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CBD Amplifies The Adverse Effects Of THC, New Study Finds

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A new study has unearthed a controversy on the interaction between the psychoactive cannabinoid THC and its mellow counterpart CBD. For the longest time, it’s been believed that combining CBD with THC enhances the therapeutic benefits of both while limiting some of the adverse effects attached to THC.

The exact mechanisms have been hypothesized with the message being loud and clear: CBD is THC’s perfect complement and antidote. But results from this new study found that this is not entirely the case.

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Details of the study

A group of researchers from the Behavioral Pharmacology Research Unit at Johns Hopkins University conducted a randomized clinical trial to investigate the effects and side effects of cannabis edibles containing both THC and CBD in equal amounts.

The study model was a double blind crossover that included 18 healthy adults. This involved three randomized outpatient test sessions; each session one week apart. The participants were divided into three groups and offered brownies containing either of the three:

  • No cannabis extract (placebo)
  • 20 mg Δ9-THC with no CBD
  • 20 mg Δ9-THC + 640 mg CBD

The group that received CBD in addition to THC experienced more severe adverse effects compared to the THC only group. Researchers found that CBD inhibits the breakdown (metabolism) of THC, thus increasing its adverse effects by increasing circulating levels and active metabolite.

Contradictory Evidence: Is There an Ideal Way to Mix CBD With THC?

There are a number of studies that contradict the major claim in this article, that CBD worsens the adverse effects of THC. Let’s look at a few:

A 2019 study was conducted by the Western University to investigate how CBD affects the psychiatric side effects of THC. The rats offered THC were more anxious and fearful while the rats that were offered both CBD and THC were less anxious and fearful.

RELATED: Does CBD Minimize The Harmful Effects Of THC? New Study Has Answer

The researchers found that CBD attenuates some of the psychotropic side effects caused by THC by inhibiting THC’s ability “to overstimulate the ERK pathway.” The results of the study were published in the Journal of Neuroscience.

A different systematic review investigated the influence of CBD on the acute effects of THC. The researchers found that in most studies CBD reduced the adverse effects of THC. However,  these studies have used different ratios of THC to CBD.

RELATED: If THC Percentage Doesn’t Matter, Why Not Just Smoke CBD?

With the medical cannabis industry taking shape, it’s imperative to speed up research so as to find the best ways to offer cannabinoids to patients.

This article originally appeared on MyCannabis.com and has been reposted with permission.



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How Cannabis Can Help You During Lent

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Even a planned sacrifice can use a little help, here is how marijuana can help you during Lent

Today is Ash Wednesday and the start of Lent. This time is observed in many Christian traditions, including Catholic, Lutheran, Moravian, Anglican, United Protestant, and Orthodox. It is usually a 40-day period, which echoes the time Jesus spent fasting in the desert. The time is thought to symbolize testing, trial, and renewal. In addition to donating time, talent and treasure along with self reflection, the true believer believes you should give us something you love. For some it is wine or alcohol, for others it could be more.Here is how cannabis can help you during Lent.

RELAETD: Is GERD Helped By Cannabis

Cannabis use during Lent, a traditional Christian period of fasting and spiritual reflection, is a complex and controversial topic requiring careful consideration. While some may view cannabis as incompatible with Lenten practices, others argue it can potentially aid in spiritual growth and personal reflection when used mindfully. Done correctly, it can help you reach your goals.

Studies suggest cannabis can be used as a replacement for alcohol and can improve overall health. It offers a range of benefits for those seeking to reduce or eliminate their alcohol consumption. CBD and THC drops are becoming popular substitutes, providing natural relaxation without the negative side effects associated with drinking. Unlike alcohol, which can lead to dehydration, impaired judgment, and potential long-term health risks, cannabis promotes relaxation and improved sleep quality without causing hangovers.

Studies suggest cannabis may help individuals maintain alcohol abstinence, with some patients reporting it as an effective substitute. The trend of replacing alcohol with cannabis is growing, with daily cannabis use surpassing daily alcohol use in the United States for the first time. Cannabis-infused beverages are also on the rise, offering a diverse range of options for those looking to socialize without alcohol.

In addition, many adherents of Lent are older, and a key benefit of cannabis is relief. For those dealing with chronic pain or anxiety, cannabis may offer relief without breaking Lenten commitments to abstain from other substances. Medical marijuana users have reported significant improvements in quality of life, pain levels, and overall functioning. This could allow individuals to focus more deeply on their spiritual practices without being hindered by physical discomfort.

Part of the  sacrifice is to reflect on the spiritual journey. Cannabis can promote introspection and heightened awareness, which aligns with Lenten goals of self-examination and spiritual growth. However, it’s crucial to approach this mindfully and avoid using cannabis as an escape or distraction from the purpose of Lent.



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Can CBD Provide Some Foot Pain Relief

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It hobbles millions – but CBD could be step in the right direction for foot pain.

Roughly 75% of people suffer some type of foot pain at some point. But can CBD provide some foot pain relief? Foot pain can be debilitating, affecting daily activities and overall quality of life. Conditions like gout, plantar fasciitis, neuroma, neuropathy, and metatarsalgia are common causes of foot discomfort. While traditional treatments often come with side effects, CBD oil has emerged as a promising alternative for managing foot pain. Here’s why CBD is gaining attention for its potential benefits in alleviating foot-related issues.

RELAETD: Is GERD Helped By Cannabis

CBD, or cannabidiol, is a non-psychoactive compound found in cannabis plants. Unlike THC, CBD does not produce intoxicating effects, making it a safe option for those seeking pain relief without altering their mental state. CBD interacts with the body’s endocannabinoid system (ECS), which plays a crucial role in regulating pain, inflammation, and mood.
Photo by 2H Media via Unsplash

CBD has been shown to reduce inflammation, a key factor in many foot pain conditions. By minimizing swelling and redness, CBD can help alleviate discomfort associated with conditions like gout and plantar fasciitis.

CBD’s ability to modulate pain perception makes it effective for managing chronic pain. It can increase levels of anandamide, a compound associated with pain regulation, potentially reducing pain perception.

For conditions like neuropathy, where nerve damage leads to pain, CBD’s neuroprotective qualities can help mitigate symptoms. It may reduce neuropathic pain by interacting with receptors in the nervous system.

CBD products come in various forms, including topical creams, gels, and oils, which can be applied directly to the affected area. This localized application avoids systemic side effects and ensures targeted relief.

While more research is needed to fully understand CBD’s effects on chronic pain, existing studies suggest it is generally safe and well-tolerated. Common side effects are mild and include fatigue, decreased appetite, and dry mouth. The FDA has not approved CBD for pain management, but it is approved for certain epilepsy conditions, indicating its potential therapeutic benefits. As research continues to uncover the full potential of CBD, it may become a valuable tool in the arsenal against foot pain, providing comfort and improving quality of life for many.



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5 Ideas To Have A Fun Single’s Valentine’s Day

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Valentine’s Day is considered a big night for couples – but if you are single, it can be tough…here are some ways to make it fun

It is day of love, candy, silliness and more….but for some, it is a tough day emotionally. It is one of the busiest restaurant days and flowers and candy abound everywhere you look. But what if you are single or taking a break for the big night.  Just because you are single, doesn’t mean you have to hide, rather it gives the chance to do something special for yourself.  Here are 5 ideas on having a fun single’s Valentine’s Day.

RELATED: Science Says Medical Marijuana Improves Quality Of Life

Gather your closest and/or your most fun friends and celebrate with a Guy/Galentine’s Day party. This can be a fun way to spend time with people you love and appreciate. You can play games, share snacks, and enjoy each other’s company without the pressure of romantic expectations. It’s a great way to remind yourself that you’re never truly alone on Valentine’s Day.

Treat yourself to a day of pampering. Book a spa appointment or create your own DIY spa day at home with face masks, bubble baths, and your favorite music. Self-care is essential for mental and physical well-being, and Valentine’s Day is the perfect excuse to prioritize it. Whether it’s a relaxing bath or a rejuvenating facial, make sure you feel loved and cared for by yourself.

Chill out with cannabis and let your body relax.  Watch a movie or lose yourself in music. marijuana taps into our minds in all sorts of ways, many of which seem to positively influence how we perceive things, including music. It also accesses a special neurotransmitter system, the endocannabinoid system, which regulates appetite, pain, mood and memory. The way the plant activates this system explains a lot of the unique effects. The THC in marijuana can increase dopamine release in the brain’s reward centers, leading to feelings of pleasure and euphoria.

Indulge in hobbies or interests. It can a be a chance to spend time iwth a new or existing activity you love, but might night share with others. Whether it’s gaming, cooking, or learning a new language, stepping out of your comfort zone can be incredibly rewarding. You might discover a new passion or talent, and it’s a great way to keep your day exciting and productive

Sometimes, the best way to celebrate Valentine’s Day is by taking a solo trip or exploring new places in your city. Whether it’s hiking a scenic trail, visiting a local museum, or trying a new restaurant, getting out and experiencing new things can be incredibly liberating. It’s a chance to focus on yourself and enjoy and discover new things.



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