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MeO-DMT – The Most Powerful Psychedelic Ever Made Gets Tested on First Human Patients in London

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Beckley Psytech, a private psychedelics medicine company, announced on Monday that the first patient has been dosed in a new research study. This study investigates the neurophysiological effects of BPL-003, the company’s innovative synthetic intranasal formulation of 5-MeO-DMT (mebufotenin), on the human brain. Beckley Psytech is funding this research at Imperial College London through a research grant.

 

This announcement follows an update from several weeks ago regarding the company’s two-part Phase IIa study, which is evaluating BPL-003 in patients with treatment-resistant depression.

 

“We are very proud to support world-leading researchers at Imperial College London in understanding how our lead compound, BPL-003, works in the human brain,” stated Dr Rob Conley, Chief Scientific and Medical Officer at Beckley Psytech. “Literature suggests an association between the intensity of psychedelic experiences and positive treatment outcomes, so we are eager to explore this further. We hope to uncover new insights that can inform our ongoing clinical studies of BPL-003 for Treatment-Resistant Depression and Alcohol Use Disorder.”

 

The new research at Imperial College will involve up to 20 healthy volunteers. During separate research visits over a month, participants will receive a 12mg dosage of BPL-003 and a placebo. Participants will have high-density electroencephalograms (HD-EEGs) performed at this time to gauge their brains’ electrical activity.

 

Unveiling New Perspectives

 

The group seeks to learn more about the effects of intranasal 5-MeO-DMT on brain activity and the processes that underlie psychedelic experiences’ reported “mystical experiences” and ego disintegration events. The project, which is being directed by Imperial College London doctoral student Tommaso Barba, is being overseen by Drs. Christopher Timmermann and David Erritzoe. The study is expected to yield preliminary results in 2026.

 

Our concept of consciousness might be completely altered by this groundbreaking study, which is the first to examine the effects of 5-MeO-DMT on the human brain. Leading the DMT Research Group at the Imperial College London’s Centre for Psychedelic Research, Timmermann said, “5-MeO-DMT is a powerful psychedelic that exhibits promise in inducing ego-dissolution states and offering insights into the interplay between experience, self-awareness, and brain function.”

 

Barba, overseeing the study, remarked, “Commencing the dosing phase of this significant study is particularly exhilarating. Despite its potency, the effects of 5-MeO-DMT on the brain remain largely uncharted. Our research is poised to propel our understanding of these compounds forward, potentially shedding light on the intricate relationship between psychedelics and the dissolution of our conventional self-perception.”

 

Potential Implications for Mental Health Treatment

 

The findings from this study might have far-reaching ramifications for mental health therapy. If BPL-003 proves helpful in altering brain activity and creating favorable psychological states, it might become a significant tool in treating disorders like treatment-resistant depression and alcohol use disorder. These disorders are generally difficult to control with present medicines, and the novel mode of action of 5-MeO-DMT could give new hope to patients who have not responded to standard treatments. By knowing how this chemical impacts the brain, researchers can create tailored strategies that harness its therapeutic potential.

 

Additionally, the potential of 5-MeO-DMT to elicit deep experiences such as ego disintegration and mystical states may play a vital part in its therapeutic benefits. These experiences are supposed to assist patients in breaking away from ingrained patterns of thought and behavior, giving a fresh viewpoint that can aid healing and personal growth. If the study verifies these results, it might lead to the creation of new treatment procedures that incorporate the use of psychedelics in a controlled, clinical context, increasing their advantages while avoiding hazards.

 

Furthermore, the success of this research might open the door for more general acceptance and usage of psychedelic-assisted therapy in the medical world. As additional information accumulates confirming the safety and efficacy of molecules like 5-MeO-DMT, regulatory obstacles may be lowered, allowing for greater access to these new medicines. This might revolutionize the landscape of mental health care, bringing new options for millions of individuals living with severe, treatment-resistant disorders, and eventually enhancing the quality of life for many.

 

Advancing the Field of Psychedelic Research

 

This study is part of a larger initiative to develop the area of psychedelic research. Beckley Psytech and Imperial College London hope that by giving empirical data on the effects of 5-MeO-DMT, they will contribute to a growing body of research that supports psychedelic therapy. The rigorous scientific process used in this study assures that the data produced is robust and dependable, establishing a high bar for future research in this field. This fundamental study is critical for establishing the scientific credibility required to integrate psychedelic medicines into standard medical practice.

 

Furthermore, the partnership between Beckley Psytech and Imperial College London is a prime example of how psychedelic research is increasingly bridging the gap between the public and commercial sectors. To speed up invention and discovery, these kinds of collaborations are essential. Academic academics who may not otherwise have the resources to study new areas in psychology and neuroscience might do so thanks to private sponsorship. This collaboration quickens the process of translating research discoveries into patient-beneficial therapeutic applications while also advancing scientific knowledge.

 

Apart from its direct scientific objectives, this research also acts as a trigger for a more extensive shift in the way society views psychedelics. Psychedelics have been vilified and rejected historically; nevertheless, new scientific data is forcing a reevaluation of them. Public and regulatory views are starting to change as studies like this one show their potential advantages, opening the door for legislative reforms that may allow for broader therapeutic usage. Beckley Psytech and Imperial College London are contributing to the reshaping of the narrative around these strong chemicals and their potential to enhance lives and alter mental health care by expanding the area of psychedelic research.

 

Bottom Line

 

The ground-breaking study carried out by Imperial College London and Beckley Psytech is a major advancement in the realm of psychedelic science. This study intends to provide new insights into consciousness and the therapeutic potential of psychedelics by investigating the neurophysiological effects of 5-MeO-DMT on the human brain. The results might completely change the way mental health treatments are provided, giving those with diseases like depression and alcoholism who have not responded to previous treatments fresh hope. As this study develops, it has the potential to improve many people’s quality of life by expanding our scientific understanding and paving the path for psychedelic therapies to be more widely accepted and integrated into conventional medicine.

 

PSYCHEDELICS FOR DEPRESSION TESTING BEGINS, READ ON..

PSYCHEDELICS FOR DEPRESSION

ERASING DEPRESSION WITH PSYCHEDELICS – PATIENT ZERO BEGINS!



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Magic Mushrooms – Should They Be Dried Out or Fresh When You Eat Them?

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If you’re considering trying magic mushrooms, you might be curious about the differences between fresh and dried varieties. Experienced users often have varying opinions on this matter. Some prefer fresh mushrooms, while others only consume them dried.

 

While many knowledgeable fans suggest dried mushrooms, some insist on consuming them raw. Of course, there are benefits and drawbacks to using fresh and dried mushrooms. We’ll talk about these variations in dose, potency, flavor, and storage.

 

We can assist you whether you’re getting ready for your first trip on psychedelic mushrooms or just want to improve your experience because there’s always something new to learn.

 

The Difference Between Fresh and Dried Mushrooms

 

Once you’ve decided to explore the realm of magic mushrooms, one of the most important decisions you’ll need to make is whether to utilize fresh or dried mushrooms. Both varieties include the hallucinogenic chemical psilocybin, therefore either will provide a psychedelic experience. However, the difference between fresh and dried mushrooms will influence dose, flavor, and storage parameters. We’ll look at these distinctions in detail below.

 

The Strength/Potency of Mushrooms

The efficacy of fresh and dried magic mushrooms differs significantly. Many users say fresh magic mushrooms are more potent than dried ones. Although not everyone shares this viewpoint, most people appear to concur. Because fresh mushrooms tend to generate a more intense trip, some users may find them more enticing.

 

Another important point is that psilocybin, the main element in magic mushrooms, is not psychoactive on its own. When psilocybin is eaten, a hallucinogenic component called psilocin is formed. Psilocybin is far more stable in fresh mushrooms than in dried mushrooms. Psilocybin breaks down in the presence of light and oxygen, which explains its stability.

 

The longer a mushroom is preserved (particularly if it is dried), the less psilocybin it contains. Because of this deterioration, fresh mushrooms might have more potent effects, and some users prefer to ingest mushrooms immediately after collecting them from a grow kit.

 

Onset and Duration

The onset of effects can vary between dried and fresh mushrooms, although individual factors also play a role. Some users report that dried mushrooms produce a faster onset, leading to a more rapid and intense experience. However, the duration of the trip is generally similar, lasting about 4 to 6 hours regardless of whether the mushrooms are fresh or dried.

 

Storage

Fresh mushrooms can have more powerful benefits, but they are more difficult to keep. Fresh mushrooms may only be stored in the refrigerator for a maximum of 5–10 days, so keep that in mind before purchasing any. In addition, compared to dried mushrooms, there’s a greater chance of spoiling. Drying the mushrooms is a sensible method of preventing waste, as a grow kit may produce a sizable harvest. When dried properly, mushrooms last for several months or even a year without losing much of their strength.

 

Difference in Taste

What flavor do magic mushrooms taste like, exactly? The usual mushrooms you get in supermarkets don’t taste like these. The taste and texture of magic mushrooms are unique, with a deep earthy flavor. Take this into consideration if you’ve never used mushrooms before. Due to the sometimes disagreeable texture of dried mushrooms, many people find fresh mushrooms to be more appetizing than dried ones.

 

Magic mushrooms, either fresh or dried, don’t have a very pleasant flavor. It is possible to improve their taste, though. They are a great addition to dishes, sauces, and tea. When heating, however, exercise caution because extreme heat can degrade psilocybin and lessen the efficacy of the mushrooms.

 

Dosage

Dried mushrooms have lost around 90% of their moisture compared to fresh ones. As a result, they weigh substantially less and have far greater psilocybin concentrations. To acquire the same impact as fresh mushrooms, use a lower amount of dried ones. For example, if you require 10 to 20 grams of fresh mushrooms for a light dosage, you should have only 1 to 2 grams of dried mushrooms. Although this may appear to be a small amount, remember that one gram of dried mushrooms has the same amount of psilocybin as ten grams of fresh mushrooms.

 

How To Consume Fresh Mushrooms

 

Here’s a guide on how to best consume fresh mushrooms:

 

1. Harvesting Fresh Mushrooms:

Fresh mushrooms, also known as “wet” mushrooms, are typically harvested before drying. Handle them carefully to maintain their potency. Look for mushrooms with fully developed caps and stems, and harvest by gently twisting or cutting them at the base of the stem.

 

2. Cleaning and Preparation:

After harvesting, clean the mushrooms properly. Use a soft brush or damp cloth to remove dirt and debris. Avoid using water, as mushrooms can absorb moisture, potentially reducing their potency. Trim any damaged or discolored parts.

 

3. Consuming Fresh Mushrooms:

Fresh mushrooms can be consumed in various ways. Here are a few popular methods:

 

a) Eating Raw: The simplest method is eating them raw. Chew thoroughly and swallow. Note that the taste and texture can be quite strong and may be unappealing to some.

 

b) Blending into Smoothies: Blend fresh mushrooms into smoothies with other fruits and ingredients to mask the taste. The sweetness and flavors of the fruits can help camouflage the mushroom’s earthy flavor.

 

c) Combining with Food: Use fresh mushrooms in your preferred dishes. Add them chopped to pasta recipes, stir-fries, and salads. Their strength may be somewhat reduced by cooking, so adjust the dosage appropriately.

 

4. Dosage and Caution:

As you eat fresh mushrooms, figure out how much is right. The potency of fresh mushrooms is influenced by their higher water content compared to dried ones. Generally speaking, you want to use around ten times as much fresh mushroom weight as dried mushroom weight. For instance, 20 grams would be the same amount of fresh mushrooms if the suggested dosage for dry mushrooms was 2 grams. However, individual sensitivity levels and the potency of mushrooms might differ, so if you’re not sure or are inexperienced, start with a lesser dosage.

 

Bottom Line

 

The decision between fresh and dried magic mushrooms ultimately comes down to taste and usefulness. Although fresh mushrooms have a more strong flavor and are frequently chosen for their texture, they are more difficult to preserve and decay more rapidly. However, because of their concentrated strength, dried mushrooms are simpler to store for longer periods and allow for a more exact dosage. Knowing these distinctions will enable you to make an informed decision that best fits your requirements and tastes, regardless of whether you’re taking psychedelics for the first time or want to maximize your experience.

 

ARE MAGIC MUSHROOMS HEALTHY, READ ON…

HEALTH BENEFITS OF MAGIC MUSHROOMS

WHAT ARE THE HEALTH BENEFITS OF MAGIC MUSHROOMS?



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Not Afraid to Die – How Psychedelics Can Help Terminal Patients at the End of Life Stage

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How Psychedelics Can Help Patients At The End Stage Of Life

 

Psychedelic drugs have long been associated with fun and recreation.


Tripping out to magic mushrooms, getting high on LSD or ketamine, spending hours in ecstasy thanks to MDMA.. these are experiences that can only be associated with positive and fun times, right? Of course! But that’s not all. While we also know that psychedelics can bring about spiritual and religious experiences, recent research and anecdotes have proven that psychedelics may also be an essential tool for patients of terminal illness – as they face the last few months or years of their lives.

 

It turns out that psychedelics actually have emotional as well as psychological benefits for terminally ill patients. Anxiety about their final day, or general death anxiety, is just one of the most common yet debilitating concerns that the terminally ill have to contend with. They also face a wide range of mental and emotional issues that can make daily life difficult, especially as their illness progresses.


Other issues that patients at the end stage of life experience include depression, suicidal ideation, fear, loss, grief, anger, frustration, regret, isolation, loneliness, and denial. The right spiritual and psychological care can help them move towards a space of peace and acceptance, instead, which are much more positive and helpful emotions. Using cannabis in hospice care is on the ballot in some states as well. How can psychedelics help with that?

 

 

Psychedelics Helps Reduce Severe Anxiety Among Terminal Patients

 

In 2016, Anthony Bossis co-authored a groundbreaking study of 29 cancer patients. During the study, he and his team discovered that just one dose of psilocybin greatly reduced anxiety and depression, which also contributed to a reduction in the hopelessness and demoralization caused by cancer among the patients. In addition, psilocybin “improved spiritual wellbeing, and increased quality of life,” they said.

In a Washington Post article on psychedelics and terminal illness, Bossis explains that exposure to psychedelics can help terminally ill patients feel a greater connection to something other than their physical selves. “After this experience, people often say, ‘I realized I’m not just my cancer. I’m not just this body. I’m something more enduring,’ he said.


There is likely a strong correlation between the spiritual experience brought about by psychedelics and the reduction of anxiety.

 

Psychedelics Reduces Fear Of Death

 

In 2022, Johns Hopkins Medicine released the results of a poll of over 3,000 adults which helped them compare near-death experiences with psychedelic drugs. The participants were divided into several groups: those who had non-drug related near death experiences, while the rest had psychedelic experiences with either LSD, ayahuasca, psilocybin, or DMT.

The researchers found interesting results, particularly that there were significant similarities among people’s attitudes towards death. Specifically, they found that just one treatment with psilocybin resulted in a sustained reduction in depression and anxiety among patients with terminal cancer. They found that around 90% of the participants, both who had near death experiences and psychedelic experiences, reported a decrease in death anxiety when they considered how their perceptions changed afterwards.

Meanwhile, many participants belonging to both categories said that their experience was among the top most significant and meaningful in their lives. They also admitted to having strong to moderate positive changes that affected their well-being and life purpose afterwards.

 

Psychedelics Reduces Depression Among Cancer Patients

 

In 2021, researchers at the Aquilino Cancer Center enrolled 30 cancer patients with major depressive disorder into a feasibility study. They were given a 25mg dose containing synthetic psilocybin called COMP360; each of them were also provided with one-on-one support with therapists over the course of their 6-8 hour treatment.

 

What followed was 8 weeks of monitoring to observe any changes in symptoms of depression. Half of the study’s participants were already taking antidepressants for their depression, and others were being treated for cancer. However, most of the patients didn’t have any previous experience with psychedelics. Using the Montgomery-Asberg Depression Rating Scale (MADRS), participants were asked to rate their depression symptoms through a survey.


While all 30 patients started with a 25.9 MADRS score, which reveals moderate depression, the period following psilocybin therapy reduced the score by 19.1 on average. “Cancer can ravage a patient’s entire life. In addition to attacking the body, cancer also impacts a patient’s mental and emotional wellbeing. It’s time we practice whole-person healing in oncology, which means meeting all the needs of our patients, both physical and psychological,” said Paul Thiambi, MD, one of the researchers in the trial.

 

Current Challenges Among Clinical Trials

 

Studying the benefits of psychedelic drugs for the terminally ill is still at its infancy. While the medical industry has surely made strides in this aspect, there’s also still a lot that we don’t know. Researchers face several obstacles that prevent them from making solid claims at this point, especially the fact that it’s difficult to ensure both participants and researchers alike have no clue they’re using the real thing or a placebo.


Furthermore, how psilocybin works in the human body is still largely mysterious. While we can certainly say that many terminally ill participants surely report less anxiety and depression after taking psychedelics, we aren’t sure how it works to cause that. There are some studies that point to stronger mystical or spiritual experiences, even among patients who weren’t actually religious, after taking psilocybin or other psychedelic drugs.

 

On top of that, there’s also the ethics and legalities that surround it. In most states, psychedelics resides in a legal gray area. Even if patients themselves want to access psychedelics, medical institutions and the law can make it challenging because of the ethical considerations of doing so.

 

Conclusion

 

No matter which way you look at it, psychedelics as a tool for terminally ill patients is indeed promising. Everyone wants to meet their final days with as much grace as possible.  

 

Thanks to the promise of psychedelics, we may be looking at a big shift in how traditional end-of-life care is approached. Terminally ill patients don’t have to go living their last few months under psychological and emotional distress; a small amount of psychedelic treatments could go a long way. One thing’s for sure: use must be properly managed in order to maximize the drug’s benefits and safety.

 

CANANBIS OR PSYCHEDELICS FOR END OF LIFE, READ ON..

marijuana in hospice

SHOULD CANNABIS BE PART OF HOSPICE END OF LIFE CARE?



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The FIFA Cannabis Cup? – Authorities Tell Football Fans to Get High and Not Drunk before European Football Match

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German police would rather have cannabis in their country than have to deal with rude, drunk football fans from England. They shared this view recently, as they get ready for a big sports event that will change the area.

 

The UEFA Euro 2024 is set to take place in Germany from June 14 to July 14. Fans from all over Europe are getting ready for the tournament. Among the 24 teams competing for the European Championship trophy are England and Scotland. Last weekend, about 40,000 fans of the England team, known as the Three Lions, gathered in Gelsenkirchen for England’s first game against Serbia.

 

To handle the large crowds and prevent trouble, a huge security operation was set up. Many news media outlets report that the operation was bigger than ever before to stop any “hooliganism.” English football fans have been warned not to chant offensive songs that might anger fans from other teams.

 

The 2024 UEFA European Football Championship is the 17th time this event has been held. It is organized by UEFA and features men’s national teams from its member countries. The team that wins Euro 2024 will go on to play in the 2025 CONMEBOL–UEFA Cup of Champions against the winner of the 2024 Copa América.

 

German police hope that by being strict and prepared, they can keep the peace and ensure that everyone enjoys the football matches without any major incidents. They believe that keeping order is crucial for the success of this major international event.

 

In an unconventional move, German police are encouraging England fans heading to UEFA Euro 2024 to choose cannabis over beer to maintain peace. At the Veltins Arena in Gelsenkirchen, low-alcohol beer will be served to minimize potential trouble, but the local police are promoting another strategy: offering pot to fans.

 

Cannabis, known for inducing a calmer state of mind, is seen as a way to keep emotions in check and prevent aggression. “It’s no problem for fans to smoke cannabis on the street,” a Gelsenkirchen Police spokesperson told The Sun. “If we see a group of people drinking alcohol and looking a bit aggressive, and another group smoking cannabis, of course we’ll look at the group drinking alcohol. Drinking alcohol can make someone more aggressive, and smoking cannabis puts people in a chill mood. We want to prevent violence and keep people safe.”

 

The spokesperson emphasized that the focus will be on monitoring fans consuming alcohol, which has a higher potential for inciting violence. “That’s why we have safety precautions in place regarding alcohol.”

 

Chief Inspector Christof Burghardt echoed these sentiments, describing England’s opening game as “high-risk” due to the historical presence of hooligans on both sides. “Serbia has many hooligans. The English guys, with alcohol, they are very aggressive. So it’s a great job to do this, to prepare, so that hopefully nothing will happen,” Burghardt told Sky News.

 

Burghardt highlighted the importance of early intervention to prevent violence. “The biggest challenge for us will be to identify violent, disruptive groups at an early stage, to separate them from peaceful and law-abiding fans.”

 

By encouraging cannabis use and limiting alcohol, German authorities aim to create a safer, more relaxed environment for all fans attending Euro 2024. This approach marks a significant shift in crowd control strategy, focusing on reducing aggression and ensuring the safety and enjoyment of the event for everyone.

 

Germany Legalizes Recreational Cannabis Use

Germany has taken a bold step by legalizing cannabis for personal use, effective April 1, 2024. This groundbreaking move ends the prohibition for adults, allowing possession, home cultivation, and the establishment of cannabis clubs.

 

The legislative journey began with the Bundestag, Germany’s parliamentary chamber, which approved the bill earlier in the year. The final nod came from the Bundesrat in March, representing the country’s 16 federal states. Under the CanG bill, adults aged 18 and older can possess up to 25 grams of cannabis and store up to 50 grams at home. Additionally, individuals are permitted to grow up to three cannabis plants per household.

 

On July 1, Germany’s cannabis legalization plan fully rolled out, introducing non-commercial cannabis clubs. These clubs provide members access to legally cultivated cannabis and are capped at 500 members each. While the legislation allows for these clubs, it does not extend to for-profit cannabis producers or retailers, maintaining a strictly non-commercial approach.

 

This progressive change in policy marks a significant shift in Germany’s approach to cannabis, promoting safe and regulated use among adults. By establishing cannabis clubs and permitting limited personal cultivation, Germany aims to create a controlled and responsible environment for cannabis consumption. This historic move is set to influence cannabis policies across Europe and offers a new model for regulation and community-based cannabis use.

 

“The fight was worth it,” proclaimed Health Minister Karl Lauterbach on X, as reported by Politico. “Please use the new option responsibly.” He added, “Hopefully, this is the beginning of the end for the black market.”

 

With the Bundesrat’s approval, Germany is set to join Malta and Switzerland in the elite group of European nations embracing limited cannabis legalization. This historic move allows adults to legally possess and grow cannabis, offering a safer alternative for inebriation at football events.

 

For British football fans, this new law presents an opportunity to reshape their reputation. By choosing cannabis over alcohol, they can enjoy the games without the aggression often fueled by excessive drinking. This shift could lead to a more relaxed and peaceful atmosphere at matches, aligning with Germany’s innovative approach to crowd management.

 

As Germany leads the way in cannabis reform, the impact on sports events and public behavior will be closely watched. This bold step not only marks a significant policy change but also sets a new standard for responsible enjoyment and public safety at large gatherings.

 

Germany’s recent cannabis legalization allows adults to possess and cultivate it, aiming to curb violence and reshape fans’ reputations, ensuring a safer and more relaxed atmosphere at the tournament.

 

SOCCER MOMS LIKE WEED TOO, READ ON…

SOCCER MOMS LIKE WEED

SOCCER MOM RUNS MILLION DOLLAR MARIJUANA GROW!



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