Connect with us

Psychedelics

Canada: Advocates, MPs call on federal government to expand access to psychedelics as medical treatments

Published

on


Green Party Leader Elizabeth May wants Canada to consider expanding access to psychedelics as medical treatments.

May was among the MPs who joined a delegation of patients and health-care practitioners trying to lobby the federal government to make psilocybin – the psychedelic compound produced by magic mushrooms – more readily available.

The group is calling on lawmakers to advance clinical trials to better understand how it could be used for medical treatment of some mental disorders, such as depression and anxiety.

Psilocybin is listed under the Controlled Drugs and Substances Act and its medical use is restricted to people taking part in clinical trials or those who get an exemption.

Spencer Hawkswell, the CEO of the company leading the delegation, says they are lobbying for “compassionate access” for medicine that he says could be life-affirming.

May says the federal government should expand access to psilocybin before Canada’s assisted-dying laws are expanded to include people whose sole underlying condition is a mental disorder.

Read more at

https://www.theglobeandmail.com/politics/article-advocates-mps-call-on-federal-government-to-expand-access-to/



Source link

Continue Reading

business

Ketamine Healthcare via Enthea; Now Nationwide

Published

on

By


Ketamine is one of the up-and-comers in the new hallucinogen craze that’s taking over; and it just got pushed to a whole new level. According to recent reports, ketamine is now offered by healthcare provider Enthea, throughout the entire US.

A bit about ketamine and hallucinogens

First off, ketamine isn’t a psychedelic. It’s often classified that way today, as a means of simplifying for the public, what is actually a complicated categorization system of drugs. There are different kinds of hallucinogens, and psychedelics are one grouping. However this grouping only consists of LSD, DMT, psilocybin, and mescaline. Though MDMA is often included in this group, its technically classified as a psychostimulant. These drugs (psychedelics and MDMA) are specifically known to cause an agonist response at serotonin receptors; which means they raise the amount of serotonin in the system.

Ketamine is classified as a dissociative hallucinogen, along with drugs like PCP and DXM. These drugs have a primary action as antagonists at NMDA receptors, among other actions. The other official grouping of hallucinogens, is deliriants; a classing which involves plants like datura, and compounds like scopolamine, or even the allergy medicine Benadryl. These are all anticholinergics, which means they have an antagonistic effect at acetylcholine receptors, and decrease acetylcholine in the system.

Ketamine is a synthetic, lab-made drug, which was formulated in 1962 by the pharmaceutical company Parke-Davis. The idea was to find a powerful anesthetic, which didn’t cause damage, or lower vital body processes; like blood pressure, or breathing rates. Ketamine works as a sedative, but not as a hypnotic; meaning it makes a person drowsy, without putting them to sleep. It causes what’s described as “electrophysiological and functional dissociation between thalamocortical and limbic systems.” In my personal experience it quite literally feels like the parts of the brain are moving away from each other.

Enthea healthcare provides clinic and at-home ketamine therapy
Enthea healthcare provides clinic and at-home ketamine therapy

Unlike a lot of the drugs we speak about here, ketamine is not a Schedule I compound. In fact, it’s a Schedule III compounds, legal for medical use as an anesthetic in humans and animals. However, as per FDA rules for off-label prescribing; wherein a drug can be prescribed by a physician for uses other than what its officially cleared for; ketamine has been at the center of a growing gray medical market. Legal by off-label prescribing, but with no governmental regulation for what its being used for.

This loophole spawned an entire industry of clinics that offer treatments for pain and different psychological disorders. And patients don’t need to worry about their primary care physician (or specialist) giving them a prescription; they can get it directly from the clinic. This is a major benefit, as individual doctor opinions do not update at the same speeds.

Ketamine now offered as healthcare throughout US

Gray markets present an issue for government bodies. Unlike defined black markets, they aren’t necessarily illegal; in fact, by definition, they’re not. But they’re also not legal markets, which means they’re hard to go after legally, but they also provide no additional tax benefit to regulating bodies. As such, regulating bodies either want to get rid of them (think vapes and cannabinoids), or formally regulate them. Currently with ketamine, there’s a standstill; and this is being taken advantage of by Enthea Healthcare.

I’ve covered Enthea before, and its pioneering efforts to provide ketamine as a basic healthcare benefit. The company is the first licensed workplace healthcare provider for psychedelic therapies, and plans to utilize other hallucinogens for treatment upon their approval. Due to recently closed deals, Enthea expanded out to the point of now offering this coverage nationwide.

I reported last year that Enthea partnered with Dr. Bronner’s, making for the first offering of ketamine therapy as a part of worker healthcare. In late summer, Enthea released a progress report indicating that so far these ketamine treatments have been used by a small percentage of the staff, and provided positive benefits.

As per its report: 7% of Dr. Bronner’s staff utilized ketamine services since their initiation into the healthcare program. Initial reporting indicates that workers experiencing PTSD, general anxiety issues, or major depressive disorder, reported improvements of 86%, 65%, and 67% respectively. While no one said ketamine treatments will help everyone; imagine the possible improvement if these percents are relevant across an entire population’s use.

Employment healthcare options to treat stress and depression
Employment healthcare options to treat stress and depression

Now, Enthea is expanding its coverage further with new deals. According to Live5News, Enthea’s new deals are with the clinic chains Skylight Psychedelics and Innerwell. Both provide ketamine therapy throughout the US, which expands Enthea’s reach. The first, offers treatments in its Skylight Journey Centers, as well as at-home treatments, for those who prefer not to be in a clinic.

The second, Innerwell, provides therapy as a combination approach; involving a team of holistic therapists, along with standard medical approaches, and coaching. The company seeks to use data and patient outcomes, to drive the direction of treatment. This company also provides in-house and at-home services.

What does a company need to do to offer these services to their workers? Simply add it on to the plan, as they would for dental or vision coverage. All the employer must do, is sign up. Enthea handles everything else, including: a providers network, established policy which includes standards of care, treatment authorization and reimbursement for companies, educational services, and specifically tailored plans for a company’s precise needs.

Sherry Rais, Enthea’s co-founder and CEO stated, “Nationwide availability represents a pivotal moment in accomplishing Enthea’s mission of helping employers with workplace mental health challenges. Our services at Enthea make it easy on businesses to embrace this safe and effective treatment offering for their employees and we’re proud to have the potential to impact the millions of people in the US living with mental health conditions.”

The problem of workplace depression

How necessary is it to find better treatments and services for employees? I suppose that’s a matter of opinion. Some people love getting up every day to navigate their work environment. Others cringe at the sound of each alarm; sickened by another day of office politics, possible bulling by bosses or peers, long work days away from family, and feelings of being overworked and underpaid. Let’s take a closer look at the issue of workplace depression.

According to an American Psychological Association 2021 Work and Well-being Survey, 59% of respondents said that just within the past month, their work was impacted by work-place stress. A huge 87% said they believe that better handling by employers could reduce mental health issues in workplace environments.

Employers can institute a benefits policy they think is best for workers
Employers can institute a benefits policy they think is best for workers

Further to this, a CDC informational page on workplace depression, states that depression causes a loss of 200 million working days a year, combined. This overall costs employers approximately $17 – $44 billion yearly. Depression issues lead to missed work days, and simply not being present or productive while at work.

According to NORC in conjunction with University of Chicago’s National Safety Council; “employers that support mental health see a return of $4 for every dollar invested in mental health treatment.” This indicates that if employers are more thoughtful of their employee’s issues and mindsets; they can improve their own spending, and essentially, waste less.

What jobs cause the most stress? According to the CDC, 10.8% of personal care and service workers report workplace stress, making for the highest stress jobs. Food industry workers clock in at 10.3% who experience stress. Lower stress jobs such as engineering, architecture, and surveying, report that only about 4.3% of employees are stressed.

Life, physical, and social science workers also experience lower stress, at a rate of 4.4%; the same as installation, maintenance, and repairmen. Of course, not everyone understands the concept of their own depression, or wants to admit to it in any context, given the massive stigma attached. I expect these numbers are actually incredibly low for these reasons of possible skewed reporting.

The National Safety Council, for its part, contributes that mental health issues among workers accounts for an extra $3,000 yearly per worker in healthcare services; and that the cost for days lost to stress-related issues is $4,783 per employee, every year. It’s a bad cycle. Stress issues lower worker ability, which means employers lose out as well. Perhaps this makes them then put more stress on employees.

Conclusion

So far, the broad use of ketamine therapy for workplace employees is still a new and growing concept. With the help of Enthea, however, it can now be utilized by any employer in the US who wants to offer ketamine, and other psychedelic treatments, as they become available. If you are an employer, and you want to offer your employees these services, go here. And if you’re an employee who wants coverage of these services; you’ll soon have a growing number of workplaces offering it. Just hold tight.

Hey there drug aficionados! Thanks for making your way to Cannadelics.com. We’re an independent publication in the drug space, here to bring you cutting-edge reporting every day. Don’t be a stranger; join us regularly for updates; and sign up to the Cannadelics Weekly Newsletter, so you’re never late to get the news.



Source link

Continue Reading

estrogen and psilocybin

How Estrogen Alters Psilocybin’s Effects

Published

on

By


The numerous benefits of psychedelics have been coming to light in recent years, and women are taking notice. With little options in the way of pharmaceutical drugs, especially when it comes to treating mental illness and hormonal imbalances, it’s no surprise that women are experimenting with hallucinogens to see what can actually help. And better yet, a recent study found that psilocybin can help regulate menstrual issues. Let’s dig deeper into how and why psychedelics are so valuable for the fairer sex.

Women and psychedelics 

The psychedelic renaissance is in full swing, and women are at the heart of it. After decades of prohibition and condemnation (following a brief period of them being studied and used medicinally), the western world is finally starting to reexamine the many therapeutic benefits of these substances. LSD, Ketamine, MDMA, and psilocybin have been undergoing various clinical trials to see how they can be utilized to address a growing mental health crisis in the United States.  

Jennifer Gural, a psychotherapist from Los Angeles, California, commented about how hallucinogens have helped change her life, and how she began using them to help her female patients as well. “It shifted the focus of my life,” she stated. “It really helped me to tackle how my brain works and how I was thinking … It was such a profoundly life-changing experience. I have done ayahuasca and I’ve done psilocybin. I don’t know if I’ll ever do it again, but I’m open to that if it’s needed—which I think is how we should use psychedelics.”  

While there seems to be a recent influx of ladies trying psychedelics, self-medicating is nothing new for women. This could stem from frustrations with our existing health-care system, and how it has been historically geared toward treating men and either dismissing our issues or over-medicating us.  

As women – daughters, mothers, sisters, grandmothers, wives, friends – we have many struggles that we are often forced to face alone. Women are more likely to suffer from PTSD than men – particularly women of color, transgender, and gender-diverse individuals. Women also deal with depression and anxiety more often, and one in seven women have postpartum depression after childbirth.  

New studies have found that even a couple experiences with psychedelics, especially when combined with talk therapy, can lead to lifechanging, psychological developments. As a matter of fact, MDMA and psilocybin have been labeled as “breakthrough therapies” by the FDA, a designation given to “promising drugs proposed to fill an unmet need”. With so many pharmaceutical antidepressant and antianxiety drugs on the market, and the number of mental disorders still rising, we can clearly see that treating our troubled human minds is that unmet need.  

Is this the beginning of a brighter, more beautiful future for women’s healthcare? One where common mental illnesses, chronic pain, and hormonal conditions are treated successfully with psychedelic trips, rather than a lifetime of pharmaceutical medications? It seems quite promising.  

The new research on psilocybin and estrogen 

Although no clinical trials have been conducted, researchers from John Hopkins University have been looking over case files and anecdotal reports on women and psychedelics, and how estrogen can change the effects of psilocybin specifically. We know that estrogen can impact binding at serotonin receptor sites, and because most hallucinogens interact with serotonin receptors as well, experts believe that our cycles can influence how psilocybin works in our bodies, and vice versa, the psilocybin itself can have an impact on our hormones.  

Based on the aforementioned case studies, researchers discovered that psilocybin seemed to help regulate menstrual cycles. One of the women studied had premenstrual dysphoric disorder, which is a very severe form of PMS, and she used psilocybin to help regulate it. In another case, a woman suffered from polycystic ovarian syndrome and was having irregular periods. At one point, menstruation completely stopped for a while, but after taking psilocybin, it came back.  

“Our menstrual cycles occur along the hypothalamic-pituitary-gonadal (HPG) axis, so as one hormone kicks off, it tells another hormone what to do in this feedback loop and that’s the trajectory of our menstrual cycles,” says Jennifer Chesak, author of The Psilocybin Handbook for Women. “We also have the axis that manages our stress response, the hypothalamic-pituitary-adrenal (HPA) axis. These two axes sort of overlap, and so they each impact one another. When we use psilocybin, we are at doing something along that stress response along the HPA axis.” 

Chesak added: “We already know from research outside of psychedelics, that these two axes do impact each other: our stress response can impact our cycle, and our cycles can impact our stress response. So, it’s not a stretch to think that when we are using psilocybin, that something is going on with our stress response that then impacts the menstrual cycle” 

Although we only have these few case studies and anecdotal reports at the moment, the results are telling. And it begs the question of when we can see a real clinical trial on this topic, so we can better understand the mechanisms of how it works from a scientific perspective. 

Aside from medical benefits, do women experience psychedelics differently than men? 

Honestly, who really knows? Obviously, no studies have been done on whether women trip differently than men. But it’s possible that because women tend to be more emotional, empathetic, and receptive to spiritual experiences – this could be beneficial to producing better and more positive, even more therapeutic highs.  

Historically, statistics indicate that men use more drugs than women – and this across the board, from illicit drugs to legal substances like tobacco and alcohol. And since most research is still conducted on male subjects, female drug use patterns and their subsequent experiences remain somewhat of an enigma.  

However, we do know that in general, psychotropic drugs impact women differently than men, but sex-based responses to medications are often overlooked. It wasn’t until the 1990s that women were even allowed to participate in clinical trials in the United States, and many studies are still done using a larger number of male participants.  

Despite this, women are twice as likely as men to be prescribed psychotropic medication (back to that overmedicating issue), and recent research shows that factors like different hormones, body composition, and metabolism can cause different drug-reactions. For example, the sleep medication Ambien was found to be twice as potent for women.  

Additionally, experts claim that women are “between 50 and 75 percent more likely to experience side effects”. An analysis of existing clinical trials published June 5, 2020, in the journal Biology of Sex Differences, authored by Prendergast and Irving Zucker of UC Berkley, they noted 86 drugs which presented “clear evidence of sex differences in how the body broke down the drug.” They found that “For nearly all of these drugs, women metabolized them more slowly than men, leading to higher levels of exposure to the drug; in 96% of cases, this resulted in significantly higher rates of adverse side effects in women.” 

Final thoughts 

To reiterate, because the foundation of modern medicine is structured around research performed almost exclusively on men, most of what science tells us about the prevention, diagnosis, and treatment of illness may not be applicable to women. With so much of our population feeling like they are not understood by healthcare professionals, it’s no surprise that a growing number of women are self-medicating with cannabis, psychedelics, and other natural, alternative solutions.

As we learn more about how psilocybin and other hallucinogens interact with female hormones, we can better understand how to use these incredible products to improve our health, and our lives.  

Welcome cannabis aficionados! Thanks for making your way to Cannadelics.com, an independent news site going deep into the worlds of cannabis, psychedelics, and well beyond. We’re big on updates, so come by regularly. And get yourself signed up to the Cannadelics Weekly Newsletter, for the best in related product offerings, as well.



Source link

Continue Reading

bolivian torch

Top Mescaline Producing Cacti from Around the World 

Published

on

By


When we think of trippy cacti, mescaline generally comes to mind. And rightfully so, as very few other cactus compounds are truly psychedelic. That being said, most people tend to associate mescaline with peyote, but peyote is illegal in the United States. What many don’t realize is that many other, completely legal cactus species contain mescaline also. Let’s learn more about a few of the more popular varieties.

What is mescaline? 

Mescaline (3,4,5-Trimethoxyphenethylamine) is a naturally occurring, plant-based psychedelic protoalkaloid belonging to the phenethylmine class. Like other drugs from this class, mescaline has an affinity for serotonin receptors. Although it binds to virtually all serotonin receptors in the brain but has a stronger affinity for the 1A and 2A/B/C receptors. 

Aside from Peyote, which is the most well-known, mescaline can be synthesized from a few other cactus species as well, a few of which we’ll discuss in further detail later on. It’s known for its powerful hallucinogenic properties, comparable to those of LSD and psilocybin

Mescaline

A common dose for mescaline is roughly 200 to 400 mg, depending on the person’s size, level of experience with the compound, and other factors. Traditionally, San Pedro dosing is calculated at roughly 3.75 mg/kg of weight. However, potency can vary wildly from cactus to cactus, so it can be quite difficult to get consistency in dosing. For example, 50 grams of powdered cactus can have anywhere from 150 mg to 1,150 mg of mescaline. Factors such as where and how the cactus grew (the plant’s terroir) and access to water and sunlight can influence the plant’s potency.  

Mescaline produces a number of effects, including intense hallucinogens, with both open and closed-eye visuals; distortion in time, sound and vision; an increase in introspective and conceptual thinking; the loss of ego; and feelings of euphoria. It’s often considered gentler than other psychedelics with less negative come-down, while possibly producing greater insight than these other compounds. It’s the subject of a growing body of research for its potential medical properties. 

Mescaline has a rich history of traditional and spiritual use dating back thousands of years. Native Americans have long used peyote as a religious sacrament and in the early 1800s (aka Peyotism), the modern-day Native American Church (NAC) was formed. The 1994 amendment to the American Indian Religious Freedom Act legalized the use of peyote for members of this church. However, it’s banned for everyone else in the United States.  

Mescaline-producing cacti 

Many cacti are known to be psychoactive, containing phenethylamine alkaloids such as mescaline, or other mind-altering compounds. Cacti that produce mescaline specifically, can be found growing throughout North and South America, with more prominence in certain areas such as most of Mexico and the Andes region which stretches throughout Venezuela, Colombia, Ecuador, Peru, Bolivia, Chile and Argentina.  

The two genera that are most often used for spiritual and ritualistic purposes are Echinopsis, which contains the San Pedro cactus group; and Lophophora, which has peyote. Several other species contain mescaline and are just as potent, but do not have the same historical background.  

Peyote  

Peyote (Lophophora williamsii), or “the sacred one”, is by far the most well-known of the mescaline cactus types. It’s been talked about in movies, literature, and music, and also depicted in many types of visual artwork such as paintings and photographs. It’s a very slow-growing, spinless, flowering, button cactus that is greenish-blue in color, sometimes with hints of grey.  

DIY Peyote mescaline extraction
Peyote cactus buttons

The Peyote cactus grows among thorny shrubs in the high desert regions of Central Mexico to Southwestern Texas, mainly between 330 and 4,920 ft, although in some rare circumstances, it has been found at elevations as high as 6,200 feet.  

It’s a very hardy plant that can grow in many different types of increment weather conditions. Mainly, it just needs that dry desert air. It’s common to find it growing on or near limestone hills. It flowers in between March and May, and the flowers are pink and white with thigmotactic anthers. It grows in the wild from central Mexico to Southern Texas.  

In traditional peyote preparations, the top of the cactus is cut off, leaving the large tap root along with a small, green photosynthesizing area where new heads can grow. These heads are then dried to make disc-shaped buttons. The buttons are chewed or soaked in water to make a beverage. An average dried button weighs about 2 grams, and it would take 6-10 buttons to produce psychedelic effects. Peyote is extremely bitter though, so more contemporary users will usually grind the dried buttons into a powder and pour into capsules to consume. 

San Pedro  

San Pedro (Trichocereus/Echinopsis pachanoi) is a tall, thin flowering columnar cactus that grows in clumps. Each column has 7-9 ridges with small clusters of spines along the edges. The clump can grow up to 14 feet tall and contain a substantial amount of mescaline. It hails from the Andes Mountain region of South America. It also grows well in the Southwestern US, as far north as Colorado, although it truly thrives in California and Arizona, where it can be seen with regularity in residential areas and shopping centers. 

San Pedro cactus columns

Their fast growing nature has seen San Pedro cacti become very popular in the last decade, although it too steeped in history. Use of San Pedro can be traced back to the pre-Columbian Chavin culture that developed in Peru between 1300 to 200 BCE. This is evidenced by numerous stone carvings depicting mythical beings holding San Pedro cacti, the oldest of which was discovered in an old temple at Chavin de Huantar in the northern highlands of Peru. Numerous other artifacts from the region bore San Pedro symbolism as well, and perhaps the most concrete proof of its use are the 3,000-year-old cactus cigars found in the same cave as the carvings. 

Even today, San Pedro is sold at numerous markets in the country and in 2022, the Peruvian Ministry of Culture declared the traditional use of San Pedro cactus in northern Peru as part of their cultural heritage. Traditionally, San Pedro can be consumed either on its own or mixed with other plants in a psychedelic, ceremonial brew called cimora. 

It can also be bought online or at gardening stores in the US with relative ease because it’s federally legal. And because there are now laws against possession of San Pedro, it’s one of the longest-studied psychedelics, as well as the first cactus to be labeled with the term (psychedelic). Dosing can be challenging as potency varies considerably. There are San Pedro that are completely inactive and won’t do anything, and there are some that are strong enough that you only need a couple inches of fresh plant to feel a good high – so there is a certain level of trial and error involved to figure out what is best for each person.  

Peruvian Torch 

Peruvian Torch, or Trichocereus Peruvianis, is often confused for San Pedro but it’s slightly different. It’s distinguished by its blue shade and longer spines. Not only are the spines longer, but they’re also a different color – San Pedro spines are yellow, whereas the Peruvian Torch spines start off as a brownish-yellow and turn to bone white as they age. 

Blue Peruvian Torch cactus with brownish/yellowish spines

Additionally, Peruvian Torch is said to be much more potent than San Pedro, although honestly, it’s hard to find any reliable information on this other than word-of-mouth and reddit posts. It seems that, although some of the highest recorded concentrations of mescaline have been from San Pedro cactus varieties, so have some of the lowest. Peruvian torch seems to be more consistent on the higher end.

Bolivian Torch  

Bolivian Torch, or Echinopsis lageniforis, is another fast-growing columnar cactus that bears many similarities to San Pedro and Peruvian Torch. Origins of its use can be tracked back to the indigenous shamans of La Paz, Bolivia, who would refer to this cactus as “Achuma” or “Wachuma”.  

Bolivian Torch has much higher levels of mescaline than both Peruvian Torch and San Pedro with roughly 0.56 percent by dry weight, although concentrations did vary a bit based on the location of the cactus. All you need is about 0.3 to 0.4 grams to produce the desired effects, which is typically a noticeable psychedelic experience. They also get quite tall, up to 15 feet and some of the mature ones produce a big, blooming flower right on the top. 

Although most people think of peyote when they think of psychedelic cacti, there are many other species that produce the compound, as well as other psychoactive agents.
Bolivian Torch

Interestingly, they still are not as popular as one would expect, given the benefits of choosing this cactus over other mescaline producing varieties. One reason is because they simply are not very well known. Another reason is because people often use the names Bolivian Torch, Peruvian Torch, and San Pedro interchangeably, believing they are all different terms for the same cactus when in fact, they only look similar and all contain mescaline.  

Other psychedelic cacti 

There are roughly 300 cactus types that produce psychoactive compounds. It’s usually mescaline, but not always; although the other psychedelic cacti are even less researched than the mescaline ones, so very little is known about the potential of these agents. There could be several hallucinogens in these cacti that are yet to be discovered.  

Another species of cactus, the Echinocereus triglochidiatus, is suspected to contain a tryptamine-derivative that is similar to 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), although again, there is not much literature on the subject.  

Some other fairly well-known psychoactive cacti (among psychonauts and botanists at least) are Ariocarpus species with numerous phenethylamines, which are often referred to as “maddening drugs”. However, the mechanisms of how these compounds work is still not very well understood. Additionally, some cacti contain stimulants, and others contain compounds that can be used for pain relief.  

Final thoughts 

Plants are fun, and while trying to research psychedelic cacti it becomes abundantly clear that there is so much in nature that we still know nothing about. A lot of cacti contain mescaline, and we’re now learning that several contain other psychoactive compounds, many of which have yet to be studied in any capacity. It’s exciting to think what the future of psychedelics holds.

Welcome cannabis aficionados! Thanks for making your way to Cannadelics.com, an independent news site going deep into the worlds of cannabis, psychedelics, and well beyond. We’re big on updates, so come by regularly. And get yourself signed up to the Cannadelics Weekly Newsletter, for the best in related product offerings, as well.



Source link

Continue Reading
Advertisement

Trending

Copyright © 2021 The Art of MaryJane Media