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Forget Highest THC Levels, What are the 5 Most Potent Psychedelics Out There?



Psychedelic substances can profoundly alter our perception of reality, revealing new dimensions and possibilities. With their vast potential, we are just beginning to tap into their full potential. Although the strength of psychedelics is challenging to quantify, their potency cannot be denied. From natural psychedelics to laboratory-created compounds, these drugs can trigger mystical experiences, transporting users to otherworldly realms.


As the effects of psychedelics vary significantly from person to person, it is challenging to determine which is the strongest. However, a few drugs are known for their particularly intense effects. Here are what could be considered the top five most potent psychedelics.



DMT is a powerful substance with two variations: N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine.

The first form, N, N-Dimethyltryptamine, is the more commonly encountered molecule and can be found in many living organisms. This type of DMT is found in Ayahuasca brews and in its powdered form, which can be smoked or vaped.


On the other hand, 5-MEO-Dimethyltryptamine, with a 5-MEO molecular tail, is less commonly found in nature and less accessible as a drug. This form is found in the venom of a specific toad consumed in some shamanic rituals. Additionally, it can be delivered through the nasal passages using “Yopo.” In modern times, it has been paired with ibogaine to explore its potential in addressing addiction.


Despite their different origins, both forms of DMT are known for their incredible potency and intense effects.


Effects of DMT

Both N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine are among the most potent drug experiences one can have. If not the strongest, they are certainly in the running for the title.


N, N-Dimethyltryptamine is a powerful hallucinogen that elicits varying effects depending on the dosage. At lower doses, it can induce intense visual hallucinations, both with eyes closed and open. At higher doses, it can transport users to entirely new realms, where they may encounter otherworldly beings of a mystical nature.


5-MEO-DMT, on the other hand, elicits a strange shift in perspective that is often described as a near-death experience. Being less well-known and less commonly encountered, it remains a largely mysterious substance with obscure, hard-to-define effects. Regardless, its potency cannot be disputed.



Mescaline is a potent psychedelic alkaloid most frequently discovered in certain species of cacti, such as Peyote and San Pedro. With a rich history of shamanic use stretching back centuries, this hallucinogenic compound has captivated the imaginations of people across the world. Its fame reached new heights with the publication of “The Teachings of Don Juan,” a book that chronicled the journey of an anthropologist who ventured to Mexico to explore the use of Peyote with a shaman. This fascinating tale introduced Mescaline and its powerful effects to a broader audience, solidifying its place in the annals of psychedelic history.


Effects of Mescaline

Mescaline is said to produce effects that are similar to those of psilocybin, although this comparison is likely a pale one. The effects of Mescaline can be profound and include significant mental, visual, and auditory distortions, including closed and open-eye visuals. Some users report a greater detachment between mind and body, but this is not necessarily experienced as a negative. Wide open spaces enhance the Mescaline experience, while enclosed spaces and forests may feel constricting.


As with all psychedelics, Mescaline provides a deep, reflective, and philosophical experience. However, thoughts and emotions may come and go more quickly with Mescaline than with other psychedelics such as LSD. This makes Mescaline a valuable tool for exploring the self and contemplating big questions. In some cases, total ego death is possible with Mescaline use.



MDMA, commonly known as the party drug, is a unique substance that defies categorization. While it may not strictly be classified as a psychedelic or hallucinogen, its effects are undeniably trippy. Users often report feeling an intense rush of energy and an overwhelming sense of empathy and connection to others.


Contrary to its ancient counterparts, MDMA is a relatively new drug, with its origins dating back just over a century. Developed by the pharmaceutical company Merck in 1912, it was initially used for therapeutic purposes but was soon embraced by the recreational scene in the 1960s and 1970s.


However, with the increasing stigma and outlawing of psychedelics during that time, MDMA faced the same fate and was banned along with other drugs in the same category. Despite this, it remains a popular substance and continues to evoke strong emotions and trippy experiences for those who use it.


Effects of MDMA

MDMA is a powerful and complex drug that induces feelings of happiness, empathy, and love, making it popular in social settings. However, high doses can cause intense hallucinations and physical effects such as elevated heart rate and blood pressure, jaw clenching, and body temperature, making it dangerous if taken in excess or with other drugs.


Despite its euphoric effects, it also has a brutal come-down, leading to physical exhaustion and emotional turmoil. These side effects are usually minimal when taken occasionally and in moderation.



LSD, the mind-bending compound more commonly known as “acid,” is a psychedelic of legendary proportions. With just 25 micrograms, you’ll be launched into a world of intense, vivid hallucinations and mind-bending experiences. One microgram is a millionth of a gram, making LSD one of the most potent drugs on the planet.

Typically consumed in tab form, the liquid LSD is placed under the tongue, absorbed through the mucous membrane, and into the bloodstream. Alternatively, it can be directly dropped onto the tongue.


Albert Hoffman created this mind-altering substance in 1938 and went on to be the subject of military research exploring its potential to enhance soldiers’ abilities. However, these trials proved to be unsuccessful, and LSD instead became synonymous with the hippie movement and a symbol of countercultural expression.


Effects of LSD

LSD is a potent psychedelic known for its fear-inducing and misunderstood reputation. However, it can also lead to enjoyable experiences if approached with caution. LSD can cause powerful changes in perception, vision, and sound, along with altered thoughts that can lead to deep philosophical conversations. Despite its association with the “bad trip” and the hippy movement, LSD remains one of the most potent drugs in the world.



Salvia divinorum, also known as the “Seer’s Sage,” may be legal in some areas, but it is by no means a mild or inconsequential substance. It is incredibly potent, particularly in extract form, which can be a hundred times stronger than the naturally grown leaf.


While some might try it out of curiosity as teenagers, it is not uncommon for people to never revisit this drug after their initial experience. This has less to do with its quality and more with the assumption that its legality equates to a lack of potency. Salvia divinorum is anything but mild.


Effects of Salvia

Salvia’s effects are akin to those of DMT but with a potent rush that can make you feel hurtling through space, even when you’re stationary. With its intense visuals and otherworldly experiences, it’s essential to proceed cautiously when trying salvia for the first time. Always start with a low dose to get a better handle on the power of this mind-bending substance. Don’t be fooled by its legal status – salvia is a severe drug and not to be taken lightly.



Psychedelics are potent substances that can have both profound and potentially dangerous effects. From LSD to MDMA, salvia, and more, it’s crucial to approach these drugs with caution and understanding and to understand both the positive and negative consequences that can come with their use.


Whether for personal exploration or social situations, it’s essential to respect these substances’ power and use them responsibly. With this understanding in mind, the world of psychedelics can offer an incredible journey of self-discovery and growth.





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Does Cannabis Cure Postpartum Depression? One Mom Swears It Did the Trick for Her!




cannabis for postpartum depression

Early pregnancy is rife with postpartum depression and other mood problems. We realize it’s an overstatement, but those first few days, weeks, and months are HARD. Sleep deprivation, aching, leaking, or engorged breasts… throw in mental health difficulties, and you have a recipe for total exhaustion.


Fortunately, there is less stigma associated with postpartum depression (PPD) than formerly. PPD is being discussed more frequently, and there is a better awareness of new parents’ symptoms and many remedies. Many moms are finding success with prioritizing rest, exercise, Vitamin D, and even using CBD to assist control anxiety when diagnosed and addressed early.

The Rise of CBD as a Postpartum Mood Disorder Remedy

Over the past few years, CBD has gained remarkable popularity as a remedy for addressing symptoms linked to postpartum mood disorders, such as anxiety, irritability, and insomnia. Additionally, it has shown promise in supporting the physical recovery process following childbirth.


Georgeana Ortiz, the founder of the CBD company Cerena, emphasizes, “CBD serves as an excellent gateway, beckoning you to step away from the turmoil within your mind and transition into a composed and collected state of being. Ultimately, CBD is a pivotal component in facilitating your journey to move beyond self-imposed barriers and return to a state of thriving rather than merely surviving.”


While both THC and CBD are cannabinoids, CBD has no hallucinogenic effects. In other words, it won’t get you high. When selecting a CBD product, search for a high-quality, full-spectrum oil tailored to your needs or symptoms. Cerena, for example, makes a full-spectrum, certified organic CBD oil called “Calma” that’s expressly intended to relieve stress and anxiety.


Natasha’s Journey: From Postpartum Depression to CBD Advocate

In a noteworthy case, a woman claims to have treated her postpartum depression using cannabis oil. Natasha Doran, 33, began dealing with her mental health issues after giving birth to her son, Isaac, now four, in May 2019.


Despite attempting therapy and medication, she experienced “no improvement” in her severe daily panic attacks. After contacting her general practitioner, engaging in online therapy, and commencing antidepressant treatment, she felt “worse than ever.”


By June 2020, her ability to leave the house had deteriorated, and she was grappling with debilitating insomnia. At the suggestion of a friend, Natasha decided to give CBD oil a chance and made her initial online purchase of a 10ml bottle for £60.


Cannabidiol, a chemical compound in cannabis with purported medical benefits, became her solution. She started by taking a daily drop under her tongue, and soon, she noted a significant alleviation of her anxiety and depression symptoms.


Just six months after incorporating CBD into her routine, Natasha found herself back at the gym, enjoying restful nights and free from panic attacks. She was so impressed by the positive impact of the hemp product that she decided to start her own company, which she named Hemp-Aid Limited, in November 2022, leading her to leave her previous role at a nursery.


In Moreton on the Wirral, Natasha reflected, “She couldn’t sleep, and leaving the house was daunting. There were moments when she felt utterly hopeless. Initially skeptical, she conducted thorough research on CBD before giving it a try, despite initial reservations from her family.”


“After several months of incorporating CBD into her daily routine, she felt a renewed sense of purpose. She eagerly reconnected with friends, resumed gym visits, and arranged playdates for her son. In essence, CBD gave her life back.”


Despite a smooth pregnancy, Natasha had a “traumatic” childbirth experience with her first son at Whiston Hospital in Prescot, Lancashire. Isaac was born with the umbilical cord wrapped around his neck, and the resulting C-section led to severe pain due to blood clots. Reflecting on this period, Natasha, a former nursery manager, confessed that she lost herself after the birth.


She reflected that the surgery left her in considerable pain, which wasn’t the most auspicious start to her journey into motherhood. Following a hospital stay that lasted a week, Natasha soon found herself in profound depression after returning home with her newborn.


In her own words, Natasha explained that she initially thought her feelings were typical for a new mother. However, when she lost all motivation to venture outside, she recognized something was amiss. She felt compelled to act when concerned about her son Isaac’s social development due to her isolation.


After enduring four years of disappointment with traditional treatments, she confided in her partner, who suggested experimenting with CBD oil. Describing her experience, Natasha recounted that the impact was immediate.

She felt an incredible sense of relaxation and tranquility. She regained control over her heart rate and thought patterns, which was one of the best periods of sleep she had experienced in a long time.

She abstained from alcohol, which significantly contributed to her relief from depression. She now enjoys a profound sense of health and fitness. “I’ve never been this committed to a healthy lifestyle. After several months of incorporating CBD into her daily routine, she extensively researched improving her overall well-being.”


She continues incorporating CBD oil into her daily regimen and has taken it further by establishing her own company, Hemp Aid Limited. Natasha expressed her motivation, saying, “The health benefits are remarkable. CBD cured her post-natal depression when she felt utterly hopeless, and now she aspires to provide the same relief to others.


According to the NHS website, “some products claiming to be medical cannabis, such as CBD oil or hemp oil, are legally available to buy as food supplements from health stores.” However, there is no guarantee that products are of high quality or give any health benefits.”


“There is insufficient scientific evidence to support the claim that CBD is an effective treatment for depression or anxiety,” according to the Anxiety and Depression Association of America. That isn’t to say it wouldn’t help, but there haven’t been enough well-controlled clinical research to support CBD as a treatment for anxiety or depression.Much more research is needed to assess CBD as a potential therapy for anxiety and depression.”


While CBD has shown promise in addressing various health issues, including postpartum depression, it is important to approach its use cautiously. The quality and effectiveness of CBD products can vary, and there is still a need for more comprehensive scientific research and clinical trials to establish its efficacy as a treatment for these conditions. Individuals considering CBD for mental health concerns should consult with healthcare professionals and make informed decisions regarding its use.





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Can You Mix Two Different Cannabis Strains Together and Smoke It? What Happens to Your High?




combining cannabis strains

While you’ve likely experienced smoking from a pipe or bowl with traces of a different weed strain, combining two strains isn’t typically the first choice for most people. The question is, can you deliberately craft distinct highs by combining different cannabis strains and experimenting like a scientist? Some individuals believe it’s possible, while others remain skeptical.


Blending different strains can enhance the renowned entourage effect of cannabis. This effect occurs when various components of cannabis synergize to create a potent high, surpassing the effects of consuming a single cannabinoid in isolation. The entourage effect leads many to argue that using just one cannabinoid for relaxation or therapeutic? What happens when you combine two cannabis strains isn’t as effective as consuming the entire plant, including its terpenes.


If you’re pursuing truly unique effects, mixing two strains can deliver just that, for better or worse. Nevertheless, it’s worth noting that combining strains isn’t overly complex. While the outcome might range from a powerful high to one that tucks you in for the night, especially when you’ve acquired high-quality cannabis, there’s generally no reason to anticipate adverse consequences.

The Entourage Effect

While further research is essential, the existing knowledge suggests that when you blend specific cannabinoids and terpenes tailored to your body’s needs, it can result in a synergistic phenomenon known as the Entourage Effect. This effect can offer a more complete cannabis experience compared to consuming isolated cannabinoids such as THC or CBD.

This phenomenon is rooted in the fact that each of us possesses our internal endocannabinoid system (ECS), with the prefix “endo” indicating its presence within the body.


By blending two or more varieties of cannabis, you expand your body’s and endocannabinoid system’s exposure to a broader array of cannabinoids and terpenes. In doing so, you potentially unlock the health benefits associated with these additional compounds.

The advantages of mixing strains extend beyond simply enhancing potential medicinal benefits. Even recreational users can employ the concept of strain mixing to regulate the potency and effects of their cannabis consumption.


As an example, suppose a potent strain yields unwanted effects when consumed. Blending it with a strain featuring lower THC levels and elevated cannabidiol (CBD) content can alleviate some of these undesirable outcomes. CBD achieves this by diminishing THC’s tendency to bind strongly to cannabinoid receptors within our endocannabinoid system (ECS), thereby assisting in reducing any adverse consequences that might arise from high-THC cannabis.


This is just one example of how the interplay between cannabinoids and terpenes with our ECS significantly influences the potency and effects of various cannabis strains. Consequently, this variation is why two individuals consuming the same strain may encounter distinctly divergent effects.

Mixing Strains of Weed

To create a mix of weed strains, often called a “weed salad,” the simplest approach is to grind your cannabis flowers and combine the two chosen strains. From there, various options open, including smoking, vaping, or crafting your cannabutter.


Now, let’s explore the more intricate aspect: determining the ideal blend for your needs. Should you combine an Indica with a Sativa? Is it acceptable to mix two Indicas or two Sativas? If you decide to mix Sativa and Indica strains, how should you balance the proportions of each? Can you blend older cannabis with fresher batches? What about combining high-THC cannabis with low-THC cannabis or CBD strains?


Given the many variables involved, here are some tips to note when mixing different cannabis strains;

Tip 1: Mix Weed with Similar Scents

You’re likely aware that the distinctive aroma of each cannabis strain is attributed to its terpenes. Additionally, you recognize that the fragrance of a cannabis flower can play a pivotal role in gauging whether its effects align with your body and endocannabinoid system. If a strain’s aroma doesn’t resonate with you, it might indicate that it’s not a suitable match for your system, and your overall experience may be less enjoyable.


Therefore, our initial advice is to combine strains with comparable, pleasant scents or scents that you believe would harmonize well. Conversely, a strain with an appealing aroma could indicate that it will likely complement your system.


If you are uncertain, you can begin by grinding and blending a small quantity. Afterward, taste it and decide if you wish to proceed with mixing a larger batch.

Tip 2: Mix Complement Flavours

For instance, consider combining a strain with a tea-like flavor with another boasting a lemon haze profile. This combination could deliver a refreshing and enjoyable session.

Alternatively, if you have a penchant for cheese strains, you might experiment by mixing cheesecake with strawberry cookies OG for a unique taste experience.


Keep in mind that the ideal cannabis blend varies from person to person. What provides an exceptional experience for you might be less enjoyable for someone else. Therefore, don’t hesitate to let your creativity run wild and concoct various strains with flavors that pique your interest. We recommend starting with a small blend to ensure it aligns with your preferences before proceeding with a larger mix.


Tip 3: Mix Strains With Similar Effects

This tip may well be the most important of all. A practical approach to blending cannabis strains is considering how each strain influences your mood and sensations.

For instance, if you acquire a strain that imparts an invigorating and mentally uplifting high but induces a slight sense of anxiety, you could mitigate any adverse effects by combining it with a more soothing strain.


Conversely, come across a strain that delivers a relaxing, full-body effect but tends to induce couch lock. Mix it with a strain that offers a gentle, uplifting sensation to counteract the couch lock effect.


A helpful guideline to remember is to refrain from mixing strains at opposite ends of the spectrum. A highly energizing and euphoric strain may not harmonize well with one that provides intense, full-bodied relaxation.


Before embarking on your strain mixing journey, consider this vital question: Are you aiming for an indica-like relaxation without an instant knockout? If so, consider pairing an Indica strain with a hybrid that can elevate your high into an enjoyable yet tranquil experience.


Lastly, exercise caution when combining two potent strains. Mixing two strains introduces you to an entirely novel experience, one that has the potential to yield a new, albeit unfavorable, high—the kind where you feel both hyperactive and simultaneously inclined to sleep for extended periods.


Begin with a measured approach, and don’t hesitate to seek guidance at your dispensary. Ultimately, the goal is to have an enjoyable time and explore new horizons.





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More New York Cannabis Program Litigation: First Amendment Challenge to Third-Party Website Rules




On September 18, 2023, a new lawsuit was filed by, inter alia, Leafly Holdings, Inc. (“Leafly”) against the New York State Office of Cannabis Management (“OCM”) and New York State Cannabis Control Board (the “Cannabis Control Board”).

The lawsuit

This legal proceeding involves a First Amendment and other challenges to certain regulations adopted by the Cannabis Control Board. The regulations, known as Resolution 2023-32, introduce new rules under Parts 123 and 124 of the Revised Adult-Use Cannabis Regulations, which significantly restrict the ability of New York dispensaries and consumers to use third-party websites that aggregate information about cannabis products. The petitioners, including Leafly, Stage One Cannabis, LLC (“Stage One Dispensary”), and Rosanna St. John, are seeking to have these regulations invalidated on the grounds that they are arbitrary, capricious, and in violation of both the United States Constitution and the New York Constitution. They are also requesting a temporary halt to the enforcement of these regulations until the legal proceedings are resolved.

The specific provisions being challenged are:

  1. The Third-Party Marketing Ban (9 N.Y.C.R.R. §§ 123.10(g)(21) and 124.5(a)), which restricts certain types of marketing by third-party websites.
  2. The Pricing Ban (9 N.Y.C.R.R. § 124.1(b)(5)(ii)), which imposes limitations on pricing information.
  3. The Third-Party Order Ban (9 N.Y.C.R.R. § 123.10(g)(23)), which restricts the ability to place orders through third-party websites.
  4. The Third-Party All-Licensee Listing Mandate (9 N.Y.C.R.R. § 124.1(b)(2)), which requires third-party websites to list all cannabis licensees.
  5. The Third-Party Distributor Listing Mandate (9 N.Y.C.R.R. § 124.1(c)(1)-(2)), which mandates the listing of third-party distributors.

The arguments

The petitioners argue that the Third-Party Marketing Ban and the Pricing Ban infringe upon free speech rights protected by the First Amendment of the U.S. Constitution and Article I, § 8 of the New York Constitution by limiting lawful commercial speech. They also claim that all the challenged regulations are arbitrary and capricious because they either conflict with New York’s Cannabis Law, lack a rational basis, or exceed the authority of the Cannabis Control Board.

What the plaintiffs want

Furthermore, the petitioners are requesting a temporary stay on the enforcement of these regulations, asserting that they are likely to succeed in their legal challenge and that they are facing irreparable harm due to the violation of their constitutional rights and potential business losses. They argue that maintaining the status quo is in the best interest of justice, and they urge the court to invalidate these regulations on the grounds of being arbitrary, capricious, irrational, and unconstitutional.


This First Amendment challenge is just the latest litigation, unfortunately, in a program that has seen a number of misfires and delays. We will continue to monitor this lawsuit, while awaiting answers on fundamental issues that the Cannabis Control Board has inexplicably failed to address. Stay tuned to our New York coverage for more.

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