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LSD Effective in Treating Anxiety, Phase II Clinical Trial Shows



A new drug known as MM-120, which is a more pharmacologically optimized form of popular psychedelic lysergic acid diethylamide (LSD), just entered phase II clinical trials for the treatment of generalized anxiety disorder (GAD) and other mental health disorders.  

What is LSD? 

LSD is a potent hallucinogenic which belongs to a class of drugs called ergolines (more specifically, LSD is an ergoline-based tryptamine compound), meaning it’s derived from the ergot fungus. Despite this, it still requires a lot of human processing to become LSD, so it’s not considered a natural entheogen like psilocybin or mescaline. LSD was first synthesized by Swiss chemist Albert Hoffman in 1938, but it wasn’t until 1943 that its effects were fully realized when Hoffman accidentally ingested a small amount from his lab.  

As a psychedelic, standard effects include various sensory hallucinations (visual, auditory, sensory, olfactory, etc.), as well as altered perception, feelings, and thoughts. Something that makes LSD unique is the duration and intensity of the hallucinogenic trip, which often ranges from 6 to 12 hours but has been reported to last even longer. This could be due to the way the drug binds to receptors in the brain. 

Like other tryptamines, LSD interacts with serotonin receptors, in particular, receptor 5-HT2AR. Something interesting that happens when LSD binds to 5-HT2AR, is that the receptor closes over the molecule, preventing it from leaving the brain quickly. This could explain why the effects of LSD seem to last after it has left the bloodstream.  

From this point, the serotonin receptor will activate two signaling pathways between the cells, via G-proteins and β-arrestins. LSD function primary through the latter, but that’s not always the case. Overall, ergoline compounds can be a bit mysterious in their processes, because different subgroups can have different effects on serotonin receptors. Add to that, newer research found that ergoline compounds can actually modify the structure of the receptors they interact with, in order to activate different effects.  

MM-120 clinical trials  

MM-120 (lysergide d-tartrate) is a new drug developed by MindMed, a biotech company the focuses on psychedelic-based medications. This drug is a “new and improved” version of LSD that is currently undergoing clinical trials for the treatment of generalized anxiety disorder (GAD). The most recent results from phase II of testing found that the drug candidate, particularly at the 100 µg dose, “demonstrated effectiveness, significantly reducing anxiety symptoms.” 

MindMed logo (source:

Dr. Daniel Karlin, chief medical officer of MindMed, explained the key findings in an interview with Medical News Today: “MindMed conducted this study with participation from 198 patients, all of whom suffered with a primary psychiatric diagnosis of generalized anxiety disorder (GAD), across 20 clinical sites in the United States.” 

“Participants were divided into 5 study arms; each arm received a single dose of a lysergide-based drug candidate, called MM-120 (lysergide d-tartrate), or a placebo,” Dr. Karlin continued. “Among the four groups that received a dose of MM-120, doses were 25, 50, 100, or 200 µg of MM-120. Importantly, no form of additional therapy was given to any participant. The study design evaluated the stand-alone effects of the drug candidate, MM-120,” he added. 

Karlin continued: “The data available to us at this time show that patients experienced meaningful and lasting symptom reduction. Four weeks following a single dose of MM-120, 78% of participants who received either a 100 or 200 µg dose measured as having a clinically significant response to the drug. 50% of participants who received the 100 µg dose were considered to be in clinical remission at Week 4, meaning that the patient no longer suffered from clinically significant symptoms of GAD.”  

Psychedelics for mental health disorders  

Over the years, psychedelics have proven themselves to be one of the most successful treatment options for many different mental health disorders. An overwhelming 82% percent of Americans are in favor of accelerating research on this front, but federal regulations have really been a stick in the wheel of progress here. Given the introspective and sentient nature of psychedelics, it makes sense that using them therapeutically can help a person be more honest, open, and transparent.  

Although discussion of using psychedelics therapeutically is pretty fresh for most of us, many cultures have been utilizing entheogens medicinally and in religious rituals for thousands of years. Even scientists in United States and Europe were conducting research on psychedelic compounds for the treatment of mental illnesses, and it all really began to gain traction throughout the 1940s and 1950s. 

In 1943, Swiss-chemist Albert Hofmann first synthesized lysergic acid diethylamide and by the early 1950s, psychiatrist Humphry Osmond had already pioneered a treatment regimen using LSD to cure alcoholism and other mental disorders; with relative success might I add. Osmond is the one who coined the term ‘psychedelic’, meaning ‘mind manifesting’. He also oversaw author Aldous Huxley’s infamous, therapeutic mescaline trip in 1953.  

Psychedelics have been proven effective in treating various mental health disorders

Numerous psychedelic studies were in the works during that time, but all that research was derailed for social and political reasons when entheogenic compounds were banned at the start of the 1970s. Fast forward a few decades, and we are now beginning to see a growing acceptance of these compounds, especially the naturally-derived ones, and thus, an uptick in research. One of the main areas of interest is how psychedelics can help with mental health disorders such as depression, PTSD, and addiction.  

“The evidence suggests mystical experiences help people gain a new perspective on their issues,” said Matthew Johnson, the Susan Hill Ward professor in psychedelics and consciousness at the Johns Hopkins School of Medicine. “We think the long-term biological changes will be similar to those with successful psychotherapy. Essentially, the person has learned something about this problematic behavior in their life and changed their life as a result.” 

Final thoughts 

MM-120 is the closest we’ve ever had to a clinically-proven and FDA-approved LSD-based medication. Phase II trials are currently underway, so it’s well on the path to becoming available via prescriptions in select markets, although it could still be some time before we can expect more widespread use of this drug.

Hello readers. We’re happy to have you with us at; a news source here to bring you the best in independent reporting for the growing cannabis and hallucinogen fields. Join us frequently to stay on top of everything, and subscribe to our Cannadelics Weekly Newsletter, for updates straight to your email. Check out some awesome promos for cannabis buds, smoking devices and equipment like vapes, edibles, cannabinoid compounds, amanita mushroom products, and a whole bunch more. Let’s all get stoned together!

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Cannabis and Fitness: Enhancing Your Workout Experience




In the realm of muscle building, cannabis can complement traditional approaches by addressing key aspects of the process. Cannabis’s pain-relieving properties can alleviate post-exercise soreness, facilitating faster recovery and subsequent workouts. Moreover, cannabis may reduce stress levels, promote better sleep, stimulate appetite, and enhance focus, all of which are conducive to muscle growth and development.

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A Comprehensive Guide to Improving Your Pet’s Wellness




CBD for Pets: A Comprehensive Guide to Improving Your Pet’s Wellness

Learn about the potential benefits of CBD for pets, the science behind it, and discover how to safely incorporate this natural compound into your pet’s routine for better health and well-being.

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A Guide to Medical Marijuana for Chronic Pain Relief: Strains, Delivery Methods, and Obtaining a Cannabis Card




Chronic pain affects millions of people worldwide, significantly impacting their quality of life and often leading to the development of other health conditions. Traditional treatments with prescription medications can sometimes be insufficient or accompanied by undesirable side effects, leaving patients in search of alternative methods for pain relief. Medical marijuana has emerged as a promising option for many chronic pain sufferers seeking an effective and natural treatment that offers a safer alternative to prescription opioids and other medications.

In this ultimate guide to medical marijuana for chronic pain relief, we delve into the diverse world of medical cannabis strains and delivery methods specifically tailored to address chronic pain and provide valuable information on obtaining a medical cannabis card. 

With a solid understanding of the components and benefits of medical marijuana, patients can begin their journey to effectively manage chronic pain, improve their well-being, and regain control over their lives.

Understanding Chronic Pain and Medical Marijuana

Chronic pain is defined as persistent discomfort lasting longer than three to six months or beyond the expected duration of injury healing. This complex and multifaceted condition is linked to various medical conditions such as arthritis, fibromyalgia, neuropathy, and inflammatory disorders. Standard medical treatments, including opioids and over-the-counter pain relievers, often provide limited relief and may carry the risk of addiction or adverse side effects.

Medical marijuana has demonstrated potential as a safe and effective alternative for chronic pain management, offering patients symptom relief and improved overall functionality. The cannabis plant contains numerous active compounds, most notably cannabinoids like THC and CBD, which interact with the body’s endocannabinoid system to modulate pain sensations. Additionally, terpenes found in cannabis can also contribute to the plant’s pain-relieving properties.

Choosing the Right Strains for Chronic Pain Relief

Various strains of medical marijuana possess distinct properties, resulting from different cannabinoid and terpene profiles. Finding the most suitable strain for chronic pain management depends on several factors, including the type and intensity of pain, individual tolerance levels, and desired effects. Some strains to consider for chronic pain relief include:

1. Harlequin: A CBD-dominant strain known for its remarkable pain relief and anti-inflammatory properties without overpowering psychoactive effects. Harlequin is ideal for patients seeking clear-headed pain relief during daytime hours.

2. ACDC: Another CBD-rich strain noted for its analgesic and anti-inflammatory effects, this plant offers minimal THC content and is excellent for patients managing neuropathic pain without strong psychoactive effects.

3. Blackberry Kush: Noted for its high THC content, Blackberry Kush provides substantial pain relief and relaxation, making this strain ideal for patients experiencing severe chronic pain who also require help falling asleep.

Exploring Delivery Methods for Chronic Pain Management

The most effective ways of administering medical marijuana for chronic pain relief can vary significantly from person to person. Key factors to consider may include the speed of onset, duration of relief, ease of administration, and personal preference. Common delivery methods include:

1. Inhalation (Smoking or Vaporizing): Inhalation offers a faster onset of effects, generally providing relief within minutes. However, the benefits may wane after a few hours. Vaporizing, or vaping, is often viewed as a healthier alternative to smoking due to reduced exposure to combustion byproducts.

2. Oral (Edibles, Capsules, or Tinctures): Oral administration often provides a longer duration of pain relief, but it can take up to two hours to experience the full effects. This method is preferable for patients seeking sustained relief and is particularly useful for patients with gastrointestinal or digestive pain.

3. Topical (Creams or Balms): Topical applications of medical marijuana-infused products are designed for localized pain relief, offering targeted relief directly to affected areas like muscles, joints, or the site of inflammation without systemic effects.

Obtaining a Medical Cannabis Card and Accessing Medical Marijuana

Navigating the process to legally obtain medical marijuana can seem intimidating, but with the proper guidance, patients can ensure they have access to the relief they seek. To access medical cannabis for chronic pain management:

1. Review State Laws: Familiarize yourself with the specific regulations in your state regarding medical marijuana and qualifying conditions, as laws and requirements vary significantly.

2. Consult with a Medical Professional: Schedule an appointment with a healthcare provider experienced in prescribing medical marijuana to discuss your chronic pain, potential benefits, and risks associated with treatment.

3. Apply for a Medical Cannabis Card: Following a recommendation from a medical professional, submit the required documentation and fees to obtain a medical cannabis card, granting you legal access to medical marijuana treatment.

4. Locate a Reputable Dispensary: Find a trusted and reputable medical marijuana dispensary in your area, where knowledgeable staff can guide you in choosing the best strains and delivery methods for your specific needs.

Responsible Use and Expectations for Chronic Pain Relief

When incorporating medical marijuana into a chronic pain treatment plan, adherence to responsible use guidelines and proper dosing is crucial. Start with low doses and gradually increase if necessary, paying close attention to the effects and potential side effects. Remember to monitor progress and adjust the strain, delivery method, or dosage as needed to find the optimal balance for relief.

Chronic pain sufferers should maintain realistic expectations when using medical marijuana, understanding that while it may provide significant relief, it may not completely alleviate all pain symptoms. Incorporating other supportive therapies, such as physical therapy, relaxation techniques, or cognitive-behavioral therapy, can contribute to a comprehensive care plan for effective pain management.

Overall, medical marijuana offers a promising and versatile option for managing chronic pain, empowering patients with the knowledge and tools to access personalized and effective care.

Embracing the Power of Medical Marijuana for Chronic Pain Relief

In conclusion, medical marijuana has demonstrated compelling potential as an alternative treatment for chronic pain sufferers seeking a safer and more natural approach. By understanding the different strains and delivery methods available, obtaining a medical cannabis card, and following responsible use practices, patients can unlock the pain-relieving powers of this versatile plant. At United Patients Group, we strive to provide comprehensive resources, expert guidance, and trustworthy product recommendations to empower patients to make informed decisions when incorporating medical marijuana into their pain management plans.

At United Patients Group, our mission is to empower patients with knowledge and resources to make informed decisions about incorporating medical marijuana into their treatment plans and to ensure they can do so safely and effectively. Explore our extensive archive of expert articles, product reviews, patient success stories, and premium products and begin your journey to a more comfortable and fulfilling life!

The post A Guide to Medical Marijuana for Chronic Pain Relief: Strains, Delivery Methods, and Obtaining a Cannabis Card appeared first on United Patients Group.

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