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LSD Effective in Treating Anxiety, Phase II Clinical Trial Shows

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A new drug known as MM-120, which is a more pharmacologically optimized form of popular psychedelic lysergic acid diethylamide (LSD), just entered phase II clinical trials for the treatment of generalized anxiety disorder (GAD) and other mental health disorders.  

What is LSD? 

LSD is a potent hallucinogenic which belongs to a class of drugs called ergolines (more specifically, LSD is an ergoline-based tryptamine compound), meaning it’s derived from the ergot fungus. Despite this, it still requires a lot of human processing to become LSD, so it’s not considered a natural entheogen like psilocybin or mescaline. LSD was first synthesized by Swiss chemist Albert Hoffman in 1938, but it wasn’t until 1943 that its effects were fully realized when Hoffman accidentally ingested a small amount from his lab.  

As a psychedelic, standard effects include various sensory hallucinations (visual, auditory, sensory, olfactory, etc.), as well as altered perception, feelings, and thoughts. Something that makes LSD unique is the duration and intensity of the hallucinogenic trip, which often ranges from 6 to 12 hours but has been reported to last even longer. This could be due to the way the drug binds to receptors in the brain. 

Like other tryptamines, LSD interacts with serotonin receptors, in particular, receptor 5-HT2AR. Something interesting that happens when LSD binds to 5-HT2AR, is that the receptor closes over the molecule, preventing it from leaving the brain quickly. This could explain why the effects of LSD seem to last after it has left the bloodstream.  

From this point, the serotonin receptor will activate two signaling pathways between the cells, via G-proteins and β-arrestins. LSD function primary through the latter, but that’s not always the case. Overall, ergoline compounds can be a bit mysterious in their processes, because different subgroups can have different effects on serotonin receptors. Add to that, newer research found that ergoline compounds can actually modify the structure of the receptors they interact with, in order to activate different effects.  

MM-120 clinical trials  

MM-120 (lysergide d-tartrate) is a new drug developed by MindMed, a biotech company the focuses on psychedelic-based medications. This drug is a “new and improved” version of LSD that is currently undergoing clinical trials for the treatment of generalized anxiety disorder (GAD). The most recent results from phase II of testing found that the drug candidate, particularly at the 100 µg dose, “demonstrated effectiveness, significantly reducing anxiety symptoms.” 

MindMed logo (source: www.mindmed.co)

Dr. Daniel Karlin, chief medical officer of MindMed, explained the key findings in an interview with Medical News Today: “MindMed conducted this study with participation from 198 patients, all of whom suffered with a primary psychiatric diagnosis of generalized anxiety disorder (GAD), across 20 clinical sites in the United States.” 

“Participants were divided into 5 study arms; each arm received a single dose of a lysergide-based drug candidate, called MM-120 (lysergide d-tartrate), or a placebo,” Dr. Karlin continued. “Among the four groups that received a dose of MM-120, doses were 25, 50, 100, or 200 µg of MM-120. Importantly, no form of additional therapy was given to any participant. The study design evaluated the stand-alone effects of the drug candidate, MM-120,” he added. 

Karlin continued: “The data available to us at this time show that patients experienced meaningful and lasting symptom reduction. Four weeks following a single dose of MM-120, 78% of participants who received either a 100 or 200 µg dose measured as having a clinically significant response to the drug. 50% of participants who received the 100 µg dose were considered to be in clinical remission at Week 4, meaning that the patient no longer suffered from clinically significant symptoms of GAD.”  

Psychedelics for mental health disorders  

Over the years, psychedelics have proven themselves to be one of the most successful treatment options for many different mental health disorders. An overwhelming 82% percent of Americans are in favor of accelerating research on this front, but federal regulations have really been a stick in the wheel of progress here. Given the introspective and sentient nature of psychedelics, it makes sense that using them therapeutically can help a person be more honest, open, and transparent.  

Although discussion of using psychedelics therapeutically is pretty fresh for most of us, many cultures have been utilizing entheogens medicinally and in religious rituals for thousands of years. Even scientists in United States and Europe were conducting research on psychedelic compounds for the treatment of mental illnesses, and it all really began to gain traction throughout the 1940s and 1950s. 

In 1943, Swiss-chemist Albert Hofmann first synthesized lysergic acid diethylamide and by the early 1950s, psychiatrist Humphry Osmond had already pioneered a treatment regimen using LSD to cure alcoholism and other mental disorders; with relative success might I add. Osmond is the one who coined the term ‘psychedelic’, meaning ‘mind manifesting’. He also oversaw author Aldous Huxley’s infamous, therapeutic mescaline trip in 1953.  

Psychedelics have been proven effective in treating various mental health disorders

Numerous psychedelic studies were in the works during that time, but all that research was derailed for social and political reasons when entheogenic compounds were banned at the start of the 1970s. Fast forward a few decades, and we are now beginning to see a growing acceptance of these compounds, especially the naturally-derived ones, and thus, an uptick in research. One of the main areas of interest is how psychedelics can help with mental health disorders such as depression, PTSD, and addiction.  

“The evidence suggests mystical experiences help people gain a new perspective on their issues,” said Matthew Johnson, the Susan Hill Ward professor in psychedelics and consciousness at the Johns Hopkins School of Medicine. “We think the long-term biological changes will be similar to those with successful psychotherapy. Essentially, the person has learned something about this problematic behavior in their life and changed their life as a result.” 

Final thoughts 

MM-120 is the closest we’ve ever had to a clinically-proven and FDA-approved LSD-based medication. Phase II trials are currently underway, so it’s well on the path to becoming available via prescriptions in select markets, although it could still be some time before we can expect more widespread use of this drug.

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Can CBD Oils Help With Anxiety & Depression

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War, relationships, political news, work at home or office, all adding to the stress of life.  For some, they can manage it and move forward, for others, it can be a pit of sadness…but most it seems experience anxiety and depression at some point. In a surprise, the Census Bureau’s Household Pulse Survey finds  half (50%) of adults ages 18-24 reported anxiety and depression symptoms. It can causes sleep deprivation, loss of energy, and high blood pressure and general uneasiness.

It is tough to deal with it while maintain your life. It is always good to talk to a trained medical professional and there are prescriptions, but can CBD oils help with anxiety & depression?

california's absurd stance on CBD cosmetics
Photo by Anshu A via Unsplash

What Is CBD?

Cannabidiol(CBD) can be extracted from cannabis plants, marijuana leaves, and hemp flowers. CBD products act as a natural remedy.  By consuming or using this product you will not get high or have any psychotic reaction. Numerous studies have been carried out on different products of CBD and a quality check has also been approved by the FDA.

Reports say that CBD has less than 0.3 % THC, which is very safe than a lot of other drugs and pills that are taken for mental health.

RELATED: How To Find High-Quality CBD Oil

CBD products are now legally consumed and distributed in many states and countries. The list includes countries like German, Canada, Denmark, Sweden, The USA & The UK.

Just like different brands of marijuana, there are also various brands of CBD oils available.

In the USA you can only use CBD products for medical purposes. It has to be prescribed by a licensed doctor for you to buy and consume it.

If your state has legalized the sale and consumption of cannabis products then it will be easier to find CBD oils in some particular cannabis clinics, shops, and online stores like CBD Oil Uk.

The Difference Between Stress And Anxiety

Stress is a short-term ailment that can happen regularly or once in a while and does not cause any serious damages. Besides, it can be managed easily.

If you face problems like frustration, exhaustion, muscle pain, digestive issues, and difficulty sleeping frequently then it is likely you are dealing with stress.

Anxiety is more severe than stress. It can not be alleviated easily. Instead, it is considered as non-stop excessive worry and fear even when everything is perfectly fine in your life.

Anxiety leads to a set of symptoms that are almost identical to stress but very serious. These include insomnia, difficulty in concentration, fatigue, and muscle tension.

It is important to differentiate the signs of stress and anxiety. Stress is a common cause of anxiety and to avoid anxiety symptoms, it is important to catch them early.

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Photo by Christin Hume via Unsplash

How CBD Products Can Help

Here are 4 ways CBD products can help reduce anxiety and depression-

1.CBD Improves Your Sleep Cycle

People suffering from anxiety often complain about the lack of sleep.

Excessive anxiety often interrupts your sleep cycle and lack of sleep can, in turn, result in more anxiety.

CBD has claimed to reduce anxiety levels. It has even shown positive results in clinical trials that is why the FDA has approved CBD in the first place.

RELATED: 5 Ways To Incorporate Effective CBD Products Into Your Everyday Life

CBD helps calm our minds and increases the chances of falling asleep naturally and without any disruption.

Also, studies have proven that little extra dosage of CBD creates a sedative effect on your body and helps to sleep and lets your brain rest. CBD products are now used to treat people with insomnia as well.

2.CBD Reduces Pain & Inflammation

Earlier we have discussed that stress and anxiety can cause muscle pain, headaches, and chronic inflammation.

CBD products are completely natural. The products have been proven to be a muscle relaxant and work better than any standard painkillers since it has no side effects.

CBD also works as anti-inflammatory drugs. It controls cytokine production which is generally responsible for various inflammatory diseases in our body.

This increased inflammation is also connected to higher levels of anxiety. Just like sleep and anxiety, this one is also a chain reaction.

Inflammatory diseases like psoriasis and arthritis can cause depression and anxiety in the long run. CBD oil helps to reduce inflammation and pain by reducing cytokine and affecting CB-2 receptors. This reduces pain and decreases the chance of getting an anxiety attack.

3. CBD improves mood

CBD is considered as a “Neuroprotective” material. “Neuroprotective” actually means it will protect nerve cells by keeping a safe functioning state of the nervous system.

Moreover, it decreases the oxidative stress of your brain.

By keeping your negative emotions in check, CBD helps you to improve your mood and keeps your brain calm and relaxed. It reduces unnecessary stress and anxiety.

4. CBD Helps Enhance Metabolism

If you have a poor digestive and metabolism system, it will affect your quality of life.

It will make you feel bloated and lethargic. Illness disrupts the natural functioning of your body and if it becomes more serious it causes stress and ultimately, leads to anxiety.

If you start consuming CBD regularly, it will improve your metabolism, burn unnecessary fat, and make you feel better.

Here Are The Most Popular Conditions CBD Can Treat
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How To Choose CBD Products

CBD has various types of products in the market including oil, tablets, edibles, beverages, creams, and vape. Although the overall vape sales slowed down during this year. Things are starting to look better.

But still, the CBD oils are the most popular ones by a large margin. Each of the types provides almost the same benefits with some unique advantages of their own.  CBD oils have to be consumed daily and provide the most health benefits. They are also the most concentrated ones.  CBD gummies are sweet and take a long time to take effect. CBD lotions are best for exterior physical discomfort.

Depending on your medical condition, you should consult with a healthcare professional who has experience with CBD to choose the right product.

 



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How Quick Can A Cannabis Gummy Calm You Down

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So days are more challenging than others and your brain goes into overdrive.  They can help, but how quick can a cannabis gummy calm you down.

Even the most upbeat, can do people can get overwhelmed and have rough moments.  But it a surprised earthquake, a flat tire, or just the day going sideways….it can start the mental path of anxiety.  The science and medical community have proven cannabis, in moderation, can reduce anxiety – but how quick can a cannabis gummy calm you down.

Low dose THC or cbd can help manage a rough day.  Gummies are easy to have with you, are discreet and can give a dose you can manage.  BDSA, a leading analytics firm which covers the cannabis industry, released data saying 49% of people who have consumed some marijuana product have used a gummy.

RELATED: 5 Morning Activities To Help You Feel Happier

Gummies are quick and, if you are not a regular user, can have 2.5-5mg dose which it good to take off the edge.  It can take from 30 minutes to an hour.  It is important to not overdose, so it is important to wait at least an hour before adding more into your system. Wana Brands have responded and developed a blend of CBD, CBG, and L-theanine (a soothing amino acid found in green tea). They can help slow spiraling thoughts within 5-15 minutes. The are low dose only one milligram of THC allowing you to take one without feeling high.

While many people report positive effects from using marijuana to cope with stress and anxiety, it’s not recommended for everyone. Individuals with diagnosed psychiatric disorders including a history CBD doesn’t the intoxicating THC, which is why it’s legal to sell online and in stores. It has  positive effects on stress and anxiety. For a majority of cases is a better alternative than marijuana for someone looking to get relief from their stress and anxiety.

RELATED: The Most Popular Marijuana Flavors

The good thing is science and the medical community back the use of cannabis and cbd as a way to relieve some anxiety.  This is unlike the old adage of having a cigarette to calm down, which was not proven.  Rather, Nicotine creates an immediate sense of relaxation, so people smoke in the belief it reduces stress and anxiety. This feeling is very temporary and soon gives way to withdrawal symptoms and increased cravings. Smoking reduces withdrawal symptoms but doesn’t reduce anxiety or deal with the underlying reason.



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Can Medical Marijuana Help During The Adderall Shortage

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Roughly 2.6% (139.8 million) of adults worldwide some form of ADHD.  With the Adderall shortage, what are the options?

In October 2022, the US Food and Drug Administration announced a shortage of Adderall.  The issue has has not be resolved and now, it seems, it is starting to have a larger effect on patients. South America (11.8%) has highest rate and Japan and Finland the lowest. American  about average (7%).  The average monthly prescription fill rate was 11% lower in the first half of 2023 than it was in the first half of 2022, and it did not show steady signs of improvement through the end of 2023.

More research needs to be done, but can medical marijuana help during the Adderall Shortage – or in general?  While scientists are still research cannabis and ADHD, there is some early data suggesting cannabis may be a helpful therapy.

RELATED: Science Says Medical Marijuana Improves Quality Of Life

Attention deficit hyperactivity disorder (ADHD) is a neurological condition which makes it difficult to focus and can lead to impulsivity and hyperactivity. ADHD is the official medical diagnosis, whereas Attention Deficit Disorder (ADD) is a now-outdated term that describes people with primarily inattentive symptoms.

While those diagnosed with ADHD may encounter trouble in school or work, most have gone on to lead successful lives. While there is no cure for ADHD, there are treatments that can help manage symptoms. Common treatments include medication, therapy, and lifestyle changes.

Can CBD Be Used To Treat ADHD Symptoms?
Photo by Katja Kircher/Getty Images

However, some people do not respond well to medication or cannot tolerate the side effects. As a result, many people turn to natural treatments like cannabis and CBD to treat their ADHD symptoms.  Any medical marijuana given to someone under 21 should be discussed with a health care professional as the research is still out and the brain is still developing.

It is worth noting there is some inconclusive evidence suggesting CBD might be used as an adjunctive treatment in schizophrenia, and a few isolated studies show CBD’s efficacy in social anxiety.

Two ways data based ways medical marijuana can help with symptoms of ADHD are sleep issues and reducing anxiety.  One of the most common reasons Americans use medical cannabis is to help with insomnia. Most people know what it is like trying to fall asleep when your mind is full of thoughts or concerns. Certain types of cannabis may help turn your busy brain into a blank board, allowing a solid night of sleep.

Another common medical reason is to manage anxiety and stress.  But certain strains of cannabis produce the same anxiety symptoms, so you have to be careful about the type of medical cannabis you choose. Stimulating cannabis strains can have a calming effect on people with ADHD symptoms. When consumed responsibly, Sativa cannabis may help calm social anxiety while allowing you to remain focused, alert, and conversational.

If you have been diagnosed with ADHD, have an open, fact based discussion with your health care profession about blending medical marijuana into your treatment.



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