Medical Marijuana

Cannabidiol in Epilepsy Treatment: Understanding CBD’s Role

Published

1 year ago

February 6, 2024

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By: Juan Sebastian Chaves Gil

The therapeutic use of cannabidiol (CBD) is a subject of controversy. While its application to treat various conditions such as anxiety, stress, insomnia, or certain chronic pains is on the rise, scientific and clinical evidence regarding the effects of this component of cannabis remains limited. In 2017, the World Health Organization (WHO) concluded that CBD has only been proven effective in some types of epilepsy after clinical trials, as research for other diseases is less advanced.

Several studies have shown the positive effects of cannabidiol in the treatment of refractory epilepsies, those that do not respond to conventional antiepileptic medications. However, neurologist Ángel Aledo Serrano warns about the need for caution and the importance of using it under the prescription and supervision of a neurologist.

There is a positive perception of CBD due to its natural origin, but Dr. Aledo emphasizes that it is crucial to adjust expectations, as it is not a universal remedy or healthier than other medications just because it comes from a plant.

In Spain, the only scientifically endorsed medication for certain epilepsies and authorized by the Spanish Agency of Medicines and Medical Devices (AEMPS) is Jazz Pharmaceuticals’ Epidyolex. This medication is indicated for Dravet Syndrome, Lennox-Gastaut Syndrome, and Tuberous Sclerosis, all of which are rare epileptic syndromes that are difficult to control with conventional medications.

Dravet Syndrome, a common genetic epilepsy, was the first to demonstrate the beneficial effects of CBD. Its application began ten years ago with the case of Charlotte Figi, an American girl with this syndrome, whose epileptic seizures significantly improved with a CBD-rich and low-THC cannabis treatment.

Despite the proven efficacy in Dravet Syndrome, Epidyolex has recently obtained approval in Spain to treat epileptic seizures associated with tuberous sclerosis, a rare genetic disease.

Regarding administration, cannabidiol can be used in children and adults of various ages, although its effectiveness is not as supported in children under 2 years old due to a lack of research. Epidyolex is presented in syrup form and is taken twice a day, with precautions regarding dosage to avoid adverse effects. Dr. Aledo highlights that the use of CBD is not as common as other antiepileptics due to its specific indication for rare and severe epilepsies.

Additionally, he underscores that its high cost, approximately 1,000 euros per bottle of Epidyolex, also contributes to its limited use.

As for the effects, cannabidiol improves the quality of life by reducing the frequency and intensity of epileptic seizures, although it rarely eliminates them entirely. Moreover, it can have a positive impact on cognition and behavior.

However, potential adverse effects, such as drowsiness, dizziness, diarrhea, and blood abnormalities, especially in liver transaminases, should be considered and monitored regularly.

Although Epidyolex is the only scientifically endorsed cannabidiol for epilepsy and is only available in hospital pharmacies, CBD is legally sold in parapharmacies in various forms and brands not scientifically tested. This poses risks as it lacks the necessary medical supervision, as the amount of cannabidiol and other components is not guaranteed and can vary, leading to intoxication or insufficient doses. Dr. Aledo emphasizes the importance of caution and consultation with a specialist in refractory epilepsies before resorting to products without scientific endorsement.

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Cannabis

Mixed Messages From The Feds About Cannabis

Published

3 days ago

March 28, 2025

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The federal administration is all over the board around fed cannabis policy…and millions of patients are worried.

The industry employees over 440,000 workers at all lives and is driven in a large part by mom and pop businesses. Millions use medical marijuana for health issues ranging from chronic pain to sleep. But there are mixed messages from the feds about cannabis, and people are very worried. The federal government’s stance on marijuana has become increasingly complex, as recent developments show conflicting approaches to the drug’s potential benefits and risks. On one hand, there’s a push for research into medical marijuana for veterans, while on the other, a campaign against cannabis use is being launched.

The juxtaposition of initiatives highlights the federal government’s inconsistent approach to marijuana policy. While some departments are exploring the potential benefits of cannabis, others are actively working to discourage its use. This dichotomy is further exemplified by ongoing legislative efforts. For instance, Rep. Brian Mast (R-FL) has reintroduced the Veterans Equal Access Act, which would allow VA doctors to recommend medical marijuana to patients in states where it’s legal. Meanwhile, documents from an ongoing lawsuit suggest that the DEA may have weighted the marijuana rescheduling process to ensure rejection of moving the drug from Schedule 1 to Schedule 3.

The Department of Defense (DOD) has allocated nearly $10 million in funding for research into the therapeutic potential of MDMA for active-duty military members. This initiative, driven by congressional efforts, aims to explore MDMA’s effectiveness in treating conditions such as post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Rep. Morgan Luttrell (R-TX) expressed pride in this development, stating that it could be a “game-changer” for service members battling these combat-related injuries.

Additionally, a bipartisan effort in Congress has been pushing for VA research on medical marijuana for PTSD and other conditions affecting veterans. The VA Medicinal Cannabis Research Act, introduced in both the Senate and House, would mandate studies on how cannabis affects the use of addictive medications and impacts various health outcomes for veterans.

In stark contrast to these research initiatives, the Drug Enforcement Administration (DEA) has partnered with an anti-cannabis nonprofit to launch a social media campaign targeting young people. The campaign, set to run ahead of April 20 (4/20), aims to “flood” Instagram with anti-cannabis content. The DEA is offering monetary incentives to students for creating and posting anti-THC videos, with payments ranging from $25 to $50 depending on the type of content produced.

This approach has raised eyebrows, as it seems to contradict the growing acceptance and legalization of marijuana across the United States. Critics argue that such campaigns may be out of touch with current societal trends and scientific understanding of cannabis.

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Cannabis

Could Medical Marijuana Help Pope Francis

Published

7 days ago

March 24, 2025

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The administration has spent very mixed signals…will consumers turn to hemp if marijuana is outlawed again?

He is one of the most globally well known figures and now he has health issue. The Pope resides in Vatican City, the world’s smallest country, and given its unique status , there is no healthcare system, medical centers, or hospitals. All patients must access clinics and hospitals in Rome for care. One of the most ancient cities in the world, Rome has a robust healthcare system. It includes the renowned Policlinico Universitario Gemelli, which is considered one of the largest private university hospitals in Europe and the best in Italy. But it isn’t global known like the Mayo Clinic, Cleveland Clinic, or Toronto General. Thinking outside the box, could medical marijuana help Pope Francis?

As the Pope continues his recovery from pneumonia and mild kidney issues, medical experts are exploring innovative treatments that could potentially aid in his healing process. One such treatment gaining attention is medical marijuana, which has shown promise in addressing various health conditions.

Medical marijuana might offer relief for Pope Francis’s respiratory challenges. Certain cannabinoids, particularly CBD, have demonstrated anti-inflammatory properties that could help reduce lung inflammation associated with pneumonia. While smoking cannabis is not recommended for respiratory conditions, alternative delivery methods such as vaporization or edibles could potentially provide therapeutic benefits without irritating the lungs

gold and multicolored cathedral interior

As the Pope recovers, pain management is likely a key concern. Medical marijuana has shown potential as a pain adjuvant, potentially reducing the need for opioids in patients with chronic conditions. This could be particularly beneficial for elderly patients like Pope Francis, who may be more susceptible to the side effects of traditional pain medications.

Recent studies have explored the relationship between cannabis and kidney function. While more research is needed, some evidence suggests that cannabis does not negatively affect kidney function in healthy individuals. For patients with chronic kidney disease (CKD), careful monitoring and dosage adjustment may be necessary to ensure safe use.

Medical marijuana has been associated with improvements in various symptoms that could enhance the Pope’s quality of life during recovery. These include better sleep, reduced anxiety, and increased appetite. Such benefits could contribute to a more comfortable and efficient healing process.

While the potential benefits of medical marijuana are intriguing, it’s important to approach any treatment the same caution as any elderly patient. A personalized treatment plan, developed in consultation with medical professionals, would be essential to ensure safety and efficacy. As the world watches the Pope’s recovery, the consideration of medical marijuana as a complementary treatment option offers a ray of hope. While more research is needed to fully understand its effects on specific conditions, the potential benefits for pain management, inflammation reduction, and overall well-being make it an intriguing possibility.

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Cannabis

Mormons And Marijuana – The Fresh Toast

Published

7 days ago

March 24, 2025

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Medical marijuana has become widely accepted – what do Mormon’s allow?

Mormons are advised to abstain from coffee, tea, and alcohol as part of the Word of Wisdom,” a health code received by the church’s founder, Joseph Smith, which is now considered scripture. They are allowed hot chocolate, but not anything else with caffeine. But what about Mormons and marijuana? It seems the Church of Jesus Christ of Latter-day Saints, commonly known as the Mormon church, has evolved its stance on cannabis and medical marijuana over the years, balancing religious principles with changing societal attitudes and medical research.

RELAETD: Is GERD Helped By Cannabis

Traditionally, the Mormon church has opposed the use of substances that are “harmful, illegal, or addictive or that impair judgment,” as stated in its official handbook. This stance has historically included cannabis, alongside tobacco, alcohol, and coffee. But in recent years, the church has nuanced its position, particularly regarding medical marijuana. In 2016, the church supported efforts to legalize CBD oil in Utah, while still opposing whole-plant cannabis remedies. By 2018, the church played a significant role in Utah’s medical marijuana legalization process. Initially opposing a ballot measure, the church later helped broker a compromise that led to a more conservative medical marijuana program. Then in 2019, the church clarified its stance in its youth magazine, stating that while marijuana may be legal in many places, its use is still against the Word of Wisdom (the church’s health code). However, it acknowledged that medical uses were being studied.

white ceramic cup on brown wooden table

Utah, home of the Mormon church headquarters, generally has lower liquor and tobacco sales compared to other states, with Utah collecting the lowest per-capita alcohol taxes in the nation, and having strict regulations on alcohol and tobacco sales. This clearly shows their beliefs have become somewhat off a cultural norm. Currently, the church’s current stance on medical marijuana is it does not oppose medical marijuana when used as prescribed by a competent physician. This includes vaping marijuana when authorized based on medical necessity. But, the church continues to strongly oppose recreational marijuana use.

Additionally, the church advises caution, comparing marijuana to opioids and other addictive substances that should be avoided except under proper medical care.

In Utah, the church initially opposed a broad medical marijuana ballot initiative in 2018. But as cannabis was proven to have medical benefits, they facilitated negotiations between lawmakers, advocates, and other stakeholders to create a restrictive medical marijuana law. The resulting program includes limitations such as prohibiting smoking of marijuana flower (only vaporization is allowed), lower purchase limits, and requiring a pharmacist at every dispensary.

The church’s stance continues to evolve and in 2020, the church updated its handbook to explicitly allow vaping of medical marijuana when authorized by a medical provider. Church leaders have emphasized the need for prompt action on medical marijuana legislation, recognizing the urgency for those who may benefit from it. The church maintains that it respects the counsel of medical professionals and supports scrutiny of new drugs by medical scientists and official approval bodies.

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