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Cannabis and Dementia – What We Now Know and Don’t Know

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Dementia, an umbrella term encompassing various neurodegenerative disorders, has become a growing concern worldwide. With the legalization of medical and recreational marijuana in many regions, the relationship between marijuana and dementia has come under increasing scrutiny. While some studies suggest potential benefits of marijuana in treating dementia symptoms, others raise concerns about its potential risks. In this comprehensive article, we will delve into the complex interplay between dementia and marijuana, examining the current research and its implications for patients and healthcare professionals.

 

Understanding Dementia

Dementia is a collective term for various progressive neurological disorders that significantly impair cognitive functions such as memory, thinking, and reasoning. It affects millions globally, particularly older adults, and is not a normal part of aging. Understanding dementia involves recognizing its symptoms, types, causes, and the impact it has on individuals and caregivers.

Common Types of Dementia

  • Alzheimer’s Disease: The most prevalent form, accounting for 60-80% of cases.

  • Vascular Dementia: Caused by reduced blood flow to the brain, often following strokes.

  • Lewy Body Dementia: Associated with abnormal protein deposits in the brain.

  • Frontotemporal Dementia: Affects the frontal and temporal lobes, impacting personality and behavior.

 

Common Symptoms of Dementia

  • Memory loss and confusion.

  • Difficulty in communication and understanding.

  • Changes in mood and behavior.

  • Impaired judgment and decision-making.

Marijuana and Dementia: Potential Benefits

Recent studies have explored the potential benefits of marijuana in treating dementia symptoms and even preventing the progression of the disease. The two main components of marijuana, cannabidiol (CBD) and tetrahydrocannabinol (THC), have shown promising results in various cannabis strains for dementia studies.

Marijuana may help alleviate various symptoms associated with dementia, such as agitation, anxiety, aggression, and sleep disturbances, significantly improving the quality of life for individuals living with these conditions.It may also help manage appetite loss and depression commonly experienced by dementia patients

Certain cannabinoids found in marijuana, such as THC and CBD, may have cognitive-enhancing effects. These compounds have been shown to modulate neurotransmitter systems involved in memory and cognition, potentially improving cognitive function in individuals with dementia

 

Cannabinoids found in marijuana possess neuroprotective properties, meaning they may help protect brain cells from damage and promote their survival.

This could potentially slow down the progression of neurodegenerative diseases like Alzheimer’s by reducing inflammation, oxidative stress, and excitotoxicity in the brain.

 

Chronic inflammation is believed to play a role in the progression of dementia. Marijuana has been shown to have anti-inflammatory effects, potentially reducing inflammation in the brain and mitigating the damage caused by neuroinflammation

 

 

Loss of appetite and unintended weight loss are common issues in individuals with dementia. Marijuana, particularly strains containing THC, may stimulate appetite and help manage weight loss by activating cannabinoid receptors involved in regulating hunger and satiety

Marijuana and Dementia: Potential Risks

While some studies suggest potential benefits of marijuana in treating dementia, there are also concerns about its potential risks. Long-term marijuana use has been linked to a higher risk of developing dementia, particularly Alzheimer’s disease.

 

  • Cognitive Impairment

  • Long-term cannabis use has been linked to cognitive deficits. Research indicates that individuals who use cannabis regularly may experience declines in cognitive function, including memory, attention, and processing speed, which are critical for daily functioning.

  • Hippocampal Atrophy: Studies have shown that long-term cannabis users exhibit hippocampal atrophy, a condition associated with memory loss and a known risk factor for dementia. The hippocampus is vital for learning and memory, and its deterioration can increase the likelihood of developing Alzheimer’s disease.

 

  • Increased Risk of Dementia

  • Potential for Increased Dementia Risk: Some research suggests that chronic marijuana use may contribute to an increased risk of developing dementia, particularly Alzheimer’s disease. Long-term users may have lower blood flow to the brain, affecting cognitive functions and potentially leading to neurodegenerative diseases.

  • Cognitive Decline in Midlife: A longitudinal study found that individuals who used cannabis from adolescence into midlife experienced a decline in IQ and cognitive performance, raising concerns about their long-term cognitive health and risk for dementia.

  • Interaction with Other Substances

Poly-Substance Use: Many long-term cannabis users also consume other substances, such as alcohol and tobacco, making it difficult to isolate the specific effects of marijuana on cognitive function and dementia risk. This complicates the understanding of marijuana’s role in cognitive decline and dementia development.

 

  • Side Effects and Drug Interactions

  • Potential Side Effects: Marijuana use can lead to various side effects, including dizziness, confusion, and impaired motor skills, which can be particularly concerning for older adults and those already experiencing cognitive decline.

  • Medication Interactions: Cannabis may interact with other medications commonly prescribed to dementia patients, potentially leading to adverse effects or reduced efficacy of treatments.

 

Considerations for Healthcare Professionals

Healthcare professionals play a crucial role in guiding patients and their families when it comes to the use of marijuana for dementia. While the research is promising, there are still many unanswered questions, and the potential risks must be carefully weighed against the potential benefits.

  • Healthcare professionals should stay informed about the latest research on marijuana and dementia and discuss the potential risks and benefits with patients and their families.

  • They should also consider the patient’s overall health, medication regimen, and individual circumstances when making recommendations about the use of marijuana for dementia.

  • Patients and their families should be advised to consult with a healthcare professional before using marijuana for dementia, as it may interact with certain medications and have side effects.

 

 Clinical Trials and Future Research

As the research on marijuana and dementia continues to evolve, clinical trials are essential for understanding the potential benefits and risks of using marijuana for dementia. Patients and their families can get involved in clinical trials to access potentially life-changing medications and contribute to the advancement of medical knowledge.

  • Healthcare professionals should encourage patients and their families to participate in clinical trials on marijuana and dementia.

  • Patients can learn more about clinical trials and how to get involved through organizations such as the Alzheimer’s Association and the National Institutes of Health.

 

Conclusion

The relationship between dementia and marijuana is complex and multifaceted. While some studies suggest potential benefits of marijuana in treating dementia symptoms and even preventing the progression of the disease, others raise concerns about its potential risks. Healthcare professionals must stay informed about the latest research and carefully weigh the potential risks and benefits when making recommendations about the use of marijuana for dementia. As the research continues to evolve, clinical trials will play a crucial role in advancing our understanding of this complex relationship and developing effective treatments for dementia patients.

 

SENIORS, WEED, AND DEMENTIA, READ ON…

SENIORS WITH DEMENTIA USING CANNABIS

CAN CANNABIS HELP SENIORS WHO SHOW SIGNS OF DEMENTIA?



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Webinar Replay: Post-Election Cannabis Wrap – Smoke ’em if You’ve Got ’em

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On Thursday, November 7th, Vince Sliwoski, Aaron Pelley and Fred Rocafort held a post election discussion “Post-Election Cannabis Wrap – Smoke ’em if You’ve Got ’em”. Watch the replay!

Key Takeaways from the “Smoke ’em if You’ve Got ’em – 2024 Post Election Cannabis Wrap” Webinar:

  1. Panelists:
    • Vince Sliwoski: Oregon Business lawyer specializing in cannabis and commercial real estate.
    • Aaron Pelley: Experienced in cannabis law since Washington’s legalization in 2012.
    • Fred Rocafort: Trademark attorney working closely with the cannabis team.
  2. Election Results Overview:
    • Most 2024 cannabis ballot measures did not pass.
    • Florida, South Dakota, and North Dakota saw failures.
    • Nebraska became the 39th state to legalize cannabis for medical use when it passed two cannabis initiatives, Initiatives 437 and 438.
  3. Federal and State-Level Developments:
    • Medical use is currently legal in 38 states, and 24 states allow recreational use.
    • Republican support for marijuana legalization is growing.
  4. Federal Policy Implications:
    • Schedule III Rescheduling: The process to move cannabis to Schedule III is ongoing, which could significantly impact the industry.
    • Importance of Federal Appointments: The future of cannabis policy depends heavily on who is appointed to key positions in the administration.
  5. International and Domestic Trade:
    • Schedule III status could ease import/export restrictions on cannabis.
    • Unified control of House, Senate, and presidency might expedite legislative progress.
  6. Economic and Industry Impact:
    • Cannabis stocks experienced volatility post-election, reflecting investor uncertainty.
    • Federal legalization and banking reforms are crucial for industry stability and growth.
  7. Future Outlook:
    • The potential for federal rescheduling remains strong, with hearings scheduled for early 2025.
    • State-level initiatives and regulatory developments will continue to shape the industry.

Watch the replay!



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I Had Just One Puff

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“How Long Does One Puff of Weed Stay in Your System?”… This topic can be difficult to answer since it is dependent on elements such as the size of the hit and what constitutes a “one hit.” If you take a large bong pull then cough, it might linger in your system for 5-7 days. A moderate dose from a joint can last 3-5 days, whereas a few hits from a vaporizer may last 1-3 days.

 

The length of time that marijuana stays in the body varies based on a number of factors, including metabolism, THC levels, frequency of use, and hydration.

 

Delta-9-tetrahydrocannabinol, or THC, is the primary psychoactive component of cannabis. THC and its metabolites, which remain in your body long after the effects have subsided, are detected by drug tests.

 

Since these metabolites are fat-soluble, they cling to bodily fat molecules. They could thus take a while to fully pass through your system, particularly if your body fat percentage is higher.

 

THC is absorbed by tissues and organs (including the brain, heart, and fat) and converted by the liver into chemicals such as 11-hydroxy-THC and carboxy-THC. Cannabis is eliminated in feces at a rate of around 65%, while urine accounts for 20%. The leftover amount might be kept within the body.

 

THC deposited in bodily tissues ultimately re-enters the circulation and is processed by the liver. For frequent users, THC accumulates in fatty tissues quicker than it can be removed, thus it may be detectable in drug tests for days or weeks following consumption.

 

The detection time varies according to the amount and frequency of cannabis usage. Higher dosages and regular usage result in longer detection times.

 

The type of drug test also affects detection windows. Blood and saliva tests typically detect cannabis metabolites for shorter periods, while urine and hair samples can reveal use for weeks or even months. In some cases, hair tests have detected cannabis use over 90 days after consumption.

 

Detection Windows for Various Cannabis Drug Tests

 

Urine Tests

Among all drug tests, urine testing is the most commonly used method for screening for drug use in an individual.

 

Detection times vary, but a 2017 review suggests the following windows for cannabis in urine after last use:

 

– Single-use (e.g., one joint): up to 3 days

– Moderate use (around 4 times a week): 5–7 days

– Chronic use (daily): 10–15 days

– Chronic heavy use (multiple times daily): over 30 days

 

Blood Tests

Blood tests generally detect recent cannabis use, typically within 2–12 hours after consumption. However, in cases of heavy use, cannabis has been detected up to 30 days later. Chronic heavy use can extend the detection period in the bloodstream.

 

Saliva Tests

THC can enter saliva through secondhand cannabis smoke, but THC metabolites are only present if you’ve personally smoked or ingested cannabis.

 

Saliva testing has a short detection window and can sometimes identify cannabis use on the same day. A 2020 review found that THC was detectable in the saliva of frequent users for up to 72 hours after use, and it may remain in saliva longer than in blood following recent use.

 

In areas where cannabis is illegal, saliva testing is often used for roadside screenings.

 

Hair Tests

Hair follicle tests can detect cannabis use for up to 90 days. After use, cannabinoids reach the hair follicles through small blood vessels and from sebum and sweat surrounding the hair.

 

Hair grows at approximately 0.5 inches per month, so a 1.5-inch segment of hair close to the scalp can reveal cannabis use over the past three months.

 

Factors Affecting THC and Metabolite Retention

 

The length of time THC and its metabolites stay in your system depends on various factors. Some, like body mass index (BMI) and metabolic rate, relate to individual body processing, not the drug itself.

 

Other factors are specific to cannabis use, including:

 

– Dosage: How much you consume

– Frequency: How often you use cannabis

– Method of consumption: Smoking, dabbing, edibles, or sublingual

– THC potency: Higher potency can extend detection time

 

Higher doses and more frequent use generally extend THC retention. Cannabis consumed orally may remain in the system slightly longer than smoked cannabis, and stronger cannabis strains, higher in THC, may also stay detectable for a longer period.

 

How Quickly Do the Effects of Cannabis Set In?

 

When smoking cannabis, effects appear almost immediately, while ingested cannabis may take 1–3 hours to peak.

 

The psychoactive component THC produces a “high” with common effects such as:

 

– Altered senses, including perception of time

– Mood changes

– Difficulty with thinking and problem-solving

– Impaired memory

 

Other short-term effects can include:

– Anxiety and confusion

– Decreased coordination

– Dry mouth and eyes

– Nausea or lightheadedness

– Trouble focusing

– Increased appetite

– Rapid heart rate

– Restlessness and sleepiness

 

In rare cases, high doses may lead to hallucinations, delusions, or acute psychosis.

 

Regular cannabis use may have additional mental and physical effects. While research is ongoing, cannabis use may increase the risk of:

 

– Cognitive issues like memory loss

– Cardiovascular problems including heart disease and stroke

– Respiratory illnesses such as bronchitis or lung infections

– Mood disorders like depression and anxiety

 

Cannabis use during pregnancy can negatively impact fetal growth and development.

 

Duration of Effects

Short-term effects generally taper off within 1–3 hours, but for chronic users, some long-term effects may last days, weeks, or even months. Certain effects may even be permanent.

 

Bottom Line

The amount of time that cannabis remains in your system following a single use varies greatly depending on individual characteristics such as body fat, metabolism, frequency of use, and mode of intake. Frequent users may maintain traces of THC for weeks, whereas infrequent users may test positive for as little as a few days. Hair tests can disclose usage for up to 90 days, while blood and saliva tests identify more recent use. Urine tests are the most popular and have varying detection durations. The duration that THC and its metabolites are detectable will ultimately depend on a number of factors, including dose, strength, and individual body chemistry.

 

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HOW LONG DOES WEED STAY IN YOUR URINE FOR A DRUG TEST?



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Is Kratom Addictive? Understanding Dependence, Risks, and Safe Usage

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Is kratom addictive? Discover the potential for dependence on Kratom, the risks involved with its use, and how to approach its consumption responsibly.

From 2011 to 2017, over 1,800 calls to poison centers involved kratom in the U.S. This significant number highlights the concern regarding kratom addiction.

However, without Food and Drug Administration (FDA) oversight, and due to various consumption methods like teas and capsules, there are significant health risks. Safe use of kratom is now in question due to these issues.

Research debates how dependence develops, outlining signs like loss of control and withdrawal symptoms. These signs are seen in regular kratom users. Ironically, some people switch from drugs like heroin to kratom, looking for a legal alternative.

Understanding Kratom: Origins and Prevalence

Kratom comes from the Mitragyna speciosa tree in Southeast Asia. It can act like a stimulant or like opioids, based on how much you take. People use it in different ways, for a small energy boost or stronger effects at higher doses.

The legal status of kratom in the U.S. is complicated and changing. It’s a hot topic because some worry about its misuse. It’s still legal in several states. This shows how different places handle drug rules. The National Institute on Drug Abuse is looking into its medical benefits. But, the FDA hasn’t approved it for medical use yet. The DEA calls it a “drug of concern,” which means policies might change.

  • From 2011 to 2017, poison control centers in the U.S. got over 1,800 reports about kratom. This shows it’s widely used and might pose health risks.

  • Kratom’s main ingredients bind to opioid receptors very strongly, stronger than morphine even. This fact is key to understanding its effects.

  • As more people use kratom, more are reporting serious health problems. These include liver and heart issues, and tough withdrawal symptoms, particularly in those already sick.

The statistics show mounting worries about kratom in the U.S. As its use grows, it’s becoming more important to health policies and laws. What happens next will depend on further research and legal decisions.

Is Kratom Addictive: Investigating the Substance’s Nature

The question of kratom’s addictiveness focuses on how it affects brain receptors and its long-term health implications. The ongoing debate highlights concerns about dependence and the risk of addiction. Scientists are closely looking at these issues.

How Kratom Works in the Brain

Kratom’s main alkaloids, mitragynine and 7-hydroxymitragynine, bind to the brain’s opioid receptors, similar to painkillers and narcotics. This connection suggests a potential risk of dependence. These alkaloids are key to kratom’s pain relief but also point to possible addiction concerns, especially with frequent, high-dose usage.

Patterns and Consequences of Long-term Use

  • Using kratom often, especially in large doses, can increase the risk of dependence and intense withdrawal symptoms, similar to opioid withdrawal.

  • Although some use it for pain or to improve mood, long-term kratom users might see serious health problems, like liver damage and mental health issues.

  • Withdrawal symptoms, including irritability, nausea, and sleep problems, show kratom’s impact on one’s physical and mental health.

Assessment of Addiction Risks

Studies indicate a significant risk of addiction to kratom, especially with high doses or frequent use. Dependence develops as the body gets used to kratom, leading to tolerance and a need for more to feel its effects. Withdrawal symptoms emphasize this risk, as highlighted by health experts.

Physiological Effects: Kratom’s Impact on the Body

There is a lot of debate about the safety and use of kratom. This herbal extract comes from the Mitragyna speciosa plant. It has drawn attention for its possible harmful effects on the body. The FDA has issued many warnings about kratom, raising safety concerns.

  • Kratom Adverse Effects: Kratom users have reported side effects like nausea, vomiting, and confusion. More serious issues include high blood pressure and liver damage. These problems highlight the risks of using kratom.

  • Herbal Extract Safety: Some kratom products contain heavy metals and pathogens. These can cause severe health issues, including death. This shows the importance of safety in herbal products.

  • FDA Warnings and Regulations: The FDA has linked kratom to over 35 deaths and warns against using it. They point out the lack of medical uses and the risk of addiction.

  • Physiological Impact: Kratom’s effects depend on the dose and the user’s body. Yet, it can lead to dangerous outcomes like liver damage and seizures.

  • Safety Concerns from Authorities: Federal agencies like the DEA are worried about kratom’s safety. Although not a controlled substance, monitoring suggests users should be careful.

Kratom might offer temporary relief for some ailments, but it comes with significant risks. The FDA’s warnings should make people think twice. If considering kratom, it’s crucial to talk to a doctor first. Experts stress the need for safety and caution with herbal extracts.

Conclusion

Kratom’s role in health and regulation is complex, with views and research findings widely varied. Some people use kratom for its claimed health benefits, but it’s a hot topic. Experts advise caution and suggest consulting a doctor before using kratom due to the unclear effects.

Clinical studies using scores like SOWS and COWS haven’t confirmed withdrawal symptoms from kratom. This adds to the debate, especially when some users report withdrawal. This makes kratom a controversial subject among different findings and user experiences.

When it comes to treating opioid addiction, kratom can be both helpful and harmful. Some have used it successfully to fight addiction. Yet, some states have banned it. This highlights the need for regulations and consistent product quality. It also raises questions about kratom’s legal status due to mixed actions by authorities.

The situation shows how complex kratom is in the realm of substance use and law. Without clear evidence supporting either its benefits or risks, it poses a challenge. More research is needed to guide regulations and health advice. For now, anyone thinking of using kratom should be careful, seek medical advice, and keep up with laws and health guidelines.

 

WHAT IS KRATOM ANYWAY? READ ON…

WHAT IS KRATOM

WHAT IS KRATOM AND WHY ARE YOU HEARING ABOUT IT NOW?



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