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Cannabidiol in Epilepsy Treatment: Understanding CBD’s Role

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By: Juan Sebastian Chaves Gil

The therapeutic use of cannabidiol (CBD) is a subject of controversy. While its application to treat various conditions such as anxiety, stress, insomnia, or certain chronic pains is on the rise, scientific and clinical evidence regarding the effects of this component of cannabis remains limited. In 2017, the World Health Organization (WHO) concluded that CBD has only been proven effective in some types of epilepsy after clinical trials, as research for other diseases is less advanced.

Several studies have shown the positive effects of cannabidiol in the treatment of refractory epilepsies, those that do not respond to conventional antiepileptic medications. However, neurologist Ángel Aledo Serrano warns about the need for caution and the importance of using it under the prescription and supervision of a neurologist.

There is a positive perception of CBD due to its natural origin, but Dr. Aledo emphasizes that it is crucial to adjust expectations, as it is not a universal remedy or healthier than other medications just because it comes from a plant.

In Spain, the only scientifically endorsed medication for certain epilepsies and authorized by the Spanish Agency of Medicines and Medical Devices (AEMPS) is Jazz Pharmaceuticals’ Epidyolex. This medication is indicated for Dravet Syndrome, Lennox-Gastaut Syndrome, and Tuberous Sclerosis, all of which are rare epileptic syndromes that are difficult to control with conventional medications.

Dravet Syndrome, a common genetic epilepsy, was the first to demonstrate the beneficial effects of CBD. Its application began ten years ago with the case of Charlotte Figi, an American girl with this syndrome, whose epileptic seizures significantly improved with a CBD-rich and low-THC cannabis treatment.

 

Despite the proven efficacy in Dravet Syndrome, Epidyolex has recently obtained approval in Spain to treat epileptic seizures associated with tuberous sclerosis, a rare genetic disease.

Regarding administration, cannabidiol can be used in children and adults of various ages, although its effectiveness is not as supported in children under 2 years old due to a lack of research. Epidyolex is presented in syrup form and is taken twice a day, with precautions regarding dosage to avoid adverse effects. Dr. Aledo highlights that the use of CBD is not as common as other antiepileptics due to its specific indication for rare and severe epilepsies.

Additionally, he underscores that its high cost, approximately 1,000 euros per bottle of Epidyolex, also contributes to its limited use.

As for the effects, cannabidiol improves the quality of life by reducing the frequency and intensity of epileptic seizures, although it rarely eliminates them entirely. Moreover, it can have a positive impact on cognition and behavior.

However, potential adverse effects, such as drowsiness, dizziness, diarrhea, and blood abnormalities, especially in liver transaminases, should be considered and monitored regularly.

Although Epidyolex is the only scientifically endorsed cannabidiol for epilepsy and is only available in hospital pharmacies, CBD is legally sold in parapharmacies in various forms and brands not scientifically tested. This poses risks as it lacks the necessary medical supervision, as the amount of cannabidiol and other components is not guaranteed and can vary, leading to intoxication or insufficient doses. Dr. Aledo emphasizes the importance of caution and consultation with a specialist in refractory epilepsies before resorting to products without scientific endorsement.



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Cannabis Can Help A Sore Throat

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There is a buzz about sore throats today. While they are most common in colder months, spring allergies bring the pain also. This is often due to postnasal drip, which is when mucus from the nose and sinuses drains down the back of the throat, causing irritation and a scratchy feeling. Overuse of the voice, like talking loudly or singing for long periods, can tire out and strain the muscles in your throat, causing them to feel sore. The good news is cannabis can help a sore throat.

RELATED: How Hemp Helps You Sleep

For those seeking natural alternatives to manage cold symptoms, cannabis is emerging as a promising option for throat irritation. Increasing research at medical center specifically targeting sore throats shows early insights. The data suggests cannabinoids and terpenes could offer symptom relief through their unique properties.

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Photo by Esther Kelleter / EyeEm/Getty Images

Cannabis contains compounds like THC and CBD, which studies indicate possess anti-inflammatory properties that may reduce throat swelling and irritation. Terpenes such as eucalyptol—found in some strains—are traditionally associated with decongestant effects, potentially easing respiratory discomfort. These components work synergistically to calm inflamed tissues, though their direct impact on sore throats requires further clinical validation.

Smoking cannabis while ill remains controversial due to potential throat irritation from heat and smoke. Instead, experts recommend gentler options:

  • Edibles/lozenges: THC or CBD-infused products bypass inhalation, delivering localized relief without aggravating the throat.

  • Cannabis tea: Warm beverages with cannabis extracts may soothe scratchy throats while providing hydration.

  • Tinctures: Sublingual CBD oils allow precise dosing and avoid respiratory irritation.

Beyond direct throat relief, cannabis may improve overall wellness during illness. THC’s appetite-stimulating properties can combat reduced hunger, while its relaxing effects might promote restorative sleep. CBD’s muscle-relaxing qualities could help alleviate the body aches often accompanying colds.

RELATED: How To Stop Coughing So Hard From Marijuana Smoke

While preliminary findings are encouraging, users should consult healthcare providers before combining cannabis with conventional cold medications due to potential interactions. Starting with low-dose CBD products may offer benefits without psychoactive effects. As legalization expands, more targeted research is expected to clarify cannabis’s role in respiratory health.

Innovative cannabis formulations—from throat-calming lozenges to anti-inflammatory teas—are redefining how we approach minor ailments. For those navigating cold season, these plant-based solutions present a compelling fusion of traditional herbal wisdom and modern cannabinoid science

 



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Mixed Messages From The Feds About Cannabis

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The federal administration is all over the board around fed cannabis policy…and millions of patients are worried.

The industry employees over 440,000 workers at all lives and is driven in a large part by mom and pop businesses.  Millions use medical marijuana for health issues ranging from chronic pain to sleep.  But there are mixed messages from the feds about cannabis, and people are very worried. The federal government’s stance on marijuana has become increasingly complex, as recent developments show conflicting approaches to the drug’s potential benefits and risks. On one hand, there’s a push for research into medical marijuana for veterans, while on the other, a campaign against cannabis use is being launched.

RELATED: Music Is A Turn On Like Sex And Marijuana

The juxtaposition of initiatives highlights the federal government’s inconsistent approach to marijuana policy. While some departments are exploring the potential benefits of cannabis, others are actively working to discourage its use. This dichotomy is further exemplified by ongoing legislative efforts. For instance, Rep. Brian Mast (R-FL) has reintroduced the Veterans Equal Access Act, which would allow VA doctors to recommend medical marijuana to patients in states where it’s legal. Meanwhile, documents from an ongoing lawsuit suggest that the DEA may have weighted the marijuana rescheduling process to ensure rejection of moving the drug from Schedule 1 to Schedule 3.

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The Department of Defense (DOD) has allocated nearly $10 million in funding for research into the therapeutic potential of MDMA for active-duty military members. This initiative, driven by congressional efforts, aims to explore MDMA’s effectiveness in treating conditions such as post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Rep. Morgan Luttrell (R-TX) expressed pride in this development, stating that it could be a “game-changer” for service members battling these combat-related injuries.

Additionally, a bipartisan effort in Congress has been pushing for VA research on medical marijuana for PTSD and other conditions affecting veterans. The VA Medicinal Cannabis Research Act, introduced in both the Senate and House, would mandate studies on how cannabis affects the use of addictive medications and impacts various health outcomes for veterans.

RELATED: The Science Behind Why Music Sounds So Much Better When You’re High

In stark contrast to these research initiatives, the Drug Enforcement Administration (DEA) has partnered with an anti-cannabis nonprofit to launch a social media campaign targeting young people. The campaign, set to run ahead of April 20 (4/20), aims to “flood” Instagram with anti-cannabis content. The DEA is offering monetary incentives to students for creating and posting anti-THC videos, with payments ranging from $25 to $50 depending on the type of content produced.

This approach has raised eyebrows, as it seems to contradict the growing acceptance and legalization of marijuana across the United States. Critics argue that such campaigns may be out of touch with current societal trends and scientific understanding of cannabis.



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Could Medical Marijuana Help Pope Francis

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The administration has spent very mixed signals…will consumers turn to hemp if marijuana is outlawed again?

He is one of the most globally well known figures and now he has health issue. The Pope resides in Vatican City, the world’s smallest country, and given its unique status , there is no healthcare system, medical centers, or hospitals. All patients must access clinics and hospitals in Rome for care. One of the most ancient cities in the world, Rome has a robust healthcare system. It includes the renowned Policlinico Universitario Gemelli, which is considered one of the largest private university hospitals in Europe and the best in Italy. But it isn’t global known like the Mayo Clinic, Cleveland Clinic, or Toronto General. Thinking outside the box, could medical marijuana help Pope Francis?

As the Pope continues his recovery from pneumonia and mild kidney issues, medical experts are exploring innovative treatments that could potentially aid in his healing process. One such treatment gaining attention is medical marijuana, which has shown promise in addressing various health conditions.

RELATED: Couples Using Cannabis Can Increase Intimacy

Medical marijuana might offer relief for Pope Francis’s respiratory challenges. Certain cannabinoids, particularly CBD, have demonstrated anti-inflammatory properties that could help reduce lung inflammation associated with pneumonia. While smoking cannabis is not recommended for respiratory conditions, alternative delivery methods such as vaporization or edibles could potentially provide therapeutic benefits without irritating the lungs

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As the Pope recovers, pain management is likely a key concern. Medical marijuana has shown potential as a pain adjuvant, potentially reducing the need for opioids in patients with chronic conditions. This could be particularly beneficial for elderly patients like Pope Francis, who may be more susceptible to the side effects of traditional pain medications.

Recent studies have explored the relationship between cannabis and kidney function. While more research is needed, some evidence suggests that cannabis does not negatively affect kidney function in healthy individuals. For patients with chronic kidney disease (CKD), careful monitoring and dosage adjustment may be necessary to ensure safe use.

Medical marijuana has been associated with improvements in various symptoms that could enhance the Pope’s quality of life during recovery. These include better sleep, reduced anxiety, and increased appetite. Such benefits could contribute to a more comfortable and efficient healing process.

RELATED: Marijuana Use And Guy’s Member

While the potential benefits of medical marijuana are intriguing, it’s important to approach any treatment the same caution as any elderly patient. A personalized treatment plan, developed in consultation with medical professionals, would be essential to ensure safety and efficacy. As the world watches the Pope’s recovery, the consideration of medical marijuana as a complementary treatment option offers a ray of hope. While more research is needed to fully understand its effects on specific conditions, the potential benefits for pain management, inflammation reduction, and overall well-being make it an intriguing possibility.



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