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Forget Highest THC Levels, What are the 5 Most Potent Psychedelics Out There?

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Psychedelic substances can profoundly alter our perception of reality, revealing new dimensions and possibilities. With their vast potential, we are just beginning to tap into their full potential. Although the strength of psychedelics is challenging to quantify, their potency cannot be denied. From natural psychedelics to laboratory-created compounds, these drugs can trigger mystical experiences, transporting users to otherworldly realms.

 

As the effects of psychedelics vary significantly from person to person, it is challenging to determine which is the strongest. However, a few drugs are known for their particularly intense effects. Here are what could be considered the top five most potent psychedelics.

 

DMT

DMT is a powerful substance with two variations: N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine.

The first form, N, N-Dimethyltryptamine, is the more commonly encountered molecule and can be found in many living organisms. This type of DMT is found in Ayahuasca brews and in its powdered form, which can be smoked or vaped.

 

On the other hand, 5-MEO-Dimethyltryptamine, with a 5-MEO molecular tail, is less commonly found in nature and less accessible as a drug. This form is found in the venom of a specific toad consumed in some shamanic rituals. Additionally, it can be delivered through the nasal passages using “Yopo.” In modern times, it has been paired with ibogaine to explore its potential in addressing addiction.

 

Despite their different origins, both forms of DMT are known for their incredible potency and intense effects.

 

Effects of DMT

Both N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine are among the most potent drug experiences one can have. If not the strongest, they are certainly in the running for the title.

 

N, N-Dimethyltryptamine is a powerful hallucinogen that elicits varying effects depending on the dosage. At lower doses, it can induce intense visual hallucinations, both with eyes closed and open. At higher doses, it can transport users to entirely new realms, where they may encounter otherworldly beings of a mystical nature.

 

5-MEO-DMT, on the other hand, elicits a strange shift in perspective that is often described as a near-death experience. Being less well-known and less commonly encountered, it remains a largely mysterious substance with obscure, hard-to-define effects. Regardless, its potency cannot be disputed.

 

Mescaline

Mescaline is a potent psychedelic alkaloid most frequently discovered in certain species of cacti, such as Peyote and San Pedro. With a rich history of shamanic use stretching back centuries, this hallucinogenic compound has captivated the imaginations of people across the world. Its fame reached new heights with the publication of “The Teachings of Don Juan,” a book that chronicled the journey of an anthropologist who ventured to Mexico to explore the use of Peyote with a shaman. This fascinating tale introduced Mescaline and its powerful effects to a broader audience, solidifying its place in the annals of psychedelic history.

 

Effects of Mescaline

Mescaline is said to produce effects that are similar to those of psilocybin, although this comparison is likely a pale one. The effects of Mescaline can be profound and include significant mental, visual, and auditory distortions, including closed and open-eye visuals. Some users report a greater detachment between mind and body, but this is not necessarily experienced as a negative. Wide open spaces enhance the Mescaline experience, while enclosed spaces and forests may feel constricting.

 

As with all psychedelics, Mescaline provides a deep, reflective, and philosophical experience. However, thoughts and emotions may come and go more quickly with Mescaline than with other psychedelics such as LSD. This makes Mescaline a valuable tool for exploring the self and contemplating big questions. In some cases, total ego death is possible with Mescaline use.

 

MDMA

MDMA, commonly known as the party drug, is a unique substance that defies categorization. While it may not strictly be classified as a psychedelic or hallucinogen, its effects are undeniably trippy. Users often report feeling an intense rush of energy and an overwhelming sense of empathy and connection to others.

 

Contrary to its ancient counterparts, MDMA is a relatively new drug, with its origins dating back just over a century. Developed by the pharmaceutical company Merck in 1912, it was initially used for therapeutic purposes but was soon embraced by the recreational scene in the 1960s and 1970s.

 

However, with the increasing stigma and outlawing of psychedelics during that time, MDMA faced the same fate and was banned along with other drugs in the same category. Despite this, it remains a popular substance and continues to evoke strong emotions and trippy experiences for those who use it.

 

Effects of MDMA

MDMA is a powerful and complex drug that induces feelings of happiness, empathy, and love, making it popular in social settings. However, high doses can cause intense hallucinations and physical effects such as elevated heart rate and blood pressure, jaw clenching, and body temperature, making it dangerous if taken in excess or with other drugs.

 

Despite its euphoric effects, it also has a brutal come-down, leading to physical exhaustion and emotional turmoil. These side effects are usually minimal when taken occasionally and in moderation.

 

LSD

LSD, the mind-bending compound more commonly known as “acid,” is a psychedelic of legendary proportions. With just 25 micrograms, you’ll be launched into a world of intense, vivid hallucinations and mind-bending experiences. One microgram is a millionth of a gram, making LSD one of the most potent drugs on the planet.

Typically consumed in tab form, the liquid LSD is placed under the tongue, absorbed through the mucous membrane, and into the bloodstream. Alternatively, it can be directly dropped onto the tongue.

 

Albert Hoffman created this mind-altering substance in 1938 and went on to be the subject of military research exploring its potential to enhance soldiers’ abilities. However, these trials proved to be unsuccessful, and LSD instead became synonymous with the hippie movement and a symbol of countercultural expression.

 

Effects of LSD

LSD is a potent psychedelic known for its fear-inducing and misunderstood reputation. However, it can also lead to enjoyable experiences if approached with caution. LSD can cause powerful changes in perception, vision, and sound, along with altered thoughts that can lead to deep philosophical conversations. Despite its association with the “bad trip” and the hippy movement, LSD remains one of the most potent drugs in the world.

 

Salvia

Salvia divinorum, also known as the “Seer’s Sage,” may be legal in some areas, but it is by no means a mild or inconsequential substance. It is incredibly potent, particularly in extract form, which can be a hundred times stronger than the naturally grown leaf.

 

While some might try it out of curiosity as teenagers, it is not uncommon for people to never revisit this drug after their initial experience. This has less to do with its quality and more with the assumption that its legality equates to a lack of potency. Salvia divinorum is anything but mild.

 

Effects of Salvia

Salvia’s effects are akin to those of DMT but with a potent rush that can make you feel hurtling through space, even when you’re stationary. With its intense visuals and otherworldly experiences, it’s essential to proceed cautiously when trying salvia for the first time. Always start with a low dose to get a better handle on the power of this mind-bending substance. Don’t be fooled by its legal status – salvia is a severe drug and not to be taken lightly.

 

Conclusion

Psychedelics are potent substances that can have both profound and potentially dangerous effects. From LSD to MDMA, salvia, and more, it’s crucial to approach these drugs with caution and understanding and to understand both the positive and negative consequences that can come with their use.

 

Whether for personal exploration or social situations, it’s essential to respect these substances’ power and use them responsibly. With this understanding in mind, the world of psychedelics can offer an incredible journey of self-discovery and growth.

 

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Psychedelics Can Help with Which Severe Mental Health Disorders?

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Which Severe Mental Disorders Can Psychedelics Help With?

Severe mental illnesses refer to conditions that leave the patient with significant functional impairment and extreme symptoms. Sometimes, these may include serious symptoms such as psychosis, which can have harmful consequences if they aren’t diagnosed and treated early on.

Common treatments for serious mental health disorders vary; they usually include a combination of somatic and psychotherapeutic treatments. When it comes to medications, these can include antidepressants, antipsychotics, mood stabilizers, and anti-anxiety medications. Severe cases of depression may require neurofeedback, and other brain stimulation therapies to work. Until now, there is no one-size fits-all solution for mental health disorder treatments; many patients usually find success, if any, in using a combination of therapies for many years – sometimes, for life.

In fact, many patients even develop a tolerance to medications. This can make it difficult to find drugs that work, yet even then, most medications come with unwanted side effects.

But the rise of psychedelic use has brought about promise for those struggling with mental health problems, and their families. No other medication can induce psychological and neurobiological changes the way psychedelics can, thereby improving cognitive function and emotional processing. Psychedelics activate serotonin receptors, enhance neuroplasticity, and disrupt the default mode networks that cause rigid thinking and worsen depression. Because of this, psychedelics are considered a revolutionary treatment for severe mental health conditions that are resistant to treatment.

Check out this list of severe mental health disorders, and how psychedelics can help treat them.

Schizophrenia

Schizophrenia is a severe, chronic mental health disorder that greatly affects the way a person thinks, behaves, and fees. The main symptom of schizophrenia is a serious disconnection and detachment from reality, which can manifest through symptoms of psychosis. These may include delusions, hallucinations, disorganized behavior, and disorganized thinking.

Schizophrenia can be extremely challenging to treat and manage due to many factors, most especially the fact that the symptoms drastically differ from one patient to another. Also, many individuals with this condition don’t respond to conventional treatment.

Many studies have shown that psychedelics are promising for treating schizophrenia and managing its symptoms, allowing patients to regain control and enjoy a better quality of life. That said, it must be acknowledged that small doses of psychedelics are needed because larger doses may have negative effects. Keeping the doses at a clinically accepted low level can induce powerful anti-inflammatory properties especially benefiting patients’ brain function.

Additionally, regulated doses have been found to be well-tolerated and effective in treating several mental illnesses, including schizophrenia, which is notoriously difficult to treat.

 

Borderline Personality Disorder

Borderline personality disorder or BPD is a very complex mental health disorder whose hallmark symptoms include unstable relationships, severe emotional dysregulation, and constant impulsive actions. For this reason, it can also be known as emotionally unstable personality disorder. Some severe cases include high suicidal tendencies.

Successful treatment can feel like an uphill battle, as many patients often drop out. It has become critical to develop new treatments for BPD which have less side effects, and are certainly much more effective.

However, some research has pointed to psychedelic therapy. In one study in particular, authors found that MDMA combined with psychotherapy is effective and safe for treating borderline personality disorder. Researchers found that it provides a safe and beneficial alternative even for treating chronic PTSD, a co-occurring disorder of BPD. The researchers also found that MDMA was effective even when administered just twice or thrice during the course of a treatment, whereas psychotropic drugs commonly prescribed in psychiatry often must be taken everyday for a certain period of time.

The treatment, known as MDMA-assisted psychotherapy, is gaining traction for treating other complex mental health disorders as well.

 

Severe Anxiety Disorders

Severe anxiety disorders significantly impact the daily life, as well as quality of life, of patients. Whereas generalized anxiety disorders may be occasional bouts of anxiety, severe anxiety is intense, persistent, and chronic.

Patients with severe anxiety disorders excessively ruminate and worry about things that often can’t be controlled, even without a trigger. It can manifest physically, such a through hyperventilation, shakes, sweating, and a racing heart. Long term effects include insomnia, headaches, fatigue, and difficulty thinking straight. The severe anxiety is so debilitating that it requires serious and professional interventions for patients to regain their quality of life.

Thankfully, a handful of various psychedelics have shown promising results for treating severe anxiety disorders, even where conventional medications have failed. Psilocybin is one of the most widely studied psychedelics for treating chronic anxiety; studies show that it has long-lasting results in anxiety management, with excellent results observed months even after the last treatment.

LSD (lysergic acid diethylamide), or also known as acid, has also been widely studied for mental health disorders especially anxiety. According to studies, LSD can enhance cognitive flexibility and reduce anxiety scores especially when used in psychotherapy. As a result, patients can break rigid mental thought patterns that can influence anxiety-driven behaviors. LSD interacts with serotonin receptors in the brain, such as 5-HT1A and many others, which help regulate mood and reduce anxious behaviors.

MDMA’s potential for treating anxiety and other mental health disorders likewise continues to grow. Patients who struggle with anxiety show positive responses to MDMA; it has been shown to strengthen emotional processing while improving the coping mechanisms of patients. Also known by its street drug names molly or ecstasy, MDMA works well in modulating neurotransmitters in the brain, including dopamine, serotonin, and norepinephrine. These all play an important role in regulating one’s emotions and improve overall mood.

CONCLUSION

If you or a loved one are struggling with mental health disorders and would like to experiment with psychedelics, it’s always recommended to do so in a clinical setting. These are not conditions wherein self-medicating is advisable, because of the harmful side effects of taking too much or too little, as well as the potential interactions of psychedelics with other medications.

Therapy sessions in a controlled environment is the best, safest way to medicate with psychedelics for severe mental health disorders. Reach out to a medical professional to get started, but do your own research.

 

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How Worried Should You Be about Schizophrenia and Psychosis if You Smoke Weed?

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Should You Really Be Worried About Schizophrenia and Psychosis If You Smoke Weed?

Occasionally, a study on cannabis and schizophrenia or psychosis makes its way to the internet and becomes viral for a few weeks. It gets republished and circulated across numerous news channels and social media sites, spreading often unnecessarily alarming news and fear-mongering.

So what’s the truth behind it? Should you really worry about developing schizophrenia and psychosis if you smoke weed?

Let’s get the facts sorted first.

 

Schizophrenia

Schizophrenia is a chronic mental health disorder characterized by hallucinations, delusions, cognitive distortion, trouble thinking straight, and lack of motivation. Extreme cases of schizophrenia can also lead to episodes of psychosis or delusion, which is what occurs when an individual can no longer tell the difference between reality and fiction. Being severely disconnected from reality can occur among patients of schizophrenia and psychosis, but these can be caused by a wide range of physical or mental conditions.

What Causes Schizophrenia?

There is no one known cause for schizophrenia, though several environmental and genetic factors can contribute to its symptoms. It’s also known to run in families, so if someone in your family tree has had schizophrenia, it’s important to practice caution when using drugs and alcohol.

Certain environmental triggers can cause psychotic or schizophrenic episodes, particularly going through extremely stressful life events. Stressful environments, such as fast-paced cities, may also trigger symptoms. Other factors include the experience of childhood trauma, or certain changes in brain chemistry.


Cannabis: Treatment Or Cause?

The symptoms of schizophrenia can be managed or reduced through the use of antipsychotic medications, which are typically the first line of defense for this condition. First-generation antipsychotics, such as Chlorpromazine, Perphenazine, and Fluphenazine, are examples of widely-used schizophrenia treatments. Second-generation antipsychotic treatments include Aripiprazole, Lurasidone, Clozapine, Quetiapine, and several others. In some occasions, doctors may also prescribe antidepressants if antipsychotic drugs don’t help with the depressive episodes that may be associated with schizophrenia.

However, many antipsychotic medications come with unwanted side effects. They commonly include sexual dysfunction, weight gain, sedation, heart problems, difficulty urinating, and many more.

The use of cannabis-based medications for treating the symptoms of schizophrenia has been gaining traction in the medical and scientific community over the past few years. That said, we must differentiate the compounds used in cannabis because we can’t generalize all the compounds in the plant and its effects on the human body. Tetrahydrocannabinol (THC), the psychoactive compound in marijuana, and cannabidiol (CBD), a relaxing, non-psychoactive compound, both work differently in the human body.

What The Research Says

Several studies have shown that CBD could be promising for treating and even mitigating the symptoms of schizophrenia and psychosis. This is especially true if the condition is in its early stages.

For example, in a review conducted in 2021, scientists found that CBD may be beneficial in adjusting the levels of different brain chemicals which have been associated with symptoms of psychosis. One of these is anandamide – and the study found that CBD can increase its levels in the brain.

Anandamide is an endocannabinoid, and it’s believed to help reduce psychotic episodes through several mechanisms in the brain. For one, high levels of anandamide have been observed as successful in mitigating acute cases of schizophrenia.

Meanwhile, another review discovered minor albeit significant evidence that CBD could possibly reduce the symptoms of schizophrenia when administered in high doses. In the review, the researchers noted that 800 mg of CBD were given to patients over the course of 4 weeks. The results were similar to those yielded by amisulpride, an antipsychotic drug which is used in the treatment of psychosis. A similar trial found that 1,000 mg of CBD given to patients over 6 weeks was effective in reducing schizophrenia symptoms.

The results of a 2024 clinical trial also found that CBD was successful in mitigating the symptoms of patients who were at high risk for psychosis. For the study, there were 31 patients involved; they were given either 600 mg of CBD or a placebo everyday for 3 weeks. However, they weren’t given any prescription drugs during the course of the study. Researchers analyzed their baseline at 7 and then again at 21 days.

“Short-term treatment with CBD can ameliorate the symptoms of CHR state for psychosis and is well tolerated. These results highlight the potential of CBD as a novel treatment for psychosis, and the need for large-scale efficacy studies to further evaluate its clinical utility,” concluded the study’s authors.

So Who Needs To Worry About Schizophrenia and Cannabis Use?

Smoking pot won’t make you go psychotic. It doesn’t cause schizophrenia per se.

That said, those with pre-existing mental health conditions must tread lightly and be very cautious when it comes to using high THC products. In other words, if you already have a family history of schizophrenia or have had a history of psychotic episodes, THC may not be the medicine or recreational drug for you. Individuals with bipolar disorder, delusional disorder, or other similar personality and mood disorders with a tendency to have episodes of psychosis should first seek out medical attention.

Products containing high levels of THC may not be recommended in these situations, though CBD may help reduce symptoms. If you aren’t sure, it’s always best to consult with your medical provider.

 

Conclusion

Even if there is promising evidence that CBD can be beneficial for schizophrenia, we must be careful not to consider it as a substitute for any kind of medical treatment. There are many different types of cannabis products out there but there isn’t one-size-fits-all solution for mental health disorders. So while most people wouldn’t have a problem smoking weed, there is a small subset of the population as mentioned earlier – who do have to be careful.

 

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What are Cannabis Dissolvables? Are These Products Trendy, or are They Worth Trying?

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What are Cannabis Dissolvables? Are These Products Trendy, or are They Worth Trying?

For cannabis enthusiasts who enjoy experimenting with consumption in an array of forms, or even for medical marijuana patients who simply want to look for the most convenient way to medicate, we’re spoiled with choices these days.

From vaping to smoking, edibles and beverages, tinctures, topicals, pills, and suppositories, there’s a way to medicate for everyone. But recently, a new way to consume marijuana has had some people talking: cannabis dissolvables! You might have heard about them as dissolvable cannabis powder or THC powder; these revolutionary powders are manufactured with cannabinoids and designed to be mixed into your food or drink. Upon consumption, you can enjoy the effects of cannabis within minutes.

But they work just like edibles, then, don’t they?

Nope!

Dissolvable cannabis powders are known for their fast-acting effects, which means that you can expect to feel the impact of the cannabinoids within minutes of consuming it in your food and drink. That’s because cannabis powders are water-soluble, allowing almost immediate absorption of the cannabinoids in your bloodstream. On the other hand, edibles can sometimes take up to 90 minute to take effect.

Why You Should Try Dissolvable Cannabis Powders

There are several reasons why you should give dissolvables a try:

 

  1. There are odorless and flavorless options in the market: Marijuana dissolvable powders that are neutrally flavored make it a breeze to add to your favorite drinks and food, without worrying about altering its flavor. Gone are the days when you’d be surprised by the often-undesirable flavors of supplement powders; now with flavorless cannabis powders, you can easily medicate while still enjoying the taste of your favorite food and drinks.

Smoothies, baked goods, juices, coffee, and oatmeal are just some examples of common items you can easily add THC powders to. That said, you can also find flavored options in the market if that’s what you prefer.

  1. High bioavailability: Cannabis powders are formulated to be absorbed efficiently. This way, your body can metabolize and absorb all or most of the cannabinoids in the product. Thanks to enhanced absorption, you can maximize the benefits of the cannabinoids.

  2. Accurate dosing: For consumers who prioritize precision dosing in cannabis, powders are superior when it comes to this. Getting an accurate dose is so easy, since packets are already pre-measured. Meanwhile, powders can also easily be measured using a spoon. This offers total control over how much you’re ingesting, which is particularly important for medical users who require consistent dosing for symptom relief.

  3. Discretion: When you add cannabis powders to your food or beverages, they don’t have that notorious smell that cannabis smoke is known for. Because they are either odorless or have a neutral odor, there’s no need to worry that taking it out and mixing it into a drink will alert people around you.

  4. Low or no calories: Most cannabis powders have little to no calories, so it’s a healthy choice for calorie-conscious individuals. Whether you are looking to make a healthier choice or simply want to experiment with cannabis formulations in the kitchen, dissolvable cannabis powders are an easy way to do so.

 

What Conditions Can Cannabis Powders Help With?

 

While dissolvable cannabis can benefit all patients, cannabis powders have a particular advantage for patients of certain conditions:

 

  • Nausea and vomiting: Patients who are undergoing chemotherapy, or recovering from eating disorders, may find that medicating with cannabis simply through food and drink is an efficient way to medicate. These conditions make it difficult to keep nutrients down due to the constant urge to vomit, but that makes it even more important to eat – in order to have the necessary vitamins and minerals to recover. Mixing cannabis powders in water or juices provides a gentle alternative to medicating and keeping food down.

  • Pain: Fast-acting cannabis works so well for pain relief. If you suffer from chronic pain and rely on cannabis for symptom relief, you can explore using cannabis powders. Thanks to its excellent bioavailability and quick results, there’s no need to wait several minutes to feel better. Powder can interact with the endocannabinoid system fast in order to reduce inflammation within minutes and positively affect the pain perception pathways.

  • Insomnia and sleep problems: Cannabis is an excellent natural medication for treating insomnia and other sleep problems. This is especially true if symptoms from another condition can cause difficulty falling or staying asleep, such as pain or general discomfort caused by inflammatory conditions. Consuming cannabis powders a few minutes before bedtime can help you hit two birds with one stone: enjoy relief from your symptoms, while easing into a comfortable state of sleep.

  • Anxiety relief: Many cannabis drink mixes are made with CBD, which provides excellent relief from anxiety. Start your day with a healthy dose of CBD to mitigate anxiety, and help you get through the day with some peace of mind.

 

In addition, many powder mixes are also formulated with other healthy ingredients. These vary from one product to another, and may include electrolytes, functional ingredients, hemp, terpenes, and other cannabinoids.

 

Conclusion

Dissolvable cannabis powders are innovative, but they are also accessible and inclusive, offering a convenient way to medicate. Whether you are a recreational cannabis consumer or a medical marijuana patient, the benefits of cannabis dissolvable powders are endless. Check out your neighborhood dispensary to explore dissolvable cannabis and share with us your favorite way to consume it.

 

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