medication for certain epilepsies and authorized by the Spanish Agency of Medicines and Medical Devices (AEMPS) is Jazz Pharmaceuticals’ Epidyolex. This medication is indicated for Dravet Syndrome, Lennox-Gastaut Syndrome, and Tuberous Sclerosis, all of which are rare epileptic syndromes that are difficult to control with conventional medications.

Dravet Syndrome, a common genetic epilepsy, was the first to demonstrate the beneficial effects of CBD. Its application began ten years ago with the case of Charlotte Figi, an American girl with this syndrome, whose epileptic seizures significantly improved with a CBD-rich and low-THC cannabis treatment.

 

Despite the proven efficacy in Dravet Syndrome, Epidyolex has recently obtained approval in Spain to treat epileptic seizures associated with tuberous sclerosis, a rare genetic disease.

Regarding administration, cannabidiol can be used in children and adults of various ages, although its effectiveness is not as supported in children under 2 years old due to a lack of research. Epidyolex is presented in syrup form and is taken twice a day, with precautions regarding dosage to avoid adverse effects. Dr. Aledo highlights that the use of CBD is not as common as other antiepileptics due to its specific indication for rare and severe epilepsies.

Additionally, he underscores that its high cost, approximately 1,000 euros per bottle of Epidyolex, also contributes to its limited use.

As for the effects, cannabidiol improves the quality of life by reducing the frequency and intensity of epileptic seizures, although it rarely eliminates them entirely. Moreover, it can have a positive impact on cognition and behavior.

However, potential adverse effects, such as drowsiness, dizziness, diarrhea, and blood abnormalities, especially in liver transaminases, should be considered and monitored regularly.

Although Epidyolex is the only scientifically endorsed cannabidiol for epilepsy and is only available in hospital pharmacies, CBD is legally sold in parapharmacies in various forms and brands not scientifically tested. This poses risks as it lacks the necessary medical supervision, as the amount of cannabidiol and other components is not guaranteed and can vary, leading to intoxication or insufficient doses. Dr. Aledo emphasizes the importance of caution and consultation with a specialist in refractory epilepsies before resorting to products without scientific endorsement.



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Veterans With PTSD Are Given A Little Hope

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Some good new from the government about veterans who are suffering from PTSD and are using marijuana.

While our military is generally honored, medical treatment for them can lag behind the praises given by politicians and bureaucrats. Almost 23% of veterans who use the Veterans Admstinatrion (VA) health care have had Post-Traumatic Stress Disorder (PTSD) at some point in their lives. In 2021, 10% of men and 19% of women veterans using VA care were diagnosed with PTSD. A study of veterans from Iraq and Afghanistan found the prevalence of PTSD varied by unit component. For example, deployed active duty veterans had an 18.5% prevalence of PTSD, while non-deployed active duty veterans had a 13.2% prevalence.  It is difficult to treat and has ruined thousands of lives. But cannabis has helped and now veterans with PTSD are given a little hope with additional medical research.

RELATED: Can CBD Oils Help With Anxiety & Depression

Cannabis has shown promising potential in alleviating symptoms PTSD, offering hope to those struggling with this debilitating condition. Earlier studies have shed light on the biological mechanisms behind cannabis’s therapeutic effects on PTSD. The Food and Drug Administration (FDA) this week authorized a long-delayed clinical trial to test whether marijuana can be used to treat post-traumatic stress disorder (PTSD) in veterans. The agency had raised a variety of objections. The change is good news for veterans and their families. And another indicator the FDA is supportive of the rescheduling.

Veterans With PTSD Given A Little Hope

One key way cannabis helps PTSD sufferers is by reducing activity in the amygdala, a part of the brain associated with fear responses to threats. This dampening of the anxiety response can help individuals manage their symptoms more effectively.Additionally, cannabis may aid in extinguishing traumatic memories through a process called ‘extinction learning’.

The cannabinoids in cannabis, particularly THC and CBD, can enhance the rate at which challenging memories are processed and reduce overall anxiety responses. Research has shown that cannabis use is associated with a reduction in overall PTSD symptoms and improved quality of life. Low doses of THC or a combination of THC and CBD have been found to be particularly effective in enhancing extinction rates for traumatic memories and reducing anxiety.

RELATED: Marijuana Use And Guy’s Member

The endocannabinoid system plays a crucial role in this process. CBD, a non-psychoactive component of cannabis, indirectly affects this system by inhibiting the uptake or enzymatic degradation of endogenous cannabinoids. This action allows for a greater effect on CB1 and CB2 receptors, which are found in brain regions important for anxiety and aversive learnin

.Cannabis may also help address specific PTSD symptoms such as sleep disturbances, recurrent fear memories, and panic episodes. While individual responses can vary, cannabis can be considered as part of a comprehensive treatment plan under medical supervision.



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Acne And CBD: Exploring Alternative Dermatological Solutions

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Cannabidiol (CBD) has been praised many times for its beneficial therapeutic properties. But does its effectiveness extend to dermatological conditions? Specifically, how does CBD help with acne? As acne remains one of the most common skin issues affecting millions worldwide, the quest for effective treatments is ever-present, and the exploration of cannabis in this domain is gaining momentum.

Due to its low likelihood of side effects, CBD may prove to be a relatively safe treatment, rightfully deserving the attention of scientists and dermatologists alike. As the stigma surrounding cannabis continues to fade, more researchers are investigating how its compounds, particularly CBD, can be harnessed for therapeutic benefits beyond recreational use.

The Science Behind CBD and Acne

Professor Attila Olah’s 2014 paper, published in the Journal of Clinical Investigation, provides compelling evidence that CBD has the potential to treat acne. The study found that cannabidiol exhibits lipostatic, anticancer, and anti-inflammatory properties. This is particularly relevant for those suffering from acne, as inflammation plays a critical role in its development.

lipophilic cannabinoids

Furthermore, the same study showed that Cannabidiol can stop the proliferation of sebocytes, the grease-producing cells of the sebaceous glands. While Cannabidiol does not cause existing sebocytes to die off, it significantly reduces their reproduction. By curbing the overproduction of sebum, one of the leading causes of acne, CBD offers a promising alternative to conventional treatments that often come with a host of side effects.

Moreover, Cannabidiol’s universal anti-inflammatory effect helps reduce the inflammation associated with acne, providing relief to those who experience painful cystic acne or inflamed lesions. This dual action of reducing sebum production and inflammation makes CBD a compelling candidate for acne treatment, and for its potential for many others medical applications as well.

Complementary Research on Phytocannabinoids

A 2016 report published in Experimental Dermatology complemented this research by analyzing the effects of other phytocannabinoids on acne. Researchers found that phytocannabinoids such as CBD, CBC, CBDV, and THCV may prove to be “new effective and safe agents against skin inflammation.” This broadens the scope of cannabis’ potential in skincare, suggesting that other compounds may also contribute to treatment efficacy.

In another fascinating study, patients applied a cream containing 3% cannabis seed extract twice a day for 12 weeks. Remarkably, the treatment led to a significant reduction in sebum secretion and redness, further underscoring the anti-acne properties of cannabis derivatives. Such findings point towards the therapeutic promise of cannabis-based skincare products, which may offer a more natural alternative to traditional treatments.

Ongoing Clinical Trials and Future Implications

Lastly, a synthetic CBD formulation for external use, known as BTX 1503, showed promising results when tested on volunteers. Its effectiveness is currently being evaluated in a randomized, double-blind clinical trial, which could pave the way for new, scientifically-backed treatments. The potential to provide an effective, low-side-effect solution for acne could transform the approach to skincare, especially for those seeking alternatives to harsher chemical treatments.

Conclusion

As research into the therapeutic benefits of cannabis continues to evolve, the potential of CBD in treating acne is becoming increasingly apparent. With its anti-inflammatory properties and ability to regulate sebum production, cannabidiol represents a safe and promising avenue for those struggling with this prevalent skin condition.

As we await further clinical studies and advancements in cannabis-based skincare, individuals interested in exploring CBD for acne treatment should consult with healthcare professionals to ensure a safe and informed approach.

Disclaimer: This content is meant for educational purposes only. It has been compiled with research from external sources. It is not meant to substitute any medical or legal advice. Please see your local laws for the legality of cannabis use and make sure you are under medical professional supervision when applying this knowledge.

FREQUENTLY ASKED QUESTIONS (FAQ)

How can cannabis seeds help with acne?

Cannabis seeds can be a starting point for cultivating plants that produce CBD, which has been shown to help with acne. CBD reduces the proliferation of sebocytes, the grease-producing cells in the sebaceous glands, and its anti-inflammatory properties help reduce the redness and swelling associated with acne. However, always consult with a healthcare professional before starting any new treatment.

Are there other cannabinoids from cannabis seeds that can aid in acne treatment?

Yes, besides CBD, other cannabinoids such as CBC, CBDV, and THCV, which can be derived from cannabis seeds, have shown potential in treating acne. Research indicates these compounds might serve as effective and safe agents against skin inflammation. Growing the right strains can provide a variety of these beneficial cannabinoids.

Is it safe to use products derived from cannabis seeds for acne treatment?

Products derived from cannabis seeds, particularly those high in CBD, are generally considered safe due to their low likelihood of side effects. However, it’s crucial to consult with a healthcare professional before using any cannabis-based treatment, especially if you have sensitive skin or are taking other medications. Always ensure that any treatment is supervised by a medical professional.



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What’s Next For Legal Marijuana

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Going into 2025,  the cannabis industry will have to be more limber. 

The election is done and Donald Trump will be returning to the White House and Republicans having greater control in Congress. The election showed the majority of people want recreational in Florida, Nebraska will finally have medical marijuana, and cannabis wasn’t a deciding factor in swinging votes. With the House firmly in Republican hands, Mike Johnson has greater power to battle legal cannabis, but don’t count the industry out yet.

Nebraska, passed two ballot initiatives to legalize medical marijuana and regulate the industry on Tuesday. A whopping 67% of the public said yes, which is great for a traditional lyconservative state.  Nebraska was one of the few holdouts for medical marijuana. The legality of the ballot initiatives is being questioned regarding discrepancy over fraudulent signatures and fraudulent notarizations. It is a civil case with a ruling expected after the election is cleared up. The Governor spoke out against cannabis. Those arguing on behalf of the petitioners said there was no “clear and convincing evidence” of fraud, and throwing out entire petitions would punish thousands of Nebraskan voters. If the cannabis backers and voters win the civil suit, medical marijuana should start by the end of 2025.

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Photo by CapturedNuance/Getty Images

While the initiative failed to reach the 60% of votes needed in Florida, it garnered an impressive 56% of public support. Showing the population of the sunshine state is for fully legal weed, but could be 4 years until it is available. There are issues are Governor DeSantis use of public assets to combat the issue, so my legal wrangling in Florida.

A portion of the industry supported the incoming president, but the biggest industry influence for the upcoming administration will be alcohol and pharmaceutical companies.  Alcohol alone is probably one of the biggest investors in the industry with over $13 billion. Wana Brands, which is partial owned by Constellation, launched hemp gummies that can be sold in most states and are as effective as THC gummies. A smart expansion of their products.

Cannabis is popular with the public with Pew Research saying 88+% of the population supporting legalization in some form.  Even the traditional AARP has come around to extoll the medical and wellness benefits of the plant.  A clearer pathway will be laid out in December with the DEA rescheduling.



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