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CBD Amplifies The Adverse Effects Of THC, New Study Finds

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A new study has unearthed a controversy on the interaction between the psychoactive cannabinoid THC and its mellow counterpart CBD. For the longest time, it’s been believed that combining CBD with THC enhances the therapeutic benefits of both while limiting some of the adverse effects attached to THC.

The exact mechanisms have been hypothesized with the message being loud and clear: CBD is THC’s perfect complement and antidote. But results from this new study found that this is not entirely the case.

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Details of the study

A group of researchers from the Behavioral Pharmacology Research Unit at Johns Hopkins University conducted a randomized clinical trial to investigate the effects and side effects of cannabis edibles containing both THC and CBD in equal amounts.

The study model was a double blind crossover that included 18 healthy adults. This involved three randomized outpatient test sessions; each session one week apart. The participants were divided into three groups and offered brownies containing either of the three:

  • No cannabis extract (placebo)
  • 20 mg Δ9-THC with no CBD
  • 20 mg Δ9-THC + 640 mg CBD

The group that received CBD in addition to THC experienced more severe adverse effects compared to the THC only group. Researchers found that CBD inhibits the breakdown (metabolism) of THC, thus increasing its adverse effects by increasing circulating levels and active metabolite.

Contradictory Evidence: Is There an Ideal Way to Mix CBD With THC?

There are a number of studies that contradict the major claim in this article, that CBD worsens the adverse effects of THC. Let’s look at a few:

A 2019 study was conducted by the Western University to investigate how CBD affects the psychiatric side effects of THC. The rats offered THC were more anxious and fearful while the rats that were offered both CBD and THC were less anxious and fearful.

RELATED: Does CBD Minimize The Harmful Effects Of THC? New Study Has Answer

The researchers found that CBD attenuates some of the psychotropic side effects caused by THC by inhibiting THC’s ability “to overstimulate the ERK pathway.” The results of the study were published in the Journal of Neuroscience.

A different systematic review investigated the influence of CBD on the acute effects of THC. The researchers found that in most studies CBD reduced the adverse effects of THC. However,  these studies have used different ratios of THC to CBD.

RELATED: If THC Percentage Doesn’t Matter, Why Not Just Smoke CBD?

With the medical cannabis industry taking shape, it’s imperative to speed up research so as to find the best ways to offer cannabinoids to patients.

This article originally appeared on MyCannabis.com and has been reposted with permission.



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The Economic Impact of Cannabis

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The Economic Impact of Cannabis: A Growth Engine for Local Economies

The rapid expansion of the cannabis industry is reshaping local economies, injecting over $100 billion into the US economy in 2023, with a projected 12.5% growth in 2024. This significant impact is supported by companies like Seed Connect, a US-based cannabis seed bank.

Beyond direct sales, the broader economic ripple effect benefits various sectors, enhancing both community development and financial prosperity. The contribution of cannabis to local economies extends beyond mere financial injections.

RELATED: California or New York, Which Has The Biggest Marijuana Mess

For every $10 spent on cannabis products, an additional $18 flows back into the economy, driving economic activity that supports small businesses, creates jobs, and generates substantial tax revenue.  This multiplier effect underscores cannabis as a robust driver of local economic growth.

marijuana money
Photo by Cappi Thompson/Getty Images

States like California, Colorado, and Washington have seen cannabis tax revenues surpass those from alcohol, highlighting the industry’s potential as a significant fiscal contributor.

The ongoing legalization and increasing acceptance of cannabis across the U.S. promise to amplify these economic benefits. Furthermore, the cannabis sector has become a critical employment hub, supporting over 400,000 full-time jobs nationwide.  This number is expected to rise as the market expands, illustrating the industry’s role in fostering a diverse range of job opportunities across retail, cultivation, and beyond.

The economic dynamics of the cannabis industry also include enhancing public health outcomes.

RELATED: Cannabis Industry Employs The Same As These Companies

Many localities utilize cannabis tax revenues to fund public services such as education and healthcare, directly benefiting community welfare.

Moreover, the industry’s growth encourages sustainable agricultural practices and technological innovations that further enhance its economic and environmental impact.

Considering these factors, the economic influence of cannabis not only represents a compelling narrative for States contemplating or already benefiting from legalization but also positions the industry as a pivotal element in future economic planning.

Investors, policymakers, and community leaders are increasingly recognizing the potential for sustained economic benefits, making cannabis a crucial area of interest in economic development discussions.

As the cannabis industry continues to evolve, its capacity to contribute to economic stability and growth becomes ever more apparent, ensuring a dynamic and resilient future for local economies.



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These Two Iconic Cannabis Companies Could Disappear

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Both were high flying symbols of the promise of the legal cannabis industry.  Both, at one point, led by an Adam and both made mainstream headlines.  Now, as the cannabis world take another key step toward mainstreaming, these two iconic cannabis companies could disappear. Both High Times and Medmen went into receivership in the month of April.

RELATED: California or New York, Which Has The Biggest Marijuana Mess

As the cannabis industry enters a new era, both companies straddled the gulf between the weed wild wild west and today’s market-price/share-price focus.  Early on, each became the darling of media attention and part of the general population’s conversation. Medmen’s antics saw them skewered on the hit show South Park.  Both became regulars on Cheddar as industry thought leaders. High Times, the founder of the original cannabis cup, made high flying deals, did a controversial “non” public offering, and, in looks, expanded into dispensaries.  Both are now in court waiting to see what happens to the companies and assets.

Photo courtesy of Medmen

Medmen hit the market in 2010 with co-founder in Adam Bierman and Andrew Modlin. In 2018 MedMen West Hollywood was one of the first legal cannabis dispensaries to open in California. Hailed as the Apple Store of weed, their slick design captured the feel of the new wider market and set the pace for of retails wishing to attract an expanding mainstream consumer. From there came an expansion including an expensive sort of store on 5th Ave in New York City, greenhouse grows, a REIT, and lots of press.  Things began changing when they went public with a reverse merger.  Things took an ugly turn with a messy lawsuit with the outgoing CFO, the the Journal of the American Medical Association called them out for their marketing, and things went down hill quickly. On March 11, 2024, it was reported by several sources that Medmen had closed operations everywhere except for in San Diego and near LA International Airport. It was announced the company is $411 million in debt while awaiting the court’s decision about their future.

RELATED: Cannabis Industry Employs The Same As These Companies

High Times was the leader of the marijuana movement, helping people learn, engage and get stoned. They taught people the value of medical marijuana and brought celebrities to the forefront of the movement. Then the 44-year-old magazine was sold to a group of investors led by Adam Levin and the Los Angeles-based Oreva Capital for $42 million. Rumor has it, the founder’s widow is still owed money from this deal. Levin claimed he could raise the value of the company to $100s of million of dollars, but followed was a messy, tangled trip leaving heartbroken investors behind. Multi rounds of funding with a variety of valuations, a semi-offering to the general public at $11 a share, cancelled cannabis cups, and a web of activities raised eyebrows. From a practical point of you, the site never really looked at the new legal market, they figured the newbies would immediately embrace the legacy culture. Instead, companies like Wana Brands appealed to them with gummies named Calm. The movement moved on and High Times tried to enter the dispensary market. Now all the assets sit with a receiver and the fate of the legendary leader is unknown.

These are the tails of a fast rising, consumer driven, mainstreaming industry.



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The Benefits Of Consuming Marijuana Alone

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Some times you want to relax and just chill in your own head – and that is 100% ok

Trivia night, parties, hanging with friends, sporting events…all group activities when you might imbibe in something to add to the fun atmosphere. Heading to a bar, going out to eat, or family events might including a bit of booze or a small toke.  Both can put you in the right mood. But here are the benefits of consuming marijuana alone.

RELATED: Science Explains How Marijuana Inspires Awe 

Drinking alone can cause issues as alcohol can have different effects. A big difference between marijuana and alcohol is the latter is a depressant. Cannabis, in the right dosage,  tends to reduce anxiety and can help battle depression.  Also, overindulges with weed leads to falling asleep, where overdoing it with cocktails can lead to blackout and serious help issues.

13 songs to add to your smoke sesh playlist
Photo by Matthew Henry via Burst

Marijuana is surprisingly effective and malleable when consumed alone. If you challenge yourself, it can be used for different activities including creative, social and physical. When getting the dosage right, weed can act as a stimulant for your brain, helping you journal and doodle, or for your body, pushing you to workout or clean and sort through your closet.

Another benefit is you can enjoy the wonder of being in a high state of mine.  Experts express they love watching a movie on a large screen as it makes them feel they are in the movie (probably not a good idea to watch horror films). It can almost make you feel like you meld with music. when you’re high because cannabis affects your sense of timing. When you smoke weed, your brain slows down and becomes more sensitive to the rhythms in music. It makes it easier to appreciate the subtleties in the music

Personal reflection and growth are other prime reasons for solo cannabis consuming. It allows individuals to immerse themselves in a deep journey into their own being, stripped of the distractions and outside influences that often cloud our understanding.  For introverts, this can be time to balance and recharge.

RELATED: How To Know If You’re Buying High Quality Marijuana

The best part about marijuana is you can enjoy it without ahangover allowing you the next day to be productive.  Before diving in to your solo marijuana journey and all of the perks it can result in, here are the best & safest practices.



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