Medical Marijuana

Cannabidiol in Epilepsy Treatment: Understanding CBD’s Role

Published

1 year ago

February 6, 2024

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By: Juan Sebastian Chaves Gil

The therapeutic use of cannabidiol (CBD) is a subject of controversy. While its application to treat various conditions such as anxiety, stress, insomnia, or certain chronic pains is on the rise, scientific and clinical evidence regarding the effects of this component of cannabis remains limited. In 2017, the World Health Organization (WHO) concluded that CBD has only been proven effective in some types of epilepsy after clinical trials, as research for other diseases is less advanced.

Several studies have shown the positive effects of cannabidiol in the treatment of refractory epilepsies, those that do not respond to conventional antiepileptic medications. However, neurologist Ángel Aledo Serrano warns about the need for caution and the importance of using it under the prescription and supervision of a neurologist.

There is a positive perception of CBD due to its natural origin, but Dr. Aledo emphasizes that it is crucial to adjust expectations, as it is not a universal remedy or healthier than other medications just because it comes from a plant.

In Spain, the only scientifically endorsed medication for certain epilepsies and authorized by the Spanish Agency of Medicines and Medical Devices (AEMPS) is Jazz Pharmaceuticals’ Epidyolex. This medication is indicated for Dravet Syndrome, Lennox-Gastaut Syndrome, and Tuberous Sclerosis, all of which are rare epileptic syndromes that are difficult to control with conventional medications.

Dravet Syndrome, a common genetic epilepsy, was the first to demonstrate the beneficial effects of CBD. Its application began ten years ago with the case of Charlotte Figi, an American girl with this syndrome, whose epileptic seizures significantly improved with a CBD-rich and low-THC cannabis treatment.

Despite the proven efficacy in Dravet Syndrome, Epidyolex has recently obtained approval in Spain to treat epileptic seizures associated with tuberous sclerosis, a rare genetic disease.

Regarding administration, cannabidiol can be used in children and adults of various ages, although its effectiveness is not as supported in children under 2 years old due to a lack of research. Epidyolex is presented in syrup form and is taken twice a day, with precautions regarding dosage to avoid adverse effects. Dr. Aledo highlights that the use of CBD is not as common as other antiepileptics due to its specific indication for rare and severe epilepsies.

Additionally, he underscores that its high cost, approximately 1,000 euros per bottle of Epidyolex, also contributes to its limited use.

As for the effects, cannabidiol improves the quality of life by reducing the frequency and intensity of epileptic seizures, although it rarely eliminates them entirely. Moreover, it can have a positive impact on cognition and behavior.

However, potential adverse effects, such as drowsiness, dizziness, diarrhea, and blood abnormalities, especially in liver transaminases, should be considered and monitored regularly.

Although Epidyolex is the only scientifically endorsed cannabidiol for epilepsy and is only available in hospital pharmacies, CBD is legally sold in parapharmacies in various forms and brands not scientifically tested. This poses risks as it lacks the necessary medical supervision, as the amount of cannabidiol and other components is not guaranteed and can vary, leading to intoxication or insufficient doses. Dr. Aledo emphasizes the importance of caution and consultation with a specialist in refractory epilepsies before resorting to products without scientific endorsement.

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boomers

Marijuana Is Helping Those Over 65

Published

1 week ago

February 13, 2025

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As people ages, the body develops more issues…marijuana can help pause or manage some of the problems.

Marijuana is helping this over 65 to continue living their best life. Cannabis has become an increasingly popular treatment option for older adults who often suffer from chronic health conditions. These conditions include chronic pain, sleep disorders, anxiety, and various neurological symptoms. In fact, the staid AARP has began helping their membership unlock the benefits of marijuana to improve day to day existence. This move is allowing boomers to travel, play and have fun with friends and family.

From chronic pain to troubles sleeping, consumed in the right doses, marijana can be beneficial. One of the areas it can help is in intimacy. The benefits of the green plant can help some seniors with sex by reducing pain and distraction. Cannabis-infused topicals can help with pain from arthritis, stiffness, or injuries. It can help people get out of their heads and be more present with their partners, giving more focus and in the moment allowing things to flow better. And like food and music, marijuana can increase sensitivity to touch and enhance sensory perception. While it isn’t approved for erectile dysfunction, it can remove other barriers.

Medical marijuana is effective in managing chronic pain, which is common among older adults. Studies have shown that a significant percentage of participants experience pain relief when using medical marijuana. It can help manage symptoms associated with neurological conditions such as Parkinson’s disease and neuropathy.

Many older adults use cannabis to alleviate sleep disturbances. Research indicates that a substantial number of users report improved sleep quality. It can also be used to treat anxiety and depression, providing relief for mental health concerns that are prevalent in this age group.

One of the significant benefits observed is the reduction in opioid use among older adults. Studies have shown that many participants decrease their reliance on opioid pain medications after starting medical marijuana treatment.

Gen Z tends to use cannabis to relief anxiety and feel happier. The plant releases dopamine, which is one of the sources of happiness. Dosing is a key factor to hitting the right spot.

Despite the promising results, there is still a lack of comprehensive research on the efficacy and safety of medical marijuana in older adults. More randomized, controlled studies are needed to fully understand its benefits and risks. Additionally, concerns about cardiovascular risks associated with marijuana use highlight the need for cautious use and monitoring in older adults.

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Cannabis

Can CBD Provide Some Foot Pain Relief

Published

1 week ago

February 13, 2025

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It hobbles millions – but CBD could be step in the right direction for foot pain.

Roughly 75% of people suffer some type of foot pain at some point. But can CBD provide some foot pain relief? Foot pain can be debilitating, affecting daily activities and overall quality of life. Conditions like gout, plantar fasciitis, neuroma, neuropathy, and metatarsalgia are common causes of foot discomfort. While traditional treatments often come with side effects, CBD oil has emerged as a promising alternative for managing foot pain. Here’s why CBD is gaining attention for its potential benefits in alleviating foot-related issues.

RELAETD: Is GERD Helped By Cannabis

CBD, or cannabidiol, is a non-psychoactive compound found in cannabis plants. Unlike THC, CBD does not produce intoxicating effects, making it a safe option for those seeking pain relief without altering their mental state. CBD interacts with the body’s endocannabinoid system (ECS), which plays a crucial role in regulating pain, inflammation, and mood.

CBD has been shown to reduce inflammation, a key factor in many foot pain conditions. By minimizing swelling and redness, CBD can help alleviate discomfort associated with conditions like gout and plantar fasciitis.

CBD’s ability to modulate pain perception makes it effective for managing chronic pain. It can increase levels of anandamide, a compound associated with pain regulation, potentially reducing pain perception.

For conditions like neuropathy, where nerve damage leads to pain, CBD’s neuroprotective qualities can help mitigate symptoms. It may reduce neuropathic pain by interacting with receptors in the nervous system.

CBD products come in various forms, including topical creams, gels, and oils, which can be applied directly to the affected area. This localized application avoids systemic side effects and ensures targeted relief.

While more research is needed to fully understand CBD’s effects on chronic pain, existing studies suggest it is generally safe and well-tolerated. Common side effects are mild and include fatigue, decreased appetite, and dry mouth. The FDA has not approved CBD for pain management, but it is approved for certain epilepsy conditions, indicating its potential therapeutic benefits. As research continues to uncover the full potential of CBD, it may become a valuable tool in the arsenal against foot pain, providing comfort and improving quality of life for many.

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cancer

Federal Funding Freeze To Hit Medical Marijuana Research

Published

2 weeks ago

February 11, 2025

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Research on Cancer, chronic pain, nausea and more are grinding to a halt due to the federal funding freeze.

New research is validating cannabis can help cancer, chronic pain or more. It is a key alternative to avoid opioid use for post surgery pain. But now the deal funding freeze to hit medical marijuana research has significant implications for various sectors of scientific research, including medical marijuana studies. While the freeze has been temporarily halted, the uncertainty it created has already affected ongoing projects and future research prospects.

Medical marijuana research has long faced challenges due to federal restrictions. Despite growing interest in its therapeutic potential, the classification of marijuana as a Schedule I drug under the Controlled Substances Act limits research opportunities. Historically, most federal funding for cannabis research has focused on its potential harms rather than its medical benefits. The National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA) are key players in controlling access to research-grade cannabis, which further complicates the process for researchers.

Federal Funding Freeze To Hit Medical Marijuana Research

Effects of the Funding Freeze

Uncertainty and Delayed Projects: The funding freeze, even if temporary, has introduced uncertainty into the research environment. Scientists rely on stable funding to plan and execute long-term studies. Any disruption can delay projects, impacting years of research efforts.
Impact on Academic Freedom: The freeze is seen as a threat to academic freedom, as researchers fear speaking out against government actions might jeopardize their funding4. This fear can particularly affect medical marijuana research, which is already controversial and underfunded.
Limited Access to Research Materials: The NIDA monopoly on research-grade cannabis has historically limited access to materials necessary for comprehensive studies6. A funding freeze exacerbates this issue by potentially reducing the already limited resources available for acquiring and studying cannabis.
State-Level Initiatives: While federal funding is crucial, some states have taken the initiative to fund medical marijuana research. However, these efforts are often insufficient to compensate for the lack of federal support

The ongoing challenges in medical marijuana research highlight the need for consistent and supportive federal policies. As more states legalize cannabis for medical use, there is a growing demand for rigorous scientific studies to validate its efficacy and safety. However, until federal restrictions are eased and funding becomes more accessible, progress in this area will remain slow.

The federal funding freeze compounds the existing barriers to medical marijuana research, further hindering efforts to explore its therapeutic potential. Addressing these challenges requires a shift in federal policy to support comprehensive and unbiased research into cannabis’s medical benefits.

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