Cannabis News
Can Taking CBD While Pregnant Cause Glucose Intolerance in Male Offspring But Not Female Children?
Published
10 months agoon
By
admin
A recent preclinical investigation reported in the Journal of Endocrinology has unveiled that prenatal exposure to cannabidiol (CBD) induces glucose intolerance in 3-month-old Wistar rats. Additionally, a Canadian research group observed changes in hepatic development and metabolic processes.
The authors stated, “CBD can traverse the placenta and enter fetal circulation, potentially affecting the development of crucial metabolic organs.” They hypothesized that maternal exposure to CBD during rat pregnancy would result in deficiencies in both pancreatic β-cell mass and glucose regulation in the offspring.
The pregnant Wistar rats were given intraperitoneal injections of 3 mg/kg CBD or a vehicle by the research team during the trial, which lasted from gestational day 6 until delivery. Male offspring exposed to CBD showed glucose intolerance but maintained normal pancreatic β/α-cell mass; nevertheless, there were no significant changes in maternal food consumption, weight gain, or neonatal outcomes.
A transcriptomic analysis was conducted on the livers of male rats exposed to CBD, revealing altered gene expression related to circadian clock machinery. Additionally, reductions in the expression of genes involved in hepatic development and metabolic processes were observed.
Remarkably, at three months of age, only male offspring exposed to CBD showed signs of glucose intolerance. The authors speculate that estrogen-mediated mechanisms may have prevented female rats from acquiring glucose intolerance, given estrogen’s established protective effect against metabolic dysfunction. To validate this theory, more research is necessary.
Previous research has linked alterations in the liver’s circadian rhythm to glucose intolerance. As a result, the scientists speculate that exposure to CBD during pregnancy and the resulting alterations in circadian gene expression may be connected to the abnormalities in glucose intolerance seen in male rats.
Although CBD has become more and more popular, especially in the last few years, the authors advise pregnant women to take it with caution since it may have negative consequences on the offspring’s metabolic health.
Gender-Specific Effects of Prenatal CBD Exposure
Intriguingly, the study’s findings underscore a notable discrepancy in the metabolic responses between male and female offspring following prenatal CBD exposure. While male rats exhibited glucose intolerance, their female counterparts appeared unaffected. This gender-specific variation prompts a deeper exploration into the underlying mechanisms driving such disparities.
Recent research suggests that estrogen, a hormone predominant in female physiology, may play a pivotal role in buffering against metabolic dysfunction. The authors speculate that estrogen-mediated processes might confer protection against glucose intolerance in female rats exposed to CBD during gestation. However, elucidating the precise molecular pathways involved warrants further investigation.
Understanding the differential susceptibility to CBD-induced metabolic alterations based on gender holds significant implications for both research and clinical practice. Unraveling the interplay between CBD exposure, hormonal dynamics, and metabolic outcomes could pave the way for tailored therapeutic strategies and inform guidelines regarding cannabinoid use during pregnancy.
Altered Gene Expression and Circadian Rhythm Disruption
The transcriptome investigation of liver tissue from male rats exposed to prenatal CBD reveals fascinating changes in gene expression patterns, notably those related to circadian clock mechanisms and hepatic development. These molecular alterations shed light on the mechanisms behind CBD-induced metabolic abnormalities.
Circadian rhythms serve an important part in the body’s metabolic activities, including glucose homeostasis. The observed disruption in circadian gene expression reveals a possible mechanism connecting prenatal CBD exposure to glucose intolerance. Disruptions in the liver’s circadian rhythm have already been linked to metabolic diseases, emphasizing the importance of these results.
Furthermore, worries regarding the long-term effects of prenatal CBD exposure on liver function and metabolic health are raised by the decreases in gene expression linked to hepatic development. Gaining knowledge of how CBD disrupts the molecular processes that control hepatic growth may help to lessen its negative effects.
This study discovers potential therapeutic targets for intervention in addition to clarifying the intricate molecular processes behind CBD’s impacts on metabolic health. It will be necessary to develop targeted therapeutics in the future that elucidate the causal relationships between altered gene expression, circadian rhythm disruption, and metabolic dysfunction to lessen the adverse effects of prenatal CBD exposure.
Implications for Maternal Health and Public Policy
The increasing evidence of the negative consequences of prenatal CBD exposure on metabolic health in children has important implications for maternal well-being and public policy addressing marijuana usage while pregnant.
Given the growing popularity of CBD products and their perceived advantages, particularly in the treatment of various health concerns such as anxiety and pain, pregnant women may be more likely to use them. However, the outcomes of this study highlight the significance of exercising caution and making educated decisions about CBD usage while pregnant.
In light of the observed gender-specific effects and potential long-term consequences on metabolic health, there is a pressing need for comprehensive public health policies addressing the use of cannabinoids, including CBD, by pregnant individuals. These policies should aim to educate healthcare providers and expectant mothers about the potential risks associated with prenatal CBD exposure and emphasize the importance of seeking professional medical advice before using such products during pregnancy.
This study also emphasizes the necessity for future research to fully evaluate the safety of cannabis usage during pregnancy and to clarify the mechanisms underlying CBD’s impacts on metabolic health. These kinds of research are going to be crucial in helping to shape evidence-based policies and guidelines that protect the health of expectant mothers and fetuses.
Ultimately, we can better protect the health of expectant mothers and their children while ensuring that access to potentially helpful therapies remains balanced with the need to mitigate potential risks by incorporating the results of preclinical research into public health initiatives and policy development.
Bottom Line
The preclinical research highlights the possible negative consequences of cannabidiol (CBD) exposure during pregnancy on the metabolic well-being of male progeny, including glucose intolerance, disturbances in hepatic development, and irregularities in circadian gene expression. The results of the study not only warn against the use of CBD during pregnancy but also emphasize the necessity of comprehensive public health policies that inform medical professionals and pregnant women about the dangers of cannabis exposure. To protect the health of mothers and fetuses, further study is necessary to understand gender-specific reactions, investigate hormonal dynamics, and develop evidence-based recommendations. Incorporating these discoveries into public health campaigns and policy formulation will facilitate well-informed decision-making, minimize possible hazards, and guarantee the availability of advantageous treatments.
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How Worried Should You Be about Schizophrenia and Psychosis if You Smoke Weed?
Published
2 days agoon
March 15, 2025By
admin
Should You Really Be Worried About Schizophrenia and Psychosis If You Smoke Weed?
Occasionally, a study on cannabis and schizophrenia or psychosis makes its way to the internet and becomes viral for a few weeks. It gets republished and circulated across numerous news channels and social media sites, spreading often unnecessarily alarming news and fear-mongering.
So what’s the truth behind it? Should you really worry about developing schizophrenia and psychosis if you smoke weed?
Let’s get the facts sorted first.
Schizophrenia
Schizophrenia is a chronic mental health disorder characterized by hallucinations, delusions, cognitive distortion, trouble thinking straight, and lack of motivation. Extreme cases of schizophrenia can also lead to episodes of psychosis or delusion, which is what occurs when an individual can no longer tell the difference between reality and fiction. Being severely disconnected from reality can occur among patients of schizophrenia and psychosis, but these can be caused by a wide range of physical or mental conditions.
What Causes Schizophrenia?
There is no one known cause for schizophrenia, though several environmental and genetic factors can contribute to its symptoms. It’s also known to run in families, so if someone in your family tree has had schizophrenia, it’s important to practice caution when using drugs and alcohol.
Certain environmental triggers can cause psychotic or schizophrenic episodes, particularly going through extremely stressful life events. Stressful environments, such as fast-paced cities, may also trigger symptoms. Other factors include the experience of childhood trauma, or certain changes in brain chemistry.
Cannabis: Treatment Or Cause?
The symptoms of schizophrenia can be managed or reduced through the use of antipsychotic medications, which are typically the first line of defense for this condition. First-generation antipsychotics, such as Chlorpromazine, Perphenazine, and Fluphenazine, are examples of widely-used schizophrenia treatments. Second-generation antipsychotic treatments include Aripiprazole, Lurasidone, Clozapine, Quetiapine, and several others. In some occasions, doctors may also prescribe antidepressants if antipsychotic drugs don’t help with the depressive episodes that may be associated with schizophrenia.
However, many antipsychotic medications come with unwanted side effects. They commonly include sexual dysfunction, weight gain, sedation, heart problems, difficulty urinating, and many more.
The use of cannabis-based medications for treating the symptoms of schizophrenia has been gaining traction in the medical and scientific community over the past few years. That said, we must differentiate the compounds used in cannabis because we can’t generalize all the compounds in the plant and its effects on the human body. Tetrahydrocannabinol (THC), the psychoactive compound in marijuana, and cannabidiol (CBD), a relaxing, non-psychoactive compound, both work differently in the human body.
What The Research Says
Several studies have shown that CBD could be promising for treating and even mitigating the symptoms of schizophrenia and psychosis. This is especially true if the condition is in its early stages.
For example, in a review conducted in 2021, scientists found that CBD may be beneficial in adjusting the levels of different brain chemicals which have been associated with symptoms of psychosis. One of these is anandamide – and the study found that CBD can increase its levels in the brain.
Anandamide is an endocannabinoid, and it’s believed to help reduce psychotic episodes through several mechanisms in the brain. For one, high levels of anandamide have been observed as successful in mitigating acute cases of schizophrenia.
Meanwhile, another review discovered minor albeit significant evidence that CBD could possibly reduce the symptoms of schizophrenia when administered in high doses. In the review, the researchers noted that 800 mg of CBD were given to patients over the course of 4 weeks. The results were similar to those yielded by amisulpride, an antipsychotic drug which is used in the treatment of psychosis. A similar trial found that 1,000 mg of CBD given to patients over 6 weeks was effective in reducing schizophrenia symptoms.
The results of a 2024 clinical trial also found that CBD was successful in mitigating the symptoms of patients who were at high risk for psychosis. For the study, there were 31 patients involved; they were given either 600 mg of CBD or a placebo everyday for 3 weeks. However, they weren’t given any prescription drugs during the course of the study. Researchers analyzed their baseline at 7 and then again at 21 days.
“Short-term treatment with CBD can ameliorate the symptoms of CHR state for psychosis and is well tolerated. These results highlight the potential of CBD as a novel treatment for psychosis, and the need for large-scale efficacy studies to further evaluate its clinical utility,” concluded the study’s authors.
So Who Needs To Worry About Schizophrenia and Cannabis Use?
Smoking pot won’t make you go psychotic. It doesn’t cause schizophrenia per se.
That said, those with pre-existing mental health conditions must tread lightly and be very cautious when it comes to using high THC products. In other words, if you already have a family history of schizophrenia or have had a history of psychotic episodes, THC may not be the medicine or recreational drug for you. Individuals with bipolar disorder, delusional disorder, or other similar personality and mood disorders with a tendency to have episodes of psychosis should first seek out medical attention.
Products containing high levels of THC may not be recommended in these situations, though CBD may help reduce symptoms. If you aren’t sure, it’s always best to consult with your medical provider.
Conclusion
Even if there is promising evidence that CBD can be beneficial for schizophrenia, we must be careful not to consider it as a substitute for any kind of medical treatment. There are many different types of cannabis products out there but there isn’t one-size-fits-all solution for mental health disorders. So while most people wouldn’t have a problem smoking weed, there is a small subset of the population as mentioned earlier – who do have to be careful.
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Cannabis News
What are Cannabis Dissolvables? Are These Products Trendy, or are They Worth Trying?
Published
3 days agoon
March 15, 2025By
admin
What are Cannabis Dissolvables? Are These Products Trendy, or are They Worth Trying?
For cannabis enthusiasts who enjoy experimenting with consumption in an array of forms, or even for medical marijuana patients who simply want to look for the most convenient way to medicate, we’re spoiled with choices these days.
From vaping to smoking, edibles and beverages, tinctures, topicals, pills, and suppositories, there’s a way to medicate for everyone. But recently, a new way to consume marijuana has had some people talking: cannabis dissolvables! You might have heard about them as dissolvable cannabis powder or THC powder; these revolutionary powders are manufactured with cannabinoids and designed to be mixed into your food or drink. Upon consumption, you can enjoy the effects of cannabis within minutes.
But they work just like edibles, then, don’t they?
Nope!
Dissolvable cannabis powders are known for their fast-acting effects, which means that you can expect to feel the impact of the cannabinoids within minutes of consuming it in your food and drink. That’s because cannabis powders are water-soluble, allowing almost immediate absorption of the cannabinoids in your bloodstream. On the other hand, edibles can sometimes take up to 90 minute to take effect.
Why You Should Try Dissolvable Cannabis Powders
There are several reasons why you should give dissolvables a try:
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There are odorless and flavorless options in the market: Marijuana dissolvable powders that are neutrally flavored make it a breeze to add to your favorite drinks and food, without worrying about altering its flavor. Gone are the days when you’d be surprised by the often-undesirable flavors of supplement powders; now with flavorless cannabis powders, you can easily medicate while still enjoying the taste of your favorite food and drinks.
Smoothies, baked goods, juices, coffee, and oatmeal are just some examples of common items you can easily add THC powders to. That said, you can also find flavored options in the market if that’s what you prefer.
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High bioavailability: Cannabis powders are formulated to be absorbed efficiently. This way, your body can metabolize and absorb all or most of the cannabinoids in the product. Thanks to enhanced absorption, you can maximize the benefits of the cannabinoids.
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Accurate dosing: For consumers who prioritize precision dosing in cannabis, powders are superior when it comes to this. Getting an accurate dose is so easy, since packets are already pre-measured. Meanwhile, powders can also easily be measured using a spoon. This offers total control over how much you’re ingesting, which is particularly important for medical users who require consistent dosing for symptom relief.
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Discretion: When you add cannabis powders to your food or beverages, they don’t have that notorious smell that cannabis smoke is known for. Because they are either odorless or have a neutral odor, there’s no need to worry that taking it out and mixing it into a drink will alert people around you.
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Low or no calories: Most cannabis powders have little to no calories, so it’s a healthy choice for calorie-conscious individuals. Whether you are looking to make a healthier choice or simply want to experiment with cannabis formulations in the kitchen, dissolvable cannabis powders are an easy way to do so.
What Conditions Can Cannabis Powders Help With?
While dissolvable cannabis can benefit all patients, cannabis powders have a particular advantage for patients of certain conditions:
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Nausea and vomiting: Patients who are undergoing chemotherapy, or recovering from eating disorders, may find that medicating with cannabis simply through food and drink is an efficient way to medicate. These conditions make it difficult to keep nutrients down due to the constant urge to vomit, but that makes it even more important to eat – in order to have the necessary vitamins and minerals to recover. Mixing cannabis powders in water or juices provides a gentle alternative to medicating and keeping food down.
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Pain: Fast-acting cannabis works so well for pain relief. If you suffer from chronic pain and rely on cannabis for symptom relief, you can explore using cannabis powders. Thanks to its excellent bioavailability and quick results, there’s no need to wait several minutes to feel better. Powder can interact with the endocannabinoid system fast in order to reduce inflammation within minutes and positively affect the pain perception pathways.
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Insomnia and sleep problems: Cannabis is an excellent natural medication for treating insomnia and other sleep problems. This is especially true if symptoms from another condition can cause difficulty falling or staying asleep, such as pain or general discomfort caused by inflammatory conditions. Consuming cannabis powders a few minutes before bedtime can help you hit two birds with one stone: enjoy relief from your symptoms, while easing into a comfortable state of sleep.
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Anxiety relief: Many cannabis drink mixes are made with CBD, which provides excellent relief from anxiety. Start your day with a healthy dose of CBD to mitigate anxiety, and help you get through the day with some peace of mind.
In addition, many powder mixes are also formulated with other healthy ingredients. These vary from one product to another, and may include electrolytes, functional ingredients, hemp, terpenes, and other cannabinoids.
Conclusion
Dissolvable cannabis powders are innovative, but they are also accessible and inclusive, offering a convenient way to medicate. Whether you are a recreational cannabis consumer or a medical marijuana patient, the benefits of cannabis dissolvable powders are endless. Check out your neighborhood dispensary to explore dissolvable cannabis and share with us your favorite way to consume it.
CAN YOU HAVE A DISSOLVABLE WEED PRODUCT? READ ON…
Cannabis News
If You are over 50, Should You Switch from Alcohol to Cannabis ASAP?
Published
3 days agoon
March 15, 2025By
admin
If You’re Over 50, You Should Consider Switching From Alcohol To Weed
Alcohol is one of the most dangerous substances on earth. Despite being notorious for its carcinogenic properties, alcohol has become part of society and culture, accepted in nearly every western nation as a means of relaxing or having fun.
While there were several decades wherein alcohol enjoyed a spotless reputation, more people are now becoming educated about the dangers of drinking even a few glasses a week. Yet, it can be so difficult to quit drinking completely because booze is literally everywhere: it’s easily accessible in shops, groceries, and bars all over. Society has normalized drinking alcohol as a way to unwind and bond with loved ones.
That said, the dangers of drinking alcohol begin to creep up as you get older. Even a few drinks can pose serious health risks, so if you’re approaching 50 and still drinking, it’s time for you to reconsider the substances you use to unwind.
Here’s why:
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As you get older, your body becomes increasingly sensitive to the impact of alcohol. It’s more serious than hangovers getting worse: once you hit your 30’s, muscle mass gradually declines each decade, and it speeds up after you hit your 60’s. The reduction in your body mass and body water causes higher blood alcohol concentrations in your system, in other words, you’ll get drunk faster, even if you’ve always drank the same amount.
The consequences for this mean a greater risk of injury and falls.
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Medical conditions can get worse. By the time you hit your forties, if you have had any health issues in the past, they may only get worse with continued alcohol consumption. Whether it’s high blood pressure, diabetes, or any other condition that can get worse with age, it will similarly worsen with alcohol consumption. To add salt to injury, continually drinking alcohol when you already have certain health problems can cause new complications, such as cognitive disorders, osteoporosis, and a significantly increased risk of cancer.
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Drinking alcohol speeds up the aging process. Research shows that drinking alcohol over long periods of time has a negative impact on your biological age, most especially if you still engage in binge-drinking. Additionally, continued alcohol consumption will harm your heart, liver, and brain – putting these organs in greater risk of disease.
It may be time to give up drinking, but that doesn’t mean that the fun has to end. Just switch it up with cannabis.
Why You Should Be Consuming Weed Instead
Switching up your substance of choice from alcohol to cannabis can have profound effects on your health, particularly as you age. There are so many different ways you can consume weed discreetly; while smoking pot is not for everyone, you can experiment with capsules, oils, tinctures, edibles, and even beverages.
As you get older, it can be easy to see how you can benefit from the therapeutic effects of cannabis, especially CBD. Cannabidiol is a non-psychoactive compound in the hemp plant, which means that it won’t get you high. Its anti-inflammatory properties and calming effects make CBD the drug of choice for the middle to older aged individuals, who still need something to “take the edge off” without having to worry about any side effects.
Other benefits of cannabis for aging include:
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Pain relief: As we get older, things suddenly start to hurt more, even for seemingly no reason. Chronic or frequent attacks of acute pain in different parts of the body become normal and even expected in your mid to late forties, but it doesn’t have to be a way of life. Cannabis provides excellent pain relieving properties, especially in cases that are related to neuropathy, arthritis, muscle pain, back pain, headaches, and much more. Making cannabis part of your lifestyle can alleviate pain and make it easy to stay active.
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Better sleep: Older adults commonly experience sleep issues. It can be difficult to fall asleep, and even stay asleep. All of this becomes much worse if you drink alcohol. However, medicating with weed is one of the best ways to enjoy deep sleep, naturally. Many people have found that giving up over-the-counter sleep aids has helped, when they turned to weed instead, to help mitigate sleep issues.
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Mental health: Whether it’s hormones, new types of stressors, or just life getting in the way, aging can make us prone to anxiety, depression, and other mental health concerns. Dealing with physical health problems and functional impairments can increase the risk of anxiety and depression. But medicating with cannabis can make these thoughts and problems more bearable.
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Relaxation: You deserve to relax more in your old age. A little weed, no matter how you prefer to take it, can heighten the pleasures that come with relaxation. It can also enhance your overall well-being and reduce stress.
Conclusion
Ditch the bottle and say hello to weed!
If you’re in your 40s or 50s and are thinking about ways to improve your overall wellbeing, quitting alcohol is one of the best things you can do today. In the meantime, replacing it with marijuana can offer a vast range of benefits for your physical and menta health. In doing so, you’ll also reduce the risks involved with aging, and improve management of age-related conditions including chronic pain, high blood pressure, diabetes, and much more.
Reminder: Older adults are recommended to consult your healthcare provider about using cannabis especially if you are already on medications.
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