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Study: More older adults are using cannabis post-pandemic

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Hunter Boyce | (TNS) The Atlanta Journal-Constitution

A new study, published in the Cannabis and Cannabinoids Research journal, found more older Americans are using cannabis today than before the pandemic. According to researchers with the University of Michigan’s Institute for Healthcare Policy and Innovation, roughly 1 in 8 Americans over 50 currently use the substance.

“As the stress of the pandemic and the increased legalization of cannabis by states converged, our findings suggest cannabis use increased among older adults nationally,” addiction psychologist and study lead Anne Fernandez told the University of Michigan.

Read the rest of this story on BostonHerald.com.



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Researchers say cannabis may help treat Covid-19

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Researchers have been investigating cannabis as a possible treatment for Covid-19 since the pandemic began in 2020. They directed much of their attention towards cannabis’ ability to dampen the immune system and quell cytokine storms, a dangerous and potentially deadly immune response that occurs in severe Covid-19 cases and leads to respiratory distress and organ failure. Since then, scientists have identified a variety of ways cannabis might be helpful in fighting the disease. 

https://www.leafly.com/news/science-tech/researchers-say-cannabis-can-help-treat-covid-19?utm_source=blast&utm_medium=email&utm_campaign=trf-nl-all



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Medical pot patients’ lives improved during 1-year study

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A recent study conducted by a group of UK-based researchers found that medical cannabis was associated with improvements in health-related quality of life, anxiety, and sleep quality. This research adds to the growing body of literature suggesting that medical cannabis can help patients with chronic health conditions improve their well-being. The study also observed a reduced use of opioid medications among cannabis patients, and found that patients prescribed dried cannabis flower (versus tinctures and lozenges) were most likely to show clinical improvement.

The complex and nuanced task of studying cannabis

The cannabis plant is an incredibly complex and variable medicine. It contains over 400 chemical compounds, more than 100 of which have known medical effects. These chemicals are present in different amounts and combinations in cannabis, depending on numerous factors: The particular strain, the way it was grown, the way it was processed, and the way it is consumed. 

The authors of this study took a different route: They studied the effects of specific regimens of medical cannabis and their effects on patients’ well-being.

When observational studies investigate cannabis use, they often capture results from a wide variety of different substances, not just cannabis. More controlled studies—there aren’t many—tend to focus on one or two isolated components of cannabis. While these studies provide more specific results, they don’t tell us much about how the various compounds interact with each other. This makes cannabis extremely challenging to study. 

The authors of this study, however, decided to take a different route: They studied the effects of specific regimens of medical cannabis and their effects on patients’ well-being. By keeping track of the particulars of the medical cannabis in question, they hoped to gather data that could give us more specific information about cannabis’ effects.  

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Can cannabis improve quality of life? 

In this study, the researchers analyzed data from a cohort of 1,378 medical cannabis patients in the UK. About 40% of the patients were already consumers when the study began; the rest were not. 

These patients had been prescribed a variety of specific cannabis options, including inhaled dried flower, sublingual oils, or a combination of the two (based on the medical needs of the patient).

At the start of the study, researchers collected information about patients’ demographics, conditions, medications, and occupations, as well as their history with cannabis, other drugs, and alcohol. Patients’ primary reasons for using cannabis varied, but the most common reasons were chronic pain, neuropathic pain, fibromyalgia, and anxiety.  

The authors found statistically significant improvements from baseline on all measures—anxiety, sleep quality, and health-related quality of life—at each benchmark.

Once the study began, patients were given a variety of self-reporting assessments they could use to describe their health-related quality of life, anxiety, and sleep quality. The first assessment was given before patients began their cannabis regimen. Patients were given additional assessments 1, 3, 6, and 12 months into the program. 

After analyzing the data from the year-long study, the authors found statistically significant improvements from baseline on all measures—anxiety, sleep quality and health-related quality of life—at each benchmark. The data suggested that cannabis was benefiting these patients. 

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Patients in the study who used opioid medications also reported reducing their opioid use during the study. The greatest reduction (5.66%) occurred after one year of cannabis use. 

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Dried cannabis flower showed the biggest improvements

In an interesting twist, the study also found that patients prescribed dried cannabis flowers—rather than sublingual cannabis options, like tinctures or lozenges, alone—experienced more substantial improvements. Dried flowers are the raw form of cannabis, usually consumed by smoking or vaporizing. Sublinguals, on the other hand, are a more processed form of cannabis which can be absorbed through the mucosal membranes in the mouth. 

While patients who used both cannabis flowers and sublingual cannabis saw similar results to those using cannabis flowers alone, patients using solely sublinguals had less significant improvements. Those patients nonetheless saw improvements from baseline at each check-in. 

While roughly one-fifth of the patients did experience negative side effects from cannabis, the majority of those side effects were moderate or mild. Researchers observed that the most common side effects were fatigue, somnolence (excessive sleepiness), dry mouth, lethargy, and headache. One of the 1,378 patients experienced a single episode of psychosis. Lastly, the patients who were already using cannabis at the onset of the study demonstrated less negative side effects than those who had been abstinent.

We need more cannabis research

While this study provides valuable insight—and supports the idea that cannabis can improve our quality of life—it does have some limitations. As an observational study, it cannot prove that cannabis caused the improvements, only that a correlation exists. Additionally, since many patients were already cannabis consumers, the study may be biased towards them, since cannabis is evidently effective for them. Future research should include randomized and controlled double-blind studies. 



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Fact check: Is legalization hurting teen mental health?

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If you read this January 10 Wall Street Journal piece, you might conclude that a wave of cannabis-induced psychosis among teenagers is sweeping the country. The story highlights research on the correlation between cannabis use and conditions like schizophrenia and bipolar disorder. It suggests access to higher-potency cannabis is leading to ever-increasing rates of psychosis in teens. 

But the actual data paints a different picture. Population studies of over 63 million people show that rates of psychosis do not go up amid legalization. Teen use rates of marijuana are actually going down. And our best science suggests that genetic factors—rather than cannabis use—are to blame for the correlation between cannabis and psychosis. 

Can cannabis really induce life-long psychotic conditions—or is this yet another example of confusing correlation with causation, a common source of “reefer madness?”

The research on cannabis and psychosis is nuanced, but it definitely shows a strong correlation—as opposed to a causation—between the two. For instance, the data is clear that acute cannabis exposure can cause you to see vivid colors, or mis-hear sounds, or get anxious. These experiences have been described as transitory “psychosis-like” episodes—particularly for occasional users

Confusing correlation with causation

With that in mind, it might not be surprising that when teens who use cannabis develop permanent psychosis-related conditions, their doctors and loved ones jump to the conclusion that cannabis caused the shift. There are numerous stories of teens who used cannabis and were subsequently diagnosed with these challenging, life-long conditions. Statistically, individuals who use cannabis are more likely to have bipolar disorder or schizophrenia than the general population

But scientists have long struggled with the question of whether cannabis use actually causes these conditions—or if a third factor drives both. Based on cases where these conditions emerge after cannabis use, researchers estimate that cannabis-induced psychosis occurs in .0027% of consumers. But even at this exceptionally rare rate, correlative studies can’t prove whether cannabis is the cause of psychosis or not. 

There are many ways to interpret the data that associate cannabis with psychosis. For example, individuals with psychosis conditions could be more likely to use cannabis in the first place, as a form of self-medication. If this were true, it would result in the same strong correlation.

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Other correlates: Alcohol, tobacco

Cannabis certainly isn’t the only factor linked with psychosis, even though it receives more publicity. Studies have found many things correlate with higher risk of psychosis, including the use of any recreational substance, like alcohol and tobacco. These substances are used at similar rates by schizophrenics as cannabis, and show similar statistical increases in psychosis risk. No one is debating, however, whether we should prohibit these substances. 

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Life stressors

Stress also frequently correlates to psychosis. The stress associated with an event like a teenager leaving home to begin college can trigger an initial psychotic episode.

One review study found that the strongest factors correlated with developing lasting psychosis include a) living in an urban area and b) being an ethnic minority. Since cannabis is often used to combat stress, it’s possible that people who are stressed out enough to develop psychosis are more likely to seek out cannabis.

Spice, K-2, and designer drugs 

And lastly, studies that associate cannabis with psychosis don’t specify which specific cannabinoids are at play. For example, businesses like head shops and truck stops sell unlicensed, unregulated—and often illegal—synthetic cannabinoids (THC-O, THC-P, HHC, etc.) that can be hundreds of times more powerful than THC alone. 

The use of dangerous synthetics like Spice prevails in states that lack access to legal botanical THC. Athletic and military THC testing regimes also induce players and servicemembers to seek out novel, dangerous synthetics that won’t show up in a drug test.

Data suggests that using synthetic cannabinoids can induce more symptoms of psychosis than natural cannabis.

cannabis use survey, youth cannabis consumption
(Iuliia Kanivets, CSA-Printstock/iStock)

Legalization isn’t increasing teen use

Some research also suggests that cannabis use among teenagers in particular has a strong correlation with a subsequent diagnosis of a psychosis-related condition. This could mean that teens are particularly vulnerable to cannabis’ effects. But it could also point towards the fact that conditions like bipolar disorder and schizophrenia are most commonly identified and diagnosed while patients are in their twenties, while cannabis use usually begins during teenage years. It is possible that individuals with these conditions would be more likely to self-medicate with cannabis; since this typically occurs before their diagnosis, doctors and scientists would assume that cannabis caused the psychosis-like condition.

While many prohibitionists would use any potential for teen psychosis as a reason to limit cannabis legalization, it’s important to note that rates of teen cannabis use are going down, not up, as states legalize cannabis. Street dealers do not check ID, but legitimate dispensaries do. This means that legalization tends to limit teen access, rather than increasing it. 

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Cannabis Legalization and Teenage Use: What Do Studies Tell Us?

Psychosis rates *do not* increase with cannabis legalization 

Fortunately, scientists dig deeper than simple correlative studies. For instance, they look at the rates of psychosis in places where cannabis is more available. If cannabis’ prevalence causes psychosis, it would follow that as cannabis access increases, we would see rising rates of psychosis. 

While legalization does increase rates of other conditions that are directly triggered by cannabis use, such as cannabinoid hyperemesis syndrome, the studies that examine psychosis rates have had very mixed results. 

The WSJ article mentioned earlier in this article cites a small Danish study that examined data collected from 6,788 people in 11 locations throughout Europe and Brazil. None had access to tested, legal cannabis.

While it did find a link between access to high-potency cannabis and psychosis, a much larger US study involving over 63 million people found that access to medical or recreational cannabis had no impact on psychosis rates at all. If we were seeing a dramatic wave of teen psychosis in the US, as suggested in the recent WSJ piece, that shift should be reflected in this large-scale population study. 

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Amid legalization, teen hospitalizations for pot down 50%, CDC finds

Genetics may drive cannabis use as well as mental health outcomes 

Psychosis rates haven’t skyrocketed with the recent increase in legal cannabis access, so why do we see any correlation between the two? 

Beyond the possibilities suggested above, genetics may play a key role. Scientists have found data that points to underlying genes that predispose someone to both psychosis and cannabis-use disorder. (Doctors diagnose cannabis-use disorder when someone experiences negative effects from cannabis use, wants to stop using it, but cannot bring themselves to quit despite repeated efforts.)

Research reviews have found that an individual who has genetics correlated with cannabis-use disorder may be more likely to develop schizophrenia, whether or not they actually ever used cannabis. This suggests that genetics, rather than cannabis, is to blame. 

One the best-designed studies just came out. In January, researchers published a rare study of more than 4,000 identical twins over time. One twin used weed while the other didn’t, and researchers tracked them for 27 years. Weed use did not predict mental health outcomes.

“Cannabis consumption did not predict within-pair differences in psychoticism.”

Zellers, 2024, Journal of Psychopathology and Clinical Science

“Cannabis consumption did not predict within-pair differences in psychoticism,” the researchers concluded.

There’s a big takeaway here: If you have a family history of mental illness, and are increasing your cannabis use, you might want to re-evaluate your habits.

The data also supports maintaining 21 as the legal appropriate age for cannabis consumption; that’s typically towards the back end of when congenital mental illness may crop up in an individual. 

While more research may shift our understanding of these issues, the current data does not suggest that cannabis use is a strong causal factor for chronic mental illness. Still, given cannabis’ ability to cause visual effects or strange thoughts, THC may be best avoided by at-risk patients. At the same time, doctors are actively evaluating whether the cannabinoid CBD can treat mental illnesses. 

As always, consult with a cannabis-specializing doctor before beginning medical use of cannabis to treat your symptoms.  



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