People with restless leg syndrome (RLS) may find “significant” long-term relief with cannabis treatment, according to a new study.

While dopamine agonists have traditionally been the “first-line treatment” for RLS, recent studies indicate that gabapentinoids are now being recommended, the researchers said. Because cannabinoids, like gabapentinoids, inhibit a certain type of amino acid associated with the disorder, scientists decided to test their therapeutic effectiveness.

The open-label exploratory study, conducted by European researchers at the University of Madrid and published in the Journal of Neurology, found that a cannabis product containing 2.7 mg of THC and 2.5 mg of CBD was “effective in reducing RLS severity” among patients with multiple sclerosis and “associated idiopathic RLS.”

“Improvements were observed after 1 to 3 months of treatment and were maintained after 1 year among patients who continued therapy,” the study of 18 patients with RLS showed. For those who remained in treatment after a year, 67 percent “continued to show sustained improvement.”

The the findings it may not be surprising that cannabis in particular is known to reduce the severity of muscle spasms and related conditions, but its effectiveness for RLS is remarkable given that no state specifically lists it as a condition for medical cannabis.

Of course, RLS can be a symptom of other general disorders like multiple sclerosis, and some states give doctors more latitude to make recommendations for medical marijuana for any condition they see fit.

In any case, research outside of Spain could be based on research into alternative treatment options that could replace dopamine agonists in the treatment of restless legs syndrome.

Officials in Massachusetts have formally certified an An initiative to roll back that state’s marijuana legalization law will appear on the November ballot.

The Commonwealth Secretariat’s Division of Elections notified organizers on Thursday that they had delivered enough valid signatures in the second round of petitions to put the measure before the voters—but just barely.

Under state law, Massachusetts ballot campaigns must submit signatures in two rounds. After the first presentation, the legislature has the opportunity to propose ballot measures after the organizers have presented the initial round of requests. Legislators in May he refused to act on the anti-marijuana measurehowever, and therefore the organizers had to present 12,429 more certified signatures by July 1 for the November vote.

“I am pleased to inform you that this Office has accepted 12,551 certified signatures received on or before July 1, 2026,” Michelle K. Tassinar of the Division of Elections wrote in a letter to one of the initial signatories. “The remaining signatures were voided for not being certified, inconsistent with the interpretation of (state law) or exceeding the number allowed for each county.”

“Therefore, the petition for the initiative will be printed on the November 3, 2026 state election ballot as required by the Constitution,” he said.

Meanwhile, a coalition of Massachusetts marijuana entrepreneurs, health care professionals and other advocates has launched a campaign to defeat the measure, which if enacted, would repeal laws that allow for the regulated commercial sale of recreational cannabis and home cultivation, while maintaining legal ownership and continuing the medical marijuana system.

In June, the campaign behind the legalization measure, the Coalition for a Healthy Massachusetts, released a signature-gatherer that it says showed “totally unacceptable” behavior in a recent video.

As Marihuana Moment reported, a The man was petitioning for the Massachusetts initiative, as well as a similar anti-cannabis proposal in Maine Recent social media posts suggested that voters who support legal access to marijuana should sign petitions to advance or support the reform.

The campaign later said it has “zero tolerance” for circulation tactics that would mislead petition signers.

“The identified canvasser was terminated immediately, in coordination with our vendor, upon learning of the alleged conduct,” the team said. “The behavior shown in the video would be completely unacceptable and does not reflect how this campaign works. We demand honesty, transparency and professionalism from everyone associated with our efforts.”

A video posted on Reddit shows the petitioner collecting signatures outside a Massachusetts retail store next to a sign that says “keep cannabis legal.”

When the petitioner confronted a marijuana reform supporter who recorded interactions with voters, it appears he was trying to convince them that getting the anti-cannabis measure on the ballot is important to defeating it later.

“This is what we’re fighting here. That’s why we’re voting no,” he said. “If we can bring this to a vote right here, we will vote no.”

The person who received the video noted that Massachusetts voters already approved the legalization of marijuana years ago, and the only way to immediately reverse it would be if the new ballot measure qualified for the November election. If the initiative doesn’t get enough signatures to go before the voters, state laws will remain the same.

“It’s my job,” insisted the applicant, however. “I know what I’m talking about.”

“It’s a group of wealthy out-of-state people who basically want to take marijuana back to the time when medical marijuana was the ticket,” he said. “We don’t want that to happen.”

The same man also appeared to be collecting extraordinary signatures A Maine measure that would repeal laws allowing the regulated sale of marijuana to adults and home cultivation rights for adults while maintaining legal ownership and adding new testing requirements for medical cannabis.

An employee of the prohibitionist organization Smart Approaches to Marijuana (SAM), of which the group is a member. SAM Action is largely funding anti-cannabis vote campaigns in both states, declined to comment on the petitioner’s conduct when reached by Marihuana Moment.

Campaigns have been accused of deceptive solicitation tactics before.

In Massachusetts, some voters reported the campaign used fake letters for other ballot measures on unrelated issues such as affordable housing and same-day voter registration. Supporters of legal cannabis filed a formal complaint about the tactics of the prohibitionist effortbut The State Voting Law Commission rejected the rebuttal.

The The measure faced a legal challenge from cannabis industry players he argued that it contains “irrelevant issues” and that the state attorney general’s official brief is “misleading and deficient.” State Supreme Court heard oral arguments on the case challenging the anti-marijuana initiative but after all he decided against the challenge.

Read state officials the letter Regarding the certification of the anti-marijuana ballot initiative: