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Forget Highest THC Levels, What are the 5 Most Potent Psychedelics Out There?



Psychedelic substances can profoundly alter our perception of reality, revealing new dimensions and possibilities. With their vast potential, we are just beginning to tap into their full potential. Although the strength of psychedelics is challenging to quantify, their potency cannot be denied. From natural psychedelics to laboratory-created compounds, these drugs can trigger mystical experiences, transporting users to otherworldly realms.


As the effects of psychedelics vary significantly from person to person, it is challenging to determine which is the strongest. However, a few drugs are known for their particularly intense effects. Here are what could be considered the top five most potent psychedelics.



DMT is a powerful substance with two variations: N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine.

The first form, N, N-Dimethyltryptamine, is the more commonly encountered molecule and can be found in many living organisms. This type of DMT is found in Ayahuasca brews and in its powdered form, which can be smoked or vaped.


On the other hand, 5-MEO-Dimethyltryptamine, with a 5-MEO molecular tail, is less commonly found in nature and less accessible as a drug. This form is found in the venom of a specific toad consumed in some shamanic rituals. Additionally, it can be delivered through the nasal passages using “Yopo.” In modern times, it has been paired with ibogaine to explore its potential in addressing addiction.


Despite their different origins, both forms of DMT are known for their incredible potency and intense effects.


Effects of DMT

Both N, N-Dimethyltryptamine, and 5-MEO-Dimethyltryptamine are among the most potent drug experiences one can have. If not the strongest, they are certainly in the running for the title.


N, N-Dimethyltryptamine is a powerful hallucinogen that elicits varying effects depending on the dosage. At lower doses, it can induce intense visual hallucinations, both with eyes closed and open. At higher doses, it can transport users to entirely new realms, where they may encounter otherworldly beings of a mystical nature.


5-MEO-DMT, on the other hand, elicits a strange shift in perspective that is often described as a near-death experience. Being less well-known and less commonly encountered, it remains a largely mysterious substance with obscure, hard-to-define effects. Regardless, its potency cannot be disputed.



Mescaline is a potent psychedelic alkaloid most frequently discovered in certain species of cacti, such as Peyote and San Pedro. With a rich history of shamanic use stretching back centuries, this hallucinogenic compound has captivated the imaginations of people across the world. Its fame reached new heights with the publication of “The Teachings of Don Juan,” a book that chronicled the journey of an anthropologist who ventured to Mexico to explore the use of Peyote with a shaman. This fascinating tale introduced Mescaline and its powerful effects to a broader audience, solidifying its place in the annals of psychedelic history.


Effects of Mescaline

Mescaline is said to produce effects that are similar to those of psilocybin, although this comparison is likely a pale one. The effects of Mescaline can be profound and include significant mental, visual, and auditory distortions, including closed and open-eye visuals. Some users report a greater detachment between mind and body, but this is not necessarily experienced as a negative. Wide open spaces enhance the Mescaline experience, while enclosed spaces and forests may feel constricting.


As with all psychedelics, Mescaline provides a deep, reflective, and philosophical experience. However, thoughts and emotions may come and go more quickly with Mescaline than with other psychedelics such as LSD. This makes Mescaline a valuable tool for exploring the self and contemplating big questions. In some cases, total ego death is possible with Mescaline use.



MDMA, commonly known as the party drug, is a unique substance that defies categorization. While it may not strictly be classified as a psychedelic or hallucinogen, its effects are undeniably trippy. Users often report feeling an intense rush of energy and an overwhelming sense of empathy and connection to others.


Contrary to its ancient counterparts, MDMA is a relatively new drug, with its origins dating back just over a century. Developed by the pharmaceutical company Merck in 1912, it was initially used for therapeutic purposes but was soon embraced by the recreational scene in the 1960s and 1970s.


However, with the increasing stigma and outlawing of psychedelics during that time, MDMA faced the same fate and was banned along with other drugs in the same category. Despite this, it remains a popular substance and continues to evoke strong emotions and trippy experiences for those who use it.


Effects of MDMA

MDMA is a powerful and complex drug that induces feelings of happiness, empathy, and love, making it popular in social settings. However, high doses can cause intense hallucinations and physical effects such as elevated heart rate and blood pressure, jaw clenching, and body temperature, making it dangerous if taken in excess or with other drugs.


Despite its euphoric effects, it also has a brutal come-down, leading to physical exhaustion and emotional turmoil. These side effects are usually minimal when taken occasionally and in moderation.



LSD, the mind-bending compound more commonly known as “acid,” is a psychedelic of legendary proportions. With just 25 micrograms, you’ll be launched into a world of intense, vivid hallucinations and mind-bending experiences. One microgram is a millionth of a gram, making LSD one of the most potent drugs on the planet.

Typically consumed in tab form, the liquid LSD is placed under the tongue, absorbed through the mucous membrane, and into the bloodstream. Alternatively, it can be directly dropped onto the tongue.


Albert Hoffman created this mind-altering substance in 1938 and went on to be the subject of military research exploring its potential to enhance soldiers’ abilities. However, these trials proved to be unsuccessful, and LSD instead became synonymous with the hippie movement and a symbol of countercultural expression.


Effects of LSD

LSD is a potent psychedelic known for its fear-inducing and misunderstood reputation. However, it can also lead to enjoyable experiences if approached with caution. LSD can cause powerful changes in perception, vision, and sound, along with altered thoughts that can lead to deep philosophical conversations. Despite its association with the “bad trip” and the hippy movement, LSD remains one of the most potent drugs in the world.



Salvia divinorum, also known as the “Seer’s Sage,” may be legal in some areas, but it is by no means a mild or inconsequential substance. It is incredibly potent, particularly in extract form, which can be a hundred times stronger than the naturally grown leaf.


While some might try it out of curiosity as teenagers, it is not uncommon for people to never revisit this drug after their initial experience. This has less to do with its quality and more with the assumption that its legality equates to a lack of potency. Salvia divinorum is anything but mild.


Effects of Salvia

Salvia’s effects are akin to those of DMT but with a potent rush that can make you feel hurtling through space, even when you’re stationary. With its intense visuals and otherworldly experiences, it’s essential to proceed cautiously when trying salvia for the first time. Always start with a low dose to get a better handle on the power of this mind-bending substance. Don’t be fooled by its legal status – salvia is a severe drug and not to be taken lightly.



Psychedelics are potent substances that can have both profound and potentially dangerous effects. From LSD to MDMA, salvia, and more, it’s crucial to approach these drugs with caution and understanding and to understand both the positive and negative consequences that can come with their use.


Whether for personal exploration or social situations, it’s essential to respect these substances’ power and use them responsibly. With this understanding in mind, the world of psychedelics can offer an incredible journey of self-discovery and growth.





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Almost 20% of Americans Now Use Cannabis Regularly and Pain Management is the #1 Reason They Use It




1 in 6 americans use weed now

The number of people using medical cannabis to address health issues is increasing. A recent study has shed more light on this growing trend.


Research conducted by experts at the University of California Los Angeles indicates that one in six primary care patients (17%) surveyed reported using cannabis primarily for medical reasons, even though they described it as recreational use. The study also found that a third of participants (34.7%) showed signs of moderate to high risk for cannabis use disorder.


This cross-sectional study, involving 175,734 patients and published last week in JAMA Network Open, asked, “What is the prevalence of past 3-month cannabis use, and what are the reasons for use among patients in a large health system?”


Interestingly, the number of people who consider themselves medical cannabis users is low.


“While most patients (76.1%) reported using cannabis to manage a health symptom, very few patients identified as medical cannabis users,” the researchers noted.


They emphasized that “given the high rates of cannabis use, especially for symptom management, and the high levels of disordered use, it is essential that health care systems implement routine screening of primary care patients.”


Fruit-Flavored Weed Strains Lead the Demand


Meanwhile, a separate survey conducted by the cannabis company NuggMD has revealed that fruit-flavored weed strains are in the highest demand. This survey found that one in four marijuana consumers use cannabis primarily to treat pain, with a significant preference for strains with fruity flavors. Slightly fewer respondents reported using cannabis to alleviate anxiety symptoms (23%), followed by those using it for stress relief (18%).


The poll, conducted in May, included feedback from 6,500 cannabis users who answered a series of questions about their habits and preferences regarding cannabis use.


A substantial portion of respondents (48%) indicated they use cannabis “anytime,” while a notable segment (29%) preferred to use it in the evening.


As cannabis continues to become more mainstream, the latest regulatory changes around the plant are not surprising. Additionally, the potential rescheduling of marijuana could further advance research into its uses and benefits.


Rising Need for Routine Screening in Healthcare Systems


The report emphasizes how important it is for healthcare institutions to regularly screen for cannabis usage. Healthcare professionals need to be aware of their patients’ cannabis usage to provide complete treatment, as a sizable number of patients use cannabis to manage health issues. Numerous patients reported taking cannabis for stress relief, anxiety reduction, and pain management—often without thinking about it as a medicinal application. The difference between the perception of cannabis usage for recreational purposes and its real medicinal use highlights the need for healthcare providers to inquire about cannabis use when seeing patients aggressively.


Routine screening can assist in identifying people who are at risk of developing cannabis use disorder. With more than a third of the study’s participants exhibiting indicators of moderate to high risk for this condition, healthcare systems must conduct regular examinations. These screens can help with early detection and intervention, preventing usage from escalating into a condition. Furthermore, knowing patients’ cannabis usage patterns might help healthcare practitioners create more effective, tailored treatment programs that take into account all elements of a patient’s lifestyle and drug use.


Improved communication between patients and providers can also be facilitated by including cannabis usage testing in basic care. Because of the stigma or concern about being judged, many patients might not willingly admit that they use cannabis. Healthcare practitioners may establish a more transparent and trustworthy atmosphere by including these conversations in standard examinations. This method improves the care of each patient individually while simultaneously advancing our knowledge of cannabis usage patterns and how they affect the health of a larger group of patients.


Furthermore, routine screening data may be used by healthcare systems to guide public health policies and activities. Healthcare professionals may make significant contributions to the continuing study and discussion around cannabis use and regulation by methodically gathering data on patients’ reasons for and methods of cannabis usage. These understandings can help legislators craft laws that encourage responsible and safe cannabis use, improving public health outcomes in the process.


Evening Use Dominates Among Cannabis Consumers


One important result from the NuggMD poll is that users prefer to use cannabis in the evening, with roughly 29% of respondents saying they use it mostly at night. This trend demonstrates how people are incorporating cannabis into their everyday lives, frequently as a way to decompress and rest after a long day. When cannabis is used in the evening, users may still benefit from its medicinal properties—such as pain and stress relief—without getting in the way of their day obligations.


This pattern of nighttime usage corresponds to the top three reasons many people use cannabis: pain treatment, anxiety relief, and stress reduction. For people suffering from chronic pain or anxiety, the evening may be tough as the day’s activities come to a close and the mind becomes preoccupied with agony or worry. Using cannabis in the evening alleviates these sensations while also encouraging greater sleep and general relaxation. The predilection for fruity-flavored strains, which are generally recognized for their soothing qualities, contributes to the nighttime usage trend by allowing users to acquire a sense of calmness.


The shift in cannabis usage into the evenings is also indicative of larger cultural shifts in cannabis acceptability and perception. Cannabis usage is becoming more widely acknowledged as a regular way to unwind after work or other everyday activities as it becomes more widely available and socially accepted. This transformation is brought about by changes in the law that facilitate easier access to cannabis as well as the expanding body of research that supports the plant’s medicinal properties. As a result, cannabis usage in the evenings may increase and become more ingrained in many people’s daily lives.


Bottom Line


The landscape of cannabis use in America is rapidly evolving, with one in six Americans turning to marijuana, predominantly fruity-flavored strains, for pain relief and other health concerns. This trend underscores a significant shift towards cannabis as a medical option, despite many users initially categorizing it as recreational. The findings highlight a crucial need for healthcare systems to implement routine screening for cannabis use, given its prevalence and potential risks of use disorder. Moreover, as regulatory frameworks continue to adapt, including potential rescheduling, there is a growing opportunity to advance research and public health initiatives surrounding cannabis. Understanding and addressing these dynamics will be essential for optimizing patient care, promoting responsible use, and shaping future policies effectively.





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Weed Smokers Needed – Get Paid to Smoke a Joint and Talk about How It Makes You Feel, Would You Join This New Medical Study?




smoke a joint for money

The cannabis industry has witnessed unprecedented growth in recent years, with increasing legalization and a burgeoning market for products. Amidst this expansion, a unique opportunity has emerged for individuals to contribute to the scientific understanding of cannabis while earning compensation. A company is willing to pay participants to consume marijuana joints and participate in research studies, sparking curiosity and interest. In this article, we’ll delve into the world of cannabis research, exploring the reasons behind this initiative, the potential benefits, and the intricacies of such studies.

The Purpose of Cannabis Research

Cannabis, a plant with a rich history, has been shrouded in mystery and controversy. As societal attitudes and laws evolve, the need for comprehensive research intensifies. Scientists aim to unravel the complexities of cannabis, investigating its effects on human physiology, psychology, and behavior. This knowledge will inform product development, potential therapeutic applications, and responsible use guidelines.


Objectives of the Study

The primary objectives of the study encompass a broad range of scientific and consumer-focused goals. By paying individuals to consume pre-rolled cannabis joints, the company aims to achieve the following:

  • Understanding Cannabis Effects: To gain a deeper understanding of the physiological and psychological effects of cannabis consumption, including both immediate and long-term impacts.

  • Consumer Preferences: To identify consumer preferences regarding different strains, potency levels, and consumption methods, which can inform product development and marketing strategies.

  • Safety and Efficacy: To assess the safety and efficacy of various cannabis products, providing valuable insights for regulatory bodies and healthcare providers.

  • Public Health Insights:To contribute to the broader body of knowledge regarding cannabis use and its implications for public health.

The Role of Cannabis in Scientific Research

Cannabis has been a subject of scientific interest for decades, with research focusing on its medicinal properties, potential health benefits, and risks. The legalization and decriminalization of cannabis in various regions have paved the way for more comprehensive studies, yet challenges remain due to regulatory constraints and the stigma associated with cannabis use.

  1. Medicinal Properties: Research has shown that cannabis can be effective in managing conditions such as chronic pain, epilepsy, and multiple sclerosis. This study aims to further explore these medicinal benefits.

  2. Recreational Use: Understanding the patterns and effects of recreational cannabis use can inform public health initiatives and harm reduction strategies.

  3. Policy Development: Data collected from such studies can support evidence-based policy development, helping to create regulations that balance public safety with individual freedoms.


Eligibility and Participation

Individuals interested in participating must meet specific criteria, including:

  • Age: 21+ years old

  • Health status: Generally healthy, with no severe medical conditions

  • Cannabis experience: Active users or willing to try cannabis

 Benefits for Participants

Participants will undergo thorough screenings, including medical evaluations and psychological assessments. Those selected will receive compensation for their involvement, which may include:

  • Financial Compensation: Participants are paid for their time and involvement, providing an additional incentive to take part in the study.

  • Personal Insights:By participating, individuals can gain a better understanding of how different cannabis products affect them personally.

  • Contributing to Science: Participants play a crucial role in advancing scientific knowledge and informing future cannabis-related policies and products.

  1. Safe Environment: The controlled setting ensures that participants can consume cannabis safely, with medical supervision and support available if needed.

Ethical Consideration

Conducting research involving cannabis consumption requires careful consideration of ethical issues to protect participants and ensure the integrity of the study

  1. Informed Consent: Ensuring that participants are fully informed about the study’s objectives, procedures, and potential risks is paramount.

  2. Confidentiality: Protecting the privacy and confidentiality of participants’ data is a key ethical concern.

  3. Risk Management: Implementing measures to mitigate any potential risks associated with cannabis consumption, including providing medical support if necessary.

  4. Regulatory Compliance: Adhering to all relevant regulations and guidelines to ensure the study is conducted ethically and legally.

Potential Challenges and Limitations

Despite the promising aspects of this initiative, several challenges and limitations must be acknowledged and addressed. This challenges include:

  • Regulatory Hurdles: Navigating the complex and often restrictive regulatory landscape surrounding cannabis research can be challenging.

  • Participant Variability: Differences in individual responses to cannabis can make it difficult to draw generalized conclusions from the data.

  • Stigma and Perception: The stigma associated with cannabis use may deter some individuals from participating in the study.

  • Data Interpretation: Ensuring the accurate interpretation of data, especially when dealing with subjective experiences and self-reported outcomes.

Implications for the Cannabis Industry

The findings from this study could have significant implications for  the cannabis industry, influencing product development, marketing strategies, and regulatory frameworks.

  1. Product Development: Insights into consumer preferences and effects can guide the development of new cannabis products that meet market demands and safety standards.

  2. Marketing Strategies: Understanding how different demographics respond to cannabis can inform targeted marketing efforts and improve consumer engagement.

  3. Regulatory Frameworks: The data collected can support the creation of evidence-based regulations that promote safe and responsible cannabis use.

  4. Industry Standards: Establishing industry-wide standards for product safety, quality, and efficacy based on scientific evidence.

Future Directions and Research Opportunities

This initiative represents a significant step forward in cannabis research, but it also highlights the need for continued exploration and study.

  1. Longitudinal Studies: Future research should include long-term studies to assess the chronic effects of regular cannabis use.

  2. Diverse Populations: Including a diverse range of participants can help ensure that findings are applicable to a broader population.

  3. Cross-Disciplinary Research: Collaborating with experts from various fields, such as pharmacology, psychology, and public health, can provide a more comprehensive understanding of cannabis use.

  4. Technological Integration: Utilizing advanced technologies, such as biometric monitoring and data analytics, can enhance the accuracy and depth of research findings.


The initiative to pay individuals for consuming pre-rolled cannabis joints as part of scientific research marks a novel and important development in the study of cannabis. By offering financial compensation and conducting the study in a controlled environment, the company aims to gather valuable data on the effects, safety, and consumer preferences related to cannabis use. This research has the potential to significantly impact public health, policy, and industry practices, contributing to a more informed and balanced understanding of cannabis. As the landscape of cannabis research continues to evolve, such initiatives underscore the importance of scientific inquiry in shaping the future of this dynamic and growing industry.





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What Hunter Biden’s Verdict Means for Cannabis Users




I wrote about Robert Hunter Biden’s indictment for violation of federal gun laws in a post entitled “What the Hunter Biden Indictment Means for Cannabis Users” back in September 2023. On June 11, 2024, a jury in a federal district court in Delaware found Hunter guilty of three felony counts. Today I want to look at how this could affect cannabis users.

Cannabis legalization and gun control laws

Below is a list of prior posts from our blog on the intersection between cannabis legalization and federal gun control laws, which give a lot of background to what this post discusses:

Without rehashing these prior posts, the main issue is that federal law prohibits ownership or possession of guns by persons who are addicted to or unlawfully use controlled substances. This includes cannabis, even in states where it is legal, and even if it is for purely medical purposes. In fact, the ATF’s required form to purchase a firearm states this clearly.

In 2022, the US Supreme Court rendered a decision in New York State Rifle & Pistol Association, Inc. v. Bruen, which changed the tests courts use to determine whether laws infringe the Second Amendment.

Following Bruen, numerous federal court challenges have been lodged against the federal prohibition on gun possession or ownership by cannabis users. Many of these cannabis-related challenges have been successful. In fact, federal courts have already found different federal firearm restrictions unconstitutional, and the US Supreme Court is expected to rule on a similar challenge (not cannabis-related) this month.

In other words, it’s likely that in the next few years the US Supreme Court will consider an appeal regarding cannabis users’ gun rights. Based on my review of the current landscape of decisions, I believe the US Supreme Court would hold that cannabis users still have Second Amendment rights, but it would qualify that decision by allowing restrictions on possession by persons under the influence of cannabis.

The Hunter Biden matter

Now, how does this relate to Hunter Biden? Hunter’s case involved allegations that he was addicted to crack cocaine (not cannabis) when he purchased a firearm. Two of the charges related to false statements on governmental forms, and one related to possession of a gun in violation of federal law. As mentioned, the jury found him guilty on all three charges.

Once the Delaware court sentences Hunter, he is likely to challenge the above-mentioned federal laws on the grounds that they are unconstitutional under Bruen. While crack is obviously much different from cannabis, federal gun control laws treat all controlled substances the same. In other words, the law that Hunter was found guilty of violating would also apply to similarly situated cannabis users. Likewise, if the law is held to be unconstitutional with respect to drug users, it would likely apply equally to Hunter and cannabis users.

All that said, the difficulty for Hunter will be in the fact that he was charged for lying on a federal form. Even if the prohibition on gun ownership by drug users were held unconstitutional, there is still the problem that what he wrote on a federal form was not accurate. This is also an issue that some of the cannabis challengers could face as well.

What’s next for cannabis users and gun control laws

Ultimately, these federal challenges have a long way to go, and there is always the possibility that he is pardoned before an appeal is exhausted. That said, it’ll be interesting to watch folks from very different political persuasions linking up to challenge federal gun laws. As always, we’ll keep posting with more updates, so stay tuned to the blog.

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